NO974105D0 - Nye kryptofyciner fra syntese - Google Patents

Nye kryptofyciner fra syntese

Info

Publication number
NO974105D0
NO974105D0 NO974105A NO974105A NO974105D0 NO 974105 D0 NO974105 D0 NO 974105D0 NO 974105 A NO974105 A NO 974105A NO 974105 A NO974105 A NO 974105A NO 974105 D0 NO974105 D0 NO 974105D0
Authority
NO
Norway
Prior art keywords
synthesis
cryptophycins
new
new cryptophycins
Prior art date
Application number
NO974105A
Other languages
English (en)
Other versions
NO974105L (no
NO326685B1 (no
Inventor
Richard Elliott Moore
Marcus A Tius
Russell A Barrrow
Jian Liang
Thomas Hughes Corbett
Frederick A Valeriote
Thomas K Hemscheidt
Original Assignee
Univ Hawaii
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/400,057 external-priority patent/US6013626A/en
Priority claimed from US08/482,141 external-priority patent/US5952298A/en
Application filed by Univ Hawaii, Univ Wayne State filed Critical Univ Hawaii
Publication of NO974105D0 publication Critical patent/NO974105D0/no
Publication of NO974105L publication Critical patent/NO974105L/no
Publication of NO326685B1 publication Critical patent/NO326685B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO19974105A 1995-03-07 1997-09-05 Kryptofyciner samt anvendelse derav og farmasoytisk blanding NO326685B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/400,057 US6013626A (en) 1993-12-21 1995-03-07 Cryptophycins from synthesis
US08/482,141 US5952298A (en) 1993-12-21 1995-06-07 Cryptophycins
PCT/US1996/003246 WO1996040184A1 (en) 1995-03-07 1996-03-07 New cryptophycins from synthesis

Publications (3)

Publication Number Publication Date
NO974105D0 true NO974105D0 (no) 1997-09-05
NO974105L NO974105L (no) 1997-11-05
NO326685B1 NO326685B1 (no) 2009-01-26

Family

ID=27016884

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19974105A NO326685B1 (no) 1995-03-07 1997-09-05 Kryptofyciner samt anvendelse derav og farmasoytisk blanding

Country Status (22)

Country Link
EP (1) EP0830136B1 (no)
JP (1) JP4181632B2 (no)
CN (1) CN1165337C (no)
AP (1) AP737A (no)
AT (1) ATE279935T1 (no)
AU (1) AU723652B2 (no)
BG (1) BG63289B1 (no)
CZ (1) CZ278197A3 (no)
DE (1) DE69633667T2 (no)
ES (1) ES2230561T3 (no)
FI (1) FI973591A0 (no)
GE (1) GEP20002206B (no)
HU (1) HU225041B1 (no)
MD (1) MD2196B2 (no)
NO (1) NO326685B1 (no)
NZ (1) NZ305571A (no)
OA (1) OA10614A (no)
PL (1) PL185949B1 (no)
RO (1) RO118931B1 (no)
SK (1) SK119997A3 (no)
TJ (1) TJ347B (no)
WO (1) WO1996040184A1 (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850057A4 (en) * 1995-08-30 2001-04-11 Lilly Co Eli Pharmaceutical compounds
WO1998008505A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Pharmaceutical compounds
AU4233997A (en) * 1996-08-30 1998-03-19 Eli Lilly And Company Process for preparing pharmaceutical compounds
US6680311B1 (en) 1996-08-30 2004-01-20 Eli Lilly And Company Cryptophycin compounds
EP0929535A4 (en) * 1996-09-06 2001-05-23 Lilly Co Eli PROCESS AND NEW INTERMEDIATE PRODUCTS
WO1998009601A2 (en) * 1996-09-06 1998-03-12 Eli Lilly And Company Process to prepare pharmaceutical compounds
KR20010029474A (ko) * 1996-09-06 2001-04-06 피터 지. 스트링거 제약 화합물의 제조 방법
CA2281107A1 (en) * 1997-02-26 1998-09-03 Eli Lilly And Company Tripeptide and tetrapeptide pharmaceutical compounds
IL131162A0 (en) * 1997-02-26 2001-01-28 Lilly Co Eli Selective epoxidation process for preparing pharmaceutical compounds
EP0870506A1 (en) * 1997-04-11 1998-10-14 Eli Lilly And Company Compositions comprising a cryptophycin compound in combination with a synchronizing or activating agent for treating cancer
EP0870501A1 (en) * 1997-04-11 1998-10-14 Eli Lilly And Company Use of specific cryptophycin derivatives for the manufacture of a medicament in the treatment of fungal infections
EP0870510A3 (en) * 1997-04-11 1999-09-15 Eli Lilly And Company Synergistic combination comprising cryptophycin derivatives and microtubule synergizing agents
JP2002527509A (ja) * 1998-10-16 2002-08-27 イーライ・リリー・アンド・カンパニー 抗腫瘍剤を製造するための立体選択的な方法
US6376230B1 (en) 1998-10-16 2002-04-23 Eli Lilly And Company Stereoselective process for producing intermediates of cryptophycins
US6103913A (en) * 1998-10-16 2000-08-15 Eli Lilly And Company Process for preparing enollactone derivatives
WO2000034252A2 (en) * 1998-12-07 2000-06-15 Eli Lilly And Company Process for the preparation of cryptophycin derivatives
US6372936B1 (en) * 1999-06-09 2002-04-16 Eli Lilly And Company Optical resolution of aminoisobobutyric acid
FR2947269B1 (fr) 2009-06-29 2013-01-18 Sanofi Aventis Nouveaux composes anticancereux
US11530204B2 (en) * 2019-09-30 2022-12-20 The Regents Of The University Of Michigan Biocatalytic synthesis of cryptophycin anticancer agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
ATE203016T1 (de) * 1993-12-21 2001-07-15 Univ Hawaii Cryptophycine

Also Published As

Publication number Publication date
JPH11510476A (ja) 1999-09-14
MD970313A (en) 1999-06-30
HUP9801880A3 (en) 1999-08-30
PL322507A1 (en) 1998-02-02
GEP20002206B (en) 2000-08-25
SK119997A3 (en) 1998-12-02
RO118931B1 (ro) 2004-01-30
EP0830136A4 (en) 2001-01-24
CN1183726A (zh) 1998-06-03
AU723652B2 (en) 2000-08-31
CZ278197A3 (cs) 1998-12-16
EP0830136B1 (en) 2004-10-20
AP737A (en) 1999-03-15
DE69633667T2 (de) 2006-03-02
HU225041B1 (en) 2006-05-29
HK1009747A1 (en) 1999-06-11
NZ305571A (en) 1999-02-25
ATE279935T1 (de) 2004-11-15
PL185949B1 (pl) 2003-09-30
HUP9801880A2 (hu) 1998-11-30
NO974105L (no) 1997-11-05
NO326685B1 (no) 2009-01-26
AP9701069A0 (en) 1997-10-30
WO1996040184A1 (en) 1996-12-19
AU5360396A (en) 1996-12-30
TJ347B (en) 2002-10-06
OA10614A (en) 2001-03-15
BG101875A (en) 1998-10-30
JP4181632B2 (ja) 2008-11-19
BG63289B1 (bg) 2001-09-28
ES2230561T3 (es) 2005-05-01
CN1165337C (zh) 2004-09-08
EP0830136A1 (en) 1998-03-25
MD2196B2 (ro) 2003-06-30
FI973591A0 (fi) 1997-09-03
DE69633667D1 (en) 2004-11-25

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