ATE282826T1 - Interaktion zwischen cyclin d1 und koaktivatoren von steroidrezeptoren - Google Patents

Interaktion zwischen cyclin d1 und koaktivatoren von steroidrezeptoren

Info

Publication number
ATE282826T1
ATE282826T1 AT99905027T AT99905027T ATE282826T1 AT E282826 T1 ATE282826 T1 AT E282826T1 AT 99905027 T AT99905027 T AT 99905027T AT 99905027 T AT99905027 T AT 99905027T AT E282826 T1 ATE282826 T1 AT E282826T1
Authority
AT
Austria
Prior art keywords
cyclin
coactivators
assays
interaction
tumors
Prior art date
Application number
AT99905027T
Other languages
English (en)
Inventor
Rene Bernards
Renate Zwijsen
Original Assignee
Topotarget Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9803035.6A external-priority patent/GB9803035D0/en
Priority claimed from GBGB9818243.9A external-priority patent/GB9818243D0/en
Application filed by Topotarget Uk Ltd filed Critical Topotarget Uk Ltd
Application granted granted Critical
Publication of ATE282826T1 publication Critical patent/ATE282826T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Inorganic Fibers (AREA)
  • Color Printing (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
AT99905027T 1998-02-12 1999-02-12 Interaktion zwischen cyclin d1 und koaktivatoren von steroidrezeptoren ATE282826T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9803035.6A GB9803035D0 (en) 1998-02-12 1998-02-12 Assay
GBGB9818243.9A GB9818243D0 (en) 1998-08-20 1998-08-20 Improvements relating to assays
PCT/GB1999/000440 WO1999041608A2 (en) 1998-02-12 1999-02-12 Interaction between cyclin d1 and steroid receptor co-activators

Publications (1)

Publication Number Publication Date
ATE282826T1 true ATE282826T1 (de) 2004-12-15

Family

ID=26313108

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99905027T ATE282826T1 (de) 1998-02-12 1999-02-12 Interaktion zwischen cyclin d1 und koaktivatoren von steroidrezeptoren

Country Status (8)

Country Link
US (2) US6350572B1 (de)
EP (1) EP1055125B1 (de)
JP (1) JP2002503811A (de)
AT (1) ATE282826T1 (de)
AU (1) AU2533499A (de)
CA (1) CA2319167A1 (de)
DE (1) DE69921967D1 (de)
WO (1) WO1999041608A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018124A1 (en) * 1997-10-07 1999-04-15 Merck & Co., Inc. Assays for nuclear receptor ligands using fret
AU2533499A (en) * 1998-02-12 1999-08-30 Prolifix Limited Interaction between cyclin d1 and steroid receptor co-activators and uses thereof in assays
US20020037514A1 (en) * 2000-03-24 2002-03-28 Klein Elliott S. Identification of nuclear receptor-dependent coregulator recruitment
DE10046647A1 (de) * 2000-09-20 2002-03-28 Ludwig Wildt Verfahren zur Bestimmung der Peptidhormon-Aktivitäten oder der Steroidhormon-Aktivitäten eines Materials oder Stoffgemisches
EP1275965A1 (de) * 2001-07-13 2003-01-15 Boehringer Ingelheim International GmbH Verfahren zum Identifizieren von Substanzen, die die Interleukin-4 (IL-4) Signalkette beeinflussen
US7226747B2 (en) 2001-07-13 2007-06-05 Boehringer Ingelheim Corporation Method of identifying substances which modulate interleukin 4(IL-4) signaling
ES2253318T3 (es) * 2001-11-07 2006-06-01 Schering Ag Cribado in vitro de ligandos del receptor de estrogeno.
US20030228607A1 (en) * 2002-04-15 2003-12-11 Wagner Brandee Lynn Screening method and modulators having an improved therapeutic profile
US20040235027A1 (en) * 2003-03-31 2004-11-25 Regent Of The University Of California Preparation and application of ligand-biopolymer conjugates
WO2005018575A2 (en) * 2003-08-26 2005-03-03 Board Of Regents, The University Of Texas System Estrogen receptor modulators and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020026037A1 (en) * 1995-06-06 2002-02-28 Jing-Shan Hu Vascular endothelial growth factor 3 antibodies
GB9608143D0 (en) * 1996-04-19 1996-06-26 Ver Nl Kanker Inst Assay
AU2533499A (en) 1998-02-12 1999-08-30 Prolifix Limited Interaction between cyclin d1 and steroid receptor co-activators and uses thereof in assays

Also Published As

Publication number Publication date
EP1055125B1 (de) 2004-11-17
US6350572B1 (en) 2002-02-26
EP1055125A2 (de) 2000-11-29
CA2319167A1 (en) 1999-08-19
US7012128B2 (en) 2006-03-14
WO1999041608A2 (en) 1999-08-19
DE69921967D1 (de) 2004-12-23
JP2002503811A (ja) 2002-02-05
US20020177177A1 (en) 2002-11-28
WO1999041608A3 (en) 1999-11-11
AU2533499A (en) 1999-08-30

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