ATE283270T1 - Condensierte pyridazine derivate,deren herstellung und verwendung - Google Patents

Condensierte pyridazine derivate,deren herstellung und verwendung

Info

Publication number: ATE283270T1
Authority: AT; Austria
Prior art keywords: substituted; group; atom; hydrogen atom; independently
Prior art date: 1997-04-25

Application number

AT98917645T

Other languages

English (en)

Inventor

Yasuhiko Kawano

Hideaki Nagaya

Michiyo Gyoten

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-25

Filing date

1998-04-23

Publication date

2004-12-15

1998-04-23 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2004-12-15 Application granted granted Critical

2004-12-15 Publication of ATE283270T1 publication Critical patent/ATE283270T1/de

Links

PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical class C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
239000004215 Carbon black (E152) Substances 0.000 abstract 1
206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
206010012438 Dermatitis atopic Diseases 0.000 abstract 1
206010039085 Rhinitis allergic Diseases 0.000 abstract 1
206010052568 Urticaria chronic Diseases 0.000 abstract 1
208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
201000010105 allergic rhinitis Diseases 0.000 abstract 1
230000001387 anti-histamine Effects 0.000 abstract 1
239000000739 antihistaminic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
208000024376 chronic urticaria Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
230000013764 eosinophil chemotaxis Effects 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
150000002430 hydrocarbons Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT98917645T 1997-04-25 1998-04-23 Condensierte pyridazine derivate,deren herstellung und verwendung ATE283270T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP10991497		1997-04-25
JP4668898		1998-02-27
PCT/JP1998/001869 WO1998049167A1 (en)	1997-04-25	1998-04-23	Condensed pyridazine derivatives, their production and use

Publications (1)

Publication Number	Publication Date
ATE283270T1 true ATE283270T1 (de)	2004-12-15

Family

ID=26386797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98917645T ATE283270T1 (de)	1997-04-25	1998-04-23	Condensierte pyridazine derivate,deren herstellung und verwendung

Country Status (9)

Country	Link
US (1)	US6248740B1 (de)
EP (1)	EP0979231B1 (de)
KR (1)	KR100389192B1 (de)
CN (1)	CN1248259A (de)
AT (1)	ATE283270T1 (de)
AU (1)	AU7079998A (de)
CA (1)	CA2285264A1 (de)
DE (1)	DE69827786T2 (de)
WO (1)	WO1998049167A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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EP1026160A4 (de)	1997-09-16	2003-01-22	Takeda Chemical Industries Ltd	Verbindungen mit stickstoffhaltigen, kondensierten ringen, verfahren zu ihrer herstellung und medikamente
CA2346659A1 (en) *	1998-10-06	2000-04-13	Michiyo Gyoten	Condensed pyridazine compounds, their production and use
CN1329614A (zh) *	1998-10-21	2002-01-02	武田药品工业株式会社	稠合的哒嗪衍生物、它们的制备方法和用途
KR20020050275A (ko) *	1999-11-11	2002-06-26	다케다 야쿠힌 고교 가부시키가이샤	융합 피리다진 유도체를 함유하는 점비제
FR2815031A1 (fr) *	2000-10-11	2002-04-12	Gilles Fillion	Compositions et methodes pour la regulation du systeme nerveux
WO2003018020A1 (en) *	2001-08-23	2003-03-06	Takeda Chemical Industries, Ltd.	Jnk inhibitors
US20040137052A1 (en) *	2001-12-25	2004-07-15	Yoshihiro Uchiyama	Acid-containing preparations
WO2004093878A1 (en)	2003-04-16	2004-11-04	Alcon, Inc.	Use of fused pyridazine derivatives for treating dry eye disorders
WO2004096794A1 (en) *	2003-05-01	2004-11-11	Vernalis Research Limited	Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disordrs
DE102005042742A1 (de) *	2005-09-02	2007-03-08	Schering Ag	Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
US7750000B2 (en)	2005-09-02	2010-07-06	Bayer Schering Pharma Ag	Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
EP1845098A1 (de) *	2006-03-29	2007-10-17	Ferrer Internacional, S.A.	Imidazo[1,2-b]pyridazinen, deren Herstellungverfahren und ihre Verwendung als GABA Rezeptor Liganden
WO2010033941A1 (en)	2008-09-22	2010-03-25	Array Biopharma Inc.	Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
MY169791A (en)	2008-10-22	2019-05-15	Array Biopharma Inc	Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors
AR077468A1 (es)	2009-07-09	2011-08-31	Array Biopharma Inc	Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
ME03376B (de)	2010-05-20	2020-01-20	Array Biopharma Inc	Makrocyclische verbindungen als trk-kinasehemmer
JP2016538306A (ja) *	2013-11-27	2016-12-08	アメリカ合衆国	複素環化合物及びその使用方法
CN105503877A (zh)	2014-09-24	2016-04-20	和记黄埔医药（上海）有限公司	咪唑并哒嗪类化合物及其用途
CN113354649B (zh)	2014-11-16	2024-12-10	阵列生物制药公司	一种新的晶型
EP3368039A1 (de)	2015-10-26	2018-09-05	The Regents of The University of Colorado, A Body Corporate	Punktmutationen bei trk-inhibitor-resistentem krebs und zugehörige verfahren
US10045991B2 (en)	2016-04-04	2018-08-14	Loxo Oncology, Inc.	Methods of treating pediatric cancers
FI3439662T3 (fi)	2016-04-04	2024-09-04	Loxo Oncology Inc	(s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita
EP3458456B1 (de)	2016-05-18	2020-11-25	Loxo Oncology Inc.	Herstellung von (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
JOP20190092A1 (ar)	2016-10-26	2019-04-25	Array Biopharma Inc	عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar)	2017-03-16	2019-09-16	Array Biopharma Inc	مركبات حلقية ضخمة كمثبطات لكيناز ros1
US10513515B2 (en)	2017-08-25	2019-12-24	Biotheryx, Inc.	Ether compounds and uses thereof
CA3106239A1 (en)	2018-07-27	2020-01-30	Biotheryx, Inc.	Bifunctional compounds as cdk modulators
WO2021222150A2 (en)	2020-04-28	2021-11-04	Anwita Biosciences, Inc.	Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3878217A (en) *	1972-01-28	1975-04-15	Richardson Merrell Inc	Alpha-aryl-4-substituted piperidinoalkanol derivatives
PH27291A (en)	1989-01-31	1993-05-04	Takeda Chemical Industries Ltd	Imidazolpyrimidazines their production and use
EP0440119A1 (de)	1990-01-31	1991-08-07	Takeda Chemical Industries, Ltd.	Imidazopyridazinverbindungen, ihre Herstellung und Verwendung
EP0444549B1 (de)	1990-03-01	1995-01-25	Takeda Chemical Industries, Ltd.	Imidazopyridazine, ihre Herstellung und Verwendung
TW211013B (de) *	1991-12-27	1993-08-11	Takeda Pharm Industry Co Ltd
LT3200B (en) *	1992-03-18	1995-03-27	Takeda Chemical Industries Ltd	Triazolopyridazine methodfor production thereof and use
DE69322673T2 (de)	1992-03-18	1999-05-06	Takeda Chemical Industries, Ltd., Osaka	Imidazopyridazine als Antiasthmatika
EP0620224B1 (de)	1993-04-12	1998-07-15	Takeda Chemical Industries, Ltd.	Triazolopyridazin-Derivate, ihre Herstellung und Verwendung
JPH0717971A (ja) *	1993-07-02	1995-01-20	Takeda Chem Ind Ltd	イミダゾール誘導体、その製造法及び用途
TW304878B (de)	1993-09-21	1997-05-11	Takeda Pharm Industry Co Ltd
WO1996008496A1 (en)	1994-09-16	1996-03-21	Takeda Chemical Industries, Ltd.	Triazolopyridazines process and intermediates for their preparation and their use as medicaments
WO1996023798A1 (en)	1995-01-30	1996-08-08	Takeda Chemical Industries, Ltd.	Cephem compounds, their production and use

1998
- 1998-04-23 CA CA002285264A patent/CA2285264A1/en not_active Abandoned
- 1998-04-23 DE DE69827786T patent/DE69827786T2/de not_active Expired - Lifetime
- 1998-04-23 AT AT98917645T patent/ATE283270T1/de not_active IP Right Cessation
- 1998-04-23 CN CN98802792A patent/CN1248259A/zh active Pending
- 1998-04-23 EP EP98917645A patent/EP0979231B1/de not_active Expired - Lifetime
- 1998-04-23 AU AU70799/98A patent/AU7079998A/en not_active Abandoned
- 1998-04-23 WO PCT/JP1998/001869 patent/WO1998049167A1/en not_active Ceased
- 1998-04-23 KR KR10-1999-7003249A patent/KR100389192B1/ko not_active Expired - Fee Related
- 1998-04-23 US US09/284,362 patent/US6248740B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU7079998A (en)	1998-11-24
EP0979231A1 (de)	2000-02-16
CA2285264A1 (en)	1998-11-05
DE69827786T2 (de)	2005-11-24
EP0979231B1 (de)	2004-11-24
DE69827786D1 (de)	2004-12-30
KR20000049156A (ko)	2000-07-25
CN1248259A (zh)	2000-03-22
US6248740B1 (en)	2001-06-19
KR100389192B1 (ko)	2003-06-27
WO1998049167A1 (en)	1998-11-05

Legal Events

Date	Code	Title	Description
2005-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE283270T1 (de)	2004-12-15	Condensierte pyridazine derivate,deren herstellung und verwendung
ATE256128T1 (de)	2003-12-15	Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung
ATE416176T1 (de)	2008-12-15	Kondensierte chinolinderivate und deren anwendung
ATE15182T1 (de)	1985-09-15	Benzochinon-derivate und deren herstellung.
BR122017028096B8 (pt)	2021-05-25	composto, composição farmacêutica, e, uso do composto
HUP0204418A2 (hu)	2003-04-28	NHE-1 inhibitor hatású N-[(helyettesített öttagú, di- vagy triaza-, kétszeresen telítetlen gyűrű)-karbonil]-guanidin-származékok és alkalmazásuk
TR200002671T2 (tr)	2000-12-21	Bisiklo(2.2.1)Heptanlar ve ilgili bileşikler
BRPI0606319A2 (pt)	2009-06-16	compostos farmacêuticos
NO972666D0 (no)	1997-06-10	Anilinderivater med nitrogenmonoksyd-synteseinhiberende aktivitet
ATE155133T1 (de)	1997-07-15	Piperazinderivate als 5-ht antagonisten
ATE144772T1 (de)	1996-11-15	Piperazinderivate
EP1400513A4 (de)	2005-04-13	Unsymmetrische cyclische diaminverbindung
CO4700298A1 (es)	1998-12-29	Derivados de 3-fenilisoquinoleina-1 (2h)-ona, su preparacion y su aplicacion en la terapeutica
ES2161828T3 (es)	2001-12-16	Derivados de piperidina y agentes antiplaquetarios que los contienen.
SE9102909D0 (sv)	1991-10-09	New use
ATE321552T1 (de)	2006-04-15	1-substituierte-phenyl-1-(1h-imidazol-4- yl)alkohole, verfahren zu deren herstellung sowie deren verwendung
ATE464295T1 (de)	2010-04-15	Cyclische diaminverbindung mit fünfgliedriger cyclischer gruppe
ATE252580T1 (de)	2003-11-15	Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten
DE69523259D1 (de)	2001-11-22	Amine Derivate, ihre Herstellung und Anwendung
DE69810373D1 (de)	2003-02-06	Pyrrolidin Derivate, Anti-ulcus und Antibakterielle Arzneimittel
ATE137747T1 (de)	1996-05-15	Aminobenzolverbindungen, herstellung und verwendung
DE69708484D1 (de)	2002-01-10	Pyridinderivate,als Arzneimittel zur Behandlung von Geschwüren und als antibakterielle Mittel
DE69918046D1 (de)	2004-07-22	Neue basische Derivate von Benz(e)isoindol-1-onen und Pyrrolo(3,4-c)chinolin-1-onen mit 5-HT3-antagonistischer Aktivität, ihre Herstellung und ihre therapeutische Verwendung
DE60106168D1 (de)	2004-11-11	Substituierte 1-aza-2-imino-heterocyclen und ihre verwendung als aktivatoren der nikotinergen acetylcholinrezeptoren
HUP9900895A2 (hu)	1999-07-28	Simaizom sejtburjánzást gátló 2-szubsztituált benzimidazolszármazékok