ATE277934T1 - Antidepressive azaheterocyclylmethylderivate von 7,8-dihydro-1,6,9-trioxa-3- azacyclopenta(a)naphthalin - Google Patents

Antidepressive azaheterocyclylmethylderivate von 7,8-dihydro-1,6,9-trioxa-3- azacyclopenta(a)naphthalin

Info

Publication number
ATE277934T1
ATE277934T1 AT02766816T AT02766816T ATE277934T1 AT E277934 T1 ATE277934 T1 AT E277934T1 AT 02766816 T AT02766816 T AT 02766816T AT 02766816 T AT02766816 T AT 02766816T AT E277934 T1 ATE277934 T1 AT E277934T1
Authority
AT
Austria
Prior art keywords
azacyclopenta
naphthaline
antidepressive
trioxa
dihydro
Prior art date
Application number
AT02766816T
Other languages
English (en)
Inventor
Megan Tran
Gary Paul Stack
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE277934T1 publication Critical patent/ATE277934T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT02766816T 2001-04-30 2002-04-25 Antidepressive azaheterocyclylmethylderivate von 7,8-dihydro-1,6,9-trioxa-3- azacyclopenta(a)naphthalin ATE277934T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28744901P 2001-04-30 2001-04-30
PCT/US2002/013117 WO2002088140A1 (en) 2001-04-30 2002-04-25 Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene

Publications (1)

Publication Number Publication Date
ATE277934T1 true ATE277934T1 (de) 2004-10-15

Family

ID=23102960

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02766816T ATE277934T1 (de) 2001-04-30 2002-04-25 Antidepressive azaheterocyclylmethylderivate von 7,8-dihydro-1,6,9-trioxa-3- azacyclopenta(a)naphthalin

Country Status (14)

Country Link
US (2) US6525075B2 (de)
EP (1) EP1392700B1 (de)
JP (1) JP2004528352A (de)
CN (1) CN1256337C (de)
AT (1) ATE277934T1 (de)
BR (1) BR0209407A (de)
CA (1) CA2445859A1 (de)
DE (1) DE60201447T2 (de)
DK (1) DK1392700T3 (de)
ES (1) ES2225798T3 (de)
MX (1) MXPA03009829A (de)
PT (1) PT1392700E (de)
TR (1) TR200402753T4 (de)
WO (1) WO2002088140A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6815448B2 (en) * 2001-05-07 2004-11-09 Wyeth Azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene as 5-HT1A antagonists
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
ES2364340T3 (es) 2004-03-30 2011-08-31 Vertex Pharmaceuticals Incorporated Azaindoles útiles como inhibidores de jak y otras proteína quinasas.
WO2008079346A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
GEP20207129B (en) 2009-06-17 2020-07-10 Vertex Pharma Inhibitors of influenza viruses replication
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
PT3068776T (pt) 2013-11-13 2019-08-26 Vertex Pharma Inibidores da replicação de vírus da gripe
HUE038820T2 (hu) 2013-11-13 2018-11-28 Vertex Pharma Eljárás influenzavírusok replikációjának inhibitorai elõállítására
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
EP3294717B1 (de) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Verfahren zur herstellung von inhibitoren der influenzavirenreplikation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU639536B2 (en) 1990-03-15 1993-07-29 Pharmacia & Upjohn Company Therapeutically useful heterocyclic indole compounds
DE4135474A1 (de) 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
DE4140540A1 (de) 1991-12-09 1993-06-17 Bayer Ag Neue azaheterocyclylmethyl-chromane
US5741789A (en) 1995-01-17 1998-04-21 Eli Lilly And Company Compounds having effects on serotonin-related systems
GB9526495D0 (en) * 1995-12-23 1996-02-28 Knoll Ag Therapeutic agents
US5869490A (en) 1996-10-15 1999-02-09 American Home Products Corporation Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
JP2001502327A (ja) * 1996-10-15 2001-02-20 アメリカン・ホーム・プロダクツ・コーポレイション ２，３，８，９―テトラヒドロ―７Ｈ―１，４―ジオキシノ［２，３―ｅ］インドール―８―オンのアザヘテロサイクリルメチル誘導体
GB9627005D0 (en) 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
GB9704948D0 (en) 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
EP0897921A1 (de) * 1997-08-22 1999-02-24 Eli Lilly And Company Limited Benzothiadiazinyl-indolderivate und ihre Verwendung als Serotoninrezeptor-liganden
US6458802B1 (en) * 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline

Also Published As

Publication number Publication date
DK1392700T3 (da) 2004-10-25
EP1392700A1 (de) 2004-03-03
CN1256337C (zh) 2006-05-17
US20030109562A1 (en) 2003-06-12
US6613913B2 (en) 2003-09-02
MXPA03009829A (es) 2005-03-07
US20020183354A1 (en) 2002-12-05
WO2002088140A1 (en) 2002-11-07
DE60201447T2 (de) 2006-02-23
ES2225798T3 (es) 2005-03-16
US6525075B2 (en) 2003-02-25
BR0209407A (pt) 2004-07-06
CA2445859A1 (en) 2002-11-07
DE60201447D1 (de) 2004-11-04
PT1392700E (pt) 2004-12-31
JP2004528352A (ja) 2004-09-16
EP1392700B1 (de) 2004-09-29
CN1503799A (zh) 2004-06-09
TR200402753T4 (tr) 2004-11-22

Similar Documents

Publication Publication Date Title
WO2002085896A8 (en) Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
MEP6508A (xx) Fenil-piperazin derivati kao inhibitori resorbucije serotonina
BR0209580A (pt) Derivados de ciclohexan-1, 4 diamina substituìdos
NO20060402L (no) 3-amino choman og 2-aminotetralinderivater
DE602005023185D1 (de) Prodrugs mit neuen biospaltbaren verbindern
ATE279415T1 (de) Antidepressiv wirksame azaheterocyclymethyl- derivative von oxaheterocycyl-anellierten (1,4)- benzodioxanen
DE60221098D1 (de) Kondensierte heterocyclische derivate
DE60201447D1 (de) Antidepressive azaheterocyclylmethylderivate von 7,8-dihydro-1,6,9-trioxa-3-azacyclopenta(a)naphthalin
SE0201544D0 (sv) Novel compounds and thier use
CY1108808T1 (el) Ενωσεις μοτιλιδης
ATE304016T1 (de) Antidepressive (sssri) azaheterocyclylmethylderivate von 7,8-dihydro-3h- 6,9-dioxa-1,3-diazacyclopenta (a) naphthalin
DE60213576D1 (de) ANTIDEPRESSIVE AZAHETEROCYCLYLMETHYL-DERIVATE VON 2,3-DIHYDRO-1,4-DIOXINOi2,3-föCHINOXALIN
PE20030061A1 (es) 1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4
EA200200137A1 (ru) Лечение невротических нарушений
DE60201592D1 (de) ANTIDEPRESSIVE INDOLTETRAHYDROPYRIDIN-DERIVATE VON 2,3-DIHYDRO-7H[1,4]DIOXINO[2,3-e]INDOL
DK1399438T3 (da) Hidtil ukendte heteroarylderivater samt fremstilling og anvendelse heraf
WO2002086504A3 (en) Individualization of therapy with gastroesophageal reflux disease agents
BRPI0408320A (pt) composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
CA2451229A1 (en) Indole derivatives
DK1558610T3 (da) Substituerede aminoquinuclidinforbindelser og deres anvendelse som delta-opioidreceptorligander
DE602004020337D1 (de) Anticholinergika enthaltende Arzneimittel zur Behandlung von Krankheiten der ableitenden Harnwege

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1392700

Country of ref document: EP

REN Ceased due to non-payment of the annual fee