ATE444773T1 - Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält - Google Patents
Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthältInfo
- Publication number
- ATE444773T1 ATE444773T1 AT02731464T AT02731464T ATE444773T1 AT E444773 T1 ATE444773 T1 AT E444773T1 AT 02731464 T AT02731464 T AT 02731464T AT 02731464 T AT02731464 T AT 02731464T AT E444773 T1 ATE444773 T1 AT E444773T1
- Authority
- AT
- Austria
- Prior art keywords
- coating containing
- agent
- microprojections
- advantageous agent
- microprojection arrangement
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28557601P | 2001-04-20 | 2001-04-20 | |
| PCT/US2002/012730 WO2002085447A2 (en) | 2001-04-20 | 2002-04-20 | Microprojection array having a beneficial agent containing coating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE444773T1 true ATE444773T1 (de) | 2009-10-15 |
Family
ID=23094848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02731464T ATE444773T1 (de) | 2001-04-20 | 2002-04-20 | Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7963935B2 (de) |
| EP (1) | EP1392389B1 (de) |
| JP (2) | JP2004528900A (de) |
| KR (1) | KR20040020889A (de) |
| CN (2) | CN101129327A (de) |
| AT (1) | ATE444773T1 (de) |
| BR (1) | BR0209046A (de) |
| CA (1) | CA2444883A1 (de) |
| DE (1) | DE60233939D1 (de) |
| ES (1) | ES2333849T3 (de) |
| IL (1) | IL158480A0 (de) |
| MX (1) | MXPA03009603A (de) |
| NO (1) | NO20034684L (de) |
| NZ (1) | NZ529029A (de) |
| WO (1) | WO2002085447A2 (de) |
| ZA (1) | ZA200309006B (de) |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7184826B2 (en) * | 1996-06-18 | 2007-02-27 | Alza Corporation | Device and method for enhancing transdermal flux of agents being delivered or sampled |
| US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
| NZ525294A (en) * | 2000-10-13 | 2005-02-25 | Alza Corp | Apparatus and method for piercing skin with microprotrusions |
| WO2002030300A2 (en) * | 2000-10-13 | 2002-04-18 | Alza Corporation | Microprotrusion member retainer for impact applicator |
| US7419481B2 (en) * | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
| US7108681B2 (en) | 2000-10-16 | 2006-09-19 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
| US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
| US7131987B2 (en) | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
| EP1333880B1 (de) * | 2000-10-26 | 2009-04-15 | Alza Corporation | Transdermales arzneistoffverabreichungssytem mit beschichteten mikrovorsprüngen |
| WO2002074173A1 (en) * | 2001-03-16 | 2002-09-26 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
| US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| WO2003048031A2 (en) * | 2001-11-30 | 2003-06-12 | Alza Corporation | Methods and apparatuses for forming microprojection arrays |
| HUP0402605A2 (hu) * | 2001-12-20 | 2005-06-28 | Alza Corporation | Eszköz mikroszkopikus bemetszések ejtésére állat bőrszövetén |
| GB0201736D0 (en) * | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | DNA dosage forms |
| TW200409657A (en) * | 2002-08-08 | 2004-06-16 | Alza Corp | Transdermal vaccine delivery device having coated microprotrusions |
| AU2003275301A1 (en) * | 2002-09-30 | 2004-04-23 | Alza Corporation | Drug delivery device having coated microprojections incorporating vasoconstrictors |
| AR042815A1 (es) * | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
| US7578954B2 (en) | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
| ES2290738T3 (es) * | 2003-06-30 | 2008-02-16 | Alza Corporation | Procedimiento para revestir microproyecciones de perforacion de la piel. |
| US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
| BRPI0412029A (pt) | 2003-06-30 | 2006-09-05 | Alza Corp | formulações para microprojeções revestidas contendo contra-ìons não-voláteis |
| AU2004253571A1 (en) * | 2003-07-02 | 2005-01-13 | Alza Corporation | Microprojection array immunization patch and method |
| EP1656178A1 (de) * | 2003-08-04 | 2006-05-17 | Alza Corporation | Verfahren und vorrichtung zur verbesserung des flusses transdermaler agentien |
| US8524272B2 (en) | 2003-08-15 | 2013-09-03 | Mylan Technologies, Inc. | Transdermal patch incorporating active agent migration barrier layer |
| JP2007503268A (ja) | 2003-08-25 | 2007-02-22 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫応答修飾化合物の送達 |
| US20050090009A1 (en) * | 2003-10-23 | 2005-04-28 | Cormier Michel J. | Compositions of stabilized DNA for coating microprojctions |
| CN1897898A (zh) * | 2003-10-24 | 2007-01-17 | 阿尔扎公司 | 用于增强透皮药物传递的预处理方法和系统 |
| KR20060120156A (ko) * | 2003-10-28 | 2006-11-24 | 알자 코포레이션 | 담배의 이용빈도를 감소시키기 위한 방법 및 장치 |
| JP2007509704A (ja) * | 2003-10-31 | 2007-04-19 | アルザ・コーポレーシヨン | 経皮的ワクチン送達のための系および方法 |
| US7097631B2 (en) | 2003-10-31 | 2006-08-29 | Alza Corporation | Self-actuating applicator for microprojection array |
| GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
| CA2560840C (en) | 2004-03-24 | 2014-05-06 | Corium International, Inc. | Transdermal delivery device |
| CA2562932A1 (en) | 2004-04-01 | 2005-10-27 | Alza Corporation | Apparatus and method for transdermal delivery of influenza vaccine |
| CA2562642A1 (en) * | 2004-04-13 | 2005-11-03 | Alza Corporation | Apparatus and method for transdermal delivery of multiple vaccines |
| US20050226922A1 (en) * | 2004-04-13 | 2005-10-13 | Mahmoud Ameri | Apparatus and method for transdermal delivery of fentanyl-based agents |
| CN100566669C (zh) * | 2004-05-13 | 2009-12-09 | 阿尔扎公司 | 甲状旁腺激素药物的透皮释放装置 |
| JP5007427B2 (ja) * | 2004-05-13 | 2012-08-22 | アルザ コーポレイション | 副甲状腺ホルモン剤の経皮送達のための装置および方法 |
| US7591806B2 (en) * | 2004-05-18 | 2009-09-22 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
| EP1786505A1 (de) * | 2004-09-08 | 2007-05-23 | Alza Corporation | Mikroprojektionsarray mit verbesserter hautadhäsion und -compliance |
| EP1827564B1 (de) * | 2004-11-18 | 2015-07-29 | 3M Innovative Properties Company | Maskierungsverfahren zum beschichten einer mikronadelanordnung |
| BRPI0517749A (pt) * | 2004-11-18 | 2008-10-21 | 3M Innovative Properties Co | dispositivo de aplicação para aplicar um dispositivo de micro-agulha a uma superfìcie de pele, e, método para usar um dispositivo de aplicação |
| JP5015787B2 (ja) | 2004-11-18 | 2012-08-29 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイの接触コーティング法 |
| US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
| MX2007006742A (es) * | 2004-12-10 | 2007-07-25 | 3M Innovative Properties Co | Dispositivo medico. |
| CN101160117A (zh) * | 2005-02-16 | 2008-04-09 | 阿尔扎公司 | 依泊汀-基药物的透皮释放装置和方法 |
| US8048017B2 (en) * | 2005-05-18 | 2011-11-01 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| US8043250B2 (en) * | 2005-05-18 | 2011-10-25 | Nanomed Devices, Inc. | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| WO2006138719A2 (en) | 2005-06-17 | 2006-12-28 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
| US20080195035A1 (en) | 2005-06-24 | 2008-08-14 | Frederickson Franklyn L | Collapsible Patch and Method of Application |
| WO2007008800A2 (en) * | 2005-07-11 | 2007-01-18 | Infotonics Technology Center, Inc. | Replaceable cartridge for allergy testing system |
| WO2007012114A1 (en) * | 2005-07-25 | 2007-02-01 | Nanotechnology Victoria Pty Ltd | Microarray device |
| DE602006020738D1 (de) | 2005-08-01 | 2011-04-28 | Hisamitsu Pharmaceutical Co | Adjuvans oder pharmazeutische zubereitung zur transdermalen oder transmukosalen verabreichung |
| AU2006291157A1 (en) * | 2005-09-12 | 2007-03-22 | Alza Corporation | Coatable transdermal delivery microprojection assembly |
| WO2007061781A1 (en) * | 2005-11-18 | 2007-05-31 | 3M Innovative Properties Company | Coatable compositions, coatings derived therefrom and microarrays having such coatings |
| US7618429B2 (en) * | 2005-12-22 | 2009-11-17 | Spamedica International Srl | Skin rejuvination resurfacing method |
| JP2009522288A (ja) * | 2005-12-28 | 2009-06-11 | アルザ コーポレイション | 安定な治療剤形 |
| EP1992386B1 (de) * | 2006-02-10 | 2011-11-09 | Hisamitsu Pharmaceutical Co., Inc. | Transdermales arzneiverabreichungsgerät mit mikronadeln |
| CN101466393A (zh) * | 2006-03-15 | 2009-06-24 | 阿尔扎公司 | 用于经皮递送甲状旁腺激素药剂以治疗骨质减少的方法 |
| US20070224252A1 (en) * | 2006-03-27 | 2007-09-27 | Trautman Joseph C | Microprojections with capillary control features and method |
| US20090099502A1 (en) | 2006-04-07 | 2009-04-16 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle Device And Transdermal Administration Device Provided With Microneedles |
| WO2007124411A1 (en) | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
| US20070293816A1 (en) * | 2006-04-25 | 2007-12-20 | Alza Corporation | Microprojection Array Application with Grouped Microprojections for High Drug Loading |
| WO2007127815A2 (en) * | 2006-04-25 | 2007-11-08 | Alza Corporation | Microprojection array application with multilayered microprojection member for high drug loading |
| US20100100005A1 (en) * | 2006-07-11 | 2010-04-22 | Infotonics Technology Center, Inc. | Minimally invasive allergy testing system with coated allergens |
| US20090182306A1 (en) * | 2006-07-21 | 2009-07-16 | Georgia Tech Research Corporation | Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal |
| WO2008011625A2 (en) * | 2006-07-21 | 2008-01-24 | Georgia Tech Researh Corporation | Microneedle devices and methods of drug delivery or fluid withdrawal |
| AU2007301170B2 (en) | 2006-09-27 | 2010-11-04 | Asahi Kasei Pharma Corporation | Agent for preventing development of reflex sympathetic dystrophy after stroke |
| US10525246B2 (en) | 2006-12-22 | 2020-01-07 | Nanomed Skincare, Inc. | Microdevice and method for transdermal delivery and sampling of active substances |
| US20080214987A1 (en) * | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
| EP2121111B1 (de) | 2007-01-22 | 2018-03-14 | Corium International, Inc. | Applikator für mikronadelanordnung |
| EP2123296B1 (de) * | 2007-01-31 | 2019-05-22 | Hisamitsu Pharmaceutical Co., Inc. | Hilfsstoff für transdermale oder transmukosale verabreichung und pharmazeutische zubereitung damit |
| JP5241517B2 (ja) * | 2007-02-06 | 2013-07-17 | 久光製薬株式会社 | アレルギー診断用マイクロニードルデバイス |
| WO2008115599A1 (en) * | 2007-03-21 | 2008-09-25 | Alza Corporation | Apparatus and method for transdermal delivery of a 5-hydroxytrytamine antagonist |
| EP2146689B1 (de) | 2007-04-16 | 2020-08-12 | Corium, Inc. | Einen wirkstoff enthaltende lösungsmittel-gegossene mikronadelanordnungen |
| US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| US20090137945A1 (en) * | 2007-11-28 | 2009-05-28 | Claire Marquez | Electro Collagen Induction Therapy Device |
| WO2009079712A1 (en) | 2007-12-24 | 2009-07-02 | The University Of Queensland | Coating method |
| WO2009094394A1 (en) * | 2008-01-23 | 2009-07-30 | Georgia Tech Research Corporation | Microneedle devices and methods of drug delivery or fluid withdrawal |
| WO2009097660A1 (en) * | 2008-02-07 | 2009-08-13 | The University Of Queensland | Patch production |
| WO2009142741A1 (en) | 2008-05-21 | 2009-11-26 | Theraject, Inc. | Method of manufacturing solid solution peforator patches and uses thereof |
| US7943187B2 (en) * | 2008-05-23 | 2011-05-17 | Bakr Rabie | Paeoniflorin preparations and uses thereof for fat reduction |
| CA2760680A1 (en) | 2008-05-23 | 2009-11-26 | The University Of Queensland | Analyte detection by microneedle patch with analyte selective reagents |
| US20110177297A1 (en) * | 2008-10-02 | 2011-07-21 | Nurim Wellness Co. Ltd. | Method of manufacturing solid microstructure and solid microstructure manufactured based on same |
| CN102325563A (zh) | 2008-12-22 | 2012-01-18 | 昆士兰大学 | 贴剂制备 |
| EP2383013A4 (de) | 2008-12-26 | 2012-11-28 | Hisamitsu Pharmaceutical Co | Mikronadelvorrichtung |
| US8062568B2 (en) * | 2009-08-27 | 2011-11-22 | Korea University Research And Business Foundation | Nano pattern writer |
| JP6327852B2 (ja) | 2010-05-04 | 2018-05-23 | コリウム インターナショナル, インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
| WO2012006677A1 (en) | 2010-07-14 | 2012-01-19 | The University Of Queensland | Patch applying apparatus |
| JP5876468B2 (ja) | 2011-02-25 | 2016-03-02 | 久光製薬株式会社 | 経皮または経粘膜投与のためのアジュバントおよびこれを含む医薬製剤 |
| US20120222979A1 (en) | 2011-03-04 | 2012-09-06 | Elwha LLC, a limited liability company of the State of Delaware | Glassy compositions |
| EP2765927B1 (de) | 2011-10-12 | 2021-02-24 | Vaxxas Pty Limited | Abgabegerät |
| US9993423B2 (en) | 2011-10-20 | 2018-06-12 | Cosmed Pharmaceutical Co., Ltd. | Microneedle deposition method |
| AU2012345768B2 (en) | 2011-11-30 | 2016-05-12 | Kindeva Drug Delivery L.P. | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
| JP2013153959A (ja) * | 2012-01-30 | 2013-08-15 | Toppan Printing Co Ltd | 針状体の構造 |
| US10980865B2 (en) | 2012-08-10 | 2021-04-20 | Aquavit Pharmaceuticals, Inc. | Direct application system and method for the delivery of bioactive compositions and formulations |
| AU2013364053B2 (en) | 2012-12-21 | 2018-08-30 | Corium Pharma Solutions, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| JPWO2014142135A1 (ja) * | 2013-03-12 | 2017-02-16 | 武田薬品工業株式会社 | マイクロニードルパッチ |
| CA2903748C (en) | 2013-03-12 | 2021-11-02 | Corium International, Inc. | Microprojection applicators |
| BR112015022625B1 (pt) | 2013-03-15 | 2023-01-31 | Corium, Inc | Aparelho de microestrutura para entrega de agente terapêutico |
| WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| US9962534B2 (en) | 2013-03-15 | 2018-05-08 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| US20160120628A1 (en) * | 2013-06-12 | 2016-05-05 | The Board Of Regents For Oklahoma State University | Fluttering ear tag for bovine vaccination |
| WO2015064710A1 (ja) | 2013-10-31 | 2015-05-07 | 久光製薬株式会社 | アジュバント組成物、これを含むアジュバント製剤、及びキット |
| RS67458B1 (sr) | 2014-03-28 | 2025-12-31 | Univ Duke | Lečenje kancera dojke pozitivnog na receptor estrogena upotrebom selektivnih modulatora receptora estrogena |
| WO2016036866A1 (en) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| US11147954B2 (en) | 2015-02-02 | 2021-10-19 | Vaxxas Pty Limited | Microprojection array applicator and method |
| KR102676629B1 (ko) | 2015-04-29 | 2024-06-18 | 래디어스 파마슈티컬스, 인코포레이티드 | 암을 치료하는 방법 |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| US11103259B2 (en) | 2015-09-18 | 2021-08-31 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
| US20180264244A1 (en) | 2015-09-28 | 2018-09-20 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
| CN108366866A (zh) * | 2015-10-12 | 2018-08-03 | 瑞弗罗医疗公司 | 具有突出的药物递送特征部的支架以及相关的系统和方法 |
| EP3416618A1 (de) | 2016-02-19 | 2018-12-26 | ZP Opco, Inc. | Verfahren zum schnellen erreichen therapeutischer konzentrationen von triptanen zur behandlung von migräne |
| JP2017164308A (ja) * | 2016-03-16 | 2017-09-21 | 凸版印刷株式会社 | 穿刺デバイス及びその製造方法 |
| KR20170115429A (ko) * | 2016-04-07 | 2017-10-17 | 랩앤피플주식회사 | 생체분해성 금속을 이용한 마이크로 니들 |
| WO2017179956A2 (ko) | 2016-04-15 | 2017-10-19 | 한국기계연구원 | 핵산필름의 제조방법과 핵산필름을 이용한 약물주입장치 |
| CA3020333A1 (en) | 2016-04-18 | 2017-10-26 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
| KR102881465B1 (ko) | 2017-01-05 | 2025-11-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
| AU2018241251B2 (en) | 2017-03-31 | 2024-06-27 | Vaxxas Pty Limited | Device and method for coating surfaces |
| EP3639010B1 (de) | 2017-06-13 | 2025-08-06 | Vaxxas Pty Limited | Qualitätskontrolle von substratbeschichtungen |
| EP4548954A3 (de) | 2017-08-04 | 2025-07-30 | Vaxxas Pty Limited | Kompakter hoher mechanischer energiespeicher und aktuator mit geringer auslösekraft für die abgabe von mikroprojektions-array-patches (map) |
| US11660264B2 (en) | 2017-08-23 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
| JP7219384B2 (ja) | 2017-08-23 | 2023-02-08 | エマージェクス ユーエスエイ コーポレーション | 片頭痛および群発頭痛の治療に適したゾルミトリプタン治療濃度を迅速に得る方法 |
| KR102146704B1 (ko) * | 2018-04-13 | 2020-08-21 | 가천대학교 산학협력단 | 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체 |
| US11660265B2 (en) | 2018-06-28 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
| CN112423844B (zh) | 2018-07-04 | 2024-08-13 | 雷迪厄斯制药公司 | Rad1901-2hcl的多晶型形式 |
| JOP20210218A1 (ar) | 2019-02-12 | 2023-01-30 | Radius Pharmaceuticals Inc | عمليات ومركبات |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE25637E (en) | 1964-09-08 | Means for vaccinating | ||
| US3136314A (en) | 1960-08-01 | 1964-06-09 | Kravitz Harvey | Vaccinating devices |
| US3556080A (en) * | 1968-04-08 | 1971-01-19 | Lincoln Lab Inc | Skin allergy testing device |
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US3760984A (en) * | 1971-09-29 | 1973-09-25 | Alza Corp | Osmotically powered agent dispensing device with filling means |
| BE795384A (fr) | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
| OA05448A (fr) | 1975-10-16 | 1981-03-31 | Manufrance Manufacture Francai | Dispositif vaccinateur multipénétrant. |
| FR2474856A1 (fr) | 1980-01-31 | 1981-08-07 | Merieux Inst | Dispositif scarificateur |
| US4473083A (en) * | 1981-12-14 | 1984-09-25 | Maganias Nicholas H | Device and method for allergy testing |
| JPS60193925A (ja) | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
| KR970008118B1 (ko) | 1987-07-09 | 1997-05-21 | 엘테에스 로오만 테라피-지스테메 게엠베하 운트 콤파니 카게 | 피부 침투성 치료 시스템 |
| CA2016900A1 (en) | 1989-07-06 | 1991-01-06 | Ronald J. Filipski | Tines structure in clinical applicator |
| EP0429842B1 (de) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten |
| US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| US5437656A (en) | 1991-02-27 | 1995-08-01 | Leonard Bloom | Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment |
| DE4222380A1 (de) | 1992-07-08 | 1994-01-13 | Ernst Peter Prof Dr M Strecker | In den Körper eines Patienten perkutan implantierbare Endoprothese |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| DE4341444C2 (de) | 1993-12-04 | 1996-03-14 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster und Verfahren zu seiner Herstellung |
| US5457041A (en) * | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
| DE69531992T2 (de) * | 1994-08-04 | 2004-07-22 | Elan Drug Delivery Ltd., Ruddington | Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US6586006B2 (en) * | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| EP0796128B1 (de) | 1994-12-09 | 1999-03-10 | Novartis AG | Transdermales system |
| JP3601102B2 (ja) | 1995-03-15 | 2004-12-15 | ブラザー工業株式会社 | インクジェット式印刷記録装置と印字システム |
| DE19514104C2 (de) | 1995-04-13 | 1997-05-28 | Behringwerke Ag | Beschichtung für in den Blutstrom oder in das Gewebe des menschlichen Körpers einbringbares Biomaterial |
| AU5869796A (en) | 1995-05-22 | 1996-12-11 | Ned A. Godshall | Micromechanical patch for enhancing the delivery of compound s through the skin |
| WO1996037155A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
| EP0844004B1 (de) * | 1995-07-03 | 2007-09-12 | Koken Co., Ltd. | Atelocollagen enthaltende gen-zusammensetzungen |
| DE19525607A1 (de) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
| US7184826B2 (en) | 1996-06-18 | 2007-02-27 | Alza Corporation | Device and method for enhancing transdermal flux of agents being delivered or sampled |
| ES2200187T3 (es) | 1996-07-03 | 2004-03-01 | Altea Therapeutics Corporation | Microporacion mecanica multiple de la piel o de la mucosa. |
| US5743960A (en) | 1996-07-26 | 1998-04-28 | Bio-Dot, Inc. | Precision metered solenoid valve dispenser |
| US5741554A (en) | 1996-07-26 | 1998-04-21 | Bio Dot, Inc. | Method of dispensing a liquid reagent |
| US5738728A (en) | 1996-07-26 | 1998-04-14 | Bio Dot, Inc. | Precision metered aerosol dispensing apparatus |
| US5916524A (en) | 1997-07-23 | 1999-06-29 | Bio-Dot, Inc. | Dispensing apparatus having improved dynamic range |
| CA2265906C (en) | 1996-09-17 | 2003-11-11 | Deka Products Limited Partnership | System for delivery of drugs by transport |
| US6197013B1 (en) * | 1996-11-06 | 2001-03-06 | Setagon, Inc. | Method and apparatus for drug and gene delivery |
| AU722574B2 (en) | 1996-12-20 | 2000-08-10 | Alza Corporation | Device and method for enhancing transdermal agent flux |
| DE19654391A1 (de) | 1996-12-27 | 1998-07-02 | Basf Ag | Katalysator zur selektiven Herstellung von Propylen aus Propan |
| ID21673A (id) | 1996-12-31 | 1999-07-08 | Shell Internationale Res Maatc | Anjungan tiang dengan alur vertikal |
| US20020009464A1 (en) * | 1997-07-03 | 2002-01-24 | Camilo Colaco | Modified glycosides, compositions comprised thereof and methods of use thereof |
| US6918901B1 (en) | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
| CN1206004C (zh) | 1997-12-11 | 2005-06-15 | 阿尔扎有限公司 | 增强透皮物剂流量的装置 |
| PT1037686E (pt) * | 1997-12-11 | 2005-10-31 | Alza Corp | Aparelho para potenciar o fluxo de agente transdermico |
| WO1999029364A1 (en) * | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
| US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
| US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| AU767122B2 (en) | 1998-06-10 | 2003-10-30 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
| DE69921489T2 (de) * | 1998-08-31 | 2005-10-27 | Johnson & Johnson Consumer Companies, Inc. | Elektrotransportvorrichtung mit klingen |
| AU2189400A (en) | 1998-12-18 | 2000-07-03 | Minimed, Inc. | Insertion sets with micro-piercing members for use with medical devices and methods of using the same |
| JP4499295B2 (ja) | 1999-01-28 | 2010-07-07 | サイト パルス サイエンシズ、インコーポレイテッド | 細胞内への巨大分子の送達 |
| US6884427B1 (en) | 1999-02-08 | 2005-04-26 | Aderans Research Institute, Inc. | Filamentary means for introducing agents into tissue of a living host |
| JP2002542183A (ja) | 1999-04-16 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | 成形可能な乾燥した医薬製剤 |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| JP4412874B2 (ja) * | 1999-06-08 | 2010-02-10 | アルテア セラピューティクス コーポレイション | 薄膜組織インターフェイスデバイスを使用する生物学的膜のミクロポレーションのための装置、およびそのための方法 |
| US6312612B1 (en) * | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US6623457B1 (en) | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| US6835184B1 (en) * | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
| US20020095134A1 (en) | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
| SE0000363L (sv) * | 2000-02-04 | 2001-08-05 | Zoucas Kirurgkonsult Ab | Belagd medicinsk anordning |
| US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
| US6537242B1 (en) | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
| US20050008683A1 (en) | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
| US6589202B1 (en) | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
| US6440096B1 (en) | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
| GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| PT1341442E (pt) | 2000-10-13 | 2005-09-30 | Alza Corp | Aplicador de impacto com um conjunto de microlaminas |
| NZ525294A (en) | 2000-10-13 | 2005-02-25 | Alza Corp | Apparatus and method for piercing skin with microprotrusions |
| WO2002030300A2 (en) | 2000-10-13 | 2002-04-18 | Alza Corporation | Microprotrusion member retainer for impact applicator |
| EP1333880B1 (de) | 2000-10-26 | 2009-04-15 | Alza Corporation | Transdermales arzneistoffverabreichungssytem mit beschichteten mikrovorsprüngen |
| GB0026957D0 (en) * | 2000-11-03 | 2000-12-20 | Eastman Kodak Co | Processing photographic materal |
| US6638246B1 (en) * | 2000-11-28 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device for delivery of a biologically active material to a lumen |
| EP1345646A2 (de) | 2000-12-14 | 2003-09-24 | Georgia Tech Research Corporation | Mikronadel-vorrichtungen und deren herstellung |
| WO2002074173A1 (en) | 2001-03-16 | 2002-09-26 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
| US20020193729A1 (en) | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
| EP1469903A2 (de) | 2001-09-28 | 2004-10-27 | BioValve Technologies, Inc. | Mikronadel mit membran |
| US6689100B2 (en) | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
-
2002
- 2002-04-20 ES ES02731464T patent/ES2333849T3/es not_active Expired - Lifetime
- 2002-04-20 JP JP2002583020A patent/JP2004528900A/ja not_active Ceased
- 2002-04-20 KR KR10-2003-7013728A patent/KR20040020889A/ko not_active Ceased
- 2002-04-20 CN CNA2007101489918A patent/CN101129327A/zh active Pending
- 2002-04-20 NZ NZ529029A patent/NZ529029A/en unknown
- 2002-04-20 AT AT02731464T patent/ATE444773T1/de not_active IP Right Cessation
- 2002-04-20 DE DE60233939T patent/DE60233939D1/de not_active Expired - Lifetime
- 2002-04-20 CN CNB028122518A patent/CN100349632C/zh not_active Expired - Fee Related
- 2002-04-20 IL IL15848002A patent/IL158480A0/xx unknown
- 2002-04-20 MX MXPA03009603A patent/MXPA03009603A/es unknown
- 2002-04-20 BR BR0209046-5A patent/BR0209046A/pt not_active IP Right Cessation
- 2002-04-20 US US10/127,108 patent/US7963935B2/en active Active
- 2002-04-20 EP EP02731464A patent/EP1392389B1/de not_active Expired - Lifetime
- 2002-04-20 CA CA002444883A patent/CA2444883A1/en not_active Abandoned
- 2002-04-20 WO PCT/US2002/012730 patent/WO2002085447A2/en not_active Ceased
-
2003
- 2003-10-20 NO NO20034684A patent/NO20034684L/no not_active Application Discontinuation
- 2003-11-19 ZA ZA200309006A patent/ZA200309006B/en unknown
-
2011
- 2011-05-06 JP JP2011103757A patent/JP5611888B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1392389B1 (de) | 2009-10-07 |
| ES2333849T3 (es) | 2010-03-02 |
| JP2011172968A (ja) | 2011-09-08 |
| IL158480A0 (en) | 2004-05-12 |
| JP2004528900A (ja) | 2004-09-24 |
| ZA200309006B (en) | 2005-02-21 |
| JP5611888B2 (ja) | 2014-10-22 |
| US7963935B2 (en) | 2011-06-21 |
| DE60233939D1 (de) | 2009-11-19 |
| NZ529029A (en) | 2005-07-29 |
| MXPA03009603A (es) | 2004-12-06 |
| CA2444883A1 (en) | 2002-10-31 |
| BR0209046A (pt) | 2004-11-09 |
| CN100349632C (zh) | 2007-11-21 |
| CN1541126A (zh) | 2004-10-27 |
| WO2002085447A3 (en) | 2003-03-06 |
| NO20034684L (no) | 2003-12-11 |
| CN101129327A (zh) | 2008-02-27 |
| KR20040020889A (ko) | 2004-03-09 |
| US20020177839A1 (en) | 2002-11-28 |
| NO20034684D0 (no) | 2003-10-20 |
| WO2002085447A8 (en) | 2004-05-13 |
| WO2002085447A2 (en) | 2002-10-31 |
| EP1392389A2 (de) | 2004-03-03 |
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