ATE273992T1 - Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten - Google Patents

Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten

Info

Publication number
ATE273992T1
ATE273992T1 AT00938426T AT00938426T ATE273992T1 AT E273992 T1 ATE273992 T1 AT E273992T1 AT 00938426 T AT00938426 T AT 00938426T AT 00938426 T AT00938426 T AT 00938426T AT E273992 T1 ATE273992 T1 AT E273992T1
Authority
AT
Austria
Prior art keywords
ascorbic acid
phytostanols
phytosterols
conjugates
treatment
Prior art date
Application number
AT00938426T
Other languages
English (en)
Inventor
James P Kutney
Yangbing Ding
Honming Chen
Duanjie Hou
Radka K Milanova
Original Assignee
Forbes Medi Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forbes Medi Tech Inc filed Critical Forbes Medi Tech Inc
Application granted granted Critical
Publication of ATE273992T1 publication Critical patent/ATE273992T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Peptides Or Proteins (AREA)
AT00938426T 1999-06-23 2000-06-20 Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten ATE273992T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33990399A 1999-06-23 1999-06-23
PCT/CA2000/000730 WO2001000653A1 (en) 1999-06-23 2000-06-20 Conjugates of phytosterol or phytostanol with ascorbic acid and use thereof in treating or preventing cardiovascular disease

Publications (1)

Publication Number Publication Date
ATE273992T1 true ATE273992T1 (de) 2004-09-15

Family

ID=23331117

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00938426T ATE273992T1 (de) 1999-06-23 2000-06-20 Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten

Country Status (20)

Country Link
US (1) US20020156051A1 (de)
EP (2) EP1189924B1 (de)
JP (1) JP2003522124A (de)
KR (1) KR100711861B1 (de)
CN (1) CN1237071C (de)
AT (1) ATE273992T1 (de)
AU (1) AU5383700A (de)
BR (1) BR0011863A (de)
CA (1) CA2377492A1 (de)
DE (1) DE60013130T2 (de)
DK (1) DK1189924T3 (de)
ES (1) ES2226856T3 (de)
HK (1) HK1049342B (de)
NO (1) NO323774B1 (de)
NZ (1) NZ516349A (de)
PT (1) PT1189924E (de)
RU (1) RU2002101483A (de)
SI (1) SI1189924T1 (de)
WO (1) WO2001000653A1 (de)
ZA (1) ZA200110483B (de)

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KR20020026053A (ko) * 2000-09-30 2002-04-06 노승권 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료
PT1333838E (pt) * 2000-10-25 2007-01-31 Forbes Medi Tech Inc Compostos que compreendem uma fracção fitoesterol e/ ou fitoestanol e ácido ascórbico e sua utilização como agentes reguladores do peso
KR100396211B1 (ko) * 2000-10-31 2003-09-17 (주)유진사이언스 천연물로 구성된 수용성 식물성 스테롤 유도체 및 이의염과 이들의 제조방법
WO2003009854A1 (en) * 2001-07-20 2003-02-06 Lonza Ag Lipid lowering composition comprising carnitine and phytosterol
WO2003026672A1 (en) * 2001-09-26 2003-04-03 Forbes Medi-Tech Inc. A method of reducing the in vivo cholesterol ester transfer protein mediated transfer of cholesteryl esters between high density lipoproteins (hdl) and low density lipoproteins (ldl)
WO2003063605A1 (en) * 2002-02-01 2003-08-07 Eugene Science Inc. Chewing gum composition containing plant sterol for decrease of flood cholesterol levels and prevention of periodontal disease
RU2334518C2 (ru) * 2002-03-14 2008-09-27 Форбз Меди-Тек Инк. Способ лечения сахарного диабета, включая состояния, ассоциированные с сахарным диабетом, и осложнения сахарного диабета
US20050118203A1 (en) * 2002-03-20 2005-06-02 Won-Tae Yoon Mixing powder of plant sterol and emulsifier, and method for preparing the same
EP1653814A4 (de) * 2002-03-20 2009-03-04 Eugene Science Inc Pflanzensterolhaltiges naghrungsmittel und verfahren zu seiner herstellung
US20030232797A1 (en) * 2002-06-06 2003-12-18 Forbes Medi-Tech Inc. Novel derivatives of androstane and androstene with ascorbic acid and use thereof in treating or preventing various conditions, diseases, and disorders
AU2003241478A1 (en) * 2002-06-10 2003-12-22 Elan Pharma International, Ltd. Nanoparticulate sterol formulations and sterol combinations
BR0311689A (pt) 2002-06-12 2008-01-15 Coca Cola Co processo para a produção de uma dispersão substancialmente estável, produto, e, composição
US7306819B2 (en) 2002-06-12 2007-12-11 The Coca-Cola Company Beverages containing plant sterols
US20040001874A1 (en) * 2002-06-24 2004-01-01 Vital Living, Inc. Safe and effective nutritional supplement formulations and associated regimens adapted to prevent and/or treat targeted diseases or medical or health conditions, and related methods
AU2003266885A1 (en) * 2002-09-25 2004-04-19 Forbes Medi-Tech Inc. Derivatives comprising sterols and/or stanols and specific classes of anti-inflammatory agents and use thereof in treating or preventing cardiovascular disease
WO2004048497A1 (ja) * 2002-11-22 2004-06-10 Nippon Suisan Kaisha, Ltd. 高度不飽和脂肪酸、その塩、またはそのエステルを含有する外用組成物
NZ545087A (en) * 2003-07-09 2009-10-30 Forbes Medi Tech Inc Novel compounds and compositions comprising sterols and/or stanols and cholesterol biosynthesis inhibitors and use thereof in treating or preventing a variety of diseases and conditions
WO2005042692A2 (en) * 2003-10-31 2005-05-12 Forbes Medi-Tech Inc. A method of inhibiting the expression of genes which mediate cellular cholesterol influx in animal cells and inhibiting the production of proteins resulting from the expression of such genes using cholesterol absorption inhibitors
GB0513881D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
US20080182801A1 (en) 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0329667D0 (en) * 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
US20050214383A1 (en) * 2004-03-29 2005-09-29 William Bubnis Multi-vitamin and mineral nutritional supplements
US20050234025A1 (en) * 2004-04-20 2005-10-20 Forbes Medi-Tech Inc. Compositions comprising one or more policosanols and/or policosanoic acids combined with sterol and/or steroid based ascorbic acid derivatives, and uses thereof
WO2006063219A2 (en) * 2004-12-09 2006-06-15 Pro-Health, Inc. Product and method for oral administration of nutraceuticals
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513888D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
GB0513883D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Diagnosis of Atherosclerosis
CL2009000409A1 (es) * 2009-02-23 2009-05-04 Rojas Alejandro Markovits Proceso para obtener una dispersión de fitoesteroles sólidos en agua.
JP5657902B2 (ja) * 2010-03-17 2015-01-21 株式会社コスモステクニカルセンター ポリオキシアルキレンステロールエーテル誘導体及び／又はポリオキシアルキレンスタノールエーテル誘導体、及びそれを含有する外用剤組成物
KR20140093661A (ko) * 2011-09-16 2014-07-28 데이비슨 로페즈, 엘엘씨 식물 스테로이드 및 그의 용도
KR102816341B1 (ko) * 2022-01-24 2025-06-05 연세대학교 산학협력단 심혈관계 질환의 예방 또는 치료용 약학적 조성물

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JPS56113800A (en) * 1980-02-14 1981-09-07 Green Cross Corp:The Water-soluble cholesterol derivative
JPH0228189A (ja) * 1988-04-25 1990-01-30 Takeda Chem Ind Ltd アスコルビン酸リン酸エステル誘導体およびその製造法
IL89850A0 (en) * 1988-04-25 1989-12-15 Takeda Chemical Industries Ltd Ester of ascorbic acid 2-phosphate
CA2028759A1 (en) * 1989-11-22 1991-05-23 Jean-Marie Cassal Steroids
DE4000397A1 (de) * 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
JPH07252294A (ja) * 1994-01-28 1995-10-03 Senju Pharmaceut Co Ltd 副腎皮質ステロイド誘導体
US5866147A (en) * 1995-05-15 1999-02-02 Avon Products, Inc. Ascorbyl-phosphoryl-cholesterol
US5951990A (en) * 1995-05-15 1999-09-14 Avon Products, Inc. Ascorbyl-phosphoryl-cholesterol
DE19701264A1 (de) * 1997-01-16 1998-07-23 Kief Lizenz Verwertungsgesells Heilmittel, enthaltend Betasitosterin und/oder Phytosterol/Betasitosteringemische
FI974648L (fi) * 1997-09-09 1999-05-06 Raisio Benecol Oy Hydroksihappo-, maitohappo- ja hydroksialkanoaattiesterit ja niiden käyttö

Also Published As

Publication number Publication date
DK1189924T3 (da) 2004-12-20
ZA200110483B (en) 2003-06-20
HK1049342B (zh) 2006-04-07
HK1049342A1 (en) 2003-05-09
NO20016294L (no) 2002-02-22
EP1420026A2 (de) 2004-05-19
EP1189924A1 (de) 2002-03-27
RU2002101483A (ru) 2003-09-20
CN1370180A (zh) 2002-09-18
SI1189924T1 (en) 2005-02-28
EP1420026A3 (de) 2004-12-15
DE60013130D1 (de) 2004-09-23
NO323774B1 (no) 2007-07-02
WO2001000653A1 (en) 2001-01-04
CN1237071C (zh) 2006-01-18
KR100711861B1 (ko) 2007-04-25
CA2377492A1 (en) 2001-01-04
NO20016294D0 (no) 2001-12-20
BR0011863A (pt) 2003-10-14
NZ516349A (en) 2004-03-26
AU5383700A (en) 2001-01-31
EP1189924B1 (de) 2004-08-18
JP2003522124A (ja) 2003-07-22
PT1189924E (pt) 2004-12-31
US20020156051A1 (en) 2002-10-24
DE60013130T2 (de) 2005-01-05
KR20020028907A (ko) 2002-04-17
ES2226856T3 (es) 2005-04-01

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