ATE267793T1 - 5,6-dihydronaphthalenylderivate mit retinoid- artiger aktivität - Google Patents

5,6-dihydronaphthalenylderivate mit retinoid- artiger aktivität

Info

Publication number
ATE267793T1
ATE267793T1 AT99948322T AT99948322T ATE267793T1 AT E267793 T1 ATE267793 T1 AT E267793T1 AT 99948322 T AT99948322 T AT 99948322T AT 99948322 T AT99948322 T AT 99948322T AT E267793 T1 ATE267793 T1 AT E267793T1
Authority
AT
Austria
Prior art keywords
dihydronaphthalenyl
derivatives
retinoid
activity
formulaepossess
Prior art date
Application number
AT99948322T
Other languages
English (en)
Inventor
Anne Marinier
Yong-Jiang Hei
Philippe Lapointe
Jean-Paul Daris
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE267793T1 publication Critical patent/ATE267793T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/66Polycyclic acids with unsaturation outside the aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99948322T 1998-09-24 1999-09-16 5,6-dihydronaphthalenylderivate mit retinoid- artiger aktivität ATE267793T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10160998P 1998-09-24 1998-09-24
PCT/US1999/021598 WO2000017147A1 (en) 1998-09-24 1999-09-16 5,6-dihydronaphthalenyl derivatives having retinoid-like activity

Publications (1)

Publication Number Publication Date
ATE267793T1 true ATE267793T1 (de) 2004-06-15

Family

ID=22285543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99948322T ATE267793T1 (de) 1998-09-24 1999-09-16 5,6-dihydronaphthalenylderivate mit retinoid- artiger aktivität

Country Status (14)

Country Link
US (1) US6194601B1 (de)
EP (1) EP1115687B1 (de)
JP (1) JP2002526465A (de)
CN (1) CN1134405C (de)
AT (1) ATE267793T1 (de)
AU (1) AU761572B2 (de)
BR (1) BR9913925A (de)
CA (1) CA2344310A1 (de)
DE (1) DE69917660T2 (de)
DK (1) DK1115687T3 (de)
ES (1) ES2221754T3 (de)
PT (1) PT1115687E (de)
TR (1) TR200100858T2 (de)
WO (1) WO2000017147A1 (de)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780676A (en) * 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
US5648385A (en) * 1994-01-03 1997-07-15 Bristol-Myers Squibb Co. Retinoid-like compounds
US5648514A (en) 1994-12-29 1997-07-15 Allergan Substituted acetylenes having retinoid-like biological activity
US5618943A (en) * 1994-12-29 1997-04-08 Allergan Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5489584A (en) * 1994-12-29 1996-02-06 Allergan, Inc. Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5514825A (en) * 1994-12-29 1996-05-07 Allergan, Inc. Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5599967A (en) * 1994-12-29 1997-02-04 Allergan Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity
US5543534A (en) * 1994-12-29 1996-08-06 Allergan Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
WO1997048672A2 (en) * 1996-06-21 1997-12-24 Allergan Sales, Inc. Substituted tetrahydronaphthalene and dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity

Also Published As

Publication number Publication date
CN1134405C (zh) 2004-01-14
WO2000017147A1 (en) 2000-03-30
DK1115687T3 (da) 2004-09-20
AU761572B2 (en) 2003-06-05
CN1319083A (zh) 2001-10-24
US6194601B1 (en) 2001-02-27
DE69917660T2 (de) 2005-06-16
CA2344310A1 (en) 2000-03-30
DE69917660D1 (de) 2004-07-01
JP2002526465A (ja) 2002-08-20
PT1115687E (pt) 2004-09-30
ES2221754T3 (es) 2005-01-01
EP1115687A1 (de) 2001-07-18
AU6152899A (en) 2000-04-10
BR9913925A (pt) 2001-06-19
EP1115687B1 (de) 2004-05-26
EP1115687A4 (de) 2002-06-05
TR200100858T2 (tr) 2001-10-22

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