ATE196802T1 - Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren - Google Patents

Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren

Info

Publication number
ATE196802T1
ATE196802T1 AT95930144T AT95930144T ATE196802T1 AT E196802 T1 ATE196802 T1 AT E196802T1 AT 95930144 T AT95930144 T AT 95930144T AT 95930144 T AT95930144 T AT 95930144T AT E196802 T1 ATE196802 T1 AT E196802T1
Authority
AT
Austria
Prior art keywords
small organic
antibodies
target
parts
domains
Prior art date
Application number
AT95930144T
Other languages
English (en)
Inventor
Arthur J Blume
Original Assignee
Dgi Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dgi Technologies Inc filed Critical Dgi Technologies Inc
Application granted granted Critical
Publication of ATE196802T1 publication Critical patent/ATE196802T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95930144T 1994-08-03 1995-08-02 Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren ATE196802T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28608494A 1994-08-03 1994-08-03
US08/473,105 US6010861A (en) 1994-08-03 1995-06-07 Target specific screens and their use for discovering small organic molecular pharmacophores
PCT/US1995/010182 WO1996004557A2 (en) 1994-08-03 1995-08-02 Target specific screens and their use for discovering small organic molecular pharmacophores

Publications (1)

Publication Number Publication Date
ATE196802T1 true ATE196802T1 (de) 2000-10-15

Family

ID=26963579

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95930144T ATE196802T1 (de) 1994-08-03 1995-08-02 Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren

Country Status (8)

Country Link
US (3) US6010861A (de)
EP (2) EP1028315A3 (de)
JP (1) JPH10507517A (de)
AT (1) ATE196802T1 (de)
AU (1) AU3363195A (de)
CA (1) CA2196679A1 (de)
DE (1) DE69519033T2 (de)
WO (1) WO1996004557A2 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
FI962269A7 (fi) * 1996-05-30 1997-12-01 Helsinki Univ Licensing Ltd Järjestelmä taudin aiheuttajia estävien peptidien seulomiseksi ja taudin aiheuttajien neutralisointikohtien kuvaamiseksi
US5928888A (en) * 1996-09-26 1999-07-27 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
AU744444B2 (en) * 1996-10-31 2002-02-21 Karo Bio Ab Identification of drugs using complementary combinatorial libraries
US6617114B1 (en) 1996-10-31 2003-09-09 Karo Bio Ab Identification of drug complementary combinatorial libraries
WO1998047087A1 (en) * 1997-04-17 1998-10-22 Glaxo Group Ltd. Statistical deconvoluting of mixtures
GB9722131D0 (en) * 1997-10-20 1997-12-17 Medical Res Council Method
EP1038021A4 (de) * 1997-12-12 2005-02-16 Jeffrey C Way Verbindungen und verfahren für die inhibierung von protein-protein-wechselwirkungen
US6846625B1 (en) 1998-01-09 2005-01-25 Cubist Pharmaceuticals, Inc. Method for identifying validated target and assay combination for drug development
US6475726B1 (en) 1998-01-09 2002-11-05 Cubist Pharmaceuticals, Inc. Method for identifying validated target and assay combinations for drug development
DE69938054T2 (de) * 1998-11-18 2009-02-12 Genentech, Inc., South San Francisco Antikörpervarianten mit höheren bindungsaffinitäten im vergleich zu parentalen antikörpern
US6329145B1 (en) 1999-02-09 2001-12-11 Gilead Science, Inc. Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand
EP1167522A4 (de) * 1999-03-10 2002-05-15 Ajinomoto Kk VERFAHREN ZUM SCREENING VON REGULATOREN DER AKTIVITäT VON BIOMOLEKüLEN
US6343257B1 (en) * 1999-04-23 2002-01-29 Peptor Ltd. Identifying pharmacophore containing combinations of scaffold molecules and substituents from a virtual library
EP2368902A3 (de) 2000-03-29 2011-12-21 DGI Bio Technologies LLC Agonisten und antagonisten der rezeptoren des insulin und des igf-1
CA2429544C (en) * 2000-11-17 2010-10-19 University Of Rochester In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
US20050196755A1 (en) * 2000-11-17 2005-09-08 Maurice Zauderer In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
US20020150895A1 (en) * 2000-12-22 2002-10-17 Raymond Wheeler Method and apparatus for filtering and extending RNA alignment coverage
US20030104402A1 (en) * 2001-01-23 2003-06-05 University Of Rochester Methods of producing or identifying intrabodies in eukaryotic cells
US20020169561A1 (en) * 2001-01-26 2002-11-14 Benight Albert S. Modular computational models for predicting the pharmaceutical properties of chemical compunds
US6989236B1 (en) * 2001-02-09 2006-01-24 University Of Kentucky Research Foundation Methods to identify plant metabolites
DE10125258A1 (de) * 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
AU2002319402B2 (en) * 2001-06-28 2008-09-11 Domantis Limited Dual-specific ligand and its use
EP1423137B1 (de) * 2001-08-06 2009-04-29 Cubist Pharmaceuticals, Inc. Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte
MXPA04001000A (es) * 2001-08-07 2004-06-25 Sunesis Pharmaceuticals Inc Mutantes de cisteina y metodos para detectar union de ligando a moleculas biologicas.
CA2479818A1 (en) * 2002-04-10 2003-10-23 Transtech Pharma, Inc. System and method for integrated computer-aided molecular discovery
US20050033470A1 (en) * 2002-06-06 2005-02-10 The Hong Kong Polytechnic University System and method for the three-dimensional analysis and reconstruction of the surface of a thin flexible material
US6728593B2 (en) 2002-06-06 2004-04-27 The Hong Kong Polytechnic University System for analysis of fabric surface
EP1600459A3 (de) * 2002-06-28 2005-12-07 Domantis Limited Ligand
US7888000B2 (en) * 2002-07-12 2011-02-15 Morehouse School Of Medicine Method for identifying salt-sensitive persons
US20040235056A1 (en) * 2003-05-07 2004-11-25 Mallouk Thomas E. Method of assembling particle libraries
GB2406094B (en) * 2003-09-17 2007-06-06 Antisoma Plc Modified antibody comprising an amino acid substitution mutation which confers increased stability
EP1522858A1 (de) * 2003-10-10 2005-04-13 Jean-Christophe Roegel Methoden für Selektion von Verbindungen unter Verwendung von Antikörpern mit Aktivität als Agonist, Antagonist oder allosterischen Modulatoren
US7737327B2 (en) * 2004-03-09 2010-06-15 The University Of Kentucky Research Foundation Methods for screening for genes and small molecules that activate mammalian receptor proteins
FR2869416B1 (fr) * 2004-04-27 2007-01-12 Centre Nat Rech Scient Cnrse Procede d'identification d'un ligand capable de moduler selectivement une cascade fonctionnelle impliquant une cible et ses applications pour le criblage a haut-debit de molecules d'interet.
US20060193849A1 (en) * 2005-02-25 2006-08-31 Antisoma Plc Biological materials and uses thereof
WO2007087266A2 (en) * 2006-01-23 2007-08-02 Errico Joseph P Methods and compositions of targeted drug development
US20120328628A1 (en) * 2006-07-07 2012-12-27 The Regents Of The University Of California Antibodies to conformationally trapped proteins
EP2045326A1 (de) * 2007-10-05 2009-04-08 Bayer CropScience AG Verfahren zum Identifizieren des Interaktionspartners eines Wirkstoffes
WO2013043582A1 (en) * 2011-09-23 2013-03-28 Merck Sharp & Dohme Corp. Cell surface display of ligands for the insulin and/or insulin growth factor 1 receptor and applications thereof
MA46523A (fr) 2016-10-12 2019-08-21 Janssen Biotech Inc Procédés de criblage de modulateurs d'une activité biologique de type gdf15
CN112924437B (zh) * 2019-12-06 2023-02-21 核工业西南物理研究院 一种激光诱导击穿光谱绝对定量分析方法
KR102580358B1 (ko) * 2021-06-17 2023-09-20 한국건설기술연구원 임의 위치 계측 및 다중 공간분해능 계측이 가능한 분포형 센싱 기법을 활용한 구조물 건전성 모니터링 장치 및 방법

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593002A (en) * 1982-01-11 1986-06-03 Salk Institute Biotechnology/Industrial Associates, Inc. Viruses with recombinant surface proteins
US4797363A (en) * 1984-03-19 1989-01-10 Board Of Trustees, University Of Illinois Bacteriophages as recognition and identification agents
US5144010A (en) * 1984-08-27 1992-09-01 The Trustees Of Columbia University In The City Of New York Method of producing monoclonal auto-anti-idiotypic antibodies
DE3546807C2 (de) * 1985-03-30 1991-03-28 Marc Genf/Geneve Ch Ballivet
US6492107B1 (en) * 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US4962777A (en) * 1985-05-21 1990-10-16 Transfresh Corporation Systems for cleaning and cooling produce
US5866363A (en) * 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US4818684A (en) * 1985-09-10 1989-04-04 The Trustees Of Columbia University In The City Of New York Auto-anti-idiotypic monoclonal antibodies to steroid receptors and uses thereof
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5030576A (en) * 1986-04-30 1991-07-09 Genentech, Inc. Receptors for efficient determination of ligands and their antagonists or agonists
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
EP0307434B2 (de) * 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Geänderte antikörper
US4963263A (en) * 1988-03-24 1990-10-16 Terrapin Technologies, Inc. Method of identity analyte-binding peptides
US5133866A (en) * 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
JPH07111427B2 (ja) * 1987-10-13 1995-11-29 テラピン テクノロジーズ，インコーポレイテッド 免疫診断薬を製造する方法
US5300425A (en) * 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5217869A (en) * 1987-10-13 1993-06-08 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
DE68909441T2 (de) * 1988-02-12 1994-02-10 British Tech Group Modifizierte Antikörper.
WO1989009233A1 (en) * 1988-03-24 1989-10-05 Terrapin Technologies, Inc. Molecular sticks for controlling protein conformation
CA1341411C (en) * 1988-04-16 2002-12-17 Lutz Riechmann Method for producing fv fragments in eukaryotic cells
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
EP0768377A1 (de) * 1988-09-02 1997-04-16 Protein Engineering Corporation Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
US5681726A (en) * 1988-09-19 1997-10-28 Stratagene Method of double stranded DNA synthesis
ES2052027T5 (es) * 1988-11-11 2005-04-16 Medical Research Council Clonacion de secuencias de dominio variable de inmunoglobulina.
US4962277A (en) * 1988-12-09 1990-10-09 Scripps Clinic And Research Foundation Deletion analogues of magainin peptides
US5198346A (en) * 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5096815A (en) * 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
US5215963A (en) * 1989-10-24 1993-06-01 Berlex Laboratories, Inc. Solubilization and purification of the active gastrin releasing peptide receptor
WO1991010907A1 (en) * 1990-01-22 1991-07-25 Synbiotics Corporation Pharmacologically active compound screening antibodies and hierarchical cluster analysis
US5427908A (en) * 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9012995D0 (en) * 1990-06-11 1990-08-01 Celltech Ltd Multivalent antigen-binding proteins
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
CA2109602C (en) * 1990-07-10 2002-10-01 Gregory P. Winter Methods for producing members of specific binding pairs
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
GB9016299D0 (en) * 1990-07-25 1990-09-12 Brien Caroline J O Binding substances
US5264563A (en) * 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
IL99553A0 (en) * 1990-09-28 1992-08-18 Ixsys Inc Compositions containing oligonucleotides linked to expression elements,a kit for the preparation of vectors useful for the expression of a diverse population of random peptides and methods utilizing the same
US5698426A (en) * 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
IL99552A0 (en) * 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
US5770434A (en) * 1990-09-28 1998-06-23 Ixsys Incorporated Soluble peptides having constrained, secondary conformation in solution and method of making same
US5871974A (en) * 1990-09-28 1999-02-16 Ixsys Inc. Surface expression libraries of heteromeric receptors
DE69131017T2 (de) * 1990-12-20 1999-07-15 Ixsys, Inc., San Diego, Calif. Optimierung von bindenden proteinen
WO1992011364A1 (en) * 1990-12-21 1992-07-09 Creative Biomolecules, Inc. Biosynthetic pdgf antagonists
US5322699A (en) * 1991-02-04 1994-06-21 The Rockefeller University Leukocyte-derived CR3 modulator, integrin modulating factor-1 (IMF-1)
FI940144A7 (fi) * 1991-07-15 1994-01-12 The Wellcome Foundation Ltd Vasta-aineiden tuotanto
NL9101290A (nl) * 1991-07-23 1993-02-16 Stichting Rega V Z W Recombinant dna-molecuul voor de expressie van een fv-fragment van een antilichaam.
US5230998A (en) * 1991-07-25 1993-07-27 Neurath Alexander R Method for the prescreening of drugs targeted to the V3 hypervariable loop of the HIV-1 envelope glycoprotein gp 120
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
PT1696031E (pt) * 1991-12-02 2010-06-25 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
US5488099A (en) * 1992-03-06 1996-01-30 Persson, Deceased; Hakan B. Multifunctional chimeric neurotrophic factors
US5597920A (en) * 1992-04-30 1997-01-28 Neurogen Corporation Gabaa receptor subtypes and methods for screening drug compounds using imidazoquinoxalines and pyrrolopyrimidines to bind to gabaa receptor subtypes
CA2149025A1 (en) * 1992-12-01 1994-06-09 Man Sung Co Humanized antibodies reactive with l-selectin
WO1994018219A1 (en) * 1993-02-02 1994-08-18 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
ATE529444T1 (de) * 1994-01-11 2011-11-15 Dyax Corp Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
DE69533472T2 (de) * 1994-01-11 2006-01-12 Dyax Corp., Cambridge Kallikreinhemmende "kunitz-domäne"-proteine und derivaten davon
US6057287A (en) * 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
US5602024A (en) * 1994-12-02 1997-02-11 Synaptic Pharmaceutical Corporation DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
US5576423A (en) * 1994-12-02 1996-11-19 Schering Corporation Antibodies to the slam protein expressed on activated T cells
US5573423A (en) * 1995-01-18 1996-11-12 Lin; Kuang-Ts'an Innovative distribution cable mounting device
US5605911A (en) * 1995-01-31 1997-02-25 Washington University Use of alpha-2 adrenergic drugs to prevent adverse effects of NMDA receptor hypofunction (NRH)
US5780426A (en) * 1995-06-07 1998-07-14 Ixsys, Incorporated Fivemer cyclic peptide inhibitors of diseases involving αv β3
US5767071A (en) * 1995-06-07 1998-06-16 Ixsys Incorporated Sevenmer cyclic peptide inhibitors of diseases involving αv β3
JPH11507246A (ja) * 1996-03-20 1999-06-29 ダイアックス コープ． 巨大分子用アフィニティ・リガンドの設計
US5862514A (en) * 1996-12-06 1999-01-19 Ixsys, Inc. Method and means for synthesis-based simulation of chemicals having biological functions
US6387879B1 (en) * 1997-12-15 2002-05-14 Dgi Biotechnologies, Inc. Compounds that bind growth to hormone receptor

Also Published As

Publication number Publication date
WO1996004557A2 (en) 1996-02-15
DE69519033T2 (de) 2001-05-17
EP0774118B1 (de) 2000-10-04
AU3363195A (en) 1996-03-04
US20040072271A1 (en) 2004-04-15
WO1996004557A3 (en) 1996-04-25
EP1028315A2 (de) 2000-08-16
EP0774118A2 (de) 1997-05-21
JPH10507517A (ja) 1998-07-21
US20030092057A1 (en) 2003-05-15
CA2196679A1 (en) 1996-02-15
US6010861A (en) 2000-01-04
DE69519033D1 (de) 2000-11-09
EP1028315A3 (de) 2004-01-02

Similar Documents

Publication Publication Date Title
DE69519033D1 (de) Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren
ATE522610T1 (de) Menschliche, metabotrope glutamatrezeptor- subtypen (hmr6) und verwandte dns-verbindungen
ATE529509T1 (de) Selektion von proteinen unter verwendung von rna- protein-fusionen
DE19782097T1 (de) Zusammensetzungen und Verfahren zur Immobilisierung von Nucleinsäuren an feste Träger
DE69638128D1 (de) Verfahren zu Chemokinrezeptor 88C
DE69737683D1 (de) Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungen
ATE335498T1 (de) Methode mit hoher durchsatzrate zur funktionellen klassifizierung von in einem genomischen versuchsansatz identifizierten proteinen
ATE273385T1 (de) Neuartige verfahren und zusammensetzungen zur entdeckung von neuen multimerischen molekülen, basierend auf einer kombinatorisichen bibliothek
DE122008000039I1 (de) Modularer Zusammenbau von Antikorpergenen, dadurchhergestellte Antikorper und deren Anwendungen.
EP0911342A4 (de) Neues protein und verfahren zu dessen herstellung
DE69714654D1 (de) Verwendung von einem Metalloporphyrinkonjugat für den Nachweis biologischer Verbindungen
DK0630405T3 (da) Hidtil ukendt 7-transmembranreceptor benævnt V28
DE58909458D1 (de) Antigenkonstrukte von "Major Histocompatibility Complex" Klasse I Antigenen mit spezifischen Trägermolekülen, ihre Herstellung und Verwendung.
DE69932712D1 (de) Vorhersage über die rezeptor-modulierende wirkung von verbindungen
ATE200579T1 (de) Screening-verfahren zur ligand-identifizierung von zielproteinen
DK0845005T3 (da) TRAF-inhibitorer
ATE174067T1 (de) Screening-verfahren für genbanken (recombinant libraries)
NO904160D0 (no) Ligandholdig medium for kromatografisk separering, og fremgangsmaate til fremstilling av mediet.
EP0574414A4 (de) Wachstumsfaktor-ligand, der an den erbb-2-rezeptor bindet und die zellulären reaktionen induziert.
DE59309978D1 (de) Verfahren zur Herstellung von rekombinanten und synthetischen Peptiden und deren Verwendung
ATE466953T1 (de) Verfahren zur identifizierung aktivierter polymer-komplexe zur sekundären stellen-spezifischen modifikation von protein ziel-gruppen.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties