ATE444773T1 - Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält - Google Patents
Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthältInfo
- Publication number
- ATE444773T1 ATE444773T1 AT02731464T AT02731464T ATE444773T1 AT E444773 T1 ATE444773 T1 AT E444773T1 AT 02731464 T AT02731464 T AT 02731464T AT 02731464 T AT02731464 T AT 02731464T AT E444773 T1 ATE444773 T1 AT E444773T1
- Authority
- AT
- Austria
- Prior art keywords
- coating containing
- agent
- microprojections
- advantageous agent
- microprojection arrangement
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28557601P | 2001-04-20 | 2001-04-20 | |
| PCT/US2002/012730 WO2002085447A2 (en) | 2001-04-20 | 2002-04-20 | Microprojection array having a beneficial agent containing coating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE444773T1 true ATE444773T1 (de) | 2009-10-15 |
Family
ID=23094848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02731464T ATE444773T1 (de) | 2001-04-20 | 2002-04-20 | Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7963935B2 (de) |
| EP (1) | EP1392389B1 (de) |
| JP (2) | JP2004528900A (de) |
| KR (1) | KR20040020889A (de) |
| CN (2) | CN100349632C (de) |
| AT (1) | ATE444773T1 (de) |
| BR (1) | BR0209046A (de) |
| CA (1) | CA2444883A1 (de) |
| DE (1) | DE60233939D1 (de) |
| ES (1) | ES2333849T3 (de) |
| IL (1) | IL158480A0 (de) |
| MX (1) | MXPA03009603A (de) |
| NO (1) | NO20034684L (de) |
| NZ (1) | NZ529029A (de) |
| WO (1) | WO2002085447A2 (de) |
| ZA (1) | ZA200309006B (de) |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2253549C (en) * | 1996-06-18 | 2005-10-25 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
| US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
| DE60138411D1 (de) * | 2000-10-13 | 2009-05-28 | Alza Corp | Vorrichtung und verfahren zum durchstechen der haut mit micronadeln |
| US7419481B2 (en) * | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
| ATE416692T1 (de) * | 2000-10-13 | 2008-12-15 | Alza Corp | Mikronadelelementhalter für schlagapplikator |
| US7108681B2 (en) | 2000-10-16 | 2006-09-19 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
| US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
| US7131987B2 (en) | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
| NZ525551A (en) * | 2000-10-26 | 2005-09-30 | Alza Corp | Transdermal drug delivery devices having coated microprotrusions |
| WO2002074173A1 (en) * | 2001-03-16 | 2002-09-26 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
| US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| US20030199810A1 (en) * | 2001-11-30 | 2003-10-23 | Trautman Joseph Creagan | Methods and apparatuses for forming microprojection arrays |
| WO2003053258A1 (en) * | 2001-12-20 | 2003-07-03 | Alza Corporation | Skin-piercing microprojections having piercing depth control |
| GB0201736D0 (en) * | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | DNA dosage forms |
| AR040819A1 (es) * | 2002-08-08 | 2005-04-20 | Alza Corp | Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas |
| EP1590033A2 (de) * | 2002-09-30 | 2005-11-02 | Alza Corporation | Wirkstoffabgabesystem mit vasokonstriktor enthaltenden überzogenen mikroprojektionen |
| AR042815A1 (es) * | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
| US7578954B2 (en) | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
| PL1638468T3 (pl) * | 2003-06-30 | 2008-01-31 | Alza Corp | Sposób powlekania mikrowystępów do przekłuwania skóry |
| US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
| KR20060038407A (ko) | 2003-06-30 | 2006-05-03 | 알자 코포레이션 | 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제 |
| CN1845708A (zh) * | 2003-07-02 | 2006-10-11 | 阿尔扎公司 | 微突出物阵列免疫贴剂和方法 |
| JP2007501071A (ja) * | 2003-08-04 | 2007-01-25 | アルザ・コーポレーシヨン | 経皮作用剤流率を向上させる方法および装置 |
| US8524272B2 (en) * | 2003-08-15 | 2013-09-03 | Mylan Technologies, Inc. | Transdermal patch incorporating active agent migration barrier layer |
| US8961477B2 (en) | 2003-08-25 | 2015-02-24 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
| WO2005042702A2 (en) * | 2003-10-23 | 2005-05-12 | Alza Corporation | Compositions of stabilized dna for coating microprojections |
| BRPI0415466A (pt) * | 2003-10-24 | 2006-12-19 | Alza Corp | método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos |
| AU2004287412A1 (en) * | 2003-10-28 | 2005-05-19 | Alza Corporation | Method and apparatus for reducing the incidence of tobacco use |
| WO2005044366A2 (en) * | 2003-10-31 | 2005-05-19 | Alza Corporation | System and method for transdermal vaccine delivery |
| ES2377647T3 (es) | 2003-10-31 | 2012-03-29 | Alza Corporation | Aplicador auto-actuado para ordenamiento de microproyecciones |
| GB0402131D0 (en) * | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
| WO2005094526A2 (en) | 2004-03-24 | 2005-10-13 | Corium International, Inc. | Transdermal delivery device |
| KR20060135931A (ko) | 2004-04-01 | 2006-12-29 | 알자 코포레이션 | 인플루엔자 백신의 경피전달 장치 및 방법 |
| CN101120101A (zh) * | 2004-04-13 | 2008-02-06 | 阿尔扎公司 | 多联疫苗透皮释放的装置和方法 |
| CA2562731A1 (en) * | 2004-04-13 | 2005-11-03 | Alza Corporation | Apparatus and method for transdermal delivery of fentanyl-based agents |
| CN100566669C (zh) * | 2004-05-13 | 2009-12-09 | 阿尔扎公司 | 甲状旁腺激素药物的透皮释放装置 |
| US7556821B2 (en) | 2004-05-13 | 2009-07-07 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
| US7591806B2 (en) * | 2004-05-18 | 2009-09-22 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
| CA2579509A1 (en) * | 2004-09-08 | 2006-03-16 | Alza Corporation | Microprojection array with improved skin adhesion and compliance |
| US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
| WO2006055799A1 (en) * | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
| CN101060883B (zh) | 2004-11-18 | 2010-06-23 | 3M创新有限公司 | 低轮廓微针阵列施放器 |
| WO2006055844A2 (en) | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
| DE602005024038D1 (de) * | 2004-12-10 | 2010-11-18 | 3M Innovative Properties Co | Medizinische vorrichtung |
| JP2008530230A (ja) * | 2005-02-16 | 2008-08-07 | アルザ・コーポレーシヨン | エリスロポエチンに基づく剤の経皮送達のための装置および方法 |
| US8048017B2 (en) * | 2005-05-18 | 2011-11-01 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| US8043250B2 (en) * | 2005-05-18 | 2011-10-25 | Nanomed Devices, Inc. | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| WO2006138719A2 (en) | 2005-06-17 | 2006-12-28 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
| EP1904158B1 (de) | 2005-06-24 | 2013-07-24 | 3M Innovative Properties Company | Faltbares Pflaster mit Mikronadelnanordnung |
| WO2007008824A2 (en) * | 2005-07-11 | 2007-01-18 | Infotonics Technology Center, Inc. | Minimally invasive allergy testing system |
| CA2614927A1 (en) * | 2005-07-25 | 2007-02-01 | Nanotechnology Victoria Pty Ltd | Microarray device |
| DE602006020738D1 (de) | 2005-08-01 | 2011-04-28 | Hisamitsu Pharmaceutical Co | Adjuvans oder pharmazeutische zubereitung zur transdermalen oder transmukosalen verabreichung |
| AU2006291157A1 (en) * | 2005-09-12 | 2007-03-22 | Alza Corporation | Coatable transdermal delivery microprojection assembly |
| CA2629193C (en) * | 2005-11-18 | 2016-03-29 | 3M Innovative Properties Company | Coatable compositions, coatings derived therefrom and microarrays having such coatings |
| US7618429B2 (en) * | 2005-12-22 | 2009-11-17 | Spamedica International Srl | Skin rejuvination resurfacing method |
| US8632801B2 (en) * | 2005-12-28 | 2014-01-21 | Alza Corporation | Stable therapeutic formulations |
| WO2007091608A1 (ja) | 2006-02-10 | 2007-08-16 | Hisamitsu Pharmaceutical Co., Inc. | マイクロニードル付き経皮薬物投与装置 |
| AU2007225056A1 (en) * | 2006-03-15 | 2007-09-20 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia |
| US20070224252A1 (en) * | 2006-03-27 | 2007-09-27 | Trautman Joseph C | Microprojections with capillary control features and method |
| WO2007116959A1 (ja) | 2006-04-07 | 2007-10-18 | Hisamitsu Pharmaceutical Co., Inc. | マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置 |
| US9119945B2 (en) | 2006-04-20 | 2015-09-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
| US20070299388A1 (en) * | 2006-04-25 | 2007-12-27 | Alza Corporation | Microprojection array application with multilayered microprojection member for high drug loading |
| US20070293816A1 (en) * | 2006-04-25 | 2007-12-20 | Alza Corporation | Microprojection Array Application with Grouped Microprojections for High Drug Loading |
| US20100100005A1 (en) * | 2006-07-11 | 2010-04-22 | Infotonics Technology Center, Inc. | Minimally invasive allergy testing system with coated allergens |
| WO2008011625A2 (en) * | 2006-07-21 | 2008-01-24 | Georgia Tech Researh Corporation | Microneedle devices and methods of drug delivery or fluid withdrawal |
| US20090182306A1 (en) * | 2006-07-21 | 2009-07-16 | Georgia Tech Research Corporation | Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal |
| CN102727870B (zh) | 2006-09-27 | 2014-04-30 | 旭化成制药株式会社 | 鲑降钙素的应用 |
| US10525246B2 (en) | 2006-12-22 | 2020-01-07 | Nanomed Skincare, Inc. | Microdevice and method for transdermal delivery and sampling of active substances |
| US20080214987A1 (en) * | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
| US8821446B2 (en) | 2007-01-22 | 2014-09-02 | Corium International, Inc. | Applicators for microneedles |
| WO2008093772A1 (ja) | 2007-01-31 | 2008-08-07 | Hisamitsu Pharmaceutical Co., Inc. | 経皮または経粘膜投与のためのアジュバントおよびこれを含む医薬製剤 |
| EP2119469B1 (de) | 2007-02-06 | 2014-05-14 | Hisamitsu Pharmaceutical Co., Inc. | Mikronadelvorrichtung zur diagnose von allergien |
| WO2008115599A1 (en) * | 2007-03-21 | 2008-09-25 | Alza Corporation | Apparatus and method for transdermal delivery of a 5-hydroxytrytamine antagonist |
| ES2817249T3 (es) | 2007-04-16 | 2021-04-06 | Corium Inc | Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| US20090137945A1 (en) * | 2007-11-28 | 2009-05-28 | Claire Marquez | Electro Collagen Induction Therapy Device |
| CA2745339C (en) * | 2007-12-24 | 2016-06-28 | The University Of Queensland | Coating method |
| WO2009094394A1 (en) * | 2008-01-23 | 2009-07-30 | Georgia Tech Research Corporation | Microneedle devices and methods of drug delivery or fluid withdrawal |
| AU2009212106B9 (en) * | 2008-02-07 | 2014-05-22 | Vaxxas Pty Limited | Patch production |
| JP5584202B2 (ja) | 2008-05-21 | 2014-09-03 | セラジェクト, インコーポレイテッド | 固溶体穿孔器パッチの製造方法及びその使用 |
| WO2009140735A1 (en) * | 2008-05-23 | 2009-11-26 | The University Of Queensland | Analyte detection by microneedle patch with analyte selective reagents. |
| US7943187B2 (en) * | 2008-05-23 | 2011-05-17 | Bakr Rabie | Paeoniflorin preparations and uses thereof for fat reduction |
| US20110177297A1 (en) * | 2008-10-02 | 2011-07-21 | Nurim Wellness Co. Ltd. | Method of manufacturing solid microstructure and solid microstructure manufactured based on same |
| WO2010071918A1 (en) | 2008-12-22 | 2010-07-01 | The University Of Queensland | Patch production |
| KR101634836B1 (ko) | 2008-12-26 | 2016-06-29 | 히사미쓰 세이야꾸 가부시키가이샤 | 마이크로 니들 디바이스 |
| US8062568B2 (en) * | 2009-08-27 | 2011-11-22 | Korea University Research And Business Foundation | Nano pattern writer |
| EP2566501B1 (de) | 2010-05-04 | 2019-03-13 | Corium International, Inc. | Verfahren und vorrichtung zur transdermalen verabreichung von parathormon mithilfe eines mikroprojektions-arrays |
| WO2012006677A1 (en) | 2010-07-14 | 2012-01-19 | The University Of Queensland | Patch applying apparatus |
| EP2679242B1 (de) | 2011-02-25 | 2020-09-09 | Hisamitsu Pharmaceutical Co., Inc. | Hilfsstoff für transdermale oder transmukosale verabreichung und pharmazeutisches präparat damit |
| US8512679B2 (en) | 2011-03-04 | 2013-08-20 | Elwha Llc | Glassy compositions |
| AU2012323782B2 (en) * | 2011-10-12 | 2017-04-06 | Vaxxas Pty Limited | Delivery device |
| US9993423B2 (en) | 2011-10-20 | 2018-06-12 | Cosmed Pharmaceutical Co., Ltd. | Microneedle deposition method |
| KR102143482B1 (ko) | 2011-11-30 | 2020-08-11 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 펩티드 치료제 및 아미노산을 포함하는 마이크로니들 장치, 이의 제조 및 사용 방법 |
| JP2013153959A (ja) * | 2012-01-30 | 2013-08-15 | Toppan Printing Co Ltd | 針状体の構造 |
| US10980865B2 (en) | 2012-08-10 | 2021-04-20 | Aquavit Pharmaceuticals, Inc. | Direct application system and method for the delivery of bioactive compositions and formulations |
| EP2934660B1 (de) | 2012-12-21 | 2019-07-17 | Corium, Inc. | Mikroarray zur freisetzung therapeutischer wirkstoffe und verfahren zur herstellung davon |
| EP4094799A1 (de) | 2013-03-12 | 2022-11-30 | Corium, Inc. | Mikroprojektionsapplikatoren |
| JPWO2014142135A1 (ja) * | 2013-03-12 | 2017-02-16 | 武田薬品工業株式会社 | マイクロニードルパッチ |
| US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| EP2968119B1 (de) | 2013-03-15 | 2019-09-18 | Corium International, Inc. | Mikroarray zur freisetzung therapeutischer wirkstoffe, verfahren zur verwendung und verfahren zur herstellung |
| US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| WO2014201259A1 (en) * | 2013-06-12 | 2014-12-18 | The Board Of Regents For Oklahoma State University | Fluttering ear tag for bovine vaccination |
| ES2744454T3 (es) | 2013-10-31 | 2020-02-25 | Hisamitsu Pharmaceutical Co | Composición de adyuvante |
| ES3055185T3 (en) | 2014-03-28 | 2026-02-10 | Univ Duke | Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator |
| US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
| WO2016123665A1 (en) | 2015-02-02 | 2016-08-11 | Vaxxas Pty Limited | Microprojection array applicator and method |
| KR20250152679A (ko) | 2015-04-29 | 2025-10-23 | 래디어스 파마슈티컬스, 인코포레이티드 | 암을 치료하는 방법 |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| WO2017045031A1 (en) | 2015-09-18 | 2017-03-23 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
| CA2999538A1 (en) | 2015-09-28 | 2017-04-06 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
| JP7145757B2 (ja) * | 2015-10-12 | 2022-10-03 | リフロー メディカル インコーポレイテッド | 突出する薬剤送達フィーチャーを有するステント、ならびに、関連のシステムおよび方法 |
| WO2017143345A1 (en) | 2016-02-19 | 2017-08-24 | Zp Opco, Inc. | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines |
| JP2017164308A (ja) * | 2016-03-16 | 2017-09-21 | 凸版印刷株式会社 | 穿刺デバイス及びその製造方法 |
| KR20170115429A (ko) * | 2016-04-07 | 2017-10-17 | 랩앤피플주식회사 | 생체분해성 금속을 이용한 마이크로 니들 |
| JP7034425B2 (ja) * | 2016-04-15 | 2022-03-14 | エーディーエムバイオサイエンス インコーポレイテッド | 核酸フィルムの製造方法及び核酸フィルムを用いた薬物注入装置 |
| US10568937B2 (en) | 2016-04-18 | 2020-02-25 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
| JP7481115B2 (ja) | 2017-01-05 | 2024-05-10 | ラジウス ファーマシューティカルズ,インコーポレイテッド | Rad1901-2hclの多形性形態 |
| ES2960937T3 (es) | 2017-03-31 | 2024-03-07 | Vaxxas Pty Ltd | Dispositivo y método para recubrir superficies |
| US11175128B2 (en) | 2017-06-13 | 2021-11-16 | Vaxxas Pty Limited | Quality control of substrate coatings |
| EP4473998A3 (de) | 2017-08-04 | 2025-02-26 | Vaxxas Pty Limited | Kompakter hoher mechanischer energiespeicher und aktuator mit geringer auslösekraft für die abgabe von mikroprojektions-array-patches (map) |
| US11660264B2 (en) | 2017-08-23 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
| EP3672570A1 (de) | 2017-08-23 | 2020-07-01 | Zosano Pharma Corporation | Verfahren zur schnellen erreichung therapeutischer konzentrationen von zolmitriptan zur behandlung von migräne und cluster-kopfschmerzen |
| KR102146704B1 (ko) * | 2018-04-13 | 2020-08-21 | 가천대학교 산학협력단 | 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체 |
| US11660265B2 (en) | 2018-06-28 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
| MX2020013713A (es) | 2018-07-04 | 2021-03-02 | Radius Pharmaceuticals Inc | Formas polimorficas de rad1901-2hcl. |
| EP3924328A1 (de) | 2019-02-12 | 2021-12-22 | Radius Pharmaceuticals, Inc. | Verfahren und verbindungen |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE25637E (en) | 1964-09-08 | Means for vaccinating | ||
| US3136314A (en) | 1960-08-01 | 1964-06-09 | Kravitz Harvey | Vaccinating devices |
| US3556080A (en) * | 1968-04-08 | 1971-01-19 | Lincoln Lab Inc | Skin allergy testing device |
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US3760984A (en) * | 1971-09-29 | 1973-09-25 | Alza Corp | Osmotically powered agent dispensing device with filling means |
| BE795384A (fr) | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
| OA05448A (fr) | 1975-10-16 | 1981-03-31 | Manufrance Manufacture Francai | Dispositif vaccinateur multipénétrant. |
| FR2474856A1 (fr) | 1980-01-31 | 1981-08-07 | Merieux Inst | Dispositif scarificateur |
| US4473083A (en) * | 1981-12-14 | 1984-09-25 | Maganias Nicholas H | Device and method for allergy testing |
| JPS60193925A (ja) | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
| DE3722775A1 (de) | 1987-07-09 | 1989-01-19 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system |
| CA2016900A1 (en) | 1989-07-06 | 1991-01-06 | Ronald J. Filipski | Tines structure in clinical applicator |
| EP0429842B1 (de) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten |
| US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| US5437656A (en) | 1991-02-27 | 1995-08-01 | Leonard Bloom | Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment |
| DE4222380A1 (de) | 1992-07-08 | 1994-01-13 | Ernst Peter Prof Dr M Strecker | In den Körper eines Patienten perkutan implantierbare Endoprothese |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| DE4341444C2 (de) | 1993-12-04 | 1996-03-14 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster und Verfahren zu seiner Herstellung |
| US5457041A (en) * | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
| ATE252373T1 (de) * | 1994-08-04 | 2003-11-15 | Elan Drug Delivery Ltd | Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung |
| US6586006B2 (en) * | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| JPH10510175A (ja) | 1994-12-09 | 1998-10-06 | ノバルティス アクチェンゲゼルシャフト | 経皮システム |
| JP3601102B2 (ja) | 1995-03-15 | 2004-12-15 | ブラザー工業株式会社 | インクジェット式印刷記録装置と印字システム |
| DE19514104C2 (de) | 1995-04-13 | 1997-05-28 | Behringwerke Ag | Beschichtung für in den Blutstrom oder in das Gewebe des menschlichen Körpers einbringbares Biomaterial |
| WO1996037155A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
| AU5869796A (en) | 1995-05-22 | 1996-12-11 | Ned A. Godshall | Micromechanical patch for enhancing the delivery of compound s through the skin |
| IL122802A0 (en) * | 1995-07-03 | 1998-08-16 | Koken Kk | Gene preparations |
| DE19525607A1 (de) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
| CA2253549C (en) * | 1996-06-18 | 2005-10-25 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
| ATE241405T1 (de) | 1996-07-03 | 2003-06-15 | Altea Therapeutics Corp | Mehrfache mechanische mikroperforierung von haut oder schleimhäuten |
| US5738728A (en) | 1996-07-26 | 1998-04-14 | Bio Dot, Inc. | Precision metered aerosol dispensing apparatus |
| US5741554A (en) | 1996-07-26 | 1998-04-21 | Bio Dot, Inc. | Method of dispensing a liquid reagent |
| US5743960A (en) | 1996-07-26 | 1998-04-28 | Bio-Dot, Inc. | Precision metered solenoid valve dispenser |
| US5916524A (en) | 1997-07-23 | 1999-06-29 | Bio-Dot, Inc. | Dispensing apparatus having improved dynamic range |
| US5983136A (en) | 1996-09-17 | 1999-11-09 | Deka Products Limited Partnership | System for delivery of drugs by transport |
| US6197013B1 (en) * | 1996-11-06 | 2001-03-06 | Setagon, Inc. | Method and apparatus for drug and gene delivery |
| EP0957972B1 (de) | 1996-12-20 | 2003-03-19 | Alza Corporation | Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses |
| DE19654391A1 (de) | 1996-12-27 | 1998-07-02 | Basf Ag | Katalysator zur selektiven Herstellung von Propylen aus Propan |
| BR9714113A (pt) | 1996-12-31 | 2000-03-21 | Shell Int Research | Plataforma de tirante |
| US20020009464A1 (en) * | 1997-07-03 | 2002-01-24 | Camilo Colaco | Modified glycosides, compositions comprised thereof and methods of use thereof |
| US6918901B1 (en) | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
| CA2313698C (en) * | 1997-12-11 | 2008-04-15 | Alza Corporation | Device for enhancing transdermal agent flux |
| DE69806963T2 (de) * | 1997-12-11 | 2002-11-21 | Alza Corp., Mountain View | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses |
| ES2314995T3 (es) | 1997-12-11 | 2009-03-16 | Alza Corporation | Dispositivo para mejorar el flujo de agentes tansdermicos. |
| US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
| US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| EP1086214B1 (de) | 1998-06-10 | 2009-11-25 | Georgia Tech Research Corporation | Mikronadel-einrichtungen und verfahren zur deren herstellung |
| US6532386B2 (en) * | 1998-08-31 | 2003-03-11 | Johnson & Johnson Consumer Companies, Inc. | Electrotransort device comprising blades |
| JP2002532165A (ja) | 1998-12-18 | 2002-10-02 | メドトロニック ミニメド インコーポレイテッド | 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法 |
| EP1163024B1 (de) * | 1999-01-28 | 2003-12-17 | Cyto Pulse Sciences, Inc. | Einbringen von makromolekülen in zellen |
| US6884427B1 (en) | 1999-02-08 | 2005-04-26 | Aderans Research Institute, Inc. | Filamentary means for introducing agents into tissue of a living host |
| JP2002542183A (ja) | 1999-04-16 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | 成形可能な乾燥した医薬製剤 |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| DK1189660T3 (da) * | 1999-06-08 | 2006-08-21 | Altea Therapeutics Corp | Apparat til mikroperforering af biologiske membraner ved hjælp af tyndfilms-vævsgrænseflade-anordninger samt fremgangsmåde til fremstilling deraf |
| US6312612B1 (en) * | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| US6623457B1 (en) | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| US6835184B1 (en) | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
| US20020095134A1 (en) | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
| SE0000363L (sv) | 2000-02-04 | 2001-08-05 | Zoucas Kirurgkonsult Ab | Belagd medicinsk anordning |
| US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
| US6537242B1 (en) | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
| US6589202B1 (en) | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
| US20050008683A1 (en) | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
| US6440096B1 (en) | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
| GB0017999D0 (en) | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| PL360978A1 (en) | 2000-10-13 | 2004-09-20 | Alza Corporation | Microblade array impact applicator |
| DE60138411D1 (de) | 2000-10-13 | 2009-05-28 | Alza Corp | Vorrichtung und verfahren zum durchstechen der haut mit micronadeln |
| ATE416692T1 (de) | 2000-10-13 | 2008-12-15 | Alza Corp | Mikronadelelementhalter für schlagapplikator |
| NZ525551A (en) | 2000-10-26 | 2005-09-30 | Alza Corp | Transdermal drug delivery devices having coated microprotrusions |
| GB0026957D0 (en) * | 2000-11-03 | 2000-12-20 | Eastman Kodak Co | Processing photographic materal |
| US6638246B1 (en) * | 2000-11-28 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device for delivery of a biologically active material to a lumen |
| EP1345646A2 (de) | 2000-12-14 | 2003-09-24 | Georgia Tech Research Corporation | Mikronadel-vorrichtungen und deren herstellung |
| WO2002074173A1 (en) | 2001-03-16 | 2002-09-26 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
| US20020193729A1 (en) | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
| EP1469903A2 (de) | 2001-09-28 | 2004-10-27 | BioValve Technologies, Inc. | Mikronadel mit membran |
| US6689100B2 (en) | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
-
2002
- 2002-04-20 AT AT02731464T patent/ATE444773T1/de not_active IP Right Cessation
- 2002-04-20 NZ NZ529029A patent/NZ529029A/en unknown
- 2002-04-20 CA CA002444883A patent/CA2444883A1/en not_active Abandoned
- 2002-04-20 JP JP2002583020A patent/JP2004528900A/ja not_active Ceased
- 2002-04-20 ES ES02731464T patent/ES2333849T3/es not_active Expired - Lifetime
- 2002-04-20 MX MXPA03009603A patent/MXPA03009603A/es unknown
- 2002-04-20 CN CNB028122518A patent/CN100349632C/zh not_active Expired - Fee Related
- 2002-04-20 WO PCT/US2002/012730 patent/WO2002085447A2/en not_active Ceased
- 2002-04-20 CN CNA2007101489918A patent/CN101129327A/zh active Pending
- 2002-04-20 US US10/127,108 patent/US7963935B2/en active Active
- 2002-04-20 EP EP02731464A patent/EP1392389B1/de not_active Expired - Lifetime
- 2002-04-20 KR KR10-2003-7013728A patent/KR20040020889A/ko not_active Ceased
- 2002-04-20 IL IL15848002A patent/IL158480A0/xx unknown
- 2002-04-20 DE DE60233939T patent/DE60233939D1/de not_active Expired - Lifetime
- 2002-04-20 BR BR0209046-5A patent/BR0209046A/pt not_active IP Right Cessation
-
2003
- 2003-10-20 NO NO20034684A patent/NO20034684L/no not_active Application Discontinuation
- 2003-11-19 ZA ZA200309006A patent/ZA200309006B/en unknown
-
2011
- 2011-05-06 JP JP2011103757A patent/JP5611888B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO20034684L (no) | 2003-12-11 |
| KR20040020889A (ko) | 2004-03-09 |
| MXPA03009603A (es) | 2004-12-06 |
| WO2002085447A3 (en) | 2003-03-06 |
| CN1541126A (zh) | 2004-10-27 |
| CN100349632C (zh) | 2007-11-21 |
| US7963935B2 (en) | 2011-06-21 |
| WO2002085447A8 (en) | 2004-05-13 |
| CA2444883A1 (en) | 2002-10-31 |
| EP1392389B1 (de) | 2009-10-07 |
| CN101129327A (zh) | 2008-02-27 |
| WO2002085447A2 (en) | 2002-10-31 |
| JP2004528900A (ja) | 2004-09-24 |
| DE60233939D1 (de) | 2009-11-19 |
| EP1392389A2 (de) | 2004-03-03 |
| ZA200309006B (en) | 2005-02-21 |
| BR0209046A (pt) | 2004-11-09 |
| NO20034684D0 (no) | 2003-10-20 |
| NZ529029A (en) | 2005-07-29 |
| US20020177839A1 (en) | 2002-11-28 |
| JP2011172968A (ja) | 2011-09-08 |
| ES2333849T3 (es) | 2010-03-02 |
| IL158480A0 (en) | 2004-05-12 |
| JP5611888B2 (ja) | 2014-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE444773T1 (de) | Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält | |
| ATE358505T1 (de) | Beschichtete endovaskuläre vorrichtung | |
| BRPI0411924A8 (pt) | Métodos e dispositivos para oclusão de lúmens de corpo e/ou para fornecimento de agentes terapêuticos | |
| FR2810539B1 (fr) | Procede et dispositif de traitement,notamment de maquillage, de coloration ou de soin cosmetique,de parties ou de la totalite du corps humain ou animal | |
| DE602005026078D1 (de) | Verwendung von Antioxidantien zur Verhinderung von Oxidation und zur Reduzierung von Wirkstoffzersetzung in wirkstoffhaltigen medizinischen Artikeln | |
| DE60124285D1 (de) | Beschichtete medizinische geräte | |
| DE602004026701D1 (de) | Implantierbares medizinprodukt zur selektiven modulation der abgabe von mitteln in situ | |
| TW200502017A (en) | Active agent delivery device having composite members | |
| MXPA03006825A (es) | Dispositivos vasculares revestidos. | |
| DE60213976D1 (de) | Vorrichtung zur manipulation von nadeln oder polierarray | |
| MXPA03003869A (es) | Dispositivos medicos revestidos. | |
| DE60124286D1 (de) | Beschichtete medizinische geräte | |
| TR200001891T2 (tr) | ASPB28- İnsan ensülini ve kullanımı. | |
| AR046697A1 (es) | Metodo y sistema de administracion transdermica de agente asistido por frecuencia | |
| ATE308968T1 (de) | Mittel zur pflege und/oder behandlung von haut und gewebe | |
| DE69332856D1 (de) | Haarnadelförmiges ribozym | |
| BRPI0416822A (pt) | método e sistema de liberação de vacina transdérmica com ultra-som | |
| AR047229A1 (es) | Administracion de conjugados polimericos de peptidos y proteinas terapeuticos por medio de microproyecciones revestidas | |
| BRPI0509493A (pt) | aparelho e método para a liberação transdérmica de vacina da influenza | |
| ATE264672T1 (de) | Vorrichtung und verwendung zur steigerung der transdermalen permeation von arzneistoffen | |
| WO2003062273A3 (en) | Modulator of the notch signalling pathway and use thereof in medical treatment | |
| DK0559145T3 (da) | Lægemiddel til truende abort | |
| EP1752189A3 (de) | Mikroprojektionsanordnung mit einem Überzug, der ein vorteilhaftes Mittel enthält | |
| ES2042818T3 (es) | Agente terapeutico para la trombocitopenia. | |
| CY1106702T1 (el) | Χρηση ενος συνδυασμου μιας πουρινης και ενος παραγοντα δοτη μονοξειδιου του αζωτου για την προληψη ή την αγωγη γενετησιων δυσλειτουργιων |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |