DK1268472T3 - 3-aminopyrazolinhibitorer af cyclinafhængige kinaser - Google Patents

3-aminopyrazolinhibitorer af cyclinafhængige kinaser

Info

Publication number: DK1268472T3
Authority: DK; Denmark
Prior art keywords: inhibitors; aminopyrazoline; cyclin; dependent kinases; useful
Prior art date: 2000-02-07

Application number

DK01948983T

Other languages

Danish (da)

English (en)

Inventor

Mark E Salvati

Spencer David Kimball

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-07

Filing date

2001-01-23

Publication date

2004-12-06

2001-01-23 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2004-12-06 Application granted granted Critical

2004-12-06 Publication of DK1268472T3 publication Critical patent/DK1268472T3/da

Links

CWZRXXJJOCTIJA-UHFFFAOYSA-N 2,3-dihydro-1h-pyrazol-5-amine Chemical compound NC1=CCNN1 CWZRXXJJOCTIJA-UHFFFAOYSA-N 0.000 title 1
108091007914 CDKs Proteins 0.000 title 1
102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 abstract 1
206010003246 arthritis Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
239000003909 protein kinase inhibitor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK01948983T 2000-02-07 2001-01-23 3-aminopyrazolinhibitorer af cyclinafhængige kinaser DK1268472T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18060900P	2000-02-07	2000-02-07
PCT/US2001/002208 WO2001057034A1 (en)	2000-02-07	2001-01-23	3-aminopyrazole inhibitors of cyclin dependent kinases

Publications (1)

Publication Number	Publication Date
DK1268472T3 true DK1268472T3 (da)	2004-12-06

Family

ID=22661092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01948983T DK1268472T3 (da)	2000-02-07	2001-01-23	3-aminopyrazolinhibitorer af cyclinafhængige kinaser

Country Status (11)

Country	Link
US (2)	US6482842B2 (de)
EP (1)	EP1268472B1 (de)
JP (1)	JP2003522174A (de)
AT (1)	ATE279410T1 (de)
AU (2)	AU2972701A (de)
CA (1)	CA2399274A1 (de)
DE (1)	DE60106409T2 (de)
DK (1)	DK1268472T3 (de)
ES (1)	ES2228905T3 (de)
PT (1)	PT1268472E (de)
WO (1)	WO2001057034A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60144277D1 (de)	2000-04-25	2011-05-05	Icos Corp	Hemmer der menschlichen phosphatidyl-inositol-3-kinase delta
US6667300B2 (en)	2000-04-25	2003-12-23	Icos Corporation	Inhibitors of human phosphatidylinositol 3-kinase delta
UA76977C2 (en)	2001-03-02	2006-10-16	Icos Corp	Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
AU2003287692A1 (en) *	2002-11-12	2004-06-03	The Board Of Trustees Of The University Of Illinois	Induction of cellular senescence by cdk4 disruption for tumor supression and regression
ATE410161T1 (de) *	2003-05-02	2008-10-15	Elan Pharm Inc	4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3- carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen
EP1655287A1 (de) *	2003-08-13	2006-05-10	BF Research Institute, Inc.	SONDE F R KRANKHEITEN MIT AMYLOIDABLAGERUNGEN, MITTEL ZUR AMYLOIDANFûRBUNG, HEILMITTEL UND VORBEUGENDES MITTEL F R KRANKHEITEN MIT AMYLOIDABLAGERUNGEN UND DIAGNOSTISCHE SONDE UND ANFûRBEMITTEL F R NEUROFIBRILLûRE VERûNDERUNGEN
WO2005047504A1 (en) *	2003-11-07	2005-05-26	The Board Of Trustees Of The University Of Illinois	Induction of cellular senescence by cdk4 disruption for tumor suppression and regression
LT2612862T (lt)	2004-05-13	2017-01-25	Icos Corporation	Chinazolinonai kaip žmogaus fosfatidilinozitol-3-kinazės delta inhibitoriai
WO2006127595A1 (en) *	2005-05-23	2006-11-30	Arena Pharmaceuticals, Inc.	5-aminopyrazole carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof
US9492449B2 (en)	2008-11-13	2016-11-15	Gilead Calistoga Llc	Therapies for hematologic malignancies
KR20170060179A (ko)	2008-11-13	2017-05-31	길리아드 칼리스토가 엘엘씨	혈액 종양에 대한 요법
CA2768843A1 (en)	2009-07-21	2011-01-27	Gilead Calistoga Llc	Treatment of liver disorders with pi3k inhibitors
ES2848273T3 (es)	2012-03-05	2021-08-06	Gilead Calistoga Llc	Formas polimórficas de (S)-2-(1-(9H-purin-6-ilamino)propilo)-5-fluoro-3-fenilquinazolina-4(3H)-ona
EP3083630B1 (de)	2013-12-20	2019-08-21	Gilead Calistoga LLC	Prozessverfahren für phosphatidylinositol-3-kinase-hemmer
JP2017500319A (ja)	2013-12-20	2017-01-05	ギリアードカリストガエルエルシー	（ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの塩酸塩の多形形態
US11021467B2 (en)	2014-06-13	2021-06-01	Gilead Sciences, Inc.	Phosphatidylinositol 3-kinase inhibitors

