ATE278402T1 - Arylpiperidinol und arylpiperidin-derivate und sie enthaltende arzneimittel - Google Patents

Arylpiperidinol und arylpiperidin-derivate und sie enthaltende arzneimittel

Info

Publication number: ATE278402T1
Authority: AT; Austria
Prior art keywords: optionally substituted; arylpiperidinol; products containing; medicinal products; methylene
Prior art date: 1996-07-22

Application number

AT97930865T

Other languages

English (en)

Inventor

Hirokazu Annoura

Kyoko Nakanishi

Shigeki Tamura

Original Assignee

Daiichi Suntory Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-22

Filing date

1997-07-22

Publication date

2004-10-15

1997-07-22 Application filed by Daiichi Suntory Pharma Co Ltd filed Critical Daiichi Suntory Pharma Co Ltd

1997-07-22 Priority claimed from PCT/JP1997/002531 external-priority patent/WO1998003172A1/ja

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE278402T1 publication Critical patent/ATE278402T1/de

Links

229940126601 medicinal product Drugs 0.000 title 1
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
208000024891 symptom Diseases 0.000 abstract 2
206010010904 Convulsion Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000002993 cycloalkylene group Chemical group 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
208000023589 ischemic disease Diseases 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT97930865T 1996-07-22 1997-07-22 Arylpiperidinol und arylpiperidin-derivate und sie enthaltende arzneimittel ATE278402T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP19212396		1996-07-22
PCT/JP1997/002531 WO1998003172A1 (en)	1996-07-22	1997-07-22	Arylpiperidinol and arylpiperidine derivatives and drugs containing the same

Publications (1)

Publication Number	Publication Date
ATE278402T1 true ATE278402T1 (de)	2004-10-15

Family

ID=16286065

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97930865T ATE278402T1 (de)	1996-07-22	1997-07-22	Arylpiperidinol und arylpiperidin-derivate und sie enthaltende arzneimittel

Country Status (9)

Country	Link
US (3)	US6455549B1 (de)
EP (1)	EP0867183B1 (de)
KR (1)	KR100537843B1 (de)
AT (1)	ATE278402T1 (de)
AU (1)	AU710594B2 (de)
CA (1)	CA2231879C (de)
DE (1)	DE69731070T2 (de)
ES (1)	ES2225979T3 (de)
HU (1)	HUP9904335A3 (de)

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CA2231879C (en) *	1996-07-22	2007-01-23	Suntory Limited	Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same
EP0958280B1 (de) *	1997-10-31	2005-05-04	Daiichi Suntory Pharma Co., Ltd.	Arylpiperidinopropanol und arylpiperazinopropanol derivate und die selbe enthaltende pharmazeutika
CA2369691A1 (en)	1999-04-09	2000-10-19	Yutaka Miyazaki	4-hydroxypiperidine derivatives having antiarrhythmic effect
AU3676100A (en) *	1999-04-09	2000-11-14	Mochida Pharmaceutical Co., Ltd.	Remedies for neuropathic pain
USRE46117E1 (en)	1999-12-22	2016-08-23	Teva Pharmaceuticals International Gmbh	Modulators of dopamine neurotransmission
US6569861B2 (en) *	2000-07-06	2003-05-27	Neurogen Corporation	Melanin concentrating hormone receptor ligands
US20020128203A1 (en) *	2000-09-20	2002-09-12	Laurent Schild	Methods of identifying inhibitory compounds and uses thereof
WO2003034544A1 (en) *	2001-10-16	2003-04-24	Fractus, S.A.	Multiband antenna
AU2003278565A1 (en) *	2002-10-25	2004-05-13	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
US20060166894A1 (en) *	2002-11-29	2006-07-27	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Ace-inhibitors having antioxidant and no-donor activity
SE0401465D0 (sv)	2004-06-08	2004-06-08	Carlsson A Research Ab	New substituted piperdines as modulators of dopamine neurotransmission
MXPA06013941A (es)	2004-06-08	2007-12-10	Neurosearch Sweden Ab	Fenilpiperidinas disustituidas, novedosas, como moduladores de la neurotransmision de dopamina y serotonina.
PL1802573T3 (pl) *	2004-10-13	2017-03-31	Teva Pharmaceuticals International Gmbh	Proces syntezy 4-(3-metanosulfonylofenylo)-1-N-propylopiperydyny
AU2005293755A1 (en) *	2004-10-13	2006-04-20	Nsab, Filial Af Neurosearch Sweden Ab, Sverige	Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines
US20080035163A1 (en) *	2006-08-10	2008-02-14	Shaahin Cheyene	Magnetic Advanced Cigarette Filtration System
US7638541B2 (en)	2006-12-28	2009-12-29	Metabolex Inc.	5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
JP5489997B2 (ja)	2007-07-19	2014-05-14	シマベイセラピューティクス，インコーポレーテッド	糖尿病および代謝疾患の治療のためのＲＵＰ３またはＧＰＲｌ１９受容体のアゴニストとしてのＮ−アザ環状置換ピロール、ピラゾール、イミダゾール、トリアゾールおよびテトラゾール誘導体
CN102203074A (zh) *	2008-06-20	2011-09-28	麦它波莱克斯股份有限公司	芳基gpr119激动剂及其用途
WO2011041154A1 (en)	2009-10-01	2011-04-07	Metabolex, Inc.	Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
EP2585048B1 (de)	2010-06-23	2018-04-11	CymaBay Therapeutics, Inc.	Zusammensetzungen von 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidin
WO2012068589A2 (en) *	2010-11-19	2012-05-24	Constellation Pharmaceuticals	Modulators of methyl modifying enzymes, compositions and uses thereof
MX347209B (es)	2011-12-08	2017-04-19	Teva Pharmaceuticals Int Gmbh	La sal de bromhidrato de pridopidina.
CA2862289C (en)	2012-02-10	2019-11-26	Constellation Pharmaceuticals, Inc.	Modulators of methyl modifying enzymes, compositions and uses thereof
AU2013243461A1 (en)	2012-04-04	2014-11-06	Teva Pharmaceuticals International Gmbh	Pharmaceutical compositions for combination therapy
WO2014151142A1 (en)	2013-03-15	2014-09-25	Constellation Pharmaceuticals, Inc.	Modulators of methyl modifying enzymes, compositions and uses thereof
WO2015023915A1 (en)	2013-08-15	2015-02-19	Constellation Pharmaceuticals, Inc.	Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof
US10577350B2 (en)	2015-08-28	2020-03-03	Constellation Pharmaceuticals, Inc.	Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
EP3493807A1 (de)	2016-08-03	2019-06-12	CymaBay Therapeutics, Inc.	Oxymethylenarylverbindungen zur behandlung von entzündlichen gastrointestinalen krankheiten oder gastrointestinalen leiden
EP3529242A1 (de)	2016-10-19	2019-08-28	Constellation Pharmaceuticals, Inc.	Synthese von ezh2-hemmern

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US3350403A (en) *	1964-04-07	1967-10-31	Aldrich Chem Co Inc	Nu-phenyl amides of 4-phenyl-4-hydroxypiperidino alkyl acids
US3301862A (en) *	1964-04-07	1967-01-31	Aldrich Chem Co Inc	Nu-cyclopropyl, amides of 4-phenyl piperidino-alkanoic acids
DE2802306A1 (de)	1977-01-27	1978-08-10	Hoechst Ag	Azacycloalkane, azacycloalkene und ihre derivate
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US5227379A (en) *	1986-11-03	1993-07-13	Novo Nordisk A/S	Piperidine compounds and their preparation and use
DK231088D0 (da) *	1988-04-28	1988-04-28	Ferrosan As	Piperidinforbindelser, deres fremstilling og anvendelse
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FR2706894A1 (en) *	1993-06-22	1994-12-30	Synthelabo	N-Phenyl-N-(piperidinoalkyl)arylamide derivatives, their preparation and their application in therapeutics
WO1995024390A1 (en) *	1994-03-11	1995-09-14	Smithkline Beecham Plc	Novel phenyl(-alkyl/alkoxy)-1-aminoalkyl-substituted piperidines and pyrrolidines as calcium channel antagonists
US6048876A (en) *	1995-01-23	2000-04-11	Suntory Limited	Medicament for the alleviation or treatment of symptom derived from ischemic disease and compound useful therefor
US5723475A (en) *	1995-02-28	1998-03-03	Suntory Limited	Arylpiperidine and arylpiperazine derivatives and medicament containing the same
CA2231879C (en) *	1996-07-22	2007-01-23	Suntory Limited	Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same
EP0958280B1 (de) *	1997-10-31	2005-05-04	Daiichi Suntory Pharma Co., Ltd.	Arylpiperidinopropanol und arylpiperazinopropanol derivate und die selbe enthaltende pharmazeutika

1997
- 1997-07-22 CA CA002231879A patent/CA2231879C/en not_active Expired - Fee Related
- 1997-07-22 EP EP97930865A patent/EP0867183B1/de not_active Expired - Lifetime
- 1997-07-22 AU AU34640/97A patent/AU710594B2/en not_active Ceased
- 1997-07-22 KR KR1019980702029A patent/KR100537843B1/ko not_active Expired - Fee Related
- 1997-07-22 HU HU9904335A patent/HUP9904335A3/hu unknown
- 1997-07-22 ES ES97930865T patent/ES2225979T3/es not_active Expired - Lifetime
- 1997-07-22 AT AT97930865T patent/ATE278402T1/de not_active IP Right Cessation
- 1997-07-22 US US09/043,563 patent/US6455549B1/en not_active Expired - Fee Related
- 1997-07-22 DE DE69731070T patent/DE69731070T2/de not_active Expired - Fee Related
2002
- 2002-07-17 US US10/196,362 patent/US6706734B2/en not_active Expired - Fee Related
2004
- 2004-03-15 US US10/799,681 patent/US7498344B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69731070T2 (de)	2005-03-17
US6455549B1 (en)	2002-09-24
ES2225979T3 (es)	2005-03-16
CA2231879A1 (en)	1998-01-29
US7498344B2 (en)	2009-03-03
KR100537843B1 (ko)	2006-04-28
HUP9904335A3 (en)	2001-07-30
DE69731070D1 (de)	2004-11-11
US20030130312A1 (en)	2003-07-10
AU710594B2 (en)	1999-09-23
AU3464097A (en)	1998-02-10
US20040186138A1 (en)	2004-09-23
US6706734B2 (en)	2004-03-16
EP0867183A1 (de)	1998-09-30
HUP9904335A2 (hu)	2000-05-28
EP0867183A4 (de)	1999-11-17
KR20000064249A (ko)	2000-11-06
EP0867183B1 (de)	2004-10-06
CA2231879C (en)	2007-01-23

Legal Events

Date	Code	Title	Description
2005-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69731070D1 (de)	2004-11-11	Arylpiperidinol und arylpiperidin-derivate und sie enthaltende arzneimittel
DE3586794D1 (de)	1992-12-10	Arzneimittel mit psychotroper wirkung.
NZ237565A (en)	1993-02-25	Substituted thiazolidinones, oxazolidinones or imidazolidinones and antiinflammatory pharmaceutical compositions thereof
NZ314508A (en)	1999-06-29	1,2-diphenylpyrrole derivatives, preparation and pharmaceutical compositions
TW224464B (de)	1994-06-01
AU563683C (en)	2001-12-20	Substituted acyl derivative of 1,2,3,4-tetrahydroiso- quinoline-3-carboxylic acid
AU1769988A (en)	1988-12-22	Benzothiazole derivative
ATE197672T1 (de)	2000-12-15	Arzneimittel gegen nervöse erkrankungen
IL123002A0 (en)	1998-08-16	1-Phenyl-2- phenylacetoxy- ethanone derivatives
EP0268281A3 (en)	1989-01-18	Pyrrolidineamide derivative having anti-prolyl endopeptidase activity, compositions comprising the same, processes for the preparation of the same, and the use of the same for the preparation of a medicament of therapeutic value
ATE109770T1 (de)	1994-08-15	Derivate der coffeinsäure und pharmazeutische zusammensetzungen, die sie enthalten.
ES2071786T3 (es)	1995-07-01	Compuestos bloqueadores de nmda, composiciones farmaceuticas, su preparacion y su uso.
PH30229A (en)	1997-02-05	Pyridyl substituted benzothiazole compounds which has useful pharmaceutical utility
DE69001004D1 (de)	1993-04-08	Zusammensetzung gegen leberkrankheiten.
FR2549064B1 (fr)	1985-10-25	Nouveaux derives de synergistines utiles pour la preparation de nouveaux medicaments antimicrobiens et leur preparation
ATE159933T1 (de)	1997-11-15	Phenylsubstituierte cycloalkyl- hydroxyharnstoffderivate als lipoxygenase-hemmer
FR2682952B1 (fr)	1993-12-03	Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent.
ATE124410T1 (de)	1995-07-15	Antihypertensive 3-piperidinylindazol-derivate.
GB8907306D0 (en)	1989-05-17	New compositions of matter
FR2444462A1 (fr)	1980-07-18	Compositions pour controler l'hypertension et les troubles intestinaux comprenant un derive de n-aryl n'2-(imidazolidinylidene)-uree
ATE87004T1 (de)	1993-04-15	Fluor enthaltende makrolid-verbindungen, pharmazeutische zusammensetzungen, welche diese enthalten und ihre verwendung fuer die herstellung von arzneimitteln.