ATE274494T1 - Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungen - Google Patents
Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungenInfo
- Publication number
- ATE274494T1 ATE274494T1 AT01940321T AT01940321T ATE274494T1 AT E274494 T1 ATE274494 T1 AT E274494T1 AT 01940321 T AT01940321 T AT 01940321T AT 01940321 T AT01940321 T AT 01940321T AT E274494 T1 ATE274494 T1 AT E274494T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolidine
- treatment
- neurodegenerative diseases
- piperidine derivatives
- piperidine
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00108610 | 2000-04-20 | ||
| PCT/EP2001/004171 WO2001081303A1 (en) | 2000-04-20 | 2001-04-11 | Pyrrolidine and piperidine derivatives and their use for the treament of neurodegenerative disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE274494T1 true ATE274494T1 (de) | 2004-09-15 |
Family
ID=8168522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01940321T ATE274494T1 (de) | 2000-04-20 | 2001-04-11 | Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6451819B2 (de) |
| EP (1) | EP1278728B1 (de) |
| JP (1) | JP4219590B2 (de) |
| KR (1) | KR100501606B1 (de) |
| CN (1) | CN1178911C (de) |
| AR (1) | AR028343A1 (de) |
| AT (1) | ATE274494T1 (de) |
| AU (2) | AU7394201A (de) |
| BR (1) | BR0110112A (de) |
| CA (1) | CA2404464C (de) |
| DE (1) | DE60105144T2 (de) |
| ES (1) | ES2225553T3 (de) |
| MX (1) | MXPA02010261A (de) |
| PE (1) | PE20011185A1 (de) |
| PT (1) | PT1278728E (de) |
| TR (1) | TR200402442T4 (de) |
| WO (1) | WO2001081303A1 (de) |
| ZA (1) | ZA200208015B (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE04548B1 (et) * | 1998-04-01 | 2005-10-17 | Nortran Pharmaceuticals Inc. | Aminotskloheksleeterhendid, nende kompositsioonid ja nende kasutamine |
| US6979685B1 (en) * | 1999-02-12 | 2005-12-27 | Cardiome Pharma Corp. | Cycloalkyl amine compounds and uses thereof |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| JPWO2002100833A1 (ja) * | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Ｒｈｏキナーゼ阻害剤 |
| US6885903B2 (en) * | 2001-07-10 | 2005-04-26 | General Electric Company | Method and system for tracking repair of components |
| EP1467986A1 (de) * | 2002-01-17 | 2004-10-20 | Eli Lilly And Company | Azacyclische verbindungen als modulatoren von acetylcholinrezeptoren |
| US7005432B2 (en) * | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
| US7866517B2 (en) * | 2002-10-31 | 2011-01-11 | Fabio Pedrini | Vehicle-mounted equipment carrier |
| ES2375820T3 (es) * | 2003-05-02 | 2012-03-06 | Cardiome Pharma Corp. | Compuestos de aminociclohexil éter y sus usos. |
| US7345086B2 (en) * | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| US7674820B2 (en) * | 2003-08-07 | 2010-03-09 | Cardiome Pharma Corp. | Ion channel modulating activity I |
| US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| GB0325956D0 (en) * | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| CA2561819A1 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| US8058304B2 (en) * | 2004-04-01 | 2011-11-15 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| EP1868598B1 (de) * | 2004-11-08 | 2014-04-23 | Cardiome Pharma Corp. | Neuer dosierungsplan für ionenkanalmodulierende verbindungen zur behandlung von akutem vorhofflimmern bei menschen |
| KR20100135847A (ko) * | 2008-03-27 | 2010-12-27 | 에보텍 뉴로사이언시즈 게엠베하 | Ｎｍｄａ ｎｒ２ｂ―서브타입 선택적 길항제를 사용한 질병 치료 방법 |
| RU2572826C2 (ru) | 2008-12-02 | 2016-01-20 | Чиралджен, Лтд. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
| SG10201403841QA (en) | 2009-07-06 | 2014-09-26 | Ontorii Inc | Novel nucleic acid prodrugs and methods of use thereof |
| JP5868324B2 (ja) * | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| CN107365339A (zh) | 2011-07-19 | 2017-11-21 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| WO2014010718A1 (ja) | 2012-07-13 | 2014-01-16 | 株式会社新日本科学 | キラル核酸アジュバント |
| EP2872147B1 (de) | 2012-07-13 | 2022-12-21 | Wave Life Sciences Ltd. | Verfahren zur herstellung von chiralen oligonukleotiden |
| RU2693381C2 (ru) | 2012-07-13 | 2019-07-02 | Уэйв Лайф Сайенсес Лтд. | Асимметричная вспомогательная группа |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| EP3095459A4 (de) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chirales nukleinsäureadjuvans mit antitumorwirkung und antitumormittel |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| CA2936712A1 (en) | 2014-01-16 | 2015-07-23 | Meena | Chiral design |
| EP3166923B1 (de) * | 2014-07-10 | 2023-03-15 | SpecGx LLC | Verfahren zur herstellung substituierter phenylalkane |
| WO2024099403A1 (zh) * | 2022-11-10 | 2024-05-16 | 北京普祺医药科技股份有限公司 | 一种具有软药性质的硫醚类化合物、药物组合物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL74140A (en) * | 1984-04-10 | 1988-05-31 | Robins Co Inc A H | Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them |
| ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
| US6015824A (en) * | 1998-02-10 | 2000-01-18 | Hoffmann-La Roche Ag | Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders |
| TWI254043B (en) * | 1999-06-08 | 2006-05-01 | Hoffmann La Roche | Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor |
-
2001
- 2001-04-11 WO PCT/EP2001/004171 patent/WO2001081303A1/en not_active Ceased
- 2001-04-11 ES ES01940321T patent/ES2225553T3/es not_active Expired - Lifetime
- 2001-04-11 CN CNB018083099A patent/CN1178911C/zh not_active Expired - Fee Related
- 2001-04-11 DE DE60105144T patent/DE60105144T2/de not_active Expired - Fee Related
- 2001-04-11 TR TR2004/02442T patent/TR200402442T4/xx unknown
- 2001-04-11 MX MXPA02010261A patent/MXPA02010261A/es active IP Right Grant
- 2001-04-11 CA CA002404464A patent/CA2404464C/en not_active Expired - Fee Related
- 2001-04-11 AU AU7394201A patent/AU7394201A/xx active Pending
- 2001-04-11 JP JP2001578398A patent/JP4219590B2/ja not_active Expired - Fee Related
- 2001-04-11 KR KR10-2002-7014043A patent/KR100501606B1/ko not_active Expired - Fee Related
- 2001-04-11 PT PT01940321T patent/PT1278728E/pt unknown
- 2001-04-11 BR BR0110112-9A patent/BR0110112A/pt not_active IP Right Cessation
- 2001-04-11 AU AU2001273942A patent/AU2001273942B2/en not_active Ceased
- 2001-04-11 AT AT01940321T patent/ATE274494T1/de not_active IP Right Cessation
- 2001-04-11 EP EP01940321A patent/EP1278728B1/de not_active Expired - Lifetime
- 2001-04-12 US US09/833,450 patent/US6451819B2/en not_active Expired - Fee Related
- 2001-04-18 AR ARP010101809A patent/AR028343A1/es unknown
- 2001-04-18 PE PE2001000354A patent/PE20011185A1/es not_active Application Discontinuation
-
2002
- 2002-10-04 ZA ZA200208015A patent/ZA200208015B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1278728A1 (de) | 2003-01-29 |
| JP2003531190A (ja) | 2003-10-21 |
| PT1278728E (pt) | 2004-10-29 |
| EP1278728B1 (de) | 2004-08-25 |
| TR200402442T4 (tr) | 2004-12-21 |
| AU2001273942B2 (en) | 2005-09-01 |
| ZA200208015B (en) | 2004-02-10 |
| US6451819B2 (en) | 2002-09-17 |
| PE20011185A1 (es) | 2001-11-14 |
| AU7394201A (en) | 2001-11-07 |
| DE60105144T2 (de) | 2005-09-08 |
| WO2001081303A1 (en) | 2001-11-01 |
| JP4219590B2 (ja) | 2009-02-04 |
| MXPA02010261A (es) | 2003-04-25 |
| DE60105144D1 (de) | 2004-09-30 |
| CN1178911C (zh) | 2004-12-08 |
| ES2225553T3 (es) | 2005-03-16 |
| BR0110112A (pt) | 2003-02-11 |
| CA2404464C (en) | 2008-03-11 |
| CA2404464A1 (en) | 2001-11-01 |
| US20010047031A1 (en) | 2001-11-29 |
| AR028343A1 (es) | 2003-05-07 |
| CN1425002A (zh) | 2003-06-18 |
| KR100501606B1 (ko) | 2005-07-18 |
| KR20030013387A (ko) | 2003-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1278728 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |