ATE451362T1 - Salze von liponsaürederivaten und deren verwendung bei der behandlung von krankheiten - Google Patents
Salze von liponsaürederivaten und deren verwendung bei der behandlung von krankheitenInfo
- Publication number
- ATE451362T1 ATE451362T1 AT04077618T AT04077618T ATE451362T1 AT E451362 T1 ATE451362 T1 AT E451362T1 AT 04077618 T AT04077618 T AT 04077618T AT 04077618 T AT04077618 T AT 04077618T AT E451362 T1 ATE451362 T1 AT E451362T1
- Authority
- AT
- Austria
- Prior art keywords
- diseases
- salts
- treatment
- acid derivatives
- liponic acid
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical class OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10562898P | 1998-10-26 | 1998-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE451362T1 true ATE451362T1 (de) | 2009-12-15 |
Family
ID=22306916
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04077618T ATE451362T1 (de) | 1998-10-26 | 1999-10-26 | Salze von liponsaürederivaten und deren verwendung bei der behandlung von krankheiten |
| AT99956698T ATE277034T1 (de) | 1998-10-26 | 1999-10-26 | Liponsaürederivate und deren verwendung bei der behandlung von krankheiten |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99956698T ATE277034T1 (de) | 1998-10-26 | 1999-10-26 | Liponsaürederivate und deren verwendung bei der behandlung von krankheiten |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6331559B1 (de) |
| EP (3) | EP2145883A1 (de) |
| JP (2) | JP4728481B2 (de) |
| AT (2) | ATE451362T1 (de) |
| AU (1) | AU774362B2 (de) |
| BR (1) | BR9914789A (de) |
| CA (1) | CA2348998C (de) |
| DE (2) | DE69941800D1 (de) |
| ES (2) | ES2229790T3 (de) |
| IL (2) | IL142824A0 (de) |
| MX (1) | MXPA01004152A (de) |
| WO (1) | WO2000024734A1 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381413B1 (en) * | 1998-04-17 | 2008-06-03 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
| CA2352144A1 (en) * | 1998-11-25 | 2000-06-02 | Yissum Research Development Company Of The Hebrew University In Jerusale M | Scavenger compounds |
| AR042572A1 (es) * | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
| IT1312060B1 (it) * | 1999-04-09 | 2002-04-04 | Antibioticos Spa | Uso dell'acido alfa lipoico nel trattamento antimetastatico. |
| ES2162586B1 (es) * | 1999-11-25 | 2002-07-01 | Moraleda Manuel Gomez | Composicion que comprende aceites ozonizados y/o otros productos naturales y/o sinteticos ozonizados, y su empleo en composiciones farmaceuticas, cosmeticas, dieteticas o de suplementos alimentarios, en los campos humano y veterinario |
| US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
| EP1172110A3 (de) * | 2000-07-07 | 2003-09-17 | Basf Aktiengesellschaft | Verwendung von Liponsäure zur Verbesserung der Bioverfügbarkeit von Mineralsalzen |
| IT1319196B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Sintesi dell'acido r(+)alfa-lipoico. |
| ATE328877T1 (de) | 2000-11-30 | 2006-06-15 | Basf Ag | Verfahren zur herstellung von liponsäure und dihydroliponsaüre |
| DE60234164D1 (de) * | 2001-03-19 | 2009-12-10 | Senju Pharma Co | Neues a-liponsäurederivat und dessen verwendung |
| US6936641B2 (en) * | 2002-06-25 | 2005-08-30 | Johnson & Johnson Vision Care, Inc. | Macromer forming catalysts |
| TWI272273B (en) * | 2002-07-16 | 2007-02-01 | Sonus Pharma Inc | Platinum compounds |
| CN100367949C (zh) | 2002-09-13 | 2008-02-13 | 有限会社绪方研究 | 黑色素消除制剂 |
| AU2004212004B2 (en) | 2003-02-13 | 2008-01-10 | Albert Einstein College Of Medicine Of Yeshiva University | Regulation of food intake and glucose production by modulation of long-chain fatty acyl-coa levels in the hypothalamus |
| US20040248982A1 (en) * | 2003-06-09 | 2004-12-09 | Dyer Gordon Wayne | Use of compounds for the inhibition of proteins and UV protection |
| AU2004248187A1 (en) * | 2003-06-12 | 2004-12-23 | University Of Colorado System Technology | Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors |
| MY157827A (en) * | 2003-06-27 | 2016-07-29 | 3M Innovative Properties Co | Sulfonamide substituted imidazoquinolines |
| WO2005070126A2 (en) | 2004-01-08 | 2005-08-04 | The Regents Of The University Of Colorado | Methods and compositions for treating human diseases and wounds with ucp and fas inhibitors |
| US7129368B2 (en) * | 2004-03-15 | 2006-10-31 | Sonus Pharmaceuticals, Inc. | Platinum carboxylate anticancer compounds |
| US7582418B2 (en) * | 2004-11-03 | 2009-09-01 | Albion Laboratories, Inc. | Antimicrobial chelates |
| EP1877060A2 (de) * | 2005-04-28 | 2008-01-16 | The Regents of the University of Colorado | Systeme und verfahren zur behandlung menschlicher entzündungskrankheiten und proliferativer erkrankungen mit einer für die hemmung des fettsäurestoffwechsels und der glykolyse sorgenden verbindung |
| WO2006118821A2 (en) * | 2005-05-02 | 2006-11-09 | The Regents Of The University Of Colorado | Systems and methods for treating human inflammatory and proliferative diseases, with a combination of compounds, or a bifunctional compound,that provides fatty acid metabolism and glycolysis inhibition |
| US20070225354A1 (en) * | 2006-03-21 | 2007-09-27 | Eric Marchewitz | Use of dihydrolipoamide for enhancing physical performance |
| US8263653B2 (en) | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
| ES2442901T3 (es) * | 2007-04-18 | 2014-02-14 | Cornerstone Pharmaceuticals, Inc. | Derivados de ácido lipoico |
| MX2009011165A (es) * | 2007-04-18 | 2009-12-09 | Cornerstone Pharmaceuticals In | Formulaciones farmaceuticas que contienen derivados del acido lipoico. |
| CA2716321A1 (en) * | 2008-02-21 | 2009-08-27 | The Regents Of The University Of Colorado | Methods for treating cancer using combination therapy |
| CN102089276A (zh) * | 2008-03-04 | 2011-06-08 | 罗伯特·绍尔 | 酶结构、活性和/或表达水平的调节 |
| AU2009251711B2 (en) | 2008-04-01 | 2014-07-17 | Antipodean Pharmaceuticals, Inc. | Compositions and methods for skin care |
| KR20110025168A (ko) * | 2008-04-04 | 2011-03-09 | 로버트 쇼어 | 약학적 조성물 |
| US9073985B2 (en) | 2008-07-14 | 2015-07-07 | The Regents Of The University Of Colorado, A Body Corporate | Methods and products for treating proliferative diseases |
| WO2010019225A1 (en) * | 2008-08-15 | 2010-02-18 | Robert Shorr | Pharmaceutical composition |
| AU2009308152B2 (en) * | 2008-10-21 | 2015-05-21 | The General Hospital Corporation | Cell transplantation |
| FR2937867B1 (fr) | 2008-11-03 | 2011-03-04 | Biorebus | Association pharmaceutique contenant l acide lipoique et l acide hydroxycitrique a titre de principes actifs. |
| WO2010062381A1 (en) * | 2008-11-28 | 2010-06-03 | Robert Shorr | Organelle-specific drug delivery |
| BRPI0916476A2 (pt) * | 2008-12-01 | 2016-02-16 | Invasc Therapeutics Inc | composição, método de tratamento para um distúrbio relacionado ao sistema renina-angiotensina-aldosterona, método para reduzir a resistência à insulina, método para tratar um distúrbio relacionado à síndrome metabólica |
| CN101787013B (zh) * | 2009-01-22 | 2013-04-24 | 杭州民生药业有限公司 | 硫辛酰胺系列衍生物、制备方法及所述衍生物的制药用途 |
| WO2010110887A1 (en) * | 2009-03-24 | 2010-09-30 | Robert Shorr | Fatty acids |
| WO2010110771A2 (en) * | 2009-03-25 | 2010-09-30 | Frank Gibson | Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof |
| WO2011046583A1 (en) * | 2009-09-11 | 2011-04-21 | Robert Shorr | Pharmaceutical exploitation of oxidative stress in transformed cells |
| WO2011138565A1 (fr) | 2010-05-05 | 2011-11-10 | Biorebus | Association pharmaceutique contenant l'acide lipoïque, l'acide hydroxycitrique et une somatostatine a titre de principes actifs |
| FR2959668B1 (fr) * | 2010-05-05 | 2012-07-13 | Biorebus | Association pharmaceutique contenant l'acide lipoique, l'acide hydroxycitrique et une somatostatine a titre de principes actifs |
| WO2011143593A1 (en) | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Conjugates of a lipoic acid derivative and anti-proliferation agent and medical uses thereof |
| WO2011143590A1 (en) | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Combination therapy compositions and methods using lipoic acid derivatives and an anti-proliferation agent |
| WO2011146635A1 (en) * | 2010-05-21 | 2011-11-24 | North Texas Medical Associates | Malignant neoplasm treatment protocol |
| JP6072684B2 (ja) | 2010-08-06 | 2017-02-01 | ザ ジェネラル ホスピタル コーポレーション ディー／ビー／エイ マサチューセッツ ジェネラル ホスピタル | 細胞処置システムおよび細胞処置装置 |
| BR112015014327A2 (pt) * | 2012-12-19 | 2020-01-28 | Cornerstone Pharmaceuticals Inc | compostos farmacêuticos |
| US9605012B2 (en) | 2013-01-17 | 2017-03-28 | Garnett Mckeen Laboratory, Inc. | Palladium-ruthenium-zinc-organo complexes and methods for their use in the treatment of inflammatory diseases |
| EP3189033B1 (de) | 2014-06-19 | 2020-08-05 | Rafael Pharmaceuticals, Inc. | Pharmazeutische verbindungen |
| ES2747702T3 (es) | 2014-06-19 | 2020-03-11 | Rafael Pharmaceuticals Inc | Compuestos farmacéuticos |
| US10052305B2 (en) | 2015-10-07 | 2018-08-21 | Buck Institute For Research On Aging | Lipoic acid and derivatives thereof for the treatment of cystinuria |
| CN117263907B (zh) * | 2023-09-23 | 2026-01-27 | 江西科技师范大学 | 一种丙酮酸脱氢酶e2抑制剂及其制备方法和应用 |
| CN117919421A (zh) * | 2023-12-28 | 2024-04-26 | 石河子大学 | 转录因子klf7在制备抑制宫颈癌进展的药物中的应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE362916C (de) | 1921-08-13 | 1922-11-02 | Eduard Duerr | Abnehmbares Mikrometer fuer Schublehren |
| GB758897A (en) * | 1953-10-19 | 1956-10-10 | Merck & Co Inc | Thio-substituted aliphatic carboxylic acids and their preparation |
| US2853497A (en) * | 1953-12-04 | 1958-09-23 | Merck & Co Inc | 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof |
| US2975198A (en) * | 1954-07-08 | 1961-03-14 | Research Corp | Lipoic acid intermediates |
| US2872458A (en) * | 1954-12-30 | 1959-02-03 | Merck & Co Inc | Addition product of a metal hydrocarbon mercaptide with an alpha-halogamma-butyrolactone |
| JPS57123107A (en) | 1981-01-26 | 1982-07-31 | Pola Chem Ind Inc | Cosmetic |
| DE3512911A1 (de) * | 1985-04-11 | 1986-10-16 | Degussa Ag, 6000 Frankfurt | Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure) |
| DE3626116A1 (de) | 1986-08-01 | 1988-02-11 | Karl Thiel | Thermostatische regeleinrichtung fuer heizungen bzw. heizaggregate |
| DE3629116A1 (de) * | 1986-08-27 | 1988-03-10 | Asta Pharma Ag | Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer |
| DE3900649A1 (de) * | 1989-01-11 | 1990-07-12 | Boehringer Mannheim Gmbh | Verfahren zur abloesung eines analyten von seinem bindeprotein |
| JPH03193758A (ja) * | 1989-12-25 | 1991-08-23 | Nisshin Oil Mills Ltd:The | 新規γ―アミノ酪酸誘導体 |
| ATE162715T1 (de) * | 1991-07-05 | 1998-02-15 | Asta Medica Ag | Verwendung von schwefel enthaltenden carbonsäuren zur bekämpfung von pathophysiologisch bedingten erregungsstörungen |
| DE4137773A1 (de) * | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
| WO1994006794A1 (en) | 1992-09-24 | 1994-03-31 | National Institutes Of Health | Aralkyl diazabicycloalkane derivatives for cns disorders |
| DE4310142A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung |
| US5463093A (en) | 1993-11-26 | 1995-10-31 | Garnett; Merrill | Palladium complexes and methods for using same in the treatment of tumors or Psoriasis |
| DE4433764A1 (de) * | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit |
| DE4439477C2 (de) * | 1994-11-08 | 1999-10-21 | Asta Medica Ag | Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie |
| DE19601787C1 (de) * | 1996-01-19 | 1997-07-24 | Asta Medica Ag | Herstellung und Verwendung von Salzen der 6,8-Bis(amidiniumthio)-octansäure |
| ATE310738T1 (de) * | 1996-07-05 | 2005-12-15 | Us Gov Health & Human Serv | Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen |
| EP0855396A1 (de) * | 1997-01-22 | 1998-07-29 | ASTA Medica Aktiengesellschaft | Metabolite von Thioctsäure und deren Verwendung |
| WO1998043621A1 (en) * | 1997-03-31 | 1998-10-08 | The Children's Medical Center Corporation | Nitrosylation to inactivate apoptotic enzymes |
| IL123887A0 (en) * | 1997-04-02 | 1998-10-30 | Sankyo Co | Dithiolan derivatives their use and pharmaceutical compositions containing the same |
| JPH11124379A (ja) * | 1997-10-17 | 1999-05-11 | Ss Pharmaceut Co Ltd | ジチオリリデンアセトアミド誘導体 |
| FR2777001B1 (fr) * | 1998-04-01 | 2000-06-09 | Cird Galderma | Derives de l'acide 6,8-dimercaptooctanoique substitues en 6-s et/ou en 8-s par le radical (3-methylthiopropanoyl) et compositions pharmaceutiques destinees au traitement des tumeurs cancereuses |
| US6204288B1 (en) * | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
| US6288106B1 (en) * | 1999-05-25 | 2001-09-11 | Chronorx, Llc | Processes for the synthesis and use of various α-lipoic acid complexes |
| US6387945B2 (en) * | 2000-04-11 | 2002-05-14 | The Regents Of The University Of California | Lipoic acid analogs |
| ES2856125T3 (es) | 2016-02-05 | 2021-09-27 | Ea Pharma Co Ltd | Derivado de sulfonamida y composición farmacéutica que contiene la misma |
-
1999
- 1999-10-26 US US09/427,477 patent/US6331559B1/en not_active Expired - Lifetime
- 1999-10-26 MX MXPA01004152A patent/MXPA01004152A/es active IP Right Grant
- 1999-10-26 ES ES99956698T patent/ES2229790T3/es not_active Expired - Lifetime
- 1999-10-26 AT AT04077618T patent/ATE451362T1/de not_active IP Right Cessation
- 1999-10-26 EP EP09012728A patent/EP2145883A1/de not_active Withdrawn
- 1999-10-26 AT AT99956698T patent/ATE277034T1/de not_active IP Right Cessation
- 1999-10-26 CA CA2348998A patent/CA2348998C/en not_active Expired - Lifetime
- 1999-10-26 EP EP04077618A patent/EP1486495B1/de not_active Expired - Lifetime
- 1999-10-26 WO PCT/US1999/025140 patent/WO2000024734A1/en not_active Ceased
- 1999-10-26 IL IL14282499A patent/IL142824A0/xx unknown
- 1999-10-26 AU AU13246/00A patent/AU774362B2/en not_active Expired
- 1999-10-26 JP JP2000578304A patent/JP4728481B2/ja not_active Expired - Lifetime
- 1999-10-26 EP EP99956698A patent/EP1124820B1/de not_active Expired - Lifetime
- 1999-10-26 BR BR9914789-0A patent/BR9914789A/pt not_active Application Discontinuation
- 1999-10-26 ES ES04077618T patent/ES2340488T3/es not_active Expired - Lifetime
- 1999-10-26 DE DE69941800T patent/DE69941800D1/de not_active Expired - Lifetime
- 1999-10-26 DE DE69920497T patent/DE69920497T2/de not_active Expired - Lifetime
-
2001
- 2001-04-26 IL IL142824A patent/IL142824A/en not_active IP Right Cessation
- 2001-09-24 US US09/962,372 patent/US6951887B2/en not_active Expired - Lifetime
-
2010
- 2010-06-02 JP JP2010126848A patent/JP5727721B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1486495B1 (de) | 2009-12-09 |
| EP2145883A1 (de) | 2010-01-20 |
| JP2002528446A (ja) | 2002-09-03 |
| DE69941800D1 (de) | 2010-01-21 |
| CA2348998C (en) | 2012-03-06 |
| JP4728481B2 (ja) | 2011-07-20 |
| US6951887B2 (en) | 2005-10-04 |
| ES2229790T3 (es) | 2005-04-16 |
| EP1124820A1 (de) | 2001-08-22 |
| MXPA01004152A (es) | 2002-06-04 |
| DE69920497T2 (de) | 2006-02-09 |
| IL142824A0 (en) | 2002-03-10 |
| AU774362B2 (en) | 2004-06-24 |
| EP1486495A1 (de) | 2004-12-15 |
| EP1124820B1 (de) | 2004-09-22 |
| WO2000024734A1 (en) | 2000-05-04 |
| AU1324600A (en) | 2000-05-15 |
| IL142824A (en) | 2010-11-30 |
| ATE277034T1 (de) | 2004-10-15 |
| CA2348998A1 (en) | 2000-05-04 |
| DE69920497D1 (de) | 2004-10-28 |
| US20020107234A1 (en) | 2002-08-08 |
| JP5727721B2 (ja) | 2015-06-03 |
| US6331559B1 (en) | 2001-12-18 |
| ES2340488T3 (es) | 2010-06-04 |
| BR9914789A (pt) | 2001-10-02 |
| JP2010248203A (ja) | 2010-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE277034T1 (de) | Liponsaürederivate und deren verwendung bei der behandlung von krankheiten | |
| ATE389649T1 (de) | Substituierte amin-derivate und deren verwendung zur behandlung von angionese-bedingten erkrankungen | |
| ATE241358T1 (de) | Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen | |
| DE69711894D1 (de) | Lipoxinverbindungen und deren verwendung zur behandlung der zellenwucherungsstörung | |
| ATE275608T1 (de) | Behandlung von mineralfüllstoffen mit phosphaten, diese füllstoffe und deren verwendung | |
| DE60233265D1 (de) | 5-sulfanyl-4h-1,2,4-triazolderivate und deren verwendung zur behandlung von somatostatine vermittelten krankheiten | |
| DE69830336D1 (de) | Ein kovalentes konjugat von clozapine und einer fettsäure und dessen verwendung zur behandlung von schizophrenie | |
| DE69724016D1 (de) | Verwendung von anti-mikrotubuli mitteln zur behandlung von entzündlichen erkrankungen der atemwege | |
| DE60013859D1 (de) | Indolderivate und deren verwendung zur behandlung von u.a. osteoporosis | |
| ATE336485T1 (de) | Substituierte heterocyclen und deren verwendung in arzneimitteln | |
| DE69519937D1 (de) | Polyamin-verbindungen zur behandlung von proliferativer erkrankungen | |
| DE69523654D1 (de) | Verwendung von Ascorbyl-gamma-Linolenat und von Ascorbyl-dihomo-gamma-linolenat zur Behandlung von Asthma, Krebs, kardiovaskulären und inflammatorischen Erkrankungen | |
| ATE375795T1 (de) | Verwendung von et743 in kombinationstherapie mit dexamethason zur behandlung von krebs | |
| EP0793660A4 (de) | 2-substituierte 1,2,5-thiadiazolidin-3-on-1,1-dioxiden, zusammensetzung und deren verwendung | |
| ATE242632T1 (de) | Verwendung von betulinsäure-derivaten zur behandlung und vorbeugung von melanomen | |
| DE3876846D1 (de) | Morpholinderivate und deren verwendung. | |
| ATE259818T1 (de) | Substituierte tricyclische verbindungen und deren verwendung zur behandlung von spla2-bedingten erkrankungen | |
| DE69931487D1 (de) | Verwendung von apomorphin zur behandlung der vorzeitigen ejakulation | |
| NO881892D0 (no) | Nitrifikasjonshemmende middel. | |
| DE69932922D1 (de) | Verwendung von alkansäuren-enthaltenden zusammensetzungen zur behandlung von nagelpilz-erkrankungen | |
| DE59900286D1 (de) | Verwendung von sphingosin-1-phosphat, sphingosin-1-phosphat-derivaten und/oder deren gemische zur behandlung von entzündlichen hautkrankheiten | |
| DE69936779D1 (de) | Verwendung von ngali nussöl zur behandlung/linderung der arthritisschmerzen und anderer ähnlichen störungen | |
| NO20003629D0 (no) | Forbindelser med veksthormonfrigjørende egenskaper | |
| ATE268170T1 (de) | Verwendung von bernsteisäure oder deren salze zur behandlung von insulinresistenz | |
| DE69934336D1 (de) | Verwendung von halofuginone zur behandlung von urethralstriktur |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |