ATE196802T1 - Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren - Google Patents
Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophorenInfo
- Publication number
- ATE196802T1 ATE196802T1 AT95930144T AT95930144T ATE196802T1 AT E196802 T1 ATE196802 T1 AT E196802T1 AT 95930144 T AT95930144 T AT 95930144T AT 95930144 T AT95930144 T AT 95930144T AT E196802 T1 ATE196802 T1 AT E196802T1
- Authority
- AT
- Austria
- Prior art keywords
- small organic
- antibodies
- target
- parts
- domains
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28608494A | 1994-08-03 | 1994-08-03 | |
| US08/473,105 US6010861A (en) | 1994-08-03 | 1995-06-07 | Target specific screens and their use for discovering small organic molecular pharmacophores |
| PCT/US1995/010182 WO1996004557A2 (en) | 1994-08-03 | 1995-08-02 | Target specific screens and their use for discovering small organic molecular pharmacophores |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE196802T1 true ATE196802T1 (de) | 2000-10-15 |
Family
ID=26963579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95930144T ATE196802T1 (de) | 1994-08-03 | 1995-08-02 | Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6010861A (de) |
| EP (2) | EP1028315A3 (de) |
| JP (1) | JPH10507517A (de) |
| AT (1) | ATE196802T1 (de) |
| AU (1) | AU3363195A (de) |
| CA (1) | CA2196679A1 (de) |
| DE (1) | DE69519033T2 (de) |
| WO (1) | WO1996004557A2 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
| FI962269A7 (fi) * | 1996-05-30 | 1997-12-01 | Helsinki Univ Licensing Ltd | Järjestelmä taudin aiheuttajia estävien peptidien seulomiseksi ja taudin aiheuttajien neutralisointikohtien kuvaamiseksi |
| US5928888A (en) * | 1996-09-26 | 1999-07-27 | Aurora Biosciences Corporation | Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities |
| JP2001510453A (ja) * | 1996-10-31 | 2001-07-31 | ノヴァロン ファーマスーチカル コーポレイション | 相補的組み合わせライブラリーを使用する薬剤の同定 |
| US6617114B1 (en) | 1996-10-31 | 2003-09-09 | Karo Bio Ab | Identification of drug complementary combinatorial libraries |
| EP0976070A1 (de) * | 1997-04-17 | 2000-02-02 | Glaxo Group Limited | Statistiches entfalten von mischungen |
| GB9722131D0 (en) * | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| WO1999031265A1 (en) * | 1997-12-12 | 1999-06-24 | Way Jeffrey C | Compounds and methods for the inhibition of protein-protein interactions |
| US6846625B1 (en) | 1998-01-09 | 2005-01-25 | Cubist Pharmaceuticals, Inc. | Method for identifying validated target and assay combination for drug development |
| US6475726B1 (en) | 1998-01-09 | 2002-11-05 | Cubist Pharmaceuticals, Inc. | Method for identifying validated target and assay combinations for drug development |
| EP1135498B1 (de) * | 1998-11-18 | 2008-01-23 | Genentech, Inc. | Antikörpervarianten mit höheren bindungsaffinitäten im vergleich zu parentalen antikörpern |
| US6329145B1 (en) | 1999-02-09 | 2001-12-11 | Gilead Science, Inc. | Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand |
| CA2367313A1 (en) * | 1999-03-10 | 2000-09-14 | Ajinomoto Co., Inc. | Method for screening biomolecule activity regulator |
| US6343257B1 (en) * | 1999-04-23 | 2002-01-29 | Peptor Ltd. | Identifying pharmacophore containing combinations of scaffold molecules and substituents from a virtual library |
| JP2004512010A (ja) | 2000-03-29 | 2004-04-22 | ディージーアイ・バイオテクノロジーズ・エル・エル・シー | インスリン及びigf−1受容体のアゴニスト及びアンタゴニスト |
| US20050196755A1 (en) * | 2000-11-17 | 2005-09-08 | Maurice Zauderer | In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells |
| JP4368196B2 (ja) * | 2000-11-17 | 2009-11-18 | ユニバーシティー オブ ロチェスター | 真核細胞において免疫グロブリン分子を製造および同定するインビトロにおける方法 |
| US20020150895A1 (en) * | 2000-12-22 | 2002-10-17 | Raymond Wheeler | Method and apparatus for filtering and extending RNA alignment coverage |
| AU2002338446A1 (en) * | 2001-01-23 | 2002-11-05 | University Of Rochester Medical Center | Methods of producing or identifying intrabodies in eukaryotic cells |
| WO2002059561A2 (en) * | 2001-01-26 | 2002-08-01 | Bioinformatics Dna Codes, Llc | Modular computational models for predicting the pharmaceutical properties of chemical compounds |
| US6989236B1 (en) * | 2001-02-09 | 2006-01-24 | University Of Kentucky Research Foundation | Methods to identify plant metabolites |
| DE10125258A1 (de) * | 2001-05-23 | 2003-01-09 | November Ag Molekulare Medizin | Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden |
| CA2447851C (en) * | 2001-06-28 | 2012-08-28 | Domantis Limited | Dual-specific ligand and its use |
| EP1423414A4 (de) * | 2001-08-06 | 2005-11-30 | Cubist Pharm Inc | Neue depsipeptide und verfahren zu deren herstellung |
| JP2005503380A (ja) * | 2001-08-07 | 2005-02-03 | サネシス ファーマシューティカルズ, インコーポレイテッド | システイン変異体および生物学的分子に結合するリガンドを検出するための方法 |
| WO2003088125A2 (en) * | 2002-04-10 | 2003-10-23 | Transtech Pharma, Inc. | System and method for integrated computer-aided molecular discovery |
| US20050033470A1 (en) * | 2002-06-06 | 2005-02-10 | The Hong Kong Polytechnic University | System and method for the three-dimensional analysis and reconstruction of the surface of a thin flexible material |
| US6728593B2 (en) | 2002-06-06 | 2004-04-27 | The Hong Kong Polytechnic University | System for analysis of fabric surface |
| EP1517921B1 (de) * | 2002-06-28 | 2006-06-07 | Domantis Limited | Dual-specifische liganden mit erhöhter halbwertszeit |
| AU2003256515A1 (en) * | 2002-07-12 | 2004-02-02 | Morehouse School Of Medicine | Method for identifying salt-sensitive persons |
| US20040235056A1 (en) * | 2003-05-07 | 2004-11-25 | Mallouk Thomas E. | Method of assembling particle libraries |
| GB2406094B (en) * | 2003-09-17 | 2007-06-06 | Antisoma Plc | Modified antibody comprising an amino acid substitution mutation which confers increased stability |
| EP1522858A1 (de) * | 2003-10-10 | 2005-04-13 | Jean-Christophe Roegel | Methoden für Selektion von Verbindungen unter Verwendung von Antikörpern mit Aktivität als Agonist, Antagonist oder allosterischen Modulatoren |
| US7737327B2 (en) * | 2004-03-09 | 2010-06-15 | The University Of Kentucky Research Foundation | Methods for screening for genes and small molecules that activate mammalian receptor proteins |
| FR2869416B1 (fr) * | 2004-04-27 | 2007-01-12 | Centre Nat Rech Scient Cnrse | Procede d'identification d'un ligand capable de moduler selectivement une cascade fonctionnelle impliquant une cible et ses applications pour le criblage a haut-debit de molecules d'interet. |
| US20060193849A1 (en) * | 2005-02-25 | 2006-08-31 | Antisoma Plc | Biological materials and uses thereof |
| US20080015194A1 (en) * | 2006-01-23 | 2008-01-17 | Joseph Errico | Methods and compositions of targeted drug development |
| WO2008006087A2 (en) * | 2006-07-07 | 2008-01-10 | The Regents Of The University Of California | Antibodies to conformationally trapped proteins |
| EP2045326A1 (de) * | 2007-10-05 | 2009-04-08 | Bayer CropScience AG | Verfahren zum Identifizieren des Interaktionspartners eines Wirkstoffes |
| US20140342932A1 (en) * | 2011-09-23 | 2014-11-20 | Merck Sharp & Dohme Corp. | Functional cell surface display of ligands for the insulin and/or insulin growth factor 1 receptor and applications thereof |
| CA3038846A1 (en) | 2016-10-12 | 2018-04-19 | Janssen Biotech, Inc. | Methods for screening for modulators of gdf15-like biological activity |
| CN112924437B (zh) * | 2019-12-06 | 2023-02-21 | 核工业西南物理研究院 | 一种激光诱导击穿光谱绝对定量分析方法 |
| KR102580358B1 (ko) * | 2021-06-17 | 2023-09-20 | 한국건설기술연구원 | 임의 위치 계측 및 다중 공간분해능 계측이 가능한 분포형 센싱 기법을 활용한 구조물 건전성 모니터링 장치 및 방법 |
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-
1995
- 1995-06-07 US US08/473,105 patent/US6010861A/en not_active Expired - Fee Related
- 1995-08-02 EP EP00111315A patent/EP1028315A3/de not_active Ceased
- 1995-08-02 WO PCT/US1995/010182 patent/WO1996004557A2/en not_active Ceased
- 1995-08-02 JP JP8506821A patent/JPH10507517A/ja not_active Ceased
- 1995-08-02 CA CA002196679A patent/CA2196679A1/en not_active Abandoned
- 1995-08-02 EP EP95930144A patent/EP0774118B1/de not_active Expired - Lifetime
- 1995-08-02 AT AT95930144T patent/ATE196802T1/de not_active IP Right Cessation
- 1995-08-02 AU AU33631/95A patent/AU3363195A/en not_active Abandoned
- 1995-08-02 DE DE69519033T patent/DE69519033T2/de not_active Expired - Fee Related
-
1999
- 1999-10-05 US US09/412,831 patent/US20030092057A1/en not_active Abandoned
-
2003
- 2003-10-08 US US10/681,669 patent/US20040072271A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040072271A1 (en) | 2004-04-15 |
| EP0774118B1 (de) | 2000-10-04 |
| US6010861A (en) | 2000-01-04 |
| WO1996004557A2 (en) | 1996-02-15 |
| EP1028315A2 (de) | 2000-08-16 |
| DE69519033T2 (de) | 2001-05-17 |
| US20030092057A1 (en) | 2003-05-15 |
| AU3363195A (en) | 1996-03-04 |
| WO1996004557A3 (en) | 1996-04-25 |
| DE69519033D1 (de) | 2000-11-09 |
| CA2196679A1 (en) | 1996-02-15 |
| JPH10507517A (ja) | 1998-07-21 |
| EP1028315A3 (de) | 2004-01-02 |
| EP0774118A2 (de) | 1997-05-21 |
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