ATE271379T1 - System zur verzögerten freisetzung säurelabiler substanzen - Google Patents
System zur verzögerten freisetzung säurelabiler substanzenInfo
- Publication number
- ATE271379T1 ATE271379T1 AT97946676T AT97946676T ATE271379T1 AT E271379 T1 ATE271379 T1 AT E271379T1 AT 97946676 T AT97946676 T AT 97946676T AT 97946676 T AT97946676 T AT 97946676T AT E271379 T1 ATE271379 T1 AT E271379T1
- Authority
- AT
- Austria
- Prior art keywords
- delayed release
- barrier
- omeprazole
- pulsatile
- acid label
- Prior art date
Links
- 230000003111 delayed effect Effects 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 230000004888 barrier function Effects 0.000 abstract 3
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- 229960000381 omeprazole Drugs 0.000 abstract 2
- 230000000541 pulsatile effect Effects 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74098196A | 1996-11-06 | 1996-11-06 | |
| PCT/US1997/020851 WO1998019668A1 (en) | 1996-11-06 | 1997-11-05 | Delayed delivery system for acid-sensitive drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE271379T1 true ATE271379T1 (de) | 2004-08-15 |
Family
ID=24978866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97946676T ATE271379T1 (de) | 1996-11-06 | 1997-11-05 | System zur verzögerten freisetzung säurelabiler substanzen |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0941074B1 (de) |
| AT (1) | ATE271379T1 (de) |
| AU (1) | AU5179898A (de) |
| DE (1) | DE69729950T2 (de) |
| NO (1) | NO992186L (de) |
| WO (1) | WO1998019668A1 (de) |
| ZA (1) | ZA979937B (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2774288B1 (fr) * | 1998-01-30 | 2001-09-07 | Ethypharm Sa | Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques |
| FR2793688B1 (fr) | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques |
| SE9902386D0 (sv) * | 1999-06-22 | 1999-06-22 | Astra Ab | New formulation |
| US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
| DE19959419A1 (de) | 1999-12-09 | 2001-06-21 | Ratiopharm Gmbh | Stabile galenische Zubereitungen umfassend ein Benzimidazol und Verfahren zu ihrer Herstellung |
| EP1108425B1 (de) * | 1999-12-16 | 2005-06-08 | Laboratorio Medinfar-Produtos Farmaceuticos, S.A. | Neue stabile mehreinheitliche substituierte Benzimidazole enthaltende pharmazeutische Präparate |
| US6500457B1 (en) * | 2000-08-14 | 2002-12-31 | Peirce Management, Llc | Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| US7300668B2 (en) | 2001-10-29 | 2007-11-27 | Massachusetts Institute Of Technology | System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing |
| US8168170B2 (en) | 2002-10-03 | 2012-05-01 | The Procter And Gamble Company | Compositions having an inner core and at least three surrounding layers |
| US8449911B2 (en) | 2003-03-12 | 2013-05-28 | Takeda Pharmaceutical Company Limited | Drug composition having active ingredient adhered at high concentration to spherical core |
| CA2547398A1 (en) * | 2003-11-28 | 2005-06-09 | Ranbaxy Laboratories Limited | Oral benzimidazole compositions comprising an active core, an optional separating layer and an enteric coating |
| US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| US20050214371A1 (en) * | 2004-03-03 | 2005-09-29 | Simona Di Capua | Stable pharmaceutical composition comprising an acid labile drug |
| JP2008502740A (ja) * | 2004-06-15 | 2008-01-31 | テバ ファーマシューティカル インダストリーズ リミティド | ベンズイミダゾール化合物の安定医薬製剤 |
| AR052225A1 (es) * | 2004-11-04 | 2007-03-07 | Astrazeneca Ab | Formulaciones de tabletas de liberacion modificada par inhibidores de la bomba de protones |
| AR051654A1 (es) * | 2004-11-04 | 2007-01-31 | Astrazeneca Ab | Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones |
| US8227476B2 (en) | 2005-08-03 | 2012-07-24 | Sprout Pharmaceuticals, Inc. | Use of flibanserin in the treatment of obesity |
| CA2626134C (en) | 2005-10-29 | 2013-12-24 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
| CN101389317A (zh) * | 2005-12-28 | 2009-03-18 | 武田药品工业株式会社 | 控制释放固体制剂 |
| ZA200805646B (en) * | 2005-12-28 | 2009-12-30 | Takeda Pharmaceutical | Controlled release solid preparation |
| DE602007004615D1 (de) | 2006-06-30 | 2010-03-18 | Boehringer Ingelheim Pharma | Flibanserin zur behandlung von harninkontinenz und assoziierten erkrankungen |
| CL2007002214A1 (es) | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
| AU2007286288A1 (en) | 2006-08-14 | 2008-02-21 | Boehringer Ingelheim International Gmbh | Formulations of flibanserin and method for manufacturing the same |
| CN104721168A (zh) * | 2006-08-25 | 2015-06-24 | 贝林格尔·英格海姆国际有限公司 | 控制释放系统及其制造方法 |
| PL2124966T3 (pl) | 2007-02-01 | 2016-01-29 | Iams Europe B V | Sposób zmniejszania reakcji zapalnej i stresu u ssaków za pomocą antymetabolitów glukozy, awokado lub ekstraktów awokado |
| UY31335A1 (es) | 2007-09-12 | 2009-04-30 | Tratamiento de sintomas vasomotores | |
| WO2009113090A2 (en) * | 2008-01-17 | 2009-09-17 | Alkem Laboratories Ltd. | Process for preparing an oral formulation of an acid-sensitive benzimidazole drug |
| US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
| CA2686480A1 (en) | 2008-12-15 | 2010-06-15 | Boehringer Ingelheim International Gmbh | New salts |
| US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| MX9600857A (es) * | 1994-07-08 | 1997-06-28 | Astra Ab | Forma de dosificacion i en tabletas, con unidades multiples. |
-
1997
- 1997-11-05 AT AT97946676T patent/ATE271379T1/de not_active IP Right Cessation
- 1997-11-05 DE DE69729950T patent/DE69729950T2/de not_active Expired - Fee Related
- 1997-11-05 EP EP97946676A patent/EP0941074B1/de not_active Expired - Lifetime
- 1997-11-05 AU AU51798/98A patent/AU5179898A/en not_active Abandoned
- 1997-11-05 ZA ZA979937A patent/ZA979937B/xx unknown
- 1997-11-05 WO PCT/US1997/020851 patent/WO1998019668A1/en not_active Ceased
-
1999
- 1999-05-05 NO NO992186A patent/NO992186L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69729950T2 (de) | 2005-07-28 |
| WO1998019668A1 (en) | 1998-05-14 |
| ZA979937B (en) | 1999-05-18 |
| NO992186D0 (no) | 1999-05-05 |
| EP0941074A1 (de) | 1999-09-15 |
| NO992186L (no) | 1999-05-05 |
| AU5179898A (en) | 1998-05-29 |
| EP0941074B1 (de) | 2004-07-21 |
| DE69729950D1 (de) | 2004-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |