ATE277034T1 - Liponsaürederivate und deren verwendung bei der behandlung von krankheiten - Google Patents
Liponsaürederivate und deren verwendung bei der behandlung von krankheitenInfo
- Publication number
- ATE277034T1 ATE277034T1 AT99956698T AT99956698T ATE277034T1 AT E277034 T1 ATE277034 T1 AT E277034T1 AT 99956698 T AT99956698 T AT 99956698T AT 99956698 T AT99956698 T AT 99956698T AT E277034 T1 ATE277034 T1 AT E277034T1
- Authority
- AT
- Austria
- Prior art keywords
- diseases
- treatment
- acid derivatives
- liponic acid
- diseased cells
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical class OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10562898P | 1998-10-26 | 1998-10-26 | |
| PCT/US1999/025140 WO2000024734A1 (en) | 1998-10-26 | 1999-10-26 | Lipoic acid derivatives and their use in treatment of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277034T1 true ATE277034T1 (de) | 2004-10-15 |
Family
ID=22306916
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04077618T ATE451362T1 (de) | 1998-10-26 | 1999-10-26 | Salze von liponsaürederivaten und deren verwendung bei der behandlung von krankheiten |
| AT99956698T ATE277034T1 (de) | 1998-10-26 | 1999-10-26 | Liponsaürederivate und deren verwendung bei der behandlung von krankheiten |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04077618T ATE451362T1 (de) | 1998-10-26 | 1999-10-26 | Salze von liponsaürederivaten und deren verwendung bei der behandlung von krankheiten |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6331559B1 (de) |
| EP (3) | EP1124820B1 (de) |
| JP (2) | JP4728481B2 (de) |
| AT (2) | ATE451362T1 (de) |
| AU (1) | AU774362B2 (de) |
| BR (1) | BR9914789A (de) |
| CA (1) | CA2348998C (de) |
| DE (2) | DE69920497T2 (de) |
| ES (2) | ES2340488T3 (de) |
| IL (2) | IL142824A0 (de) |
| MX (1) | MXPA01004152A (de) |
| WO (1) | WO2000024734A1 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381413B1 (en) * | 1998-04-17 | 2008-06-03 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
| ATE276241T1 (de) * | 1998-11-25 | 2004-10-15 | Yissum Res Dev Co | Antioxidationsmittel |
| AR042572A1 (es) * | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
| IT1312060B1 (it) * | 1999-04-09 | 2002-04-04 | Antibioticos Spa | Uso dell'acido alfa lipoico nel trattamento antimetastatico. |
| ES2162586B1 (es) * | 1999-11-25 | 2002-07-01 | Moraleda Manuel Gomez | Composicion que comprende aceites ozonizados y/o otros productos naturales y/o sinteticos ozonizados, y su empleo en composiciones farmaceuticas, cosmeticas, dieteticas o de suplementos alimentarios, en los campos humano y veterinario |
| US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
| EP1172110A3 (de) * | 2000-07-07 | 2003-09-17 | Basf Aktiengesellschaft | Verwendung von Liponsäure zur Verbesserung der Bioverfügbarkeit von Mineralsalzen |
| IT1319196B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Sintesi dell'acido r(+)alfa-lipoico. |
| AU2002229576A1 (en) | 2000-11-30 | 2002-06-11 | Basf Aktiengesellschaft | Method for producing lipoic acid and dihydrolipoic acid |
| JP4072062B2 (ja) * | 2001-03-19 | 2008-04-02 | 千寿製薬株式会社 | 新規α−リポ酸誘導体およびその用途 |
| US6936641B2 (en) * | 2002-06-25 | 2005-08-30 | Johnson & Johnson Vision Care, Inc. | Macromer forming catalysts |
| AU2003251955A1 (en) * | 2002-07-16 | 2004-02-02 | Sonus Pharmaceuticals, Inc. | Platinum compound |
| EP1547590A4 (de) * | 2002-09-13 | 2008-07-30 | Oga Res Inc | Melanin-löscher |
| CN1964630A (zh) | 2003-02-13 | 2007-05-16 | 耶希瓦大学艾伯塔·爱恩斯坦医学院 | 通过控制下丘脑的长链脂肪酰基－辅酶A(LC－CoA)的水平来调控食物摄取和葡萄糖产生 |
| US20040248982A1 (en) * | 2003-06-09 | 2004-12-09 | Dyer Gordon Wayne | Use of compounds for the inhibition of proteins and UV protection |
| AU2004248187A1 (en) * | 2003-06-12 | 2004-12-23 | University Of Colorado System Technology | Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors |
| MY157827A (en) * | 2003-06-27 | 2016-07-29 | 3M Innovative Properties Co | Sulfonamide substituted imidazoquinolines |
| US7510710B2 (en) | 2004-01-08 | 2009-03-31 | The Regents Of The University Of Colorado | Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor |
| CA2560059A1 (en) * | 2004-03-15 | 2005-09-29 | Sonus Pharmaceuticals, Inc. | Platinum carboxylate anticancer compounds |
| US7582418B2 (en) * | 2004-11-03 | 2009-09-01 | Albion Laboratories, Inc. | Antimicrobial chelates |
| WO2006116217A2 (en) * | 2005-04-28 | 2006-11-02 | The Regents Of The University Of Colorado | Therapeutic bifunctional compounds |
| JP2008543734A (ja) * | 2005-05-02 | 2008-12-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド | 脂肪酸代謝および解糖の阻害を提供する化合物の組み合わせ、または二官能性化合物を用いるヒトの炎症性および増殖性疾患を処置するためのシステムおよび方法 |
| US20070225354A1 (en) * | 2006-03-21 | 2007-09-27 | Eric Marchewitz | Use of dihydrolipoamide for enhancing physical performance |
| US8263653B2 (en) | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
| JP5412423B2 (ja) * | 2007-04-18 | 2014-02-12 | コーナーストーン ファーマシューティカルズ，インコーポレーテッド | リポ酸誘導体 |
| US20080262077A1 (en) | 2007-04-18 | 2008-10-23 | Shorr Robert G L | Pharmaceutical formulations containing lipoic acid derivatives |
| CA2716321A1 (en) * | 2008-02-21 | 2009-08-27 | The Regents Of The University Of Colorado | Methods for treating cancer using combination therapy |
| WO2009110859A1 (en) * | 2008-03-04 | 2009-09-11 | Robert Shorr | Modulation of enzymatic structure, activity, and/or expression level |
| KR101715631B1 (ko) | 2008-04-01 | 2017-03-13 | 안티포딘 파마슈티칼스, 인코포레이티드 | 피부 관리를 위한 조성물 및 방법 |
| MX2010010867A (es) * | 2008-04-04 | 2011-05-25 | Robert Shorr | Composicion farmaceutica. |
| WO2010008554A2 (en) | 2008-07-14 | 2010-01-21 | The Regents Of The University Of Colorado | Methods and products for treating proliferative diseases |
| WO2010019225A1 (en) * | 2008-08-15 | 2010-02-18 | Robert Shorr | Pharmaceutical composition |
| CA2744100C (en) | 2008-10-21 | 2020-06-30 | The General Hospital Corporation | Cell transplantation |
| FR2937867B1 (fr) * | 2008-11-03 | 2011-03-04 | Biorebus | Association pharmaceutique contenant l acide lipoique et l acide hydroxycitrique a titre de principes actifs. |
| WO2010062381A1 (en) * | 2008-11-28 | 2010-06-03 | Robert Shorr | Organelle-specific drug delivery |
| JP2012510511A (ja) * | 2008-12-01 | 2012-05-10 | インヴアスク セラピューテイックス インコーポレイテッド | レニン−アンジオテンシン−アルドステロン系阻害剤及びリポ酸化合物を含有する組成物、並びに、レニン−アンジオテンシン−アルドステロン系に関連した疾患の治療のためのそれらの使用 |
| CN101787013B (zh) * | 2009-01-22 | 2013-04-24 | 杭州民生药业有限公司 | 硫辛酰胺系列衍生物、制备方法及所述衍生物的制药用途 |
| WO2010110887A1 (en) * | 2009-03-24 | 2010-09-30 | Robert Shorr | Fatty acids |
| WO2010110771A2 (en) * | 2009-03-25 | 2010-09-30 | Frank Gibson | Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof |
| WO2011046583A1 (en) * | 2009-09-11 | 2011-04-21 | Robert Shorr | Pharmaceutical exploitation of oxidative stress in transformed cells |
| FR2959668B1 (fr) * | 2010-05-05 | 2012-07-13 | Biorebus | Association pharmaceutique contenant l'acide lipoique, l'acide hydroxycitrique et une somatostatine a titre de principes actifs |
| WO2011138565A1 (fr) | 2010-05-05 | 2011-11-10 | Biorebus | Association pharmaceutique contenant l'acide lipoïque, l'acide hydroxycitrique et une somatostatine a titre de principes actifs |
| WO2011143590A1 (en) | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Combination therapy compositions and methods using lipoic acid derivatives and an anti-proliferation agent |
| WO2011143593A1 (en) | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Conjugates of a lipoic acid derivative and anti-proliferation agent and medical uses thereof |
| WO2011146635A1 (en) * | 2010-05-21 | 2011-11-24 | North Texas Medical Associates | Malignant neoplasm treatment protocol |
| CN108504539B (zh) | 2010-08-06 | 2021-11-02 | 通用医院公司以麻省总医院名义经营 | 用于细胞处理相关应用的系统和设备 |
| AU2013364387B2 (en) * | 2012-12-19 | 2018-07-19 | Paul Bingham | Pharmaceutical compounds |
| US9605012B2 (en) * | 2013-01-17 | 2017-03-28 | Garnett Mckeen Laboratory, Inc. | Palladium-ruthenium-zinc-organo complexes and methods for their use in the treatment of inflammatory diseases |
| AU2014398233B2 (en) | 2014-06-19 | 2019-11-28 | Rafael Pharmaceuticals, Inc. | Pharmaceutical compounds |
| ES2819175T3 (es) | 2014-06-19 | 2021-04-15 | Rafael Pharmaceuticals Inc | Compuestos farmacéuticos |
| US10052305B2 (en) | 2015-10-07 | 2018-08-21 | Buck Institute For Research On Aging | Lipoic acid and derivatives thereof for the treatment of cystinuria |
| CN117263907B (zh) * | 2023-09-23 | 2026-01-27 | 江西科技师范大学 | 一种丙酮酸脱氢酶e2抑制剂及其制备方法和应用 |
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| DE362916C (de) | 1921-08-13 | 1922-11-02 | Eduard Duerr | Abnehmbares Mikrometer fuer Schublehren |
| GB758897A (en) * | 1953-10-19 | 1956-10-10 | Merck & Co Inc | Thio-substituted aliphatic carboxylic acids and their preparation |
| US2853497A (en) * | 1953-12-04 | 1958-09-23 | Merck & Co Inc | 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof |
| US2975198A (en) * | 1954-07-08 | 1961-03-14 | Research Corp | Lipoic acid intermediates |
| US2872458A (en) * | 1954-12-30 | 1959-02-03 | Merck & Co Inc | Addition product of a metal hydrocarbon mercaptide with an alpha-halogamma-butyrolactone |
| JPS57123107A (en) * | 1981-01-26 | 1982-07-31 | Pola Chem Ind Inc | Cosmetic |
| DE3512911A1 (de) * | 1985-04-11 | 1986-10-16 | Degussa Ag, 6000 Frankfurt | Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure) |
| DE3626116A1 (de) | 1986-08-01 | 1988-02-11 | Karl Thiel | Thermostatische regeleinrichtung fuer heizungen bzw. heizaggregate |
| DE3629116A1 (de) * | 1986-08-27 | 1988-03-10 | Asta Pharma Ag | Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer |
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| ES2112874T3 (es) * | 1991-07-05 | 1998-04-16 | Asta Medica Ag | Utilizacion de acidos carboxilicos con contenido en azufre para combatir trastornos de excitacion de origen patofisiologico. |
| DE4137773A1 (de) * | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
| WO1994006794A1 (en) | 1992-09-24 | 1994-03-31 | National Institutes Of Health | Aralkyl diazabicycloalkane derivatives for cns disorders |
| DE4310142A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung |
| US5463093A (en) * | 1993-11-26 | 1995-10-31 | Garnett; Merrill | Palladium complexes and methods for using same in the treatment of tumors or Psoriasis |
| DE4433764A1 (de) * | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit |
| DE4439477C2 (de) * | 1994-11-08 | 1999-10-21 | Asta Medica Ag | Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie |
| DE19601787C1 (de) * | 1996-01-19 | 1997-07-24 | Asta Medica Ag | Herstellung und Verwendung von Salzen der 6,8-Bis(amidiniumthio)-octansäure |
| AU737038B2 (en) * | 1996-07-05 | 2001-08-09 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof |
| EP0855396A1 (de) * | 1997-01-22 | 1998-07-29 | ASTA Medica Aktiengesellschaft | Metabolite von Thioctsäure und deren Verwendung |
| JP4777489B2 (ja) * | 1997-03-31 | 2011-09-21 | ザ チルドレンズ メディカル センター コーポレーション | アポトーシス性酵素を不活性化するためのニトロシル化 |
| CZ96798A3 (cs) * | 1997-04-02 | 1998-10-14 | Sankyo Company Limited | Deriváty dithiolanu, jejich příprava a jejich terapeutické účinky |
| JPH11124379A (ja) * | 1997-10-17 | 1999-05-11 | Ss Pharmaceut Co Ltd | ジチオリリデンアセトアミド誘導体 |
| FR2777001B1 (fr) * | 1998-04-01 | 2000-06-09 | Cird Galderma | Derives de l'acide 6,8-dimercaptooctanoique substitues en 6-s et/ou en 8-s par le radical (3-methylthiopropanoyl) et compositions pharmaceutiques destinees au traitement des tumeurs cancereuses |
| US6204288B1 (en) * | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
| US6288106B1 (en) * | 1999-05-25 | 2001-09-11 | Chronorx, Llc | Processes for the synthesis and use of various α-lipoic acid complexes |
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-
1999
- 1999-10-26 DE DE69920497T patent/DE69920497T2/de not_active Expired - Lifetime
- 1999-10-26 IL IL14282499A patent/IL142824A0/xx unknown
- 1999-10-26 BR BR9914789-0A patent/BR9914789A/pt not_active Application Discontinuation
- 1999-10-26 ES ES04077618T patent/ES2340488T3/es not_active Expired - Lifetime
- 1999-10-26 EP EP99956698A patent/EP1124820B1/de not_active Expired - Lifetime
- 1999-10-26 AT AT04077618T patent/ATE451362T1/de not_active IP Right Cessation
- 1999-10-26 EP EP09012728A patent/EP2145883A1/de not_active Withdrawn
- 1999-10-26 MX MXPA01004152A patent/MXPA01004152A/es active IP Right Grant
- 1999-10-26 EP EP04077618A patent/EP1486495B1/de not_active Expired - Lifetime
- 1999-10-26 DE DE69941800T patent/DE69941800D1/de not_active Expired - Lifetime
- 1999-10-26 AT AT99956698T patent/ATE277034T1/de not_active IP Right Cessation
- 1999-10-26 AU AU13246/00A patent/AU774362B2/en not_active Expired
- 1999-10-26 JP JP2000578304A patent/JP4728481B2/ja not_active Expired - Lifetime
- 1999-10-26 WO PCT/US1999/025140 patent/WO2000024734A1/en not_active Ceased
- 1999-10-26 US US09/427,477 patent/US6331559B1/en not_active Expired - Lifetime
- 1999-10-26 ES ES99956698T patent/ES2229790T3/es not_active Expired - Lifetime
- 1999-10-26 CA CA2348998A patent/CA2348998C/en not_active Expired - Lifetime
-
2001
- 2001-04-26 IL IL142824A patent/IL142824A/en not_active IP Right Cessation
- 2001-09-24 US US09/962,372 patent/US6951887B2/en not_active Expired - Lifetime
-
2010
- 2010-06-02 JP JP2010126848A patent/JP5727721B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000024734A1 (en) | 2000-05-04 |
| ES2340488T3 (es) | 2010-06-04 |
| AU774362B2 (en) | 2004-06-24 |
| MXPA01004152A (es) | 2002-06-04 |
| JP2002528446A (ja) | 2002-09-03 |
| ATE451362T1 (de) | 2009-12-15 |
| JP5727721B2 (ja) | 2015-06-03 |
| JP4728481B2 (ja) | 2011-07-20 |
| IL142824A0 (en) | 2002-03-10 |
| EP2145883A1 (de) | 2010-01-20 |
| DE69920497T2 (de) | 2006-02-09 |
| AU1324600A (en) | 2000-05-15 |
| DE69920497D1 (de) | 2004-10-28 |
| US20020107234A1 (en) | 2002-08-08 |
| EP1124820B1 (de) | 2004-09-22 |
| EP1486495B1 (de) | 2009-12-09 |
| US6331559B1 (en) | 2001-12-18 |
| CA2348998A1 (en) | 2000-05-04 |
| DE69941800D1 (de) | 2010-01-21 |
| EP1486495A1 (de) | 2004-12-15 |
| CA2348998C (en) | 2012-03-06 |
| BR9914789A (pt) | 2001-10-02 |
| IL142824A (en) | 2010-11-30 |
| JP2010248203A (ja) | 2010-11-04 |
| EP1124820A1 (de) | 2001-08-22 |
| ES2229790T3 (es) | 2005-04-16 |
| US6951887B2 (en) | 2005-10-04 |
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