ATE283270T1 - Condensierte pyridazine derivate,deren herstellung und verwendung - Google Patents
Condensierte pyridazine derivate,deren herstellung und verwendungInfo
- Publication number
- ATE283270T1 ATE283270T1 AT98917645T AT98917645T ATE283270T1 AT E283270 T1 ATE283270 T1 AT E283270T1 AT 98917645 T AT98917645 T AT 98917645T AT 98917645 T AT98917645 T AT 98917645T AT E283270 T1 ATE283270 T1 AT E283270T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- group
- atom
- hydrogen atom
- independently
- Prior art date
Links
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical class C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 206010052568 Urticaria chronic Diseases 0.000 abstract 1
- 208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 208000024376 chronic urticaria Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000013764 eosinophil chemotaxis Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10991497 | 1997-04-25 | ||
| JP4668898 | 1998-02-27 | ||
| PCT/JP1998/001869 WO1998049167A1 (en) | 1997-04-25 | 1998-04-23 | Condensed pyridazine derivatives, their production and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE283270T1 true ATE283270T1 (de) | 2004-12-15 |
Family
ID=26386797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98917645T ATE283270T1 (de) | 1997-04-25 | 1998-04-23 | Condensierte pyridazine derivate,deren herstellung und verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6248740B1 (de) |
| EP (1) | EP0979231B1 (de) |
| KR (1) | KR100389192B1 (de) |
| CN (1) | CN1248259A (de) |
| AT (1) | ATE283270T1 (de) |
| AU (1) | AU7079998A (de) |
| CA (1) | CA2285264A1 (de) |
| DE (1) | DE69827786T2 (de) |
| WO (1) | WO1998049167A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6407116B1 (en) | 1997-09-16 | 2002-06-18 | Takeda Chemical Industries, Inc. | Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs |
| AU6003099A (en) * | 1998-10-06 | 2000-04-26 | Takeda Chemical Industries Ltd. | Fused pyridazine compounds, process for the preparation of the same and uses thereof |
| ATE256128T1 (de) | 1998-10-21 | 2003-12-15 | Takeda Chemical Industries Ltd | Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung |
| CN1413112A (zh) * | 1999-11-11 | 2003-04-23 | 武田药品工业株式会社 | 含有稠合哒嗪衍生物的滴鼻剂 |
| FR2815031A1 (fr) * | 2000-10-11 | 2002-04-12 | Gilles Fillion | Compositions et methodes pour la regulation du systeme nerveux |
| EP1426050A4 (de) * | 2001-08-23 | 2005-05-25 | Takeda Pharmaceutical | Jnk-hemmer |
| AU2002357506A1 (en) * | 2001-12-25 | 2003-07-15 | Takeda Chemical Industries, Ltd. | Acid-containing preparations |
| US7235556B2 (en) | 2003-04-16 | 2007-06-26 | Alcon, Inc. | Methods of treating dry eye disorders |
| EP1618105A1 (de) * | 2003-05-01 | 2006-01-25 | Vernalis Research Limited | Azetidincarboxamid-derivate zur verwendung zur behandlung von cb1-rezeptor-vermittelten krankheiten |
| DE102005042742A1 (de) * | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| US7750000B2 (en) * | 2005-09-02 | 2010-07-06 | Bayer Schering Pharma Ag | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments |
| EP1845098A1 (de) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazinen, deren Herstellungverfahren und ihre Verwendung als GABA Rezeptor Liganden |
| SI2350075T1 (sl) | 2008-09-22 | 2014-06-30 | Array Biopharma, Inc. | Substituirane imidazo (1,2b)piridazinske spojine kot Trk kinazni inhibitorji |
| CN102264736B (zh) | 2008-10-22 | 2013-08-14 | 阵列生物制药公司 | 作为TRK激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物 |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| BR122019024201B1 (pt) | 2010-05-20 | 2021-08-03 | Array Biopharma Inc | Composto macrocíclico como inibidores de trk quinase, seu uso, e composição farmacêutica |
| CA2931804A1 (en) * | 2013-11-27 | 2015-06-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Piperidine and piperazine derivatives and their use in treating viral infections and cancer |
| CN105503877A (zh) | 2014-09-24 | 2016-04-20 | 和记黄埔医药（上海）有限公司 | 咪唑并哒嗪类化合物及其用途 |
| TWI746426B (zh) | 2014-11-16 | 2021-11-21 | 美商亞雷生物製藥股份有限公司 | (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型 |
| EP3368039A1 (de) | 2015-10-26 | 2018-09-05 | The Regents of The University of Colorado, A Body Corporate | Punktmutationen bei trk-inhibitor-resistentem krebs und zugehörige verfahren |
| UA125025C2 (uk) | 2016-04-04 | 2021-12-29 | Локсо Онколоджі, Інк. | Способи лікування дитячих ракових захворювань |
| UA125026C2 (uk) | 2016-04-04 | 2021-12-29 | Локсо Онколоджі, Інк. | РІДКІ КОМПОЗИЦІЇ (S)-N-(5-((R)-2-(2,5-ДИФТОРФЕНІЛ)ПІРОЛІДИН-1-ІЛ)ПІРАЗОЛО[1,5-a]ПІРИМІДИН-3-ІЛ)-3-ГІДРОКСИПІРОЛІДИН-1-КАРБОКСАМІДУ |
| MX392604B (es) | 2016-05-18 | 2025-03-24 | Array Biopharma Inc | Procesos para la preparacion de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo. |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| WO2020023782A1 (en) | 2018-07-27 | 2020-01-30 | Biotheryx, Inc. | Bifunctional compounds as cdk modulators |
| EP4143329A4 (de) | 2020-04-28 | 2024-10-16 | Anwita Biosciences, Inc. | Interleukin-2-polypeptide und fusionsproteine davon sowie deren pharmazeutische zusammensetzungen und therapeutische anwendungen |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3878217A (en) * | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
| PH27291A (en) | 1989-01-31 | 1993-05-04 | Takeda Chemical Industries Ltd | Imidazolpyrimidazines their production and use |
| EP0440119A1 (de) | 1990-01-31 | 1991-08-07 | Takeda Chemical Industries, Ltd. | Imidazopyridazinverbindungen, ihre Herstellung und Verwendung |
| DE69106902T2 (de) | 1990-03-01 | 1995-07-06 | Takeda Chemical Industries Ltd | Imidazopyridazine, ihre Herstellung und Verwendung. |
| TW211013B (de) * | 1991-12-27 | 1993-08-11 | Takeda Pharm Industry Co Ltd | |
| LT3200B (en) | 1992-03-18 | 1995-03-27 | Takeda Chemical Industries Ltd | Triazolopyridazine methodfor production thereof and use |
| DE69322673T2 (de) | 1992-03-18 | 1999-05-06 | Takeda Chemical Industries, Ltd., Osaka | Imidazopyridazine als Antiasthmatika |
| EP0620224B1 (de) | 1993-04-12 | 1998-07-15 | Takeda Chemical Industries, Ltd. | Triazolopyridazin-Derivate, ihre Herstellung und Verwendung |
| JPH0717971A (ja) * | 1993-07-02 | 1995-01-20 | Takeda Chem Ind Ltd | イミダゾール誘導体、その製造法及び用途 |
| TW304878B (de) | 1993-09-21 | 1997-05-11 | Takeda Pharm Industry Co Ltd | |
| CA2198019A1 (en) | 1994-09-16 | 1996-03-21 | Takeda Chemical Industries, Ltd. | Triazolopyridazines process and intermediates for their preparation and their use as medicaments |
| AU4496896A (en) | 1995-01-30 | 1996-08-21 | Takeda Chemical Industries Ltd. | Cephem compounds, their production and use |
-
1998
- 1998-04-23 AU AU70799/98A patent/AU7079998A/en not_active Abandoned
- 1998-04-23 US US09/284,362 patent/US6248740B1/en not_active Expired - Fee Related
- 1998-04-23 EP EP98917645A patent/EP0979231B1/de not_active Expired - Lifetime
- 1998-04-23 AT AT98917645T patent/ATE283270T1/de not_active IP Right Cessation
- 1998-04-23 CA CA002285264A patent/CA2285264A1/en not_active Abandoned
- 1998-04-23 CN CN98802792A patent/CN1248259A/zh active Pending
- 1998-04-23 WO PCT/JP1998/001869 patent/WO1998049167A1/en not_active Ceased
- 1998-04-23 KR KR10-1999-7003249A patent/KR100389192B1/ko not_active Expired - Fee Related
- 1998-04-23 DE DE69827786T patent/DE69827786T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998049167A1 (en) | 1998-11-05 |
| CN1248259A (zh) | 2000-03-22 |
| DE69827786D1 (de) | 2004-12-30 |
| EP0979231A1 (de) | 2000-02-16 |
| US6248740B1 (en) | 2001-06-19 |
| DE69827786T2 (de) | 2005-11-24 |
| AU7079998A (en) | 1998-11-24 |
| KR20000049156A (ko) | 2000-07-25 |
| CA2285264A1 (en) | 1998-11-05 |
| EP0979231B1 (de) | 2004-11-24 |
| KR100389192B1 (ko) | 2003-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |