BRPI0412554A - pirazolinas como antagonistas par-1 para o tratamento de doenças distúrbios cardiovascular - Google Patents

pirazolinas como antagonistas par-1 para o tratamento de doenças distúrbios cardiovascular

Info

Publication number
BRPI0412554A
BRPI0412554A BRPI0412554-1A BRPI0412554A BRPI0412554A BR PI0412554 A BRPI0412554 A BR PI0412554A BR PI0412554 A BRPI0412554 A BR PI0412554A BR PI0412554 A BRPI0412554 A BR PI0412554A
Authority
BR
Brazil
Prior art keywords
treatment
pyrazolines
par
antagonists
cardiovascular disorders
Prior art date
Application number
BRPI0412554-1A
Other languages
English (en)
Inventor
Swen Allerheiligen
Dirk Brohm
Nicole Diedrichs
Britta-Nicole Fr Hlen
Christoph Gerdes
Mark Jean Gnoth
Heike Heckroth
Walter Huebsch
Elisabeth Perzborn
Elke Stahl
Verena V Hringer
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004010545A external-priority patent/DE102004010545A1/de
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of BRPI0412554A publication Critical patent/BRPI0412554A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PIRAZOLINAS COMO ANTAGONISTAS PAR-1 PARA O TRATAMENTO DE DOENçAS CARDIOVASCULARES". A presente invenção refere-se a pirazolinas da fórmula (I) em que E representa metileno, NH, um átomo de oxigênio ou um átomo de enxofre, R¬ 2¬ representa um grupo da fórmula (II), e a processos para sua preparação bem como ao seu uso para a preparação de medicamentos para o tratamento e/ou profilaxia de doenças, particularmente de doenças cardio-vasculares, como por exemplo doenças trombo-embólicas.
BRPI0412554-1A 2003-07-15 2004-07-02 pirazolinas como antagonistas par-1 para o tratamento de doenças distúrbios cardiovascular BRPI0412554A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10331951 2003-07-15
DE102004010545A DE102004010545A1 (de) 2003-07-15 2004-03-04 Pyrazoline
PCT/EP2004/007227 WO2005007157A1 (de) 2003-07-15 2004-07-02 Pyrazoline als par-1-antagonisten zur behandlung von herz-kreislauf-erkrankungen

Publications (1)

Publication Number Publication Date
BRPI0412554A true BRPI0412554A (pt) 2006-09-19

Family

ID=34081645

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412554-1A BRPI0412554A (pt) 2003-07-15 2004-07-02 pirazolinas como antagonistas par-1 para o tratamento de doenças distúrbios cardiovascular

Country Status (8)

Country Link
EP (1) EP1648447A1 (pt)
AU (1) AU2004257406A1 (pt)
BR (1) BRPI0412554A (pt)
CA (1) CA2532316A1 (pt)
MA (1) MA27905A1 (pt)
MX (1) MXPA06000507A (pt)
NO (1) NO20060733L (pt)
WO (1) WO2005007157A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004061748A1 (de) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Azetidin-substituierte Pyrazoline
DE102004061747A1 (de) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Thiophen-substituierte Pyrazoline
DE102004061751A1 (de) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Cyanoguanidin-substituierte Pyrazoline
CA2969771A1 (en) * 2014-12-08 2016-06-16 Bayer Pharma Aktiengesellschaft Novel aryl-cyanoguanidine compounds
EP3283478A1 (en) * 2015-04-17 2018-02-21 Bayer Pharma Aktiengesellschaft Novel aryl-cyanoguanidine compounds
US20180099937A1 (en) 2015-04-17 2018-04-12 Bayer Pharma Aktiengesellschaft Novel aryl-cyanoguanidine compounds
EP3109237A1 (en) 2015-06-22 2016-12-28 AnaMar AB Novel 5-ht2 antagonists
CN111892585A (zh) * 2020-08-05 2020-11-06 杭州维坦医药科技有限公司 作为p2x3受体拮抗剂的n-甲酰胺基吡唑啉类衍生物及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE188690T1 (de) * 1990-07-13 2000-01-15 Rohm & Haas N-aryl-3-aryl-4-substituierte-4,5-dihydro-1h- pyrazol-1-carboxamide und verfahren zu deren herstellung
DE4217862A1 (de) * 1991-08-28 1993-03-04 Bayer Ag Substituierte pyrazoline
DE4217863A1 (de) * 1991-08-28 1993-03-04 Bayer Ag Substituierte pyrazoline
DE4217864A1 (de) * 1992-05-29 1993-12-02 Bayer Ag Substituierte Pyrazoline
DE4233713A1 (de) * 1992-10-07 1994-04-14 Bayer Ag Substituierte 4,5-Dihydro-1-pyrazolcarbonsäureanilide

Also Published As

Publication number Publication date
NO20060733L (no) 2006-04-10
MA27905A1 (fr) 2006-05-02
EP1648447A1 (de) 2006-04-26
WO2005007157A1 (de) 2005-01-27
AU2004257406A1 (en) 2005-01-27
MXPA06000507A (es) 2006-04-05
CA2532316A1 (en) 2005-01-27

Similar Documents

Publication Publication Date Title
NL300933I2 (nl) Letermovir
ATE365720T1 (de) Agonisten von beta-adrenorezeptoren
BRPI0409109A (pt) novos compostos
BRPI0417543A (pt) quinolinas úteis no tratamento de doença cardiovascular
ATE526331T1 (de) Pyrrolopyrimidine für pharmazeutische zusammensetzungen
SE0301009D0 (sv) Novel compounds
BR0315296A (pt) Derivados do ciclohexanol espirocìclicos
NO20064041L (no) Substituerte pyrazolin sammensetninger, deres fremstilling og anvendelse som medikamenter
BR0307564A (pt) Derivados de nicotinamida úteis como inibidores de pde4
NO20060324L (no) [1,8]Naftyridin-2-oner og relaterte forbindelser for behandling av Schizofreni
BRPI0507041A (pt) composto derivados de sulfonamida para o tratamento de doenças seus usos, processo para a preparação dos compostos e combinação de compostos
BR0315158A (pt) Compostos de pirazol para o tratamento de distúrbios neurodegenarativos
BRPI0512335A (pt) compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades e sua utilização
NO20064078L (no) Substituerte azetidinsammensetninger, deres fremstilling og anvendelse som medikamenter
BRPI0414948A (pt) derivados de pirazolo-e-imidazo pirimidina
BR0307574A (pt) Derivados de nicotinamida úteis como inibidores de pde4
BRPI0510084A (pt) benzoxazina para tratamento de doenças do trato respiratório
BR0316723A (pt) Derivados de anilinopirazol úteis para o tratamento de diabetes
CR9182A (es) Derivado de quinolina, su uso, preparacion y medicamento que lo contiene
DE602005015002D1 (de) Methylendipiperidinderivate
NO20050063L (no) 2-heteroaryl karboksamider
ATE526967T1 (de) Medikamente für inhalationen enthaltend ein anticholinergikum und ein betamimetikum
BRPI0412554A (pt) pirazolinas como antagonistas par-1 para o tratamento de doenças distúrbios cardiovascular
BRPI0518907A2 (pt) compostos, processo para a sua manufatura, composiÇÕes farmacÊuticas que os compreendem, mÉtodo para o tratamento e/ou prevenÇço de enfermidades que estço associadas com a modulaÇço de receptores de h3 e sua utilizaÇço
BRPI0411087A (pt) aperfeiçoamentos em ou relacionados a compostos orgánicos

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired