ATE273978T1 - 7-aminopyrido(2,3-d)-pyrimidine derivate zur behandlung von bronchialasthma - Google Patents

7-aminopyrido(2,3-d)-pyrimidine derivate zur behandlung von bronchialasthma

Info

Publication number: ATE273978T1
Authority: AT; Austria
Prior art keywords: optionally substituted; halogen; lower alkyl; bronchial asthma; aminopyrido
Prior art date: 1998-10-15

Application number

AT99120013T

Other languages

English (en)

Inventor

Takashi Ogino

Kazuhito Furukuwa

Original Assignee

Nippon Zoki Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-15

Filing date

1999-10-15

Publication date

2004-09-15

1999-10-15 Application filed by Nippon Zoki Pharmaceutical Co filed Critical Nippon Zoki Pharmaceutical Co

2004-09-15 Application granted granted Critical

2004-09-15 Publication of ATE273978T1 publication Critical patent/ATE273978T1/de

Links

208000006673 asthma Diseases 0.000 title abstract 2
208000030603 inherited susceptibility to asthma Diseases 0.000 title abstract 2
SZWAMIJZBXMYDW-UHFFFAOYSA-N pyrido[2,3-d]pyrimidin-7-amine Chemical class C1=NC=NC2=NC(N)=CC=C21 SZWAMIJZBXMYDW-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
JPRPJUMQRZTTED-UHFFFAOYSA-N 1,3-dioxolanyl Chemical group [CH]1OCCO1 JPRPJUMQRZTTED-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
-1 benzyloxy, carboxyl Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000000916 dilatatory effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
230000002349 favourable effect Effects 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99120013T 1998-10-15 1999-10-15 7-aminopyrido(2,3-d)-pyrimidine derivate zur behandlung von bronchialasthma ATE273978T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP10293250A JP2000119272A (ja)	1998-10-15	1998-10-15	新規７−アミノピリド〔２，３−ｄ〕ピリミジン誘導体

Publications (1)

Publication Number	Publication Date
ATE273978T1 true ATE273978T1 (de)	2004-09-15

Family

ID=17792398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99120013T ATE273978T1 (de)	1998-10-15	1999-10-15	7-aminopyrido(2,3-d)-pyrimidine derivate zur behandlung von bronchialasthma

Country Status (6)

Country	Link
US (1)	US6242452B1 (de)
EP (1)	EP0994113B1 (de)
JP (1)	JP2000119272A (de)
AT (1)	ATE273978T1 (de)
DE (1)	DE69919478T2 (de)
ES (1)	ES2224521T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI243055B (en)	2000-04-13	2005-11-11	Nippon Zoki Pharmaceutical Co	Pharmaceutical composition for use in treatment of dermatitis
US6825180B2 (en)	2001-05-18	2004-11-30	Cell Therapeutics, Inc.	Pyridopyrimidine compounds and their uses
FR2832711B1 (fr)	2001-11-26	2004-01-30	Warner Lambert Co	Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
US7019002B2 (en) *	2001-12-11	2006-03-28	Pharmacia & Upjohn, S.P.A.	Pyridopyrimidinones derivatives as telomerase inhibitors
KR100490970B1 (ko) *	2002-03-22	2005-05-24	씨제이 주식회사	신규 피리도[2,3-ｄ]피리미딘 카르보알데히드 옥심계ＰＤＥ Ⅳ 효소 저해 화합물 및 이의 제조방법
WO2004063195A1 (en) *	2003-01-03	2004-07-29	Sloan-Kettering Institute For Cancer Research	Pyridopyrimidine kinase inhibitors
WO2006019965A2 (en) *	2004-07-16	2006-02-23	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
WO2023042879A1 (ja) *	2021-09-17	2023-03-23	塩野義製薬株式会社	ウイルス増殖阻害活性を有する二環性複素環誘導体およびそれらを含有する医薬組成物
CN115974868B (zh) *	2022-11-07	2024-04-12	安徽理工大学	一种尿嘧啶衍生物的合成方法及其抗肺纤维化方面的潜在应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB989048A (en)	1962-08-02	1965-04-14	Mead Johnson & Co	Pyrido[2,3-d]pyrimidines
US3235554A (en) *	1963-11-12	1966-02-15	Searle & Co	7-amino-1-methyl-2, 4-dioxo-1, 2, 3, 4, 5, 6-hexahydropyrido[2, 3-d]-pyrimidine and related compounds
US3272816A (en) *	1965-04-28	1966-09-13	Searle & Co	7-amino-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrido[2, 3-d]pyrimidines
US3275634A (en)	1965-09-02	1966-09-27	Searle & Co	7-hydroxy-2, 4-dioxo-1, 2, 3, 4, 5, 6-hexahydropyrido[2, 3-d]pyrimidines
LU65139A1 (de)	1972-04-07	1973-10-22
DE2334266A1 (de)	1972-07-07	1974-01-31	Hisamitsu Pharmaceutical Co	Pyrido eckige klammer auf 2,3-d eckige klammer zu pyrimidin-2,4 (1h, 3h)-dione
JPS60226882A (ja)	1984-04-24	1985-11-12	Nippon Zoki Pharmaceut Co Ltd	新規ピリミドピリミジン誘導体
US4808587A (en)	1986-04-16	1989-02-28	Nippon Zoki Pharmaceutical Co., Ltd.	5-substituted pyrido[2,3-d]pyrimidine-2,4-diones
ES2031513T3 (es)	1986-08-21	1992-12-16	Pfizer Inc.	Quinazolindionas y piridopirimidinadionas.
DE4035479A1 (de)	1990-11-08	1992-05-14	Basf Ag	Substituierte pyrido (2,3-d)pyrimidin-2,4(1h,3h)-dione
US5264437A (en)	1992-03-20	1993-11-23	Syntex (U.S.A.) Inc.	Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones
US5776942A (en) *	1994-06-17	1998-07-07	Nippon Zoki Pharmaceutical Co., Ltd.	Bronchodilating pyrido 2,3-d!pyrimidine derivatives

1998
- 1998-10-15 JP JP10293250A patent/JP2000119272A/ja not_active Withdrawn
1999
- 1999-10-14 US US09/418,982 patent/US6242452B1/en not_active Expired - Fee Related
- 1999-10-15 ES ES99120013T patent/ES2224521T3/es not_active Expired - Lifetime
- 1999-10-15 AT AT99120013T patent/ATE273978T1/de not_active IP Right Cessation
- 1999-10-15 DE DE69919478T patent/DE69919478T2/de not_active Expired - Fee Related
- 1999-10-15 EP EP99120013A patent/EP0994113B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69919478T2 (de)	2005-09-08
ES2224521T3 (es)	2005-03-01
EP0994113A3 (de)	2000-05-24
EP0994113B1 (de)	2004-08-18
JP2000119272A (ja)	2000-04-25
DE69919478D1 (de)	2004-09-23
US6242452B1 (en)	2001-06-05
EP0994113A2 (de)	2000-04-19

Legal Events

Date	Code	Title	Description
2005-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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