ATE271396T1 - Prochelators von radiometall markierten molekülen - Google Patents

Prochelators von radiometall markierten molekülen

Info

Publication number: ATE271396T1
Authority: AT; Austria
Prior art keywords: sub; radiometall; prochelators; formula; labeled molecules
Prior art date: 2000-05-12

Application number

AT01955279T

Other languages

English (en)

Inventor

Helmut R Maecke

Klaus Eisenwiener

Pia Powell

Original Assignee

Univ Hospital

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-12

Filing date

2001-05-11

Publication date

2004-08-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8168693&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE271396(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-05-11 Application filed by Univ Hospital filed Critical Univ Hospital

2004-08-15 Application granted granted Critical

2004-08-15 Publication of ATE271396T1 publication Critical patent/ATE271396T1/de

Links

AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 abstract 1
-1 CCK Chemical compound 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
108010016076 Octreotide Proteins 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000000975 bioactive effect Effects 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960004679 doxorubicin Drugs 0.000 abstract 1
239000012636 effector Substances 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
238000002372 labelling Methods 0.000 abstract 1
CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
229960002700 octreotide Drugs 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
239000002534 radiation-sensitizing agent Substances 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
235000000346 sugar Nutrition 0.000 abstract 1
150000008163 sugars Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Compounds Of Unknown Constitution (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)

AT01955279T 2000-05-12 2001-05-11 Prochelators von radiometall markierten molekülen ATE271396T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00110084		2000-05-12
PCT/EP2001/005483 WO2002024235A2 (en)	2000-05-12	2001-05-11	Prochelators of radiometal labeled molecules

Publications (1)

Publication Number	Publication Date
ATE271396T1 true ATE271396T1 (de)	2004-08-15

Family

ID=8168693

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01955279T ATE271396T1 (de)	2000-05-12	2001-05-11	Prochelators von radiometall markierten molekülen

Country Status (8)

Country	Link
US (1)	US20060233704A1 (de)
EP (1)	EP1289571B1 (de)
JP (1)	JP2004509152A (de)
AT (1)	ATE271396T1 (de)
AU (2)	AU2001277488B2 (de)
DE (1)	DE60104421T2 (de)
ES (1)	ES2221903T3 (de)
WO (1)	WO2002024235A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004082722A2 (en) *	2003-03-19	2004-09-30	Universitätsspital Basel	Radiolabeled conjugates based on substance p and the uses thereof
CN1795015A (zh) *	2003-05-23	2006-06-28	埃匹克斯医药品股份有限公司	螯合配位体和造影剂的光学纯和光学富集异构体
US8986650B2 (en)	2005-10-07	2015-03-24	Guerbet	Complex folate-NOTA-Ga68
US8926945B2 (en) *	2005-10-07	2015-01-06	Guerbet	Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
US8193347B2 (en) *	2006-03-14	2012-06-05	Mallinckrodt Llc	Metal complexes of tetraazamacrocycle derivatives
US8758723B2 (en)	2006-04-19	2014-06-24	The Board Of Regents Of The University Of Texas System	Compositions and methods for cellular imaging and therapy
WO2007120153A1 (en) *	2006-04-19	2007-10-25	The Board Of Regents Of The University Of Texas System	Compositions and methods for cellular imaging and therapy
US10925977B2 (en)	2006-10-05	2021-02-23	Ceil>Point, LLC	Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
EP2384323A4 (de) *	2008-11-11	2013-07-31	Univ Nanyang Tech	Intravaskuläre kontrastmittel
HRP20221195T1 (hr)	2009-03-19	2022-12-09	The Johns Hopkins University	Spojevi koji ciljaju psma i njihova uporaba
FR2959502B1 (fr)	2010-04-30	2012-09-07	Nanoh	Nanoparticules ultrafines a matrice polyorganosiloxane fonctionnalisee et incluant des complexes metalliques ; leur procede d'obtention et leurs applications en imagerie medicale et/ou therapie
RU2457215C1 (ru) *	2011-04-07	2012-07-27	Закрытое Акционерное Общество "Фарм-Синтез"	Октапептид для получения радиофармацевтических средств, радиофармацевтическое средство на его основе и способ диагностики опухолей, экспрессирующих соматостатиновые рецепторы
KR101855509B1 (ko) *	2015-11-12	2018-05-09	한국원자력연구원	방사성 의약품의 제조를 위한 바이알 키트 및 이를 이용한 방사성 의약품의 제조 방법
CN110891614A (zh)	2017-05-05	2020-03-17	融合制药公司	Igf-1r单克隆抗体及其用途
RU2019139432A (ru)	2017-05-05	2021-06-07	Сентр фор Проуб Девелопмент энд Коммерсиализэйшн	Фармакокинетическая оптимизация бифункциональных хелатов и их применение
US10093741B1 (en)	2017-05-05	2018-10-09	Fusion Pharmaceuticals Inc.	IGF-1R monoclonal antibodies and uses thereof
WO2022211051A1 (ja) *	2021-03-31	2022-10-06	日本メジフィジックス株式会社	抗ｅｇｆｒ抗体の放射性複合体、及び、放射性医薬
DE102021109246B3 (de)	2021-04-13	2022-06-09	ITM Isotope Technologies Munich SE	Radiopharmaka zu unterschiedlichen ARTs
CN115894395A (zh) *	2023-02-13	2023-04-04	康化（上海）新药研发有限公司	一种轮环藤宁衍生物的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW213864B (de) *	1991-08-01	1993-10-01	Squibb & Sons Inc

2001
- 2001-05-11 AT AT01955279T patent/ATE271396T1/de not_active IP Right Cessation
- 2001-05-11 WO PCT/EP2001/005483 patent/WO2002024235A2/en not_active Ceased
- 2001-05-11 DE DE60104421T patent/DE60104421T2/de not_active Expired - Lifetime
- 2001-05-11 AU AU2001277488A patent/AU2001277488B2/en not_active Expired
- 2001-05-11 AU AU7748801A patent/AU7748801A/xx active Pending
- 2001-05-11 JP JP2002528305A patent/JP2004509152A/ja active Pending
- 2001-05-11 EP EP01955279A patent/EP1289571B1/de not_active Expired - Lifetime
- 2001-05-11 US US10/533,906 patent/US20060233704A1/en not_active Abandoned
- 2001-05-11 ES ES01955279T patent/ES2221903T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20060233704A1 (en)	2006-10-19
AU7748801A (en)	2002-04-02
WO2002024235A3 (en)	2002-08-29
JP2004509152A (ja)	2004-03-25
EP1289571A2 (de)	2003-03-12
DE60104421D1 (de)	2004-08-26
DE60104421T2 (de)	2005-09-22
EP1289571B1 (de)	2004-07-21
AU2001277488B2 (en)	2006-05-18
WO2002024235A2 (en)	2002-03-28
ES2221903T3 (es)	2005-01-16

Legal Events

Date	Code	Title	Description
2005-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE271396T1 (de)	2004-08-15	Prochelators von radiometall markierten molekülen
BR9808491A (pt)	2000-05-23	Compostos calcilìticos
TR200800474T2 (tr)	2008-04-21	Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
NO995906D0 (no)	1999-12-02	Radioprotektant for peptider merket med radioisotop
DE60322188D1 (de)	2008-08-28	Zytokin (zcytor17-ligand)
ATE178053T1 (de)	1999-04-15	N2s2-chelatoren des hydrazino-typs
DK0710228T3 (da)	1998-09-21	Hydraziner med N3S-konfiguration som radionuclidchelatorer
PT766678E (pt)	2002-06-28	Agentes clarificantes opticos
DE69530993D1 (de)	2003-07-10	Multikatalytische protease-inhibitoren
DK0418355T3 (da)	1994-09-12	Fremgangsmåde til immobilisering af proteiner, peptider, coenzymer, etc. på et substrat
IT1293778B1 (it)	1999-03-10	1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
AU7949391A (en)	1992-01-09	Kit for the specific assay of angiotensin ii
FR2816410B1 (fr)	2003-04-18	Necessaire de detection de la proteine esm-1 et procede de detection mettant en oeuvre ledit necessaire
ATE284407T1 (de)	2004-12-15	Pyrimidinderivate als markierte bindungspartner
NO971621D0 (no)	1997-04-09	Keratinocyttvekstfaktoranaloger
DK1279677T3 (da)	2007-05-07	GD3-mimetiske peptider
DK1292613T3 (da)	2008-11-24	Kimært GPF-Aequorin som bioluminiscerende Ca-reportere på enkeltcelleniveau
ATE356831T1 (de)	2007-04-15	Neuer galaninrezeptor
DK1127064T3 (da)	2006-05-22	Hidtil ukendte aminosyresekvenser, DNA, der koder for aminosyresekvenserme, antistoffer, der er rettet mod sådanne sekvenser, og forskellige anvendelser deraf
EA200400392A1 (ru)	2004-10-28	Связывающий каспазу-8 белок, его получение и применение
UA42797C2 (uk)	2001-11-15	Похідні хінолон- і нафтиридонкарбонової кислоти та похідні ізоіндолу для їх одержання
TR200001122T2 (tr)	2000-08-21	Farmasötikler olarak bifenil türevleri.
EA200001252A1 (ru)	2001-06-25	КОМПОЗИЦИЯ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА-β-1A(IFN-β-1A) ЧЕЛОВЕКА
BRPI9612617B8 (pt)	2021-05-25	vetor recombinante, microorganismo hospedeiro geneticamente modificado, método para determinar a presença de compostos genotóxicos em uma amostra e método para determinar tanto a genotoxicidde quanto a mutagenicidade de uma amostra
NL1012028A1 (nl)	1999-11-15	Aminozuursequentie.