ATE274053T1 - Methode zur identifizierung von verbindungen die mit rac proteine kinase interagieren - Google Patents

Methode zur identifizierung von verbindungen die mit rac proteine kinase interagieren

Info

Publication number
ATE274053T1
ATE274053T1 AT96938081T AT96938081T ATE274053T1 AT E274053 T1 ATE274053 T1 AT E274053T1 AT 96938081 T AT96938081 T AT 96938081T AT 96938081 T AT96938081 T AT 96938081T AT E274053 T1 ATE274053 T1 AT E274053T1
Authority
AT
Austria
Prior art keywords
rac
protein kinase
interact
screening
modulators
Prior art date
Application number
AT96938081T
Other languages
English (en)
Inventor
Brian Arthur Hemmings
Philip Cohen
Dario Alessi
Darren Cross
Mirjana Andjelkovic
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9523379.7A external-priority patent/GB9523379D0/en
Priority claimed from GBGB9525704.4A external-priority patent/GB9525704D0/en
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE274053T1 publication Critical patent/ATE274053T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT96938081T 1995-11-16 1996-11-05 Methode zur identifizierung von verbindungen die mit rac proteine kinase interagieren ATE274053T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9523379.7A GB9523379D0 (en) 1995-11-16 1995-11-16 Compound and method
GBGB9525704.4A GB9525704D0 (en) 1995-12-15 1995-12-15 Ligand and screening method
PCT/EP1996/004810 WO1997018303A1 (en) 1995-11-16 1996-11-05 Rac-proteine kinase as therapeutic agent or in diagnostics

Publications (1)

Publication Number Publication Date
ATE274053T1 true ATE274053T1 (de) 2004-09-15

Family

ID=26308124

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96938081T ATE274053T1 (de) 1995-11-16 1996-11-05 Methode zur identifizierung von verbindungen die mit rac proteine kinase interagieren

Country Status (9)

Country Link
EP (1) EP0862622B1 (de)
JP (1) JP4173544B2 (de)
AT (1) ATE274053T1 (de)
AU (1) AU7564396A (de)
DE (1) DE69633186T2 (de)
DK (1) DK0862622T3 (de)
ES (1) ES2227614T3 (de)
PT (1) PT862622E (de)
WO (1) WO1997018303A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9525703D0 (en) * 1995-12-15 1996-02-14 Ciba Geigy Ag Screening method
US6057117A (en) * 1996-04-04 2000-05-02 Chiron Corporation Identification and use of selective inhibitors of glycogen synthase kinase 3
CA2214841A1 (en) * 1997-10-31 1999-04-30 Lisa Mckerracher Rho antagonists and their use to block inhibition of neurite outgrowth
SE9801530D0 (sv) * 1998-04-30 1998-04-30 Pharmacia & Upjohn Ab Method for screening
US6555732B1 (en) 1998-09-14 2003-04-29 Pioneer Hi-Bred International, Inc. Rac-like genes and methods of use
PT1122262E (pt) * 1998-10-16 2010-01-27 Otsuka Pharma Co Ltd Péptidos específicos de zonas neovasculares
US7169783B2 (en) 1998-11-02 2007-01-30 Universite De Montreal (+)-Trans-4-(1-aminoethyl)-1-(4-pyridycarbamoyl)-cyclohexane and method for promoting neural growth in the central nervous system and in a patient at a site of neuronal lesion
GB9828375D0 (en) * 1998-12-22 1999-02-17 Janssen Pharmaceutica Nv Human akt-3
AU2816600A (en) * 1999-02-26 2000-09-14 University College London Mutants of rac protein
US6881555B2 (en) 1999-03-19 2005-04-19 Aventis Pharmaceuticals Inc. AKT nucleic acids, polypeptides, and uses thereof
HK1041288B (en) * 1999-03-19 2008-11-07 Aventis Pharmaceuticals Inc. AKT-3 nucleic acid, polypeptide and its use
DE60134228D1 (de) * 2000-05-30 2008-07-10 Karin Moelling Nukleinsäure moleküle kodierend für ein protein, welches mit einer ser/thr akt kinase interagiert
US6689807B1 (en) * 2000-06-08 2004-02-10 Caritas St. Elizabeth's Medical Center Of Boston, Inc. HMG CoA reductase inhibitors for promoting angiogenesis
GB0014185D0 (en) 2000-06-09 2000-08-02 Novartis Res Found Compound and method
US7399764B2 (en) 2002-10-30 2008-07-15 Merck & Co., Inc. Inhibitors of Akt activity
GB0227562D0 (en) 2002-11-26 2002-12-31 Novartis Forschungsstiftung Phorphorylated NDR Kinase
WO2006036613A2 (en) * 2004-09-17 2006-04-06 Exelixis, Inc Mracs as modifiers of the rac pathway and methods of use
CA2922575C (en) * 2013-11-01 2022-10-11 Newsouth Innovations Pty Limited Pharmaceutical combinations for the treatment of cancer

Also Published As

Publication number Publication date
WO1997018303A1 (en) 1997-05-22
DE69633186T2 (de) 2005-08-18
DK0862622T3 (da) 2004-12-20
JP4173544B2 (ja) 2008-10-29
EP0862622A1 (de) 1998-09-09
PT862622E (pt) 2005-01-31
ES2227614T3 (es) 2005-04-01
DE69633186D1 (de) 2004-09-23
EP0862622B1 (de) 2004-08-18
AU7564396A (en) 1997-06-05
JP2000500746A (ja) 2000-01-25

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