ATE273385T1 - Neuartige verfahren und zusammensetzungen zur entdeckung von neuen multimerischen molekülen, basierend auf einer kombinatorisichen bibliothek - Google Patents

Neuartige verfahren und zusammensetzungen zur entdeckung von neuen multimerischen molekülen, basierend auf einer kombinatorisichen bibliothek

Info

Publication number
ATE273385T1
ATE273385T1 AT97931506T AT97931506T ATE273385T1 AT E273385 T1 ATE273385 T1 AT E273385T1 AT 97931506 T AT97931506 T AT 97931506T AT 97931506 T AT97931506 T AT 97931506T AT E273385 T1 ATE273385 T1 AT E273385T1
Authority
AT
Austria
Prior art keywords
compositions
discovery
novel methods
molecules based
multimeric molecules
Prior art date
Application number
AT97931506T
Other languages
English (en)
Inventor
W Dorsey Stuart
Original Assignee
Univ Hawaii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hawaii filed Critical Univ Hawaii
Application granted granted Critical
Publication of ATE273385T1 publication Critical patent/ATE273385T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • C12N15/04—Fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT97931506T 1996-07-09 1997-06-30 Neuartige verfahren und zusammensetzungen zur entdeckung von neuen multimerischen molekülen, basierend auf einer kombinatorisichen bibliothek ATE273385T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/678,462 US5683899A (en) 1994-02-03 1996-07-09 Methods and compositions for combinatorial-based discovery of new multimeric molecules
PCT/US1997/011425 WO1998001534A1 (en) 1996-07-09 1997-06-30 Novel methods and compositions for combinatorial-based discovery of new multimeric molecules

Publications (1)

Publication Number Publication Date
ATE273385T1 true ATE273385T1 (de) 2004-08-15

Family

ID=24722889

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97931506T ATE273385T1 (de) 1996-07-09 1997-06-30 Neuartige verfahren und zusammensetzungen zur entdeckung von neuen multimerischen molekülen, basierend auf einer kombinatorisichen bibliothek

Country Status (9)

Country Link
US (2) US5683899A (de)
EP (1) EP0938545B1 (de)
JP (1) JP2000514296A (de)
AT (1) ATE273385T1 (de)
AU (1) AU738622B2 (de)
CA (1) CA2260360A1 (de)
DE (1) DE69730235D1 (de)
NZ (1) NZ333684A (de)
WO (1) WO1998001534A1 (de)

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US6268140B1 (en) * 1994-02-03 2001-07-31 Neugenesis Combinatorial metabolic libraries
US6420140B1 (en) * 1996-10-11 2002-07-16 Abgenix, Inc. Production of multimeric protein by cell fusion method
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AU743305C (en) 1997-01-17 2006-03-30 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US7148054B2 (en) * 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US5989814A (en) * 1997-04-01 1999-11-23 Reagents Of The University Of California Screening methods in eucaryotic cells
US6497820B1 (en) 1998-02-03 2002-12-24 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
US5968361A (en) * 1998-02-24 1999-10-19 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
ATE440959T1 (de) * 2000-06-28 2009-09-15 Glycofi Inc Verfahren für die herstellung modifizierter glykoproteine
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
AU9684601A (en) 2000-10-12 2002-04-22 Univ Rochester Compositions that inhibit proliferation of cancer cells
US7811992B2 (en) 2002-02-06 2010-10-12 Stasys Technologies, Inc. Anti-infarction molecules
EP1495055B1 (de) * 2002-04-18 2013-08-14 Genencor International, Inc. Herstellung von funktionellen antikörpern in filamentösen pilzen
EP2116604A1 (de) 2002-08-05 2009-11-11 University of Rochester Proteinumwandlungsdomäne / Deaminasechimäre Proteine, zugehörige Verbindungen und Verwendungen davon
US20040053363A1 (en) * 2002-09-18 2004-03-18 Thomas Ryll Method for production of a multimeric protein by cell fusion
US20040053359A1 (en) * 2002-09-18 2004-03-18 Thomas Ryll Method for production of a multimeric protein by cell fusion
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
US8323014B2 (en) * 2003-10-31 2012-12-04 Pirelli Pneumatici S.P.A. Expandable bladder for tyre-curing apparatuses, a manufacturing method thereof, and a process for manufacturing tyres for vehicle wheels
US20060024782A1 (en) * 2004-01-21 2006-02-02 Novozymes A/S Production of a monoclonal antibody in a heterokaryon filamentous fungus or in a filamentous fungal host cell
WO2005070962A1 (en) * 2004-01-21 2005-08-04 Novozymes A/S Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell
EP1793858A4 (de) * 2004-09-08 2008-12-10 Univ Ohio State Res Found Menschliche monoklonale anti-ctla4-antikörper zur krebsbehandlung
US8163533B2 (en) * 2004-10-15 2012-04-24 Intrexon Corporation Methods and compositions for combinatorial-based production of multivalent recombinant antigens
EP1874950B1 (de) 2005-04-05 2015-06-03 Corning Incorporated Markierungsfreie biosensoren
EP2371843B1 (de) 2005-05-19 2014-09-17 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Funktionelle Epitope des Pneumokokken-Antigens und deren Nutzung
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
EP2395076A1 (de) 2005-10-14 2011-12-14 MUSC Foundation For Research Development Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie
EP3034083B1 (de) 2006-09-21 2020-12-09 University of Rochester Antisense-oligonukleotide zur behandlung von myotoner dystrophie
EP2104516B1 (de) 2006-11-01 2015-01-07 University of Rochester Verfahren und zusammensetzungen in zusammenhang mit der struktur und funktion von apobec3g
JP2010514839A (ja) 2007-01-03 2010-05-06 バーナム インスティテュート フォー メディカル リサーチ クロット結合化合物に関連する方法および組成物
CA2677665C (en) 2007-02-08 2019-11-05 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
CA2734322A1 (en) * 2008-08-15 2010-02-18 Georgetown University Na channels, disease, and related assays and compositions
US20120070443A1 (en) 2008-12-02 2012-03-22 University Of Utah Research Foundation Pde1 as a target therapeutic in heart disease
WO2011022502A1 (en) 2009-08-18 2011-02-24 Georgetown University Boronic acid compositions and methods related to cancer
US20110081293A1 (en) 2009-10-07 2011-04-07 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
WO2011075725A1 (en) 2009-12-18 2011-06-23 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
JP6205345B2 (ja) 2011-03-28 2017-09-27 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション ウイルス侵入の阻害に関する方法および組成物
JP6725513B2 (ja) * 2014-12-16 2020-07-22 ダニスコ・ユーエス・インク ヘルパー株媒介型真菌ゲノム改変用の組成物および方法
US12025615B2 (en) 2017-09-15 2024-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
EP4038222A4 (de) 2019-10-02 2023-10-18 Arizona Board of Regents on behalf of Arizona State University Verfahren und zusammensetzungen zur identifizierung von neoantigenen zur verwendung bei der behandlung und vorbeugung von krebs

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US4486533A (en) * 1982-09-02 1984-12-04 St. Louis University Filamentous fungi functional replicating extrachromosomal element
US4727037A (en) * 1984-02-15 1988-02-23 Cetus Corporation Assay kit and method for the determination of antibody class and subclass
US4880734A (en) * 1984-05-11 1989-11-14 Chiron Corporation Eukaryotic regulatable transcription
US4816405A (en) * 1984-10-24 1989-03-28 The Regents Of The University Of California Vectors for transformation by ascomycetes
US4885249A (en) * 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
US5364770A (en) * 1985-08-29 1994-11-15 Genencor International Inc. Heterologous polypeptides expressed in aspergillus
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
ATE148171T1 (de) * 1989-02-21 1997-02-15 Univ Washington Modifizierte formen von fortpflanzungshormonen
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
JPH0763363B2 (ja) * 1991-12-25 1995-07-12 萩原 義秀 融合細胞の取得方法
US5643745A (en) * 1994-02-03 1997-07-01 University Of Hawaii Heterologous dimeric proteins produced in heterokaryons

Also Published As

Publication number Publication date
US7267944B1 (en) 2007-09-11
CA2260360A1 (en) 1998-01-15
WO1998001534A1 (en) 1998-01-15
NZ333684A (en) 2000-06-23
EP0938545A1 (de) 1999-09-01
DE69730235D1 (de) 2004-09-16
EP0938545B1 (de) 2004-08-11
AU738622B2 (en) 2001-09-20
JP2000514296A (ja) 2000-10-31
EP0938545A4 (de) 2001-04-11
US5683899A (en) 1997-11-04
AU3511997A (en) 1998-02-02

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