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* Cited by examiner, † Cited by third party
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US4416683A (en) *	1980-09-16	1983-11-22	Eli Lilly And Company	Benzamides, compositions and agricultural method
JPS6033552A (ja) *	1983-08-04	1985-02-20	Fuji Photo Film Co Ltd	カラ−画像形成方法
DE3575130D1 (de) *	1984-05-12	1990-02-08	Fisons Plc	Antiinflammatorische 1,n-diarylpyrazol-3-amine, deren zusammensetzungen und verfahren zu deren herstellung.
JPH0743522B2 (ja) *	1985-07-05	1995-05-15	コニカ株式会社	５―アミノ―１ｈ―ピラゾール系化合物を用いる写真用マゼンタカプラーの合成方法
JPH01258695A (ja) *	1988-04-07	1989-10-16	Yamanouchi Pharmaceut Co Ltd	（ピラゾリルアミノ）メチレンビス（ホスホン酸）誘導体及びその医薬
EP0646584A1 (de) *	1991-09-03	1995-04-05	Yamanouchi Pharmaceutical Co. Ltd.	Pyrazolotriazolderivate
JPH06210063A (ja) *	1993-01-14	1994-08-02	Kousaku Ishikawa	パチンコゲーム機における持ち玉返却機構
CA2203517A1 (en) *	1994-11-10	1996-05-23	Alan M. Laibelman	Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases
GB9619284D0 (en) *	1996-09-16	1996-10-30	Celltech Therapeutics Ltd	Chemical compounds
DE19744676A1 (de)	1997-10-10	1999-04-15	Forschungszentrum Borstel Zent	Kombinationspräparate für die Therapie von Tumoren
GB9904932D0 (en)	1999-03-04	1999-04-28	Glaxo Group Ltd	Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
HN2000000051A (es)	1999-05-19	2001-02-02	Pfizer Prod Inc	Derivados heterociclicos utiles como agentes anticancerosos
PE20010306A1 (es)	1999-07-02	2001-03-29	Agouron Pharma	Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
EP1199306B1 (de)	1999-07-26	2005-12-07	Banyu Pharmaceutical Co., Ltd.	Biaryl-harnstoff-derivate
MXPA02001498A (es) *	1999-08-12	2003-07-21	Pharmacia & Italia S P A	Derivados de 3(5)-amino-pirazol, procedimiento para la preparacion de los mismos y usos como agentes antitumorales.
US6387900B1 (en) *	1999-08-12	2002-05-14	Pharmacia & Upjohn S.P.A.	3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents

2001
- 2001-01-23 WO PCT/US2001/002208 patent/WO2001057034A1/en not_active Ceased
- 2001-01-23 AT AT01948983T patent/ATE279410T1/de not_active IP Right Cessation
- 2001-01-23 CA CA002399274A patent/CA2399274A1/en not_active Abandoned
- 2001-01-23 PT PT01948983T patent/PT1268472E/pt unknown
- 2001-01-23 AU AU2972701A patent/AU2972701A/xx active Pending
- 2001-01-23 AU AU2001229727A patent/AU2001229727B2/en not_active Ceased
- 2001-01-23 JP JP2001557866A patent/JP2003522174A/ja active Pending
- 2001-01-23 DE DE60106409T patent/DE60106409T2/de not_active Expired - Lifetime
- 2001-01-23 EP EP01948983A patent/EP1268472B1/de not_active Expired - Lifetime
- 2001-01-23 ES ES01948983T patent/ES2228905T3/es not_active Expired - Lifetime
- 2001-01-23 DK DK01948983T patent/DK1268472T3/da active
- 2001-02-06 US US09/777,273 patent/US6482842B2/en not_active Expired - Lifetime
2002
- 2002-08-15 US US10/219,844 patent/US6610724B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU2001229727B2 (en)	2004-10-14
PT1268472E (pt)	2005-01-31
US20010047019A1 (en)	2001-11-29
EP1268472A1 (de)	2003-01-02
ES2228905T3 (es)	2005-04-16
ATE279410T1 (de)	2004-10-15
JP2003522174A (ja)	2003-07-22
DE60106409D1 (de)	2004-11-18
WO2001057034A1 (en)	2001-08-09
US6482842B2 (en)	2002-11-19
DE60106409T2 (de)	2006-02-02
US20030018058A1 (en)	2003-01-23
AU2972701A (en)	2001-08-14
EP1268472B1 (de)	2004-10-13
CA2399274A1 (en)	2001-08-09
US6610724B2 (en)	2003-08-26

Publication	Publication Date	Title
DK1240165T3 (da)	2005-08-08	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamid-inhibitorer af cyclinafhængige kinaser
YU4903A (sh)	2006-03-03	N-/5-///5-alkil-2-oksazolil/metil/tio/-2-tiazolil/ karboksamidni inhibitori ciklin zavisnih kinaza
NZ517758A (en)	2004-06-25	Pyrazolopyrimidines useful as therapeutic agents
EE05481B1 (et)	2011-10-17	Kinasoliini derivaadid kasvajate raviks
ATE339418T1 (de)	2006-10-15	Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen
MXPA02005844A (es)	2004-08-12	Inhibidores de cinasas de proteina.
TW200607505A (en)	2006-03-01	Fused heterocyclic kinase inhibitors
NO2010002I2 (no)	2010-12-06	Toceranibfosfat.
DE60330895D1 (de)	2010-02-25	Verbindungen, die sich als inhibitoren vonjak und anderen proteinkinasen eignen
ATE371656T1 (de)	2007-09-15	Heteroaryl-pyrimidinderivate als jak-inhibitoren
DE60314603D1 (de)	2007-08-09	Zusammensetzungen brauchbar als protein-kinase- inhibitoren
ATE466580T1 (de)	2010-05-15	Azolylaminoazine als proteinkinasehemmer
ATE468336T1 (de)	2010-06-15	Azolylaminoazine als proteinkinasehemmer
ATE473980T1 (de)	2010-07-15	Triazolopyridazine als proteinkinase-inhibitoren
EA200300248A1 (ru)	2003-08-28	Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
PT1268472E (pt)	2005-01-31	Inibidores 3-aminopirazolicos de cinases dependentes da ciclina
MY125768A (en)	2006-08-30	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
CY1110666T1 (el)	2015-06-11	Πυραζολοπυριμιδινες καταλληλες για θεραπεια καρκινικων νοσων
ATE432281T1 (de)	2009-06-15	Pyrrolotriazin-kinasehemmer
DE60108626D1 (de)	2005-03-03	Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b] pyridinen als cyclin-abhängige kinase-hemmer
ATE546452T1 (de)	2012-03-15	Pyrazolopyrrolderivate als proteinkinaseinhibitoren
ATE389655T1 (de)	2008-04-15	Pyrimidinderivate
ECSP003821A (es)	2001-04-23	Inhibidores de n-(5(((5-alquil-2-oxazolil)metil)tio)-2-tiazolil)-carboxamida de cinasas dependientes de ciclina
ECSP003826A (es)	2001-07-27	Inhibidores de n-(5(((5-alquil-2-oxazolil)metil)tio)-2-tiazolil)-carboxamida de cinasas dependientes de ciclina
UY26732A1 (es)	2002-02-28	N-(5-(5-alquil-2-oxazolil)metil)tio)-2- tiazolil) carboxamidas inhibidoras de cinasa dependientes de la ciclina