IS4970A - Setnar 6,6-heteró-bísýklískar afleiður - Google Patents

Setnar 6,6-heteró-bísýklískar afleiður

Info

Publication number: IS4970A
Authority: IS; Iceland
Prior art keywords: hetero; determines; bicyclic derivatives; bicyclic; derivatives
Prior art date: 1996-08-27

Application number

IS4970A

Other languages

English (en)

Inventor

Liang Chen Yuhpyng

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-27

Filing date

1999-02-05

Publication date

1999-02-05

1999-02-05 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

1999-02-05 Publication of IS4970A publication Critical patent/IS4970A/is

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Immunology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Hematology (AREA)
Nutrition Science (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Rheumatology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Virology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)

IS4970A 1996-08-27 1999-02-05 Setnar 6,6-heteró-bísýklískar afleiður IS4970A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2465996P	1996-08-27	1996-08-27
PCT/IB1997/000904 WO1998008846A1 (en)	1996-08-27	1997-07-21	Substituted 6,6-hetero-bicyclic derivatives

Publications (1)

Publication Number	Publication Date
IS4970A true IS4970A (is)	1999-02-05

Family

ID=21821740

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS4970A IS4970A (is)	1996-08-27	1999-02-05	Setnar 6,6-heteró-bísýklískar afleiður

Country Status (40)

Country	Link
EP (1)	EP0925298B1 (is)
JP (1)	JP2000502722A (is)
KR (1)	KR100457759B1 (is)
CN (2)	CN1138774C (is)
AP (1)	AP1164A (is)
AR (2)	AR009321A1 (is)
AT (1)	ATE264327T1 (is)
AU (1)	AU726771C (is)
BG (1)	BG64316B1 (is)
BR (1)	BR9711262A (is)
CA (1)	CA2263913C (is)
CO (1)	CO4930259A1 (is)
CZ (1)	CZ67799A3 (is)
DE (1)	DE69728676T2 (is)
DK (1)	DK0925298T3 (is)
DZ (1)	DZ2299A1 (is)
EA (1)	EA002607B1 (is)
ES (1)	ES2216157T3 (is)
GT (1)	GT199700093A (is)
HR (1)	HRP970452A2 (is)
ID (1)	ID18189A (is)
IL (1)	IL128049A (is)
IS (1)	IS4970A (is)
MY (1)	MY132671A (is)
NO (1)	NO316273B1 (is)
NZ (1)	NZ333728A (is)
OA (1)	OA10980A (is)
PA (1)	PA8435001A1 (is)
PE (1)	PE108698A1 (is)
PL (1)	PL331988A1 (is)
PT (1)	PT925298E (is)
SI (1)	SI0925298T1 (is)
SK (1)	SK22599A3 (is)
TN (1)	TNSN97144A1 (is)
TR (1)	TR199900408T2 (is)
TW (1)	TW477787B (is)
UA (1)	UA66345C2 (is)
WO (1)	WO1998008846A1 (is)
YU (1)	YU35697A (is)
ZA (1)	ZA977652B (is)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6124289A (en) *	1996-07-24	2000-09-26	Dupont Pharmaceuticals Co.	Azolo triazines and pyrimidines
US6191131B1 (en)	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
US6313124B1 (en)	1997-07-23	2001-11-06	Dupont Pharmaceuticals Company	Tetrazine bicyclic compounds
US7094782B1 (en)	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
US6060478A (en) *	1996-07-24	2000-05-09	Dupont Pharmaceuticals	Azolo triazines and pyrimidines
BR9710808A (pt)	1996-08-06	1999-08-17	Pfizer	Derivados biciclicos 6,6 ou 6,7 contendo pirito ou pirimido substitu¡dos
AU6279598A (en) *	1997-02-18	1998-09-08	Neurocrine Biosciences, Inc.	Biazacyclic CRF antagonists
DE69818248T2 (de)	1997-04-22	2004-06-17	Janssen Pharmaceutica N.V.	Chinolin- und chinazolin-derivate als crf antagonisten
NL1010018C2 (nl) *	1997-09-09	1999-03-10	Duphar Int Res	Chinoline en chinazoline derivaten met corticotropine releasing factor (CRF) antagonistische werking.
US6187777B1 (en)	1998-02-06	2001-02-13	Amgen Inc.	Compounds and methods which modulate feeding behavior and related diseases
PT1129096E (pt)	1998-11-12	2003-09-30	Neurocrine Biosciences Inc	Antagonistas de receptor de crf e metodos de tratamento relacionados com os mesmos
ES2180338T3 (es)	1998-11-12	2003-02-01	Neurocrine Biosciences Inc	Antagonistas del receptor de crf y metodos relacionados.
EP1150977B1 (en) *	1999-02-12	2004-08-25	SmithKline Beecham plc	Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
US6432989B1 (en) *	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
PL354784A1 (en)	1999-09-30	2004-02-23	Neurogen Corporation	Certain alkylene diamine-substituted heterocycles
JP2003510365A (ja)	1999-10-01	2003-03-18	ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド	個人用ケア組成物により人間を鎮静するための方法
CO5271670A1 (es)	1999-10-29	2003-04-30	Pfizer Prod Inc	Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas
US6525067B1 (en) *	1999-11-23	2003-02-25	Pfizer Inc	Substituted heterocyclic derivatives
ATE319103T1 (de)	2000-01-26	2006-03-15	Em Microelectronic Marin Sa	Verfahren zur prüfung einer integrierten schaltung mit vertraulichen software- oder hardware-elementen
AU2001232271A1 (en) *	2000-02-14	2001-08-20	Japan Tobacco Inc.	Preventives/remedies for postoperative stress
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6500839B2 (en)	2000-05-18	2002-12-31	Neurocrine Biosciences, Inc.	CRF receptor antagonists and methods relating thereto
CN100525768C (zh)	2000-10-23	2009-08-12	史密丝克莱恩比彻姆公司	新化合物
DE60225127T2 (de) *	2001-04-30	2009-02-19	Glaxo Group Ltd., Greenford	Kondensierte pyrimidine als antagonisten des corticotropin releasing factor (crf)
GB0117396D0 (en) *	2001-07-17	2001-09-05	Glaxo Group Ltd	Chemical compounds
GB2411478A (en)	2002-01-29	2005-08-31	Johnson & Johnson Consumer	Method of measuring the stress or relaxation level of a mammal
KR20040103972A (ko)	2002-04-19	2004-12-09	스미스클라인 비참 코포레이션	신규 화합물
US7067658B2 (en) *	2002-09-30	2006-06-27	Bristol-Myers Squibb Company	Pyridino and pyrimidino pyrazinones
MXPA05007485A (es)	2003-01-14	2006-01-30	Arena Pharm Inc	Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia.
GB0308208D0 (en) *	2003-04-09	2003-05-14	Glaxo Group Ltd	Chemical compounds
AR045047A1 (es)	2003-07-11	2005-10-12	Arena Pharm Inc	Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
RS20060018A (sr) *	2003-07-14	2007-12-31	Arena Pharmaceuticals Inc.,	Derivati spojenih arila i heteroarila kao modulatori metabolizma u profilaksi i lečenju sa njima povezanih stanja
JP2007501822A (ja)	2003-08-12	2007-02-01	エフ．ホフマン−ラ　ロシュ　アーゲー	コルチコトロピン放出性因子（ｃｒｆ）アンタゴニストとしてのスピロ置換テトラヒドロキナゾリン
ES2293317T3 (es)	2003-08-12	2008-03-16	F. Hoffmann-La Roche Ag	Derivados de tetrahidroquinazolina com antagonistas de cfr.
TW200510425A (en)	2003-08-13	2005-03-16	Japan Tobacco Inc	Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
JP2006232849A (ja) *	2003-08-13	2006-09-07	Japan Tobacco Inc	含窒素縮合環化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用
WO2005079807A1 (en) *	2004-02-13	2005-09-01	Pfizer Products Inc.	Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists
DE102004018198A1 (de) *	2004-04-15	2005-11-03	Merck Patent Gmbh	Sulfonamide
US7767687B2 (en)	2004-12-13	2010-08-03	Biogen Idec Ma Inc.	Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
MY145343A (en)	2005-03-25	2012-01-31	Glaxo Group Ltd	Novel compounds
PE20061193A1 (es)	2005-03-25	2006-12-02	Glaxo Group Ltd	DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38
US7423042B2 (en)	2005-03-25	2008-09-09	Glaxo Group Limited	Compounds
US20080096905A1 (en)	2005-03-25	2008-04-24	Glaxo Group Limited	Process For Preparing Pyrido[2,3-D]Pyrimidin-7-One And 3,4-Dihydropyrimido{4,5-D}Pyrimidin-2(1H)-One Derivatives
BRPI0609268A2 (pt)	2005-03-31	2010-03-09	Pfizer Prod Inc	derivados de ciclopentapiridina e tetraidroquinolina
US7910595B2 (en)	2005-12-21	2011-03-22	Abbott Laboratories	Anti-viral compounds
EP1979349B1 (en)	2005-12-21	2010-07-28	Abbott Laboratories	Anti-viral compounds
WO2007081517A2 (en)	2005-12-21	2007-07-19	Abbott Laboratories	Anti-viral compounds
MX337906B (es)	2006-10-19	2016-03-28	Signal Pharm Llc	Compuestos de heteroarilo, composiciones de los mismos, y su uso como inhibidores de proteina cinasas.
US8236950B2 (en)	2006-12-20	2012-08-07	Abbott Laboratories	Anti-viral compounds
ES2637999T3 (es) *	2007-05-17	2017-10-18	Helperby Therapeutics Limited	Uso de compuestos de 4-(pirrolidin-1-il)quinolina para eliminar microorganismos clínicamente latentes
US9139592B2 (en)	2010-06-14	2015-09-22	Trt Pharma Inc.	Modulators of Nrf2 and uses thereof
EP3323818A1 (en)	2010-09-22	2018-05-23	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
KR20150046056A (ko) *	2012-08-24	2015-04-29	에프. 호프만-라 로슈 아게	신규한 바이사이클릭피리딘 유도체
RS65839B1 (sr)	2014-01-21	2024-09-30	Neurocrine Biosciences Inc	Crf1 receptor antagonisti za tretman kongenitalne adrenalne hiperplazije
PL3242666T3 (pl)	2015-01-06	2025-02-17	Arena Pharmaceuticals, Inc.	Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
KR102369405B1 (ko)	2015-06-04	2022-03-02	화이자 인코포레이티드	팔보시클립의 고체 투여 형태
BR112017027656B1 (pt)	2015-06-22	2023-12-05	Arena Pharmaceuticals, Inc.	Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo
PT3497103T (pt)	2016-08-15	2021-06-17	Pfizer	Inibidores de piridopirimidinona cdk2/4/6
US11168094B2 (en)	2017-01-06	2021-11-09	Azcuris Co., Ltd.	Quinolinone derivative and pharmaceutical composition for preventing or treating allergic diseases such as asthma or atopic dermatitis including the quinolinone derivative as active ingredient
CA3102136A1 (en)	2018-06-06	2019-12-12	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the s1p1 receptor
US20220023266A1 (en)	2018-12-07	2022-01-27	Neurocrine Biosciences, Inc.	Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia
JP7623365B2 (ja)	2019-09-27	2025-01-28	ニューロクラインバイオサイエンシーズ，インコーポレイテッド	Ｃｒｆ受容体アンタゴニストおよび使用方法
CN115160221B (zh) *	2022-07-26	2024-10-18	恩祺生物科技(上海)有限公司	德立替尼晶型化合物和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW370529B (en) *	1992-12-17	1999-09-21	Pfizer	Pyrazolopyrimidines
KR19990067704A (ko) *	1992-12-17	1999-08-25	디. 제이. 우드, 스피겔 알렌 제이	부신피질자극호르몬 유리인자 길항제로서의 피롤로피리미딘을함유하는 약학 조성물
TW530047B (en) *	1994-06-08	2003-05-01	Pfizer	Corticotropin releasing factor antagonists
DK0765327T3 (da) *	1994-06-16	1999-11-29	Pfizer	Pyrazolo- og pyrrolopyridiner
EP0729758A3 (en) *	1995-03-02	1997-10-29	Pfizer	Pyrazolopyrimidines and pyrrolopyrimidines for the treatment of neuronal and other diseases
EP0770080B1 (en) *	1995-05-12	1999-07-14	Neurogen Corporation	Novel deazapurine derivatives; a new class of crf1 specific ligands
US6403599B1 (en) *	1995-11-08	2002-06-11	Pfizer Inc	Corticotropin releasing factor antagonists
PT778277E (pt) *	1995-12-08	2003-11-28	Pfizer	Derivados heterociclicos substituidos como antagonistas do crf

1997
- 1997-07-15 TW TW086109990A patent/TW477787B/zh not_active IP Right Cessation
- 1997-07-21 AU AU33557/97A patent/AU726771C/en not_active Ceased
- 1997-07-21 CN CNB971973555A patent/CN1138774C/zh not_active Expired - Fee Related
- 1997-07-21 EA EA199900166A patent/EA002607B1/ru not_active IP Right Cessation
- 1997-07-21 SI SI9730642T patent/SI0925298T1/xx unknown
- 1997-07-21 EP EP97929464A patent/EP0925298B1/en not_active Expired - Lifetime
- 1997-07-21 NZ NZ333728A patent/NZ333728A/xx unknown
- 1997-07-21 UA UA99020647A patent/UA66345C2/uk unknown
- 1997-07-21 PL PL97331988A patent/PL331988A1/xx unknown
- 1997-07-21 ES ES97929464T patent/ES2216157T3/es not_active Expired - Lifetime
- 1997-07-21 TR TR1999/00408T patent/TR199900408T2/xx unknown
- 1997-07-21 IL IL12804997A patent/IL128049A/en not_active IP Right Cessation
- 1997-07-21 CZ CZ99677A patent/CZ67799A3/cs unknown
- 1997-07-21 CA CA002263913A patent/CA2263913C/en not_active Expired - Fee Related
- 1997-07-21 JP JP10511427A patent/JP2000502722A/ja active Pending
- 1997-07-21 SK SK225-99A patent/SK22599A3/sk unknown
- 1997-07-21 CN CNB021020574A patent/CN1191236C/zh not_active Expired - Fee Related
- 1997-07-21 BR BR9711262A patent/BR9711262A/pt not_active Application Discontinuation
- 1997-07-21 AT AT97929464T patent/ATE264327T1/de not_active IP Right Cessation
- 1997-07-21 PT PT97929464T patent/PT925298E/pt unknown
- 1997-07-21 DK DK97929464T patent/DK0925298T3/da active
- 1997-07-21 DE DE69728676T patent/DE69728676T2/de not_active Expired - Fee Related
- 1997-07-21 KR KR10-1999-7001619A patent/KR100457759B1/ko not_active Expired - Fee Related
- 1997-07-21 WO PCT/IB1997/000904 patent/WO1998008846A1/en not_active Ceased
- 1997-07-30 PA PA19978435001A patent/PA8435001A1/es unknown
- 1997-08-13 GT GT199700093A patent/GT199700093A/es unknown
- 1997-08-21 AP APAP/P/1997/001076A patent/AP1164A/en active
- 1997-08-22 PE PE1997000751A patent/PE108698A1/es not_active Application Discontinuation
- 1997-08-22 HR HR60/024,659A patent/HRP970452A2/hr not_active Application Discontinuation
- 1997-08-25 ID IDP972952A patent/ID18189A/id unknown
- 1997-08-25 AR ARP970103851A patent/AR009321A1/es not_active Application Discontinuation
- 1997-08-26 ZA ZA977652A patent/ZA977652B/xx unknown
- 1997-08-26 MY MYPI97003918A patent/MY132671A/en unknown
- 1997-08-26 DZ DZ970149A patent/DZ2299A1/fr active
- 1997-08-26 CO CO97049282A patent/CO4930259A1/es unknown
- 1997-08-26 YU YU35697A patent/YU35697A/sr unknown
- 1997-08-26 TN TNTNSN97144A patent/TNSN97144A1/fr unknown
1999
- 1999-02-05 IS IS4970A patent/IS4970A/is unknown
- 1999-02-22 BG BG103192A patent/BG64316B1/bg unknown
- 1999-02-25 NO NO19990892A patent/NO316273B1/no not_active IP Right Cessation
- 1999-02-25 OA OA9900039A patent/OA10980A/en unknown
2001
- 2001-01-10 AR ARP010100097A patent/AR026826A1/es unknown

Also Published As

Publication number	Publication date
MY132671A (en)	2007-10-31
HK1019597A1 (en)	2000-02-18
ATE264327T1 (de)	2004-04-15
KR20000035898A (ko)	2000-06-26
SI0925298T1 (en)	2004-08-31
ES2216157T3 (es)	2004-10-16
AU3355797A (en)	1998-03-19
HRP970452A2 (en)	1998-08-31
PT925298E (pt)	2004-07-30
NO316273B1 (no)	2004-01-05
NZ333728A (en)	2000-11-24
CA2263913C (en)	2004-06-29
GT199700093A (es)	1999-02-04
EA199900166A1 (ru)	1999-08-26
EP0925298A1 (en)	1999-06-30
EP0925298B1 (en)	2004-04-14
IL128049A0 (en)	1999-11-30
NO990892D0 (no)	1999-02-25
SK22599A3 (en)	2000-07-11
AU726771B2 (en)	2000-11-23
DE69728676D1 (de)	2004-05-19
ID18189A (id)	1998-03-12
IL128049A (en)	2004-12-15
EA002607B1 (ru)	2002-06-27
DK0925298T3 (da)	2004-08-09
OA10980A (en)	2001-11-02
PE108698A1 (es)	1999-01-23
NO990892L (no)	1999-02-25
CZ67799A3 (cs)	1999-11-17
PA8435001A1 (es)	2002-07-30
DZ2299A1 (fr)	2002-12-25
JP2000502722A (ja)	2000-03-07
CO4930259A1 (es)	2000-06-27
CN1228091A (zh)	1999-09-08
YU35697A (en)	1999-11-22
TNSN97144A1 (fr)	2005-03-15
BG64316B1 (bg)	2004-09-30
AU726771C (en)	2004-11-11
AR026826A1 (es)	2003-02-26
WO1998008846A1 (en)	1998-03-05
TR199900408T2 (xx)	1999-05-21
AR009321A1 (es)	2000-04-12
KR100457759B1 (ko)	2004-11-18
BG103192A (en)	1999-09-30
CA2263913A1 (en)	1998-03-05
UA66345C2 (en)	2004-05-17
ZA977652B (en)	1999-02-26
AP9701076A0 (en)	1997-10-31
PL331988A1 (en)	1999-08-16
CN1138774C (zh)	2004-02-18
TW477787B (en)	2002-03-01
DE69728676T2 (de)	2004-09-30
BR9711262A (pt)	1999-08-17
CN1191236C (zh)	2005-03-02
CN1367169A (zh)	2002-09-04
AP1164A (en)	2003-06-30

Publication	Publication Date	Title
IS4970A (is)	1999-02-05	Setnar 6,6-heteró-bísýklískar afleiður
ATE340176T1 (de)	2006-10-15	Substituierte 6,5-heterobicyclische-derivate
DE69933287D1 (de)	2006-11-02	12,13-modifizierte epothilon-derivate
DK1000048T3 (da)	2003-03-03	Substituerede 1,2,3,4-tetrahydronapthalenderivater
PT901474E (pt)	2006-07-31	Derivados de aril-pirimidina.
NO2006016I1 (no)	2006-11-27	7,8,9,10-tetrahydro-6H-6,10-metanoazepinoÄ4,5-gÜkinoksalintartrat
PT993456E (pt)	2005-01-31	4,5-diaril-imidazoles 2-substituidos
ATE231847T1 (de)	2003-02-15	Substituierte 1,2,3,4- tetrahydronaphthalinderivate
FI952424L (fi)	1995-11-20	11,21-bisfenyyli-19-norpregaanijohdannaisia
BR9506532A (pt)	1997-09-16	1,2,3,4,-Tetraidro-5-Nitro-Pirimidinas substituidas
TR199800988A3 (tr)	1998-12-21	5' Deoksi-Sitidin türevleri.
ATE246199T1 (de)	2003-08-15	3-descladinose-2,3-anhydroerythromycin-derivate
ATE227282T1 (de)	2002-11-15	2,4-diaminopyrimidin-derivate
EE04089B1 (et)	2003-08-15	1,3,4-oksadiasolooni derivaadid
DE69714358D1 (de)	2002-09-05	9,10-disubstituierte campothecinderivate mit antitumoraktivität
ATE199901T1 (de)	2001-04-15	10,11-dihydro-10-oxo-5h-dibenz(b,f)azepin-5- carboxamidderivate
TR28915A (tr)	1997-08-06	Naftokinon türevleri.
DE69722064D1 (de)	2003-06-26	1,25-Dihydroxy-16,22,23-trisdehydro-Cholecalciferol-Derivate
DK1068200T3 (da)	2005-06-20	2,4,4-trisubstituerede-1,3-dioxolanfungicider
ID24047A (id)	2000-07-06	Turunan 5-tersubstitusi-3-oksaziazolil 1,6-naftiridin-2 1h-on
BR9708948A (pt)	1999-08-03	1,3 - Benzodioxois substituídos
NO993024D0 (no)	1999-06-18	Polysakkarid-peptid-derivater
BR9508248A (pt)	1997-11-04	1,2,4,6-Tiatriazinas herbicidas
BR9510036A (pt)	1997-10-28	Derivados de 1,3,4-oxadiazina
TR199700927A3 (tr)	1999-03-22	N-Benzilazolyum türevleri.