ATE276788T1 - Mit impfstoff beschichtete nadeln - Google Patents

Mit impfstoff beschichtete nadeln

Info

Publication number
ATE276788T1
ATE276788T1 AT01962862T AT01962862T ATE276788T1 AT E276788 T1 ATE276788 T1 AT E276788T1 AT 01962862 T AT01962862 T AT 01962862T AT 01962862 T AT01962862 T AT 01962862T AT E276788 T1 ATE276788 T1 AT E276788T1
Authority
AT
Austria
Prior art keywords
skin
pharmaceutical agent
pharmaceutical
devices
present
Prior art date
Application number
AT01962862T
Other languages
English (en)
Inventor
Colin Clive Dalton
Richard Lewis Easeman
Nathalie Garcon
Original Assignee
Smithkline Beecham Biolog
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9896141&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE276788(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Biolog, Smithkline Beecham Plc filed Critical Smithkline Beecham Biolog
Application granted granted Critical
Publication of ATE276788T1 publication Critical patent/ATE276788T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/20Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0012Lipids; Lipoproteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775Apolipopeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Seal Device For Vehicle (AREA)
AT01962862T 2000-07-21 2001-07-18 Mit impfstoff beschichtete nadeln ATE276788T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0017999.4A GB0017999D0 (en) 2000-07-21 2000-07-21 Novel device
PCT/EP2001/008339 WO2002007813A1 (en) 2000-07-21 2001-07-18 Vaccines

Publications (1)

Publication Number Publication Date
ATE276788T1 true ATE276788T1 (de) 2004-10-15

Family

ID=9896141

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01962862T ATE276788T1 (de) 2000-07-21 2001-07-18 Mit impfstoff beschichtete nadeln

Country Status (13)

Country Link
US (3) US20040049150A1 (de)
EP (2) EP1301238B1 (de)
JP (2) JP4965053B2 (de)
AT (1) ATE276788T1 (de)
AU (1) AU2001283950A1 (de)
CA (2) CA2657491C (de)
CY (1) CY1107870T1 (de)
DE (2) DE60105813T2 (de)
DK (2) DK1512429T3 (de)
ES (2) ES2228937T3 (de)
GB (1) GB0017999D0 (de)
PT (2) PT1301238E (de)
WO (1) WO2002007813A1 (de)

Families Citing this family (272)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US20050002958A1 (en) * 1999-06-29 2005-01-06 Smithkline Beecham Biologicals Sa Vaccines
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
NZ525551A (en) * 2000-10-26 2005-09-30 Alza Corp Transdermal drug delivery devices having coated microprotrusions
EP1345646A2 (de) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Mikronadel-vorrichtungen und deren herstellung
DK1372708T3 (da) 2001-02-13 2008-10-20 Us Gov Sec Army Vaccine til transkutan immunisering mod rejsediarre
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
JP2004529906A (ja) 2001-03-19 2004-09-30 イオマイ コーポレイシヨン 経皮的免疫賦活
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
ATE444773T1 (de) 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
EP3251722B1 (de) * 2001-04-20 2020-06-17 ALZA Corporation Mikroprojektionsanordnung mit einer beschichtung, der ein vorteilhaftes mittel enthält und beschichtungsverfahren dafuer
US20030138434A1 (en) * 2001-08-13 2003-07-24 Campbell Robert L. Agents for enhancing the immune response
AU2002333636A1 (en) * 2001-09-14 2003-04-01 The Procter And Gamble Company Microstructures for delivering a composition cutaneously to skin using rotatable structures
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
GB0201736D0 (en) * 2002-01-25 2002-03-13 Glaxo Group Ltd DNA dosage forms
WO2003092785A1 (en) * 2002-04-30 2003-11-13 Morteza Shirkhanzadeh Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
AU2003279641B2 (en) * 2002-06-28 2009-06-18 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
CN102872526A (zh) 2002-07-19 2013-01-16 3M创新有限公司 微针装置和微针施用设备
AR040819A1 (es) * 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
US20040048002A1 (en) * 2002-09-11 2004-03-11 Shifflette J. Michael Method for coating objects
US8062573B2 (en) 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
DE10243917A1 (de) * 2002-09-20 2004-04-01 Udo Dr. Auweiler Vorrichtung zur subkutanen Abgabe eines pharmazeutischen Wirkstoffes
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7347835B2 (en) * 2003-06-10 2008-03-25 Medrx Co., Ltd. Process for producing pad base for endermism, and pad base for endermism, and injection needle
JP2005021678A (ja) * 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベースの製造方法及び経皮投薬用パッドベース、並びに注射針
JP2005021677A (ja) * 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベース、及び注射針
KR20060038407A (ko) * 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
CN1845708A (zh) * 2003-07-02 2006-10-11 阿尔扎公司 微突出物阵列免疫贴剂和方法
JP2007501071A (ja) * 2003-08-04 2007-01-25 アルザ・コーポレーシヨン 経皮作用剤流率を向上させる方法および装置
US8961477B2 (en) * 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
CA2536443A1 (en) * 2003-08-26 2005-03-03 Alza Corporation Device and method for intradermal cell implantation
US7488343B2 (en) * 2003-09-16 2009-02-10 Boston Scientific Scimed, Inc. Medical devices
EP2591786B1 (de) * 2003-10-16 2017-04-12 Cancure Limited Immunmodulierende Zusammensetzungen und ihre Verwendung
AU2004287412A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
US7361182B2 (en) * 2003-12-19 2008-04-22 Lightnix, Inc. Medical lancet
EP1706171A1 (de) * 2003-12-29 2006-10-04 3M Innovative Properties Company Medizinprodukte und diese enthaltende sets
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
KR20060135931A (ko) * 2004-04-01 2006-12-29 알자 코포레이션 인플루엔자 백신의 경피전달 장치 및 방법
US7556821B2 (en) 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060100584A1 (en) * 2004-08-10 2006-05-11 Orest Olejnik Needleless microprotrusion elastoplast system
US20060093658A1 (en) * 2004-10-26 2006-05-04 Gayatri Sathyan Apparatus and method for transdermal delivery of desmopressin
US20090004222A1 (en) 2004-11-03 2009-01-01 O'hagan Derek Influenza Vaccination
US20060135906A1 (en) * 2004-11-16 2006-06-22 Akihiko Matsumura Iontophoretic device and method for administering immune response-enhancing agents and compositions
WO2006055799A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Masking method for coating a microneedle array
JP4927752B2 (ja) 2004-11-18 2012-05-09 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイアプリケーターおよび保持装置
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
WO2006055844A2 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Method of contact coating a microneedle array
CN101060883B (zh) 2004-11-18 2010-06-23 3M创新有限公司 低轮廓微针阵列施放器
US20070292386A9 (en) * 2004-12-02 2007-12-20 Campbell Robert L Vaccine formulations for intradermal delivery comprising adjuvants and antigenic agents
WO2006062974A2 (en) 2004-12-07 2006-06-15 3M Innovative Properties Company Method of molding a microneedle
US7588705B2 (en) * 2004-12-28 2009-09-15 Nabtesco Corporation Skin needle manufacturing apparatus and skin needle manufacturing method
JP4913030B2 (ja) * 2005-01-31 2012-04-11 株式会社バイオセレンタック 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具
JP4793806B2 (ja) 2005-03-22 2011-10-12 Tti・エルビュー株式会社 イオントフォレーシス装置
US10035008B2 (en) 2005-04-07 2018-07-31 3M Innovative Properties Company System and method for tool feedback sensing
JP4959151B2 (ja) * 2005-06-14 2012-06-20 ナブテスコ株式会社 皮膚用針の製造方法及び装置
WO2006138719A2 (en) 2005-06-17 2006-12-28 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
EP1904158B1 (de) 2005-06-24 2013-07-24 3M Innovative Properties Company Faltbares Pflaster mit Mikronadelnanordnung
JP2008543528A (ja) * 2005-06-27 2008-12-04 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルカートリッジアセンブリ及び適用方法
EP2474338B1 (de) * 2005-06-27 2013-07-24 3M Innovative Properties Company Vorrichtung zum Aufbringen einer Mikronadelanordnung
JP2007014588A (ja) * 2005-07-08 2007-01-25 Nano Device & System Research Inc 経皮投与装置,経皮投与装置製造用金型
CA2614927A1 (en) * 2005-07-25 2007-02-01 Nanotechnology Victoria Pty Ltd Microarray device
DE602006020738D1 (de) 2005-08-01 2011-04-28 Hisamitsu Pharmaceutical Co Adjuvans oder pharmazeutische zubereitung zur transdermalen oder transmukosalen verabreichung
JP5000866B2 (ja) * 2005-08-01 2012-08-15 久光製薬株式会社 生体無毒性医薬物運搬用器具
US20070078414A1 (en) 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
DE102005040251A1 (de) * 2005-08-24 2007-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Transcorneales System zur Abgabe eines Arzneimittel-Wirkstoffes
CN101687094B (zh) * 2005-09-06 2012-09-26 谢拉杰克特股份有限公司 含有药物颗粒和/或药物吸附颗粒的固体溶液穿孔器
US20070073212A1 (en) * 2005-09-28 2007-03-29 Takehiko Matsumura Iontophoresis apparatus and method to deliver active agents to biological interfaces
KR20080066712A (ko) * 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법
KR20080080087A (ko) * 2005-09-30 2008-09-02 티티아이 엘뷰 가부시키가이샤 신규 약학 담체를 이용한 경피 약물 전달시스템, 장치 및방법
US20070078376A1 (en) * 2005-09-30 2007-04-05 Smith Gregory A Functionalized microneedles transdermal drug delivery systems, devices, and methods
CA2629193C (en) * 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
GB0523638D0 (en) 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
US8554317B2 (en) * 2005-11-30 2013-10-08 3M Innovative Properties Company Microneedle arrays and methods of use thereof
US8632801B2 (en) 2005-12-28 2014-01-21 Alza Corporation Stable therapeutic formulations
US20080033398A1 (en) * 2005-12-29 2008-02-07 Transcutaneous Technologies Inc. Device and method for enhancing immune response by electrical stimulation
WO2007091608A1 (ja) 2006-02-10 2007-08-16 Hisamitsu Pharmaceutical Co., Inc. マイクロニードル付き経皮薬物投与装置
WO2007098057A2 (en) * 2006-02-17 2007-08-30 Zogenix, Inc. Method and system for delivery of neurotoxins
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
JP4908893B2 (ja) * 2006-03-30 2012-04-04 久光製薬株式会社 医薬物運搬用器具とその製造方法及び医薬物運搬用器具製造用金型の製造方法
WO2007116959A1 (ja) 2006-04-07 2007-10-18 Hisamitsu Pharmaceutical Co., Inc. マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
AU2007244831A1 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with sculptured microprojections for high drug loading
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
WO2008020632A1 (en) * 2006-08-18 2008-02-21 Toppan Printing Co., Ltd. Microneedle and microneedle patch
JP4954656B2 (ja) * 2006-09-28 2012-06-20 凸版印刷株式会社 針状体および針状体の製造方法
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
JP5190382B2 (ja) * 2007-01-29 2013-04-24 株式会社 メドレックス 温度感受性物質製のマイクロニードルの製造方法
WO2008093772A1 (ja) 2007-01-31 2008-08-07 Hisamitsu Pharmaceutical Co., Inc. 経皮または経粘膜投与のためのアジュバントおよびこれを含む医薬製剤
ES2817249T3 (es) 2007-04-16 2021-04-06 Corium Inc Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
JP5298011B2 (ja) * 2007-05-15 2013-09-25 久光製薬株式会社 マイクロニードルのコーティング方法
KR20100045413A (ko) * 2007-06-14 2010-05-03 크루셀 스위츨랜드 아게 피내 인플루엔자 백신
CA2694083A1 (en) * 2007-07-26 2009-01-29 Sanofi Pasteur Limited Antigen-adjuvant compositions and methods
JP2010535591A (ja) * 2007-08-06 2010-11-25 トランスダーム, インコーポレイテッド ポリマー膜から形成される微小針アレイ
SG183726A1 (en) * 2007-08-14 2012-09-27 Hutchinson Fred Cancer Res Needle array assembly and method for delivering therapeutic agents
JP5227558B2 (ja) * 2007-09-19 2013-07-03 凸版印刷株式会社 針状体
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5419702B2 (ja) * 2007-10-18 2014-02-19 久光製薬株式会社 マイクロニードルデバイス
KR101555391B1 (ko) * 2007-11-21 2015-09-23 가부시키가이샤 바이오세렌택 체표 적용 제제 및 체표 적용 제제 보유 시트
CA2745339C (en) * 2007-12-24 2016-06-28 The University Of Queensland Coating method
AU2009212106B9 (en) 2008-02-07 2014-05-22 Vaxxas Pty Limited Patch production
JP5584202B2 (ja) 2008-05-21 2014-09-03 セラジェクト, インコーポレイテッド 固溶体穿孔器パッチの製造方法及びその使用
WO2009140735A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents.
CA2729404C (en) 2008-06-30 2016-09-27 Hisamitsu Pharmaceutical Co., Inc. Microneedle device and method for enhancing the efficacy of influenza vaccine using microneedle device
US8721574B2 (en) * 2008-09-03 2014-05-13 Dts Lab Co., Ltd Skin stimulator
JP5063544B2 (ja) * 2008-09-22 2012-10-31 富士フイルム株式会社 経皮吸収シート及びその製造方法
US8731840B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8613937B2 (en) * 2008-10-31 2013-12-24 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US9072799B2 (en) * 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US20100111836A1 (en) * 2008-10-31 2010-05-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with frozen particles
US8725420B2 (en) * 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US20100111841A1 (en) * 2008-10-31 2010-05-06 Searete Llc Compositions and methods for surface abrasion with frozen particles
US8788211B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US20100111857A1 (en) * 2008-10-31 2010-05-06 Boyden Edward S Compositions and methods for surface abrasion with frozen particles
US8721583B2 (en) * 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8603495B2 (en) * 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US9050317B2 (en) * 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US20100111831A1 (en) * 2008-10-31 2010-05-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for surface abrasion with frozen particles
US20100111834A1 (en) * 2008-10-31 2010-05-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with frozen particles
US8409376B2 (en) 2008-10-31 2013-04-02 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8762067B2 (en) * 2008-10-31 2014-06-24 The Invention Science Fund I, Llc Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US9050251B2 (en) * 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8414356B2 (en) * 2008-10-31 2013-04-09 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
US8793075B2 (en) * 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8551505B2 (en) * 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8731841B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8858912B2 (en) * 2008-10-31 2014-10-14 The Invention Science Fund I, Llc Frozen compositions and methods for piercing a substrate
US9060926B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US20100111835A1 (en) * 2008-10-31 2010-05-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with frozen particles
US8545857B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US9060931B2 (en) * 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8603494B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US9050070B2 (en) * 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8545855B2 (en) * 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9060934B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
KR101634836B1 (ko) 2008-12-26 2016-06-29 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들 디바이스
US20120004626A1 (en) 2009-01-30 2012-01-05 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
EP2429627B1 (de) 2009-04-24 2017-06-14 Corium International, Inc. Verfahren zur herstellung von mikroprojektionsarrays
EP2422836B1 (de) 2009-04-24 2015-10-07 MEDRx Co., Ltd. Arzneimittelflüssigkeitsschablone und verfahren zur anwendung des arzneimittels auf dieses verwendende mikronadeln
AU2010241740B9 (en) * 2009-04-27 2015-10-01 Intersect Ent, Inc. Devices and methods for treating pain associated with tonsillectomies
JP2011005245A (ja) * 2009-05-27 2011-01-13 Kagawa Univ 剣山型マイクロニードルの製造方法およびマイクロニードル
ES2691259T3 (es) 2009-06-10 2018-11-26 Hisamitsu Pharmaceutical Co., Inc. Dispositivo de microagujas
KR101686692B1 (ko) 2009-07-23 2016-12-14 히사미쓰 세이야꾸 가부시키가이샤 마이크로니들 어레이
EP2461818B1 (de) 2009-08-03 2018-10-17 Incube Labs, Llc Schluckbare kapsel und verfahren zur stimulation der inkretinproduktion im darmtrakt
EP2338557A1 (de) * 2009-12-23 2011-06-29 Debiotech S.A. Lösliche Mikronadel
US8759284B2 (en) 2009-12-24 2014-06-24 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
CN102905753B (zh) * 2009-12-24 2016-06-29 因卡伯实验室有限责任公司 可吞咽式药剂递送装置和药剂递送方法
CN102770176B (zh) * 2010-02-24 2015-11-25 久光制药株式会社 微针装置及其制造方法
JP5668192B2 (ja) 2010-03-10 2015-02-12 株式会社ライトニックス 医療用針及び穿刺具
EP2566501B1 (de) 2010-05-04 2019-03-13 Corium International, Inc. Verfahren und vorrichtung zur transdermalen verabreichung von parathormon mithilfe eines mikroprojektions-arrays
ES2728479T3 (es) 2010-05-28 2019-10-24 Hisamitsu Pharmaceutical Co Matriz con protuberancias finas
KR101741294B1 (ko) 2010-05-28 2017-05-29 히사미쓰 세이야꾸 가부시키가이샤 미소 돌기가 형성된 어레이를 갖는 디바이스
EP2575845B1 (de) 2010-05-28 2017-02-15 3M Innovative Properties Company Wässrige formulierungen zur beschichtung von mikronadelfeldern
CA2801151A1 (en) * 2010-06-01 2011-12-08 Novartis Ag Concentration of vaccine antigens with lyophilization
WO2011151723A2 (en) * 2010-06-01 2011-12-08 Novartis Ag Concentration of vaccine antigens without lyophilization
TWI578997B (zh) 2010-06-04 2017-04-21 輝瑞疫苗有限責任公司 用於預防或治療菸鹼成癮之共軛體
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
JP5996544B2 (ja) 2010-10-15 2016-09-21 クリアサイド・バイオメディカル・インコーポレーテッドClearside Biomedical Incorporated 眼球アクセス用装置
GB201019577D0 (en) * 2010-11-18 2010-12-29 Univ Cork Method
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
JP5675952B2 (ja) 2011-02-24 2015-02-25 久光製薬株式会社 マイクロニードルデバイス用glp−1アナログ組成物
EP2679242B1 (de) 2011-02-25 2020-09-09 Hisamitsu Pharmaceutical Co., Inc. Hilfsstoff für transdermale oder transmukosale verabreichung und pharmazeutisches präparat damit
US8512679B2 (en) 2011-03-04 2013-08-20 Elwha Llc Glassy compositions
KR101241059B1 (ko) * 2011-03-04 2013-03-11 연세대학교 산학협력단 마이크로 니들을 이용한 혈관외벽 장착 약물 전달장치 및 약물 전달방법
GB201116143D0 (en) 2011-09-16 2011-11-02 Univ Greenwich Method of coating microneedle devices
AU2012323782B2 (en) 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
EP2771043A4 (de) 2011-10-28 2015-04-29 Presage Biosciences Inc Wirkstofffreisetzungsverfahren
US9849270B2 (en) 2011-12-16 2017-12-26 3M Innovative Properties Company Foldable adhesive composite dressing
US9144671B2 (en) 2011-12-21 2015-09-29 3M Innovative Properties Company Transdermal adhesive patch assembly with removable microneedle array and method of using same
EP2794793B1 (de) 2011-12-21 2018-11-28 3M Innovative Properties Company Klebepflasteranordnung mit überzug sowie system und verfahren zu ihrer herstellung
JP6323975B2 (ja) * 2012-06-22 2018-05-16 凸版印刷株式会社 針状体の製造方法
CN104602752A (zh) * 2012-08-30 2015-05-06 帝人株式会社 涂布有药物组合物的微针阵列
CN104736192B (zh) 2012-10-10 2018-02-13 3M创新有限公司 用于将微针装置施用至皮肤的施用装置和方法
WO2014058746A1 (en) 2012-10-10 2014-04-17 3M Innovative Properties Company Force-controlled applicator for applying a microneedle device to skin
EP2919849B1 (de) 2012-11-16 2021-01-06 Kindeva Drug Delivery L.P. Kraftgesteuerter applikator zum auftragen einer mikronadelvorrichtung auf der haut
EP2934660B1 (de) 2012-12-21 2019-07-17 Corium, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe und verfahren zur herstellung davon
WO2014110016A1 (en) 2013-01-08 2014-07-17 3M Innovative Properties Company Applicator for applying a microneedle device to skin
EP4094799A1 (de) 2013-03-12 2022-11-30 Corium, Inc. Mikroprojektionsapplikatoren
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
CN105188569B (zh) * 2013-03-15 2020-11-20 考里安公司 用于递送活性剂的微结构阵列
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
EP2968119B1 (de) 2013-03-15 2019-09-18 Corium International, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe, verfahren zur verwendung und verfahren zur herstellung
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
KR101712413B1 (ko) 2013-03-22 2017-03-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 카운터 조립체를 포함하는 마이크로니들 어플리케이터
BR112015027762A2 (pt) 2013-05-03 2017-08-29 Clearside Biomedical Inc Aparelho e métodos para injeção ocular
US9895520B2 (en) 2013-05-31 2018-02-20 3M Innovative Properties Company Microneedle injection apparatus comprising a dual cover
SG11201509546PA (en) 2013-05-31 2015-12-30 3M Innovative Properties Co Microneedle injection apparatus comprising an inverted actuator
KR102274902B1 (ko) 2013-05-31 2021-07-07 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 주사 및 주입 장치 및 그의 사용 방법
WO2015023649A2 (en) 2013-08-12 2015-02-19 3M Innovative Properties Company Peptides for enhancing transdermal delivery
ES2744454T3 (es) 2013-10-31 2020-02-25 Hisamitsu Pharmaceutical Co Composición de adyuvante
US20160310412A1 (en) * 2013-12-16 2016-10-27 Takeda Pharmaceutical Company Limited Microneedle
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
JP5892303B1 (ja) * 2014-06-13 2016-03-23 凸版印刷株式会社 針状体の製造方法
JP6643793B2 (ja) * 2014-06-17 2020-02-12 凸版印刷株式会社 中空型針状体の製造方法
JP6350014B2 (ja) * 2014-06-24 2018-07-04 凸版印刷株式会社 中空型針状体の製造方法、及び中空型針状体
CA2959506C (en) 2014-08-29 2022-10-18 Corium International, Inc. Microstructure array for delivery of active agents
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
JP5967595B2 (ja) * 2014-09-08 2016-08-10 株式会社かいわ 穿刺器具
JP6432316B2 (ja) * 2014-12-04 2018-12-05 凸版印刷株式会社 針状体の製造方法
AU2016211916B2 (en) 2015-01-27 2018-10-18 3M Innovative Properties Company Alum-containing coating formulations for microneedle vaccine patches
WO2016123665A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
US9944679B2 (en) 2015-03-16 2018-04-17 The Catholic University Of America Authentic trimeric HIV-1 envelope glycoproteins comprising a long linker and tag
CN107405477B (zh) * 2015-03-18 2020-06-16 凸版印刷株式会社 药剂施予装置及药剂施予装置的制造方法
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017045031A1 (en) * 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
CA2999538A1 (en) 2015-09-28 2017-04-06 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
WO2017062727A1 (en) 2015-10-09 2017-04-13 3M Innovative Properties Company Zinc compositions for coated microneedle arrays
US20170209553A1 (en) * 2016-01-22 2017-07-27 Transderm, Inc. Delivery of botulinum with microneedle arrays
KR101746747B1 (ko) * 2016-03-03 2017-06-14 배원규 모세관력을 이용하여 약물의 전달성을 향상시킨 마이크로니들 시스템
KR101837680B1 (ko) 2016-04-14 2018-04-19 정진수 중공형 마이크로 니들 제조 방법 및 그에 의해 제조된 중공형 마이크로 니들
JP7034425B2 (ja) * 2016-04-15 2022-03-14 エーディーエムバイオサイエンス インコーポレイテッド 核酸フィルムの製造方法及び核酸フィルムを用いた薬物注入装置
EP3444004B1 (de) * 2016-04-15 2020-12-02 FUJIFILM Corporation Mikronadelarray
US10568937B2 (en) 2016-04-18 2020-02-25 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
EP3452165A1 (de) 2016-05-02 2019-03-13 Clearside Biomedical, Inc. Systeme und verfahren zur verabreichung eines augenmedikaments
EP3451951A4 (de) * 2016-05-03 2019-12-25 SRGI Holdings, LLC Medizinische systeme mit pixelanordnung, vorrichtungen und verfahren
IL305537B2 (en) 2016-08-12 2025-02-01 Clearside Biomedical Inc Devices and methods for adjusting the insertion depth of a needle for administering a drug
KR101745682B1 (ko) * 2017-01-05 2017-06-09 주식회사 쿼드메디슨 마이크로 니들 제조방법 및 이에 의해 제조된 마이크로 니들
AU2018222745B2 (en) 2017-02-17 2021-02-18 Allergan, Inc. Microneedle array with active ingredient
ES2960937T3 (es) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Dispositivo y método para recubrir superficies
US12090294B2 (en) 2017-05-02 2024-09-17 Georgia Tech Research Corporation Targeted drug delivery methods using a microneedle
IT201700048421A1 (it) * 2017-05-04 2018-11-04 Materias S R L Dispositivo per la somministrazione transdermica di molecole attive, usi di tale dispositivo e metodi di produzione di tale dispositivo e di relativi componenti
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
EP4473998A3 (de) 2017-08-04 2025-02-26 Vaxxas Pty Limited Kompakter hoher mechanischer energiespeicher und aktuator mit geringer auslösekraft für die abgabe von mikroprojektions-array-patches (map)
JPWO2019059265A1 (ja) * 2017-09-20 2019-12-19 シンクランド株式会社 マイクロニードルシート及びマイクロニードルシートの製造方法
WO2019077519A1 (en) 2017-10-17 2019-04-25 3M Innovative Properties Company APPLICATOR FOR APPLYING A SKIN INJECTION CHIP
DE102017126501A1 (de) 2017-11-10 2019-05-16 Lts Lohmann Therapie-Systeme Ag Mikronadelsystem zur Applikation eines Hepatitis-Impfstoffes
JP6375435B1 (ja) * 2017-12-26 2018-08-15 三島光産株式会社 マイクロニードルアレイ
CN111818953A (zh) * 2018-01-07 2020-10-23 亚夫拉罕·阿米尔 用于皮肤改善的高负载微针和组合物
KR102088330B1 (ko) * 2018-04-11 2020-03-12 숭실대학교산학협력단 마이크로 구조물의 피부 흡수 촉진제, 마이크로 구조물의 피부 흡수 촉진제를 포함하는 피부에 바르는 인슐린, 및 마이크로 구조물의 피부 흡수 촉진제를 포함하는 피부에 바르는 인슐린을 이용한 인슐린 투여방법
KR102080860B1 (ko) * 2018-04-11 2020-02-24 숭실대학교산학협력단 미세구조의 피부 흡수 증강제, 미세구조의 피부 흡수 증강제를 포함하는 국소 마취제, 및 미세구조의 피부 흡수 증강제를 포함하는 국소 마취제를 이용한 마취 방법
US12121618B2 (en) 2018-05-18 2024-10-22 Postech Academy-Industry Foundation Transdermal drug delivery patch and manufacturing method thereof
US11460411B2 (en) 2018-06-18 2022-10-04 Kindeva Drug Delivery L.P. Process and apparatus for inspecting microneedle arrays
US12303659B2 (en) * 2018-11-15 2025-05-20 Massachusetts Institute Of Technology Thermally controlled reconfigurable medical devices
CN109529186B (zh) * 2018-12-17 2021-05-11 广东工业大学 一种药物涂层非晶合金微针及其制作方法
GB201908043D0 (en) 2019-06-05 2019-07-17 Lekkos Vasileios Transdermal patch for therapeutic uses
JP2021040977A (ja) * 2019-09-11 2021-03-18 株式会社ライトニックス 薬物投与デバイス
KR102290268B1 (ko) * 2019-10-11 2021-08-13 부산대학교 산학협력단 이식형 물질 전달체, 및 이의 제조방법
WO2021086123A1 (ko) * 2019-10-31 2021-05-06 휴젤㈜ 보툴리눔 독소에 대한 마이크로 구조체 제형화 기술
TWI889752B (zh) * 2020-02-11 2025-07-11 瑞典商艾瑟莉恩公司 用於收集流體的微針和流體通道系統
KR102570928B1 (ko) * 2022-01-07 2023-08-28 주식회사 쿼드메디슨 입자 부착형 마이크로니들 및 이를 이용한 제조방법
WO2024097385A1 (en) 2022-11-05 2024-05-10 Kindeva Drug Delivery L.P. Microneedle array applicator and system
EP4633720A1 (de) 2022-12-16 2025-10-22 Kindeva Drug Delivery L.P. Arzneimittelabgabevorrichtung
NL2036831B1 (en) * 2024-01-18 2025-07-28 Mylife Tech B V Microneedle device, patch, applicator and method

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US2619150A (en) * 1950-01-10 1952-11-25 Modern Metal Products Company Can crushing mechanism
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3221739A (en) * 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3675766A (en) * 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
US3975350A (en) * 1972-08-02 1976-08-17 Princeton Polymer Laboratories, Incorporated Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles
US4170378A (en) * 1978-04-24 1979-10-09 Jacobsen Gerald A Combined wind deflector and window awning assembly for recreational trailers
US4473083A (en) * 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
JPS60193925A (ja) 1984-03-13 1985-10-02 Chemo Sero Therapeut Res Inst 凍結乾燥製剤化ワクチン
JPH0678226B2 (ja) * 1985-12-11 1994-10-05 株式会社林原生物化学研究所 脱水医薬品とその製造方法
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
GB8903593D0 (en) * 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
US5125894A (en) 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US5437656A (en) * 1991-02-27 1995-08-01 Leonard Bloom Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5955448A (en) * 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
ATE252373T1 (de) 1994-08-04 2003-11-15 Elan Drug Delivery Ltd Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung
US5861439A (en) 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
US5736580A (en) 1994-11-14 1998-04-07 Alza Croporation Composition, device, and method for electrotransport agent delivery
KR100201352B1 (ko) * 1995-03-16 1999-06-15 성재갑 단일주사 백신 제형
DE69628007T2 (de) * 1995-06-07 2003-11-27 Elan Drug Delivery Ltd., Ruddington Verfahren zur stabilen einarbeitung von substanzen in trockene geschäumte glasmatrizen und auf diese weise hergestellte zusammensetzungen
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
US5985312A (en) * 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
WO1997047355A1 (en) 1996-06-12 1997-12-18 Alza Corporation Reduction of skin sensitization in electrotransport drug delivery
CA2253549C (en) 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US6197013B1 (en) * 1996-11-06 2001-03-06 Setagon, Inc. Method and apparatus for drug and gene delivery
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6425915B1 (en) 1997-03-18 2002-07-30 Endotex Interventional Systems, Inc. Helical mesh endoprosthesis and methods of use
PT994887E (pt) 1997-07-03 2003-04-30 Elan Drug Delivery Ltd Glicosidos modificados composicoes que compreendem os mesmos e metodos para a sua utilizacao
JPH1157023A (ja) 1997-08-20 1999-03-02 Sekisui Chem Co Ltd 薬剤投与器具
CA2313698C (en) * 1997-12-11 2008-04-15 Alza Corporation Device for enhancing transdermal agent flux
ATE365050T1 (de) 1998-02-25 2007-07-15 Us Gov Sec Army Verwendung von hautpenetrationsförderern und für die zerstörung der oberen hautschichten geeigneten mitteln zur erhöhung der transkutanen immunantwort
EP1086214B1 (de) * 1998-06-10 2009-11-25 Georgia Tech Research Corporation Mikronadel-einrichtungen und verfahren zur deren herstellung
US6532386B2 (en) * 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
JP2002532165A (ja) 1998-12-18 2002-10-02 メドトロニック ミニメド インコーポレイテッド 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
EP1163024B1 (de) * 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Einbringen von makromolekülen in zellen
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
DK1189660T3 (da) * 1999-06-08 2006-08-21 Altea Therapeutics Corp Apparat til mikroperforering af biologiske membraner ved hjælp af tyndfilms-vævsgrænseflade-anordninger samt fremgangsmåde til fremstilling deraf
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6656147B1 (en) * 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
US6790453B2 (en) * 2001-03-14 2004-09-14 Mccormick & Company, Inc. Encapsulation compositions and process for preparing the same
GB0201736D0 (en) * 2002-01-25 2002-03-13 Glaxo Group Ltd DNA dosage forms

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ES2295768T3 (es) 2008-04-16
US20140294919A1 (en) 2014-10-02
DE60131688D1 (de) 2008-01-10
PT1512429E (pt) 2008-02-18
JP4965053B2 (ja) 2012-07-04
EP1512429B1 (de) 2007-11-28
PT1301238E (pt) 2005-01-31
DK1301238T3 (da) 2005-01-10
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US20050197308A1 (en) 2005-09-08
CA2657491A1 (en) 2002-01-31
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CY1107870T1 (el) 2013-06-19
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DE60131688T2 (de) 2008-10-30
ES2228937T3 (es) 2005-04-16
CA2416869A1 (en) 2002-01-31
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