ATE278021T1 - Rekombinante bakterienstämme zur herstellung von natürlichen nucleosiden, sowie von modifizierten analogen davon - Google Patents

Rekombinante bakterienstämme zur herstellung von natürlichen nucleosiden, sowie von modifizierten analogen davon

Info

Publication number
ATE278021T1
ATE278021T1 AT99965565T AT99965565T ATE278021T1 AT E278021 T1 ATE278021 T1 AT E278021T1 AT 99965565 T AT99965565 T AT 99965565T AT 99965565 T AT99965565 T AT 99965565T AT E278021 T1 ATE278021 T1 AT E278021T1
Authority
AT
Austria
Prior art keywords
production
bacterial strains
recombinant bacterial
natural nucleosides
modified analogues
Prior art date
Application number
AT99965565T
Other languages
English (en)
Inventor
Giuseppina Bestetti
Simona Cali
Daniela Ghisotti
Gaetano Orsini
Giancarlo Tonon
Gabriele Zuffi
Original Assignee
Keryos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keryos Spa filed Critical Keryos Spa
Application granted granted Critical
Publication of ATE278021T1 publication Critical patent/ATE278021T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT99965565T 1998-12-23 1999-12-23 Rekombinante bakterienstämme zur herstellung von natürlichen nucleosiden, sowie von modifizierten analogen davon ATE278021T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002792A IT1304500B1 (it) 1998-12-23 1998-12-23 Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati.
PCT/EP1999/010416 WO2000039307A2 (en) 1998-12-23 1999-12-23 Recombinant bacterial strains for the production of natural nucleosides and modified analogues thereof

Publications (1)

Publication Number Publication Date
ATE278021T1 true ATE278021T1 (de) 2004-10-15

Family

ID=11381317

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99965565T ATE278021T1 (de) 1998-12-23 1999-12-23 Rekombinante bakterienstämme zur herstellung von natürlichen nucleosiden, sowie von modifizierten analogen davon

Country Status (9)

Country Link
US (2) US6911341B2 (de)
EP (1) EP1141328B1 (de)
JP (1) JP2002533126A (de)
AT (1) ATE278021T1 (de)
AU (1) AU2103000A (de)
DE (1) DE69920749T2 (de)
ES (1) ES2229807T3 (de)
IT (1) IT1304500B1 (de)
WO (1) WO2000039307A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1304500B1 (it) * 1998-12-23 2001-03-19 Norpharma Spa Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati.
US7488598B2 (en) 2001-10-26 2009-02-10 Cornell Center For Technology Enterprise And Commercialization Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof
US7037718B2 (en) * 2001-10-26 2006-05-02 Cornell Research Foundation, Inc. Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof
ES2235638B1 (es) * 2003-12-17 2006-10-16 Cellerix, S.L. Nuevo vector retroviral de alto titulo y metodos de transduccion.
PL1835035T3 (pl) * 2006-03-15 2010-07-30 Explora Laboratories Sa Sposób immobilizowania komórek na żywicy
EP2338985A1 (de) * 2009-12-22 2011-06-29 Institut Univ. de Ciència i Tecnologia, s.a. Wärmebeständige Biokatalysatorkombination zur Nukleotidsynthese
JP2016198075A (ja) * 2015-04-14 2016-12-01 プラズミア バイオテック，エス．エル． シトシンヌクレオシドアナログの酵素産生
CN115279891B (zh) * 2021-06-09 2024-11-22 正大天晴药业集团股份有限公司 用于制备奈拉滨的重组基因工程菌及其应用
CN113969299B (zh) * 2021-10-17 2023-10-20 拓新药业集团股份有限公司 一种生物转化合成尿苷的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
ATE4225T1 (de) * 1980-04-23 1983-08-15 The Wellcome Foundation Limited Synthese von deazapurin-nukleosiden.
US4347315A (en) * 1980-04-25 1982-08-31 Burroughs Wellcome Co. Synthesis of ribosides using bacterial phosphorylase
US4835104A (en) 1987-06-16 1989-05-30 Ajinomoto Co., Inc., Patent & Licensing Department Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides
JP2619710B2 (ja) * 1989-02-27 1997-06-11 日本製紙 株式会社 ２′，３′−ジデオキシプリンヌクレオシド類の製造方法
EP0423641A3 (en) * 1989-10-18 1992-01-15 Nippon Mining Company Limited Expression vector, transformed microorganism, fusion protein and method for the production of platelet factor 4 or tgfalpha
JPH06253854A (ja) * 1993-02-26 1994-09-13 Yamasa Shoyu Co Ltd 組換えｄｎａ手法によるヌクレオシド・ホスホリラーゼの製造法
JP4304727B2 (ja) * 1996-11-21 2009-07-29 味の素株式会社 ヌクレオシド−５’−燐酸エステルの製造法
US6229001B1 (en) * 1997-01-03 2001-05-08 Southern Research Institute Mycobacterium fol a gene that encodes for the enzyme dihydrofolate reductase
JPH10286097A (ja) * 1997-04-15 1998-10-27 Yamasa Shoyu Co Ltd プリンアラビノシドの酵素的製造法
JP3799784B2 (ja) 1997-11-14 2006-07-19 味の素株式会社 ２，６−ジアミノプリン−２’−デオキシリボシドおよび２’−デオキシグアノシンの製造法
IT1304500B1 (it) * 1998-12-23 2001-03-19 Norpharma Spa Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati.

Also Published As

Publication number Publication date
EP1141328B1 (de) 2004-09-29
US6911341B2 (en) 2005-06-28
US20030059870A1 (en) 2003-03-27
DE69920749D1 (de) 2004-11-04
AU2103000A (en) 2000-07-31
JP2002533126A (ja) 2002-10-08
ITMI982792A1 (it) 2000-06-23
WO2000039307A3 (en) 2000-11-09
EP1141328A2 (de) 2001-10-10
US7781189B2 (en) 2010-08-24
US20050142645A1 (en) 2005-06-30
WO2000039307A2 (en) 2000-07-06
IT1304500B1 (it) 2001-03-19
DE69920749T2 (de) 2006-03-02
ES2229807T3 (es) 2005-04-16

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