ATE269406T1 - Expression von beta-2-mikroglobulin in pichia pastoris - Google Patents

Expression von beta-2-mikroglobulin in pichia pastoris

Info

Publication number
ATE269406T1
ATE269406T1 AT94912039T AT94912039T ATE269406T1 AT E269406 T1 ATE269406 T1 AT E269406T1 AT 94912039 T AT94912039 T AT 94912039T AT 94912039 T AT94912039 T AT 94912039T AT E269406 T1 ATE269406 T1 AT E269406T1
Authority
AT
Austria
Prior art keywords
microglobulin
beta
expression
pichia pastoris
amino acid
Prior art date
Application number
AT94912039T
Other languages
English (en)
Inventor
Michael George Hunter
Nigel Robert Woods
Original Assignee
Isis Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation filed Critical Isis Innovation
Application granted granted Critical
Publication of ATE269406T1 publication Critical patent/ATE269406T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18822—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Enzymes And Modification Thereof (AREA)
AT94912039T 1993-04-08 1994-04-08 Expression von beta-2-mikroglobulin in pichia pastoris ATE269406T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939307371A GB9307371D0 (en) 1993-04-08 1993-04-08 Fusion proteins
PCT/GB1994/000754 WO1994024280A1 (en) 1993-04-08 1994-04-08 Expression of beta-2-microglobulin in pichia pastoris

Publications (1)

Publication Number Publication Date
ATE269406T1 true ATE269406T1 (de) 2004-07-15

Family

ID=10733574

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94912039T ATE269406T1 (de) 1993-04-08 1994-04-08 Expression von beta-2-mikroglobulin in pichia pastoris
AT94912040T ATE298798T1 (de) 1993-04-08 1994-04-08 Fusionsproteine zwischen antigene aminosäuresequenzen und beta - 2- mikroglobulin

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT94912040T ATE298798T1 (de) 1993-04-08 1994-04-08 Fusionsproteine zwischen antigene aminosäuresequenzen und beta - 2- mikroglobulin

Country Status (8)

Country Link
US (1) US6881828B2 (de)
EP (2) EP0693125B1 (de)
AT (2) ATE269406T1 (de)
AU (2) AU6435394A (de)
DE (2) DE69434413T2 (de)
ES (1) ES2242183T3 (de)
GB (1) GB9307371D0 (de)
WO (2) WO1994024280A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2224205A1 (en) * 1995-06-07 1996-12-19 Zymogenetics, Inc. Fused soluble mhc heterodimer-peptide complexes and their uses
FR2735984B1 (fr) * 1995-06-30 1997-09-19 Inst Nat Sante Rech Med Vaccin contre des agents infectieux ayant une phase intracellulaire, composition pour le traitement et la prevention des infections a hiv, anticorps et procede de diagnostic
WO1997024446A2 (en) * 1995-12-29 1997-07-10 Chiron Corporation Gene delivery vehicle-targeting ligands
US6458354B1 (en) 1996-03-28 2002-10-01 The Johns Hopkins University Molecular complexes which modify immune responses
NZ331688A (en) 1996-03-28 2000-02-28 Univ Johns Hopkins Soluble divalent and multivalent heterodimeric analogs of proteins
US6268411B1 (en) 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
US6682741B1 (en) 1998-06-10 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services β2 microglobulin fusion proteins and high affinity variants
EP1086224B1 (de) * 1998-06-10 2006-03-29 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES B2microglobulin fusionsproteine und varianten mit hoher affinität
KR20040040475A (ko) * 2001-09-28 2004-05-12 가부시키가이샤 디나벡크 겐큐쇼 에피토프 결합 β２ｍ을 코드하는 포유동물 세포감염성 바이러스 벡터 및 그의 이용
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
CN1720326A (zh) * 2002-10-01 2006-01-11 株式会社载体研究所 通过抑制tap活性增强mhcⅰ类分子对外来表位的展示的方法
WO2004087058A2 (en) * 2003-03-28 2004-10-14 Vaccinex, Inc. Targeted mhc class i alpha3 vaccine delivery systems
WO2005099361A2 (en) * 2003-07-10 2005-10-27 Vaccinex, Inc. MHC CLASS I - PEPTIDE-ANTIBODY CONJUGATES WITH MODIFIED β2-MICROGLOBULIN
US8420102B2 (en) 2006-03-07 2013-04-16 Vaxinnate Corporation Compositions that include hemagglutinin
CA2637600A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
AU2008219020B2 (en) * 2007-02-21 2013-08-22 Vaccinex, Inc. Modulation of NKT cell activity with antigen-loaded CDId molecules
WO2010053636A1 (en) 2008-11-06 2010-05-14 Tate & Lyle Technology Ltd Enhanced production and purification of a natural high intensity sweetener
CN102325875B (zh) 2009-01-08 2018-04-10 阿尔伯爱因斯坦医学有限公司 具有细胞壁结合神经酰胺类糖脂的细菌疫苗及其应用
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
ES2973548T3 (es) 2016-12-22 2024-06-20 Cue Biopharma Inc Polipéptidos multiméricos moduladores de linfocitos T y métodos para su uso
WO2021231376A2 (en) 2020-05-12 2021-11-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
CN114958862B (zh) * 2022-05-23 2023-12-08 郑州伊美诺生物技术有限公司 检测慢性间质性肾炎的重组抗原的制备方法
EP4680649A1 (de) * 2023-03-06 2026-01-21 Joint Stock Company "Biocad" Antikörperähnliches molekül mit heterodimer des menschlichen cd1b (clusters der differenzierung 1)-proteins
WO2025064715A1 (en) * 2023-09-19 2025-03-27 Cue Biopharma, Inc. T-cell modulatory polypeptides and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733550A (en) * 1990-05-10 1998-03-31 Dana-Farber Cancer Institute, Inc. Method for enhancing the association of exogenous peptides with class I MHC molecules on the surface of antigen presenting cells with β-microglobulin
ES2096650T3 (es) * 1990-05-10 1997-03-16 Dana Farber Cancer Inst Inc Mejora de la asociacion de peptidos exogenos con moleculas de la clase i del mhc en celulas del sistema inmunitario.
US5268273A (en) * 1990-12-14 1993-12-07 Phillips Petroleum Company Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same

Also Published As

Publication number Publication date
DE69434413T2 (de) 2006-05-18
AU6435294A (en) 1994-11-08
EP0693125B1 (de) 2005-06-29
ATE298798T1 (de) 2005-07-15
DE69433845D1 (de) 2004-07-22
ES2242183T3 (es) 2005-11-01
EP0692027B1 (de) 2004-06-16
AU6435394A (en) 1994-11-08
WO1994024280A1 (en) 1994-10-27
GB9307371D0 (en) 1993-06-02
EP0692027A1 (de) 1996-01-17
WO1994024290A1 (en) 1994-10-27
EP0693125A1 (de) 1996-01-24
US20020123108A1 (en) 2002-09-05
US6881828B2 (en) 2005-04-19
DE69434413D1 (de) 2005-08-04
DE69433845T2 (de) 2005-06-23

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