BR0016882A - ésteres derivados de (rr,ss)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato - Google Patents

ésteres derivados de (rr,ss)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato

Info

Publication number
BR0016882A
BR0016882A BR0016882-3A BR0016882A BR0016882A BR 0016882 A BR0016882 A BR 0016882A BR 0016882 A BR0016882 A BR 0016882A BR 0016882 A BR0016882 A BR 0016882A
Authority
BR
Brazil
Prior art keywords
dimethylaminomethyl
hydroxybenzoate
phenyl
esters derived
hydroxycyclohexyl
Prior art date
Application number
BR0016882-3A
Other languages
English (en)
Inventor
Juan Huguet Clotet
Marisabel Mourelle Mancini
Elisabet De Ramon Amat
Original Assignee
Vita Invest Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Invest Sa filed Critical Vita Invest Sa
Publication of BR0016882A publication Critical patent/BR0016882A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"éSTERES DERIVADOS DE (RR,SS)-3-(2-DIMETILAMINOMETIL-1-HIDROXICICLOEXIL)FENIL 2-HIDROXIBENZOATO". Novos ésteres derivados de (RR,SS)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato, análogos a Tramadol, um processo para obtê-los e o uso destes compostos para a produção de um medicamento com propriedades analgésicas. Estes novos produtos de fórmula geral (I) apresentam uma atividade analgésica maior que a de tramadol.
BR0016882-3A 1999-12-30 2000-12-26 ésteres derivados de (rr,ss)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato BR0016882A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200000060A ES2160534B1 (es) 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
PCT/ES2000/000486 WO2001049650A1 (es) 1999-12-30 2000-12-26 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil)fenilo

Publications (1)

Publication Number Publication Date
BR0016882A true BR0016882A (pt) 2002-11-05

Family

ID=8491916

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016882-3A BR0016882A (pt) 1999-12-30 2000-12-26 ésteres derivados de (rr,ss)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato

Country Status (30)

Country Link
US (1) US6894076B2 (pt)
EP (1) EP1251120B1 (pt)
JP (1) JP2003519208A (pt)
KR (1) KR20020063281A (pt)
CN (1) CN1414946A (pt)
AP (1) AP1234A (pt)
AT (1) ATE284380T1 (pt)
AU (1) AU775918B2 (pt)
BG (1) BG106883A (pt)
BR (1) BR0016882A (pt)
CA (1) CA2395976A1 (pt)
CZ (1) CZ20022189A3 (pt)
DE (1) DE60016631D1 (pt)
EA (1) EA004770B1 (pt)
EE (1) EE200200365A (pt)
ES (1) ES2160534B1 (pt)
HR (1) HRP20020559A2 (pt)
HU (1) HUP0204147A3 (pt)
IL (1) IL150392A0 (pt)
IS (1) IS6440A (pt)
MA (1) MA26862A1 (pt)
MX (1) MXPA02006514A (pt)
NO (1) NO20023098D0 (pt)
NZ (1) NZ520263A (pt)
OA (1) OA12132A (pt)
PL (1) PL356056A1 (pt)
SK (1) SK9252002A3 (pt)
WO (1) WO2001049650A1 (pt)
YU (1) YU50902A (pt)
ZA (1) ZA200205193B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
TWI454288B (zh) 2008-01-25 2014-10-01 Gruenenthal Chemie 藥物劑型
ES2599031T3 (es) 2008-05-09 2017-01-31 Grünenthal GmbH Proceso para la preparación de una formulación de polvo intermedia y una forma de dosificación solida final utilizando un paso de congelación por pulverización
US8058469B2 (en) * 2008-11-03 2011-11-15 Sabic Innovative Plastics Ip B.V. Method for making carbamates, ureas and isocyanates
BR112012001466A2 (pt) 2009-07-22 2020-08-11 Grünenthal GmbH forma de dosagem resistente à falsificação para opioides sensíveis à oxidação, seu processo de fabricação, e embalagem
ES2534908T3 (es) 2009-07-22 2015-04-30 Grünenthal GmbH Forma de dosificación de liberación controlada extruida por fusión en caliente
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
WO2012028318A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polymer
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
BR112014002022A2 (pt) 2011-07-29 2017-02-21 Gruenenthal Gmbh comprimido resistente à violação proporcionando liberação de fármaco imediata
JP6063462B2 (ja) 2011-07-29 2017-01-18 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 即時薬剤放出を提供するタンパーレジスタント錠剤
BR112014019988A8 (pt) 2012-02-28 2017-07-11 Gruenenthal Gmbh Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
LT2838512T (lt) 2012-04-18 2018-11-12 GrĆ¼nenthal GmbH Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
MX2015016254A (es) 2013-05-29 2016-04-20 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal.
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
AU2014289187B2 (en) 2013-07-12 2019-07-11 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
HK1224189A1 (zh) 2013-11-26 2017-08-18 Grünenthal GmbH 通过低温研磨制备粉状药物组合物
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
WO2016170097A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
CA2998259A1 (en) 2015-09-10 2017-03-16 Grunenthal Gmbh Protecting oral overdose with abuse deterrent immediate release formulations
EP3354649B1 (en) 2015-10-15 2019-12-04 Jiangsu Hengrui Medicine Co., Ltd. Oxa spiro derivative, preparation method therefor, and applications thereof in medicines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
DE1518663A1 (de) 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3562589A (en) * 1968-09-09 1971-02-09 Ite Imperial Corp Electrically resetting undervoltage trip for circuit breakers
US5470885A (en) * 1993-09-29 1995-11-28 The Research Foundation Of The State University Of New York Fluorocarbons as anti-inflammatory agents
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
GB9924604D0 (en) * 1999-10-18 1999-12-22 European Molecular Biology Lab Embl Genetic switch

Also Published As

Publication number Publication date
DE60016631D1 (de) 2005-01-13
CA2395976A1 (en) 2001-07-12
PL356056A1 (en) 2004-06-14
HUP0204147A3 (en) 2003-10-28
CZ20022189A3 (cs) 2003-03-12
EP1251120A1 (en) 2002-10-23
EP1251120B1 (en) 2004-12-08
EE200200365A (et) 2003-10-15
HUP0204147A2 (hu) 2003-04-28
NZ520263A (en) 2004-07-30
AP1234A (en) 2003-12-28
US20030100598A1 (en) 2003-05-29
IS6440A (is) 2002-06-25
EA200200614A1 (ru) 2002-12-26
OA12132A (en) 2006-05-05
IL150392A0 (en) 2002-12-01
US6894076B2 (en) 2005-05-17
AP2002002571A0 (en) 2002-09-30
NO20023098L (no) 2002-06-26
ES2160534A1 (es) 2001-11-01
AU2012601A (en) 2001-07-16
KR20020063281A (ko) 2002-08-01
CN1414946A (zh) 2003-04-30
JP2003519208A (ja) 2003-06-17
ES2160534B1 (es) 2002-04-16
HRP20020559A2 (en) 2004-02-29
SK9252002A3 (en) 2003-04-01
BG106883A (en) 2003-05-30
ATE284380T1 (de) 2004-12-15
NO20023098D0 (no) 2002-06-26
ZA200205193B (en) 2003-06-27
YU50902A (sh) 2006-01-16
MA26862A1 (fr) 2004-12-20
EA004770B1 (ru) 2004-08-26
WO2001049650A1 (es) 2001-07-12
AU775918B2 (en) 2004-08-19
MXPA02006514A (es) 2004-07-30

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Free format text: LABORATORIOS VITA, S.A. (ES)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.