ATE284380T1 - Ester abgeleitet vom (rr,ss)-2-hydroxybenzoat des 3-(2-dimethylaminomethyl-1- hydroxycyclohexl)phenyl - Google Patents

Ester abgeleitet vom (rr,ss)-2-hydroxybenzoat des 3-(2-dimethylaminomethyl-1- hydroxycyclohexl)phenyl

Info

Publication number
ATE284380T1
ATE284380T1 AT00983358T AT00983358T ATE284380T1 AT E284380 T1 ATE284380 T1 AT E284380T1 AT 00983358 T AT00983358 T AT 00983358T AT 00983358 T AT00983358 T AT 00983358T AT E284380 T1 ATE284380 T1 AT E284380T1
Authority
AT
Austria
Prior art keywords
hydroxycyclohexl
dimethylaminomethyl
hydroxybenzoate
phenyl
esters derived
Prior art date
Application number
AT00983358T
Other languages
English (en)
Inventor
Clotet Juan Huguet
Mancini Marisabel Mourelle
Ramon Amat Elisabet De
Original Assignee
Vita Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Lab filed Critical Vita Lab
Application granted granted Critical
Publication of ATE284380T1 publication Critical patent/ATE284380T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00983358T 1999-12-30 2000-12-26 Ester abgeleitet vom (rr,ss)-2-hydroxybenzoat des 3-(2-dimethylaminomethyl-1- hydroxycyclohexl)phenyl ATE284380T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200000060A ES2160534B1 (es) 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
PCT/ES2000/000486 WO2001049650A1 (es) 1999-12-30 2000-12-26 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil)fenilo

Publications (1)

Publication Number Publication Date
ATE284380T1 true ATE284380T1 (de) 2004-12-15

Family

ID=8491916

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00983358T ATE284380T1 (de) 1999-12-30 2000-12-26 Ester abgeleitet vom (rr,ss)-2-hydroxybenzoat des 3-(2-dimethylaminomethyl-1- hydroxycyclohexl)phenyl

Country Status (30)

Country Link
US (1) US6894076B2 (de)
EP (1) EP1251120B1 (de)
JP (1) JP2003519208A (de)
KR (1) KR20020063281A (de)
CN (1) CN1414946A (de)
AP (1) AP1234A (de)
AT (1) ATE284380T1 (de)
AU (1) AU775918B2 (de)
BG (1) BG106883A (de)
BR (1) BR0016882A (de)
CA (1) CA2395976A1 (de)
CZ (1) CZ20022189A3 (de)
DE (1) DE60016631D1 (de)
EA (1) EA004770B1 (de)
EE (1) EE200200365A (de)
ES (1) ES2160534B1 (de)
HR (1) HRP20020559A2 (de)
HU (1) HUP0204147A3 (de)
IL (1) IL150392A0 (de)
IS (1) IS6440A (de)
MA (1) MA26862A1 (de)
MX (1) MXPA02006514A (de)
NO (1) NO20023098D0 (de)
NZ (1) NZ520263A (de)
OA (1) OA12132A (de)
PL (1) PL356056A1 (de)
SK (1) SK9252002A3 (de)
WO (1) WO2001049650A1 (de)
YU (1) YU50902A (de)
ZA (1) ZA200205193B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
JP5774853B2 (ja) 2008-01-25 2015-09-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 医薬投薬形
MX2010012039A (es) 2008-05-09 2010-11-30 Gruenenthal Gmbh Proceso para la preparacion de una formulacion de polvo intermedia y una forma de dosificacion solida final bajo el uso de un paso de congelacion por rocio.
US8058469B2 (en) * 2008-11-03 2011-11-15 Sabic Innovative Plastics Ip B.V. Method for making carbamates, ureas and isocyanates
ES2428938T3 (es) 2009-07-22 2013-11-12 Grünenthal GmbH Forma de dosificación resistente a la manipulación y estabilizada frente a la oxidación
BR112012001547A2 (pt) 2009-07-22 2016-03-08 Gruenenthal Gmbh forma de dosagem farmacêutica extrusada por fusão a quente
EP2383255A1 (de) 2010-04-28 2011-11-02 Lacer, S.A. Neue Verbindungen, deren Synthese und Verwendung bei der Schmerzbehandlung
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
CN103179954A (zh) 2010-09-02 2013-06-26 格吕伦塔尔有限公司 包含阴离子聚合物的抗破碎剂型
EP2530072A1 (de) 2011-06-03 2012-12-05 Lacer, S.A. Neue Verbindungen, deren Synthese und Verwendung bei der Schmerzbehandlung
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
PL2736497T3 (pl) 2011-07-29 2018-01-31 Gruenenthal Gmbh Tabletka odporna na ingerencję, zapewniająca natychmiastowe uwalnianie leku
MX356421B (es) 2012-02-28 2018-05-29 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
PL2838512T3 (pl) 2012-04-18 2018-12-31 Grünenthal GmbH Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
WO2014191396A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
MX371432B (es) 2013-05-29 2020-01-30 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido que contiene una o mas particulas.
US10624862B2 (en) 2013-07-12 2020-04-21 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
WO2015078891A1 (en) 2013-11-26 2015-06-04 Farmaceutici Formenti S.P.A. Preparation of a powdery pharmaceutical composition by means of cryo-milling
US20150320690A1 (en) 2014-05-12 2015-11-12 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
AU2016319203A1 (en) 2015-09-10 2018-02-22 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
HUE048032T2 (hu) 2015-10-15 2020-05-28 Jiangsu Hengrui Medicine Co Oxaspiro-származék, elõállítási eljárása és alkalmazásai gyógyszerekben

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
DE1518663A1 (de) 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3562589A (en) * 1968-09-09 1971-02-09 Ite Imperial Corp Electrically resetting undervoltage trip for circuit breakers
US5470885A (en) * 1993-09-29 1995-11-28 The Research Foundation Of The State University Of New York Fluorocarbons as anti-inflammatory agents
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
GB9924604D0 (en) * 1999-10-18 1999-12-22 European Molecular Biology Lab Embl Genetic switch

Also Published As

Publication number Publication date
JP2003519208A (ja) 2003-06-17
IS6440A (is) 2002-06-25
NO20023098L (no) 2002-06-26
EE200200365A (et) 2003-10-15
EA004770B1 (ru) 2004-08-26
US6894076B2 (en) 2005-05-17
YU50902A (sh) 2006-01-16
OA12132A (en) 2006-05-05
EP1251120A1 (de) 2002-10-23
NZ520263A (en) 2004-07-30
HUP0204147A2 (hu) 2003-04-28
MXPA02006514A (es) 2004-07-30
AU2012601A (en) 2001-07-16
EA200200614A1 (ru) 2002-12-26
KR20020063281A (ko) 2002-08-01
DE60016631D1 (de) 2005-01-13
CZ20022189A3 (cs) 2003-03-12
ES2160534A1 (es) 2001-11-01
SK9252002A3 (en) 2003-04-01
BG106883A (en) 2003-05-30
US20030100598A1 (en) 2003-05-29
BR0016882A (pt) 2002-11-05
HUP0204147A3 (en) 2003-10-28
ZA200205193B (en) 2003-06-27
EP1251120B1 (de) 2004-12-08
AP2002002571A0 (en) 2002-09-30
NO20023098D0 (no) 2002-06-26
ES2160534B1 (es) 2002-04-16
IL150392A0 (en) 2002-12-01
AP1234A (en) 2003-12-28
HRP20020559A2 (en) 2004-02-29
MA26862A1 (fr) 2004-12-20
AU775918B2 (en) 2004-08-19
CA2395976A1 (en) 2001-07-12
PL356056A1 (en) 2004-06-14
CN1414946A (zh) 2003-04-30
WO2001049650A1 (es) 2001-07-12

Similar Documents

Publication Publication Date Title
ATE284380T1 (de) Ester abgeleitet vom (rr,ss)-2-hydroxybenzoat des 3-(2-dimethylaminomethyl-1- hydroxycyclohexl)phenyl
FR2802655B1 (fr) Compositions photosensibles comprenant des esters d'oximes comme photoamorceurs
ATE249418T1 (de) Neuartige ester abgeleitet von substituierten phenyl-cyclohexyl-verbindungen
FI20002730L (fi) Oksiimiesteri-valokäynnisteet
DK0823895T3 (da) Fedtsyreestere som bioaktive forbindelser
NO20012265D0 (no) Dispergerbare blandinger inneholdende L-DOPA-etylester
NO20030249L (no) Oksygenerte estere av 4-jod-fenylamino-benzohydroksamsyrer
ID23472A (id) Ester-ester selulosa terkarboksilat
ID22013A (id) Senyawa-senyawa ester
ID24863A (id) Proses pembuatan vinil ester dari butenoligomeran
NO20013818L (no) Mikrobiell fremgangsmåte for fremstilling av pravastatin
GB2349336B (en) Pesticidal composition based on 2-methoxycarbonyl-4-chlorotrifluoromethanesulphonanilide & an ester of an alkanedicarboxylic, citric or fatty acid
FR2793159B1 (fr) Cloche ramasse balle
AU1093401A (en) Pharmaceutical compositions containing n-(n-(3,3-dimethylbutyl)-1-alpha-aspartyl)-l-phenylalanine methyl ester
NO20012266L (no) Fremgangsmåte for fremstilling av L-DOPA-etylester
DE50214840D1 (de) Ethylestern
DE60010725D1 (de) Herstellung von arylcarbonsäureestern
PT1165678E (pt) Utilizacao de esteres de alcanolamina de acidos gordos.
PT1098871E (pt) Derivados de ester fenilico de alfa-aminoacidos
DE69809692D1 (de) Herstellung von Carbonsäureestern
LV12147A (lv) 2-Okso-4-fenilbutanskabes etilestera sinteze no 2,2-dietoksi-4-fenilbutenskabes etilestera
ITRM990799A0 (it) Composti di esteri ciclopropancarbossilici.
EE04960B1 (et) Meetod arliminometlkarbamiinhappeestrite valmistamiseks
ATE344235T1 (de) Monohydrat des cis-lithium-cyano-4-[3- (cyclopentyloy)-4- methoxyphenylöcyclohexancarboxylats
IT1321293B1 (it) Procedimento per la preparazione di esteri pentenoici.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties