ATE276741T1 - Fenofibrathaltige galenische arzneizusammensetzungen und verfahren zu ihrer herstellung - Google Patents
Fenofibrathaltige galenische arzneizusammensetzungen und verfahren zu ihrer herstellungInfo
- Publication number
- ATE276741T1 ATE276741T1 AT00990848T AT00990848T ATE276741T1 AT E276741 T1 ATE276741 T1 AT E276741T1 AT 00990848 T AT00990848 T AT 00990848T AT 00990848 T AT00990848 T AT 00990848T AT E276741 T1 ATE276741 T1 AT E276741T1
- Authority
- AT
- Austria
- Prior art keywords
- galenic
- production
- compositions containing
- medicinal compositions
- preconcentrate
- Prior art date
Links
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002297 fenofibrate Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 239000004094 surface-active agent Substances 0.000 abstract 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 abstract 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001804 emulsifying effect Effects 0.000 abstract 1
- 239000007903 gelatin capsule Substances 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 239000004530 micro-emulsion Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000007901 soft capsule Substances 0.000 abstract 1
- 229940042585 tocopherol acetate Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9916807A FR2803203B1 (fr) | 1999-12-31 | 1999-12-31 | Nouvelles formulations galeniques du fenofibrate |
| PCT/FR2000/003738 WO2001049262A1 (fr) | 1999-12-31 | 2000-12-29 | Formulations galeniques du fenofibrate et leur procede d'obtention |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE276741T1 true ATE276741T1 (de) | 2004-10-15 |
Family
ID=9554113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00990848T ATE276741T1 (de) | 1999-12-31 | 2000-12-29 | Fenofibrathaltige galenische arzneizusammensetzungen und verfahren zu ihrer herstellung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030082215A1 (de) |
| EP (1) | EP1242047B1 (de) |
| AT (1) | ATE276741T1 (de) |
| AU (1) | AU3030801A (de) |
| DE (1) | DE60014162T2 (de) |
| ES (1) | ES2226976T3 (de) |
| FR (1) | FR2803203B1 (de) |
| WO (1) | WO2001049262A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6982281B1 (en) | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| US20030236236A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| GB0119480D0 (en) * | 2001-08-09 | 2001-10-03 | Jagotec Ag | Novel compositions |
| US20040005339A1 (en) * | 2002-06-28 | 2004-01-08 | Shojaei Amir H. | Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability |
| PL376792A1 (pl) * | 2002-10-23 | 2006-01-09 | Glaxosmithkline Biologicals S.A. | Sposoby szczepienia przeciwko malarii |
| JP2006511525A (ja) | 2002-12-13 | 2006-04-06 | ヤゴテック アーゲー | ナノ粒子状スピロノラクトン局所製剤 |
| US20040115287A1 (en) * | 2002-12-17 | 2004-06-17 | Lipocine, Inc. | Hydrophobic active agent compositions and methods |
| US9259390B2 (en) * | 2003-08-13 | 2016-02-16 | The University Of Houston System | Parenteral and oral formulations of benzimidazoles |
| CN1874758A (zh) * | 2003-10-10 | 2006-12-06 | 生命周期药物公司 | 包含贝特和史达汀的固体剂型 |
| US20050096390A1 (en) * | 2003-10-10 | 2005-05-05 | Per Holm | Compositions comprising fenofibrate and pravastatin |
| US9173847B2 (en) * | 2003-10-10 | 2015-11-03 | Veloxis Pharmaceuticals A/S | Tablet comprising a fibrate |
| KR20060085686A (ko) * | 2003-10-10 | 2006-07-27 | 라이프사이클 파마 에이/에스 | 피브레이트를 포함하는 고형 제제 |
| WO2005034908A2 (en) * | 2003-10-10 | 2005-04-21 | Lifecycle Pharma A/S | A solid dosage form comprising a fibrate and a statin |
| US8026281B2 (en) * | 2004-10-14 | 2011-09-27 | Lupin Atlantis Holdings, S.A. | Treating metabolic syndrome with fenofibrate |
| MX2007006775A (es) * | 2004-12-06 | 2008-02-25 | Reliant Pharmaceuticals Inc | Composiciones estables de fenofibrato con esteres de acido graso. |
| KR101356335B1 (ko) * | 2004-12-06 | 2014-02-06 | 릴라이언트 파마슈티컬스 인코퍼레이티드 | 지질 치료를 위한 오메가-3 지방산 및 이상지질혈증 제제 |
| EA200701913A1 (ru) * | 2005-03-08 | 2008-08-29 | Релайэнт Фармасьютикалз, Инк. | Лечение статином, омега-3 жирными кислотами и их комбинированным продуктом |
| RU2436787C2 (ru) | 2005-07-29 | 2011-12-20 | Тиботек Фармасьютикалз Лтд. | Макроциклические ингибиторы вируса гепатита с |
| WO2007014925A1 (en) | 2005-07-29 | 2007-02-08 | Tibotec Pharmaceuticals Ltd. | Macrocylic inhibitors of hepatitis c virus |
| JP2013047282A (ja) * | 2006-08-31 | 2013-03-07 | Aska Pharmaceutical Co Ltd | フェノフィブラート含有組成物 |
| JP5186159B2 (ja) * | 2006-08-31 | 2013-04-17 | あすか製薬株式会社 | フェノフィブラート含有組成物 |
| CL2007003145A1 (es) * | 2006-10-31 | 2008-01-25 | Wyeth Corp | Composicion farmaceutica que comprende un compuestos derivado de indol y un sistema portador que comprende 10-50% de un primer solubilizante, 10-50% de un segundo solubilizante y 10-30% de un diluyente; proceso de preparacion; y forma farmaceutica. |
| CN102083422A (zh) * | 2008-07-03 | 2011-06-01 | 万能药生物有限公司 | 口服生物利用度提高的非诺贝特制剂 |
| CN101711738B (zh) * | 2008-10-08 | 2012-09-05 | 中国人民解放军军事医学科学院毒物药物研究所 | 非诺贝特的口服药物组合物 |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| US20120213855A1 (en) * | 2011-02-17 | 2012-08-23 | Cima Labs Inc. | Dosage forms for weakly ionizable compounds |
| US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
| US20160361322A1 (en) | 2015-06-15 | 2016-12-15 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| KR20180128025A (ko) | 2016-03-25 | 2018-11-30 | 아디쎄오 프랑스 에스에이에스 | 지용성 활성 성분을 포함하는 나노캡슐, 그 제조 방법 및 그 용도 |
| US11559530B2 (en) | 2016-11-28 | 2023-01-24 | Lipocine Inc. | Oral testosterone undecanoate therapy |
| EP3824296A4 (de) | 2018-07-20 | 2022-04-27 | Lipocine Inc. | Lebererkrankung |
| JP7654561B2 (ja) * | 2019-04-11 | 2025-04-01 | アール.ピー. シェーラー テクノロジーズ エルエルシー | 浸透性が低いタンパク質、ペプチド、及び小分子の経口送達用の製剤 |
| EP4304569A1 (de) * | 2021-03-12 | 2024-01-17 | Nicoventures Trading Limited | Orale produkte mit selbstemulgierendem system |
| CN118304260A (zh) * | 2023-10-24 | 2024-07-09 | 浙江大学长三角智慧绿洲创新中心 | 一种非诺贝特油性制剂、口服药物和制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| FR2730231B1 (fr) * | 1995-02-02 | 1997-04-04 | Fournier Sca Lab | Association de fenofibrate et de vitamine e, utilisation en therapeutique |
| FR2737121B1 (fr) * | 1995-07-27 | 1997-10-03 | Cl Pharma | Nouvelles formulations galeniques du fenofibrate et leurs applications |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
| BE1011363A3 (fr) * | 1997-09-11 | 1999-08-03 | Smb Technology | Capsules semi-solides autoemulsionnables matricielles a action prolongee. |
| WO1999029300A1 (en) * | 1997-12-10 | 1999-06-17 | Rtp Pharma Inc. | Self-emulsifying fenofibrate formulations |
-
1999
- 1999-12-31 FR FR9916807A patent/FR2803203B1/fr not_active Expired - Fee Related
-
2000
- 2000-12-29 EP EP00990848A patent/EP1242047B1/de not_active Expired - Lifetime
- 2000-12-29 AT AT00990848T patent/ATE276741T1/de active
- 2000-12-29 ES ES00990848T patent/ES2226976T3/es not_active Expired - Lifetime
- 2000-12-29 WO PCT/FR2000/003738 patent/WO2001049262A1/fr not_active Ceased
- 2000-12-29 US US10/168,552 patent/US20030082215A1/en not_active Abandoned
- 2000-12-29 AU AU30308/01A patent/AU3030801A/en not_active Abandoned
- 2000-12-29 DE DE60014162T patent/DE60014162T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20030082215A1 (en) | 2003-05-01 |
| ES2226976T3 (es) | 2005-04-01 |
| FR2803203B1 (fr) | 2002-05-10 |
| DE60014162D1 (de) | 2004-10-28 |
| WO2001049262A1 (fr) | 2001-07-12 |
| EP1242047B1 (de) | 2004-09-22 |
| EP1242047A1 (de) | 2002-09-25 |
| DE60014162T2 (de) | 2005-09-22 |
| AU3030801A (en) | 2001-07-16 |
| FR2803203A1 (fr) | 2001-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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