ATE273385T1 - Neuartige verfahren und zusammensetzungen zur entdeckung von neuen multimerischen molekülen, basierend auf einer kombinatorisichen bibliothek - Google Patents

Neuartige verfahren und zusammensetzungen zur entdeckung von neuen multimerischen molekülen, basierend auf einer kombinatorisichen bibliothek

Info

Publication number
ATE273385T1
ATE273385T1 AT97931506T AT97931506T ATE273385T1 AT E273385 T1 ATE273385 T1 AT E273385T1 AT 97931506 T AT97931506 T AT 97931506T AT 97931506 T AT97931506 T AT 97931506T AT E273385 T1 ATE273385 T1 AT E273385T1
Authority
AT
Austria
Prior art keywords
compositions
discovery
novel methods
molecules based
multimeric molecules
Prior art date
Application number
AT97931506T
Other languages
English (en)
Inventor
W Dorsey Stuart
Original Assignee
Univ Hawaii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hawaii filed Critical Univ Hawaii
Application granted granted Critical
Publication of ATE273385T1 publication Critical patent/ATE273385T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • C12N15/04—Fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT97931506T 1996-07-09 1997-06-30 Neuartige verfahren und zusammensetzungen zur entdeckung von neuen multimerischen molekülen, basierend auf einer kombinatorisichen bibliothek ATE273385T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/678,462 US5683899A (en) 1994-02-03 1996-07-09 Methods and compositions for combinatorial-based discovery of new multimeric molecules
PCT/US1997/011425 WO1998001534A1 (en) 1996-07-09 1997-06-30 Novel methods and compositions for combinatorial-based discovery of new multimeric molecules

Publications (1)

Publication Number Publication Date
ATE273385T1 true ATE273385T1 (de) 2004-08-15

Family

ID=24722889

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97931506T ATE273385T1 (de) 1996-07-09 1997-06-30 Neuartige verfahren und zusammensetzungen zur entdeckung von neuen multimerischen molekülen, basierend auf einer kombinatorisichen bibliothek

Country Status (9)

Country Link
US (2) US5683899A (de)
EP (1) EP0938545B1 (de)
JP (1) JP2000514296A (de)
AT (1) ATE273385T1 (de)
AU (1) AU738622B2 (de)
CA (1) CA2260360A1 (de)
DE (1) DE69730235D1 (de)
NZ (1) NZ333684A (de)
WO (1) WO1998001534A1 (de)

