ATE279935T1 - Neue synthetische cryptophycine - Google Patents

Neue synthetische cryptophycine

Info

Publication number: ATE279935T1
Authority: AT; Austria
Prior art keywords: cryptophycins; new synthetic; synthetic; new; synthetic cryptophycins
Prior art date: 1995-03-07

Application number

AT96910399T

Other languages

English (en)

Inventor

Richard E Moore

Marcus A Tius

Russell A Barrow

Jian Liang

Thomas H Corbett

Frederick A Valeriote

Thomas K Hemscheidt

Trimurtulu Golakoti

Original Assignee

Univ Hawaii

Univ Wayne State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-07

Filing date

1996-03-07

Publication date

2004-11-15

1995-03-07 Priority claimed from US08/400,057 external-priority patent/US6013626A/en

1995-06-07 Priority claimed from US08/482,141 external-priority patent/US5952298A/en

1996-03-07 Application filed by Univ Hawaii, Univ Wayne State filed Critical Univ Hawaii

2004-11-15 Application granted granted Critical

2004-11-15 Publication of ATE279935T1 publication Critical patent/ATE279935T1/de

Links

229930188224 Cryptophycin Natural products 0.000 title 1
108010002156 Depsipeptides Proteins 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT96910399T 1995-03-07 1996-03-07 Neue synthetische cryptophycine ATE279935T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/400,057 US6013626A (en)	1993-12-21	1995-03-07	Cryptophycins from synthesis
US08/482,141 US5952298A (en)	1993-12-21	1995-06-07	Cryptophycins
PCT/US1996/003246 WO1996040184A1 (en)	1995-03-07	1996-03-07	New cryptophycins from synthesis

Publications (1)

Publication Number	Publication Date
ATE279935T1 true ATE279935T1 (de)	2004-11-15

Family

ID=27016884

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96910399T ATE279935T1 (de)	1995-03-07	1996-03-07	Neue synthetische cryptophycine

Country Status (22)

Country	Link
EP (1)	EP0830136B1 (de)
JP (1)	JP4181632B2 (de)
CN (1)	CN1165337C (de)
AP (1)	AP737A (de)
AT (1)	ATE279935T1 (de)
AU (1)	AU723652B2 (de)
BG (1)	BG63289B1 (de)
CZ (1)	CZ278197A3 (de)
DE (1)	DE69633667T2 (de)
ES (1)	ES2230561T3 (de)
FI (1)	FI973591A0 (de)
GE (1)	GEP20002206B (de)
HU (1)	HU225041B1 (de)
MD (1)	MD2196B2 (de)
NO (1)	NO326685B1 (de)
NZ (1)	NZ305571A (de)
OA (1)	OA10614A (de)
PL (1)	PL185949B1 (de)
RO (1)	RO118931B1 (de)
SK (1)	SK119997A3 (de)
TJ (1)	TJ347B (de)
WO (1)	WO1996040184A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0850057A4 (de) *	1995-08-30	2001-04-11	Lilly Co Eli	Pharmazeutische zusammensetzungen
WO1998008505A1 (en) *	1996-08-30	1998-03-05	Eli Lilly And Company	Pharmaceutical compounds
AU4233997A (en) *	1996-08-30	1998-03-19	Eli Lilly And Company	Process for preparing pharmaceutical compounds
US6680311B1 (en)	1996-08-30	2004-01-20	Eli Lilly And Company	Cryptophycin compounds
EP0929535A4 (de) *	1996-09-06	2001-05-23	Lilly Co Eli	Verfahren und neue zwischenprodukte
WO1998009601A2 (en) *	1996-09-06	1998-03-12	Eli Lilly And Company	Process to prepare pharmaceutical compounds
KR20010029474A (ko) *	1996-09-06	2001-04-06	피터 지. 스트링거	제약 화합물의 제조 방법
CA2281107A1 (en) *	1997-02-26	1998-09-03	Eli Lilly And Company	Tripeptide and tetrapeptide pharmaceutical compounds
IL131162A0 (en) *	1997-02-26	2001-01-28	Lilly Co Eli	Selective epoxidation process for preparing pharmaceutical compounds
EP0870506A1 (de) *	1997-04-11	1998-10-14	Eli Lilly And Company	Zusammentsetzungen enthaltend ein Cryptophycin Derivat in Kombination mit einem synchronisierten Wirkstoff oder Aktivierungsmittel zur Behandlung von Krebs
EP0870501A1 (de) *	1997-04-11	1998-10-14	Eli Lilly And Company	Verwendung von specifischen Cryptophycin Derivaten zur Herstellung eines Medikaments für die Behandlung von Pilzinfektionen
EP0870510A3 (de) *	1997-04-11	1999-09-15	Eli Lilly And Company	Synergistische Zusammensetzung enthaltend Cryptophycinderivate und synergistische mikrotubuli Mitteln
JP2002527509A (ja) *	1998-10-16	2002-08-27	イーライ・リリー・アンド・カンパニー	抗腫瘍剤を製造するための立体選択的な方法
US6376230B1 (en)	1998-10-16	2002-04-23	Eli Lilly And Company	Stereoselective process for producing intermediates of cryptophycins
US6103913A (en) *	1998-10-16	2000-08-15	Eli Lilly And Company	Process for preparing enollactone derivatives
WO2000034252A2 (en) *	1998-12-07	2000-06-15	Eli Lilly And Company	Process for the preparation of cryptophycin derivatives
US6372936B1 (en) *	1999-06-09	2002-04-16	Eli Lilly And Company	Optical resolution of aminoisobobutyric acid
FR2947269B1 (fr)	2009-06-29	2013-01-18	Sanofi Aventis	Nouveaux composes anticancereux
US11530204B2 (en) *	2019-09-30	2022-12-20	The Regents Of The University Of Michigan	Biocatalytic synthesis of cryptophycin anticancer agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4946835A (en) *	1988-07-15	1990-08-07	Merck & Co., Inc.	Antifungal fermentation product and method
US4868208A (en) *	1988-07-15	1989-09-19	Merck & Co., Inc.	Antifungal agent and method
US4845086A (en) *	1988-08-09	1989-07-04	Merck & Co., Inc.	Antifungal agent
US4845085A (en) *	1988-08-09	1989-07-04	Merck & Co., Inc.	Antifungal agent
ATE203016T1 (de) *	1993-12-21	2001-07-15	Univ Hawaii	Cryptophycine

1996
- 1996-03-07 DE DE69633667T patent/DE69633667T2/de not_active Expired - Lifetime
- 1996-03-07 HU HU9801880A patent/HU225041B1/hu not_active IP Right Cessation
- 1996-03-07 AT AT96910399T patent/ATE279935T1/de not_active IP Right Cessation
- 1996-03-07 RO RO97-01693A patent/RO118931B1/ro unknown
- 1996-03-07 MD MD97-0313A patent/MD2196B2/ro unknown
- 1996-03-07 ES ES96910399T patent/ES2230561T3/es not_active Expired - Lifetime
- 1996-03-07 GE GEAP19963909A patent/GEP20002206B/en unknown
- 1996-03-07 WO PCT/US1996/003246 patent/WO1996040184A1/en not_active Ceased
- 1996-03-07 CZ CZ972781A patent/CZ278197A3/cs unknown
- 1996-03-07 CN CNB96193140XA patent/CN1165337C/zh not_active Expired - Lifetime
- 1996-03-07 TJ TJ97000493A patent/TJ347B/xx unknown
- 1996-03-07 JP JP50044097A patent/JP4181632B2/ja not_active Expired - Lifetime
- 1996-03-07 NZ NZ305571A patent/NZ305571A/xx not_active IP Right Cessation
- 1996-03-07 SK SK1199-97A patent/SK119997A3/sk unknown
- 1996-03-07 AP APAP/P/1997/001069A patent/AP737A/en active
- 1996-03-07 PL PL96322507A patent/PL185949B1/pl unknown
- 1996-03-07 AU AU53603/96A patent/AU723652B2/en not_active Expired
- 1996-03-07 EP EP96910399A patent/EP0830136B1/de not_active Expired - Lifetime
1997
- 1997-09-03 FI FI973591A patent/FI973591A0/fi not_active Application Discontinuation
- 1997-09-04 BG BG101875A patent/BG63289B1/bg unknown
- 1997-09-05 OA OA70070A patent/OA10614A/en unknown
- 1997-09-05 NO NO19974105A patent/NO326685B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH11510476A (ja)	1999-09-14
NO974105D0 (no)	1997-09-05
MD970313A (en)	1999-06-30
HUP9801880A3 (en)	1999-08-30
PL322507A1 (en)	1998-02-02
GEP20002206B (en)	2000-08-25
SK119997A3 (en)	1998-12-02
RO118931B1 (ro)	2004-01-30
EP0830136A4 (de)	2001-01-24
CN1183726A (zh)	1998-06-03
AU723652B2 (en)	2000-08-31
CZ278197A3 (cs)	1998-12-16
EP0830136B1 (de)	2004-10-20
AP737A (en)	1999-03-15
DE69633667T2 (de)	2006-03-02
HU225041B1 (en)	2006-05-29
HK1009747A1 (en)	1999-06-11
NZ305571A (en)	1999-02-25
PL185949B1 (pl)	2003-09-30
HUP9801880A2 (hu)	1998-11-30
NO974105L (no)	1997-11-05
NO326685B1 (no)	2009-01-26
AP9701069A0 (en)	1997-10-30
WO1996040184A1 (en)	1996-12-19
AU5360396A (en)	1996-12-30
TJ347B (en)	2002-10-06
OA10614A (en)	2001-03-15
BG101875A (en)	1998-10-30
JP4181632B2 (ja)	2008-11-19
BG63289B1 (bg)	2001-09-28
ES2230561T3 (es)	2005-05-01
CN1165337C (zh)	2004-09-08
EP0830136A1 (de)	1998-03-25
MD2196B2 (ro)	2003-06-30
FI973591A0 (fi)	1997-09-03
DE69633667D1 (en)	2004-11-25

Legal Events

Date	Code	Title	Description
2005-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69635700D1 (de)	2006-03-30	Neue endoglukanase
DE69635284D1 (de)	2006-02-23	Neue substituierte napthopyrane
FI972970L (fi)	1997-09-11	Uusia yhdisteitä
FI20030370L (fi)	2003-03-12	Uusia yhdisteitä
DE69604220D1 (de)	1999-10-21	Luftentfeuchter
EP0833628A4 (de)	2002-05-02	Neue taxoide
DE69536102D1 (de)	2010-10-21	Neue streptogramine
DE69519878D1 (de)	2001-02-15	Intrafokaler dübel
EP0738153A4 (de)	2000-09-06	Synthetische insulinmimetische substanzen
DE59601652D1 (de)	1999-05-20	Spulenkörper
DE59610056D1 (de)	2003-02-20	Plastisol-zusammensetzung
NO960353L (no)	1996-07-29	4-aminobenzoylguanidinderivater
NO960392D0 (no)	1996-01-30	4-merkaptobenzoylguanidinderivater
DE59600225D1 (de)	1998-07-02	Wickelkörper
FI953052A0 (fi)	1995-06-20	Lagring och kopplingselement foer en utbredningsvals
DE69620322D1 (de)	2002-05-08	Asymmetrische Triphenylendioxazinverbindungen
KR970012123U (ko)	1997-04-25	수세미
FI952517A0 (fi)	1995-05-23	Parkeringsbetalningssystem och en fjaerrlaesanordning
SE9503561D0 (sv)	1995-10-12	New Compounds
FI954924A0 (fi)	1995-10-16	Syntetiska smoerjmedelsbasoljor
SE9501893D0 (sv)	1995-05-29	Grepp 1
UA1291S (uk)	1996-09-30	Штурмовий ніж-пістолет "касатка"
KR960031508U (ko)	1996-10-22	북직기의 북집
FI952087A0 (fi)	1995-05-02	Vaeska och i vaeskan faestbar skiva
FI950025A0 (fi)	1995-01-03	Foerfarande och anordning i fordonens bromsanordning