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US6268140B1 (en) 1994-02-03 2001-07-31 Neugenesis Combinatorial metabolic libraries
US6420140B1 (en) 1996-10-11 2002-07-16 Abgenix, Inc. Production of multimeric protein by cell fusion method
US5916771A (en) * 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US7148054B2 (en) * 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
KR100568008B1 (ko) 1997-01-17 2006-04-07 맥시겐, 인크. 반복적 서열 재조합에 의한 전세포 및 유기체의 개량 방법
US5989814A (en) * 1997-04-01 1999-11-23 Reagents Of The University Of California Screening methods in eucaryotic cells
US6497820B1 (en) 1998-02-03 2002-12-24 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
US5968361A (en) * 1998-02-24 1999-10-19 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
AU2001276842B2 (en) * 2000-06-28 2007-04-26 Glycofi, Inc. Methods for producing modified glycoproteins
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
AU2001296846B2 (en) 2000-10-12 2007-07-05 University Of Rochester Compositions that inhibit proliferation of cancer cells
KR20040096554A (ko) 2002-02-06 2004-11-16 비코르 테크놀로지스 인코포레이티드 경색방지 분자
WO2003089614A2 (en) * 2002-04-18 2003-10-30 Genencor International, Inc. Production of functional antibodies in filamentous fungi
CA2495478A1 (en) 2002-08-05 2004-02-12 University Of Rochester Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof
US20040053359A1 (en) * 2002-09-18 2004-03-18 Thomas Ryll Method for production of a multimeric protein by cell fusion
US20040053363A1 (en) * 2002-09-18 2004-03-18 Thomas Ryll Method for production of a multimeric protein by cell fusion
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
AU2003283828A1 (en) * 2003-10-31 2005-05-19 Pirelli Pneumatici S.P.A. An expandable bladder for tyre-curing apparatuses, a manufacturing method thereof, and a process for manufacturing tyres for vehicle wheels
WO2005070962A1 (en) * 2004-01-21 2005-08-04 Novozymes A/S Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell
US20060024782A1 (en) * 2004-01-21 2006-02-02 Novozymes A/S Production of a monoclonal antibody in a heterokaryon filamentous fungus or in a filamentous fungal host cell
EP1793858A4 (de) * 2004-09-08 2008-12-10 Univ Ohio State Res Found Menschliche monoklonale anti-ctla4-antikörper zur krebsbehandlung
ZA200702695B (en) * 2004-10-15 2009-12-30 Neugenesis Corp Methods and compositions for combinatorial-based production of multivalent recombinant antigens
JP5129119B2 (ja) 2005-04-05 2013-01-23 コーニング インコーポレイテッド 標識フリーバイオセンサおよび細胞
ES2431315T3 (es) 2005-05-19 2013-11-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Epítopos funcionales del antígeno PsaA de Streptococcus pneumoniae y usos de los mismos
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
EP2392646A1 (de) 2005-10-14 2011-12-07 MUSC Foundation For Research Development Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie
CA2664189C (en) 2006-09-21 2017-11-21 University Of Rochester Compositions and methods related to protein displacement therapy for myotonic dystrophy
EP2104516B1 (de) 2006-11-01 2015-01-07 University of Rochester Verfahren und zusammensetzungen in zusammenhang mit der struktur und funktion von apobec3g
WO2008085794A2 (en) 2007-01-03 2008-07-17 Burnham Institute For Medical Research Methods and compositions related to clot binding compounds
US9381226B2 (en) 2007-02-08 2016-07-05 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
AU2009281732A1 (en) * 2008-08-15 2010-02-18 Georgetown University Na channels, disease, and related assays and compositions
EP2370080A1 (de) 2008-12-02 2011-10-05 University of Utah Research Foundation Pde1 als zieltherapeutikum bei herzkrankheiten
US20120149663A1 (en) 2009-08-18 2012-06-14 Georgetown University Boronic acid compositions and methods related to cancer
WO2011043980A1 (en) 2009-10-07 2011-04-14 Sanford Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
CA2784145A1 (en) 2009-12-18 2011-06-23 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
EP2691105B1 (de) 2011-03-28 2018-07-11 University of Utah Research Foundation Verfahren und zusammensetzungen zur viruseindringungshemmung
DK3234160T3 (da) * 2014-12-16 2019-12-02 Danisco Us Inc Sammensætninger og fremgangsmåder til hjælper-stamme-medieret svampegenommodifikation
WO2019055618A1 (en) 2017-09-15 2019-03-21 Arizona Board Of Regents On Behalf Of Arizona State University METHODS OF CLASSIFYING RESPONSES TO ANTICANCER IMMUNOTHERAPY
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer

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US4486533A (en) * 1982-09-02 1984-12-04 St. Louis University Filamentous fungi functional replicating extrachromosomal element
US4727037A (en) * 1984-02-15 1988-02-23 Cetus Corporation Assay kit and method for the determination of antibody class and subclass
US4880734A (en) * 1984-05-11 1989-11-14 Chiron Corporation Eukaryotic regulatable transcription
US4816405A (en) * 1984-10-24 1989-03-28 The Regents Of The University Of California Vectors for transformation by ascomycetes
US4885249A (en) * 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
US5364770A (en) * 1985-08-29 1994-11-15 Genencor International Inc. Heterologous polypeptides expressed in aspergillus
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
AU648020B2 (en) * 1989-02-21 1994-04-14 Washington University Modified forms of reproductive hormones
US5506134A (en) * 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
JPH0763363B2 (ja) * 1991-12-25 1995-07-12 萩原 義秀 融合細胞の取得方法
US5643745A (en) * 1994-02-03 1997-07-01 University Of Hawaii Heterologous dimeric proteins produced in heterokaryons

Also Published As

Publication number Publication date
EP0938545A4 (de) 2001-04-11
EP0938545A1 (de) 1999-09-01
NZ333684A (en) 2000-06-23
CA2260360A1 (en) 1998-01-15
DE69730235D1 (de) 2004-09-16
AU3511997A (en) 1998-02-02
WO1998001534A1 (en) 1998-01-15
JP2000514296A (ja) 2000-10-31
EP0938545B1 (de) 2004-08-11
AU738622B2 (en) 2001-09-20
US5683899A (en) 1997-11-04
US7267944B1 (en) 2007-09-11

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