ATE285411T1 - 6-substituierte pyrazolo(3,4-d)pyrimidin-4-one verwendbar als cyclin-abhängige kinasehemmer - Google Patents
6-substituierte pyrazolo(3,4-d)pyrimidin-4-one verwendbar als cyclin-abhängige kinasehemmerInfo
- Publication number
- ATE285411T1 ATE285411T1 AT99951875T AT99951875T ATE285411T1 AT E285411 T1 ATE285411 T1 AT E285411T1 AT 99951875 T AT99951875 T AT 99951875T AT 99951875 T AT99951875 T AT 99951875T AT E285411 T1 ATE285411 T1 AT E285411T1
- Authority
- AT
- Austria
- Prior art keywords
- dependent kinase
- cyclin
- pyrimidine
- usable
- kinase inhibitors
- Prior art date
Links
- -1 6-SUBSTITUTED PYRAZOLO(3,4-D)PYRIMIDINE-4-ONE Chemical class 0.000 title 1
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 title 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 abstract 2
- 108090000266 Cyclin-dependent kinases Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 108091007914 CDKs Proteins 0.000 abstract 1
- 102000016736 Cyclin Human genes 0.000 abstract 1
- 108050006400 Cyclin Proteins 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- IUYQIJQHYDZUDF-UHFFFAOYSA-N pyrazolo[3,4-d]pyrimidin-4-one Chemical class O=C1N=CN=C2N=NC=C12 IUYQIJQHYDZUDF-UHFFFAOYSA-N 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10395798P | 1998-10-13 | 1998-10-13 | |
| PCT/US1999/023512 WO2000021926A2 (en) | 1998-10-13 | 1999-10-13 | 6-SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDIN-4-ONES USEFUL AS CYCLIN DEPENDENT KINASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE285411T1 true ATE285411T1 (de) | 2005-01-15 |
Family
ID=22297915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99951875T ATE285411T1 (de) | 1998-10-13 | 1999-10-13 | 6-substituierte pyrazolo(3,4-d)pyrimidin-4-one verwendbar als cyclin-abhängige kinasehemmer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6531477B1 (de) |
| EP (1) | EP1121363B1 (de) |
| JP (1) | JP2002537223A (de) |
| AT (1) | ATE285411T1 (de) |
| AU (1) | AU6422399A (de) |
| CA (1) | CA2345809C (de) |
| DE (1) | DE69922823T2 (de) |
| ES (1) | ES2235528T3 (de) |
| PT (1) | PT1121363E (de) |
| WO (1) | WO2000021926A2 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6559152B2 (en) | 1998-10-13 | 2003-05-06 | Dupont Pharmaceuticals Company | 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
| US6531477B1 (en) | 1998-10-13 | 2003-03-11 | Dupont Pharmaceuticals Company | 6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| CA2337565A1 (en) * | 2000-02-25 | 2001-08-25 | Cordis Corporation | Use of cladribine on a stent to prevent restenosis |
| GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
| WO2001095856A2 (en) * | 2000-06-15 | 2001-12-20 | Chaconne Nsi Co., Ltd. | Urea derivative useful as an anti-cancer agent and process for preparing same |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
| EP1619184A3 (de) * | 2000-08-15 | 2006-02-01 | Amgen, Inc. | Harnstoffverbindungen als Kinaseinhibitoren |
| GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| FR2821356A1 (fr) * | 2001-02-23 | 2002-08-30 | Cerep | Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations |
| US7605175B2 (en) * | 2001-03-02 | 2009-10-20 | Gpc Biotech Ag | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
| GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
| WO2003063764A2 (en) * | 2001-07-10 | 2003-08-07 | Bristol-Myers Squibb Pharma Company | 6-SUBSTITUTED PYRAZOLO [3,4-d] PYRIMIDIN-4-ONES USEFUL AS CYCLIN DEPENDENT KINASE INHIBITORS |
| CN1305857C (zh) * | 2001-09-25 | 2007-03-21 | 巴斯福股份公司 | 杀虫和杀螨的3－取代吡唑 |
| EP1436265A4 (de) * | 2001-09-27 | 2004-12-15 | Smithkline Beecham Corp | Chemische verbindungen |
| CA2463571A1 (en) * | 2001-10-15 | 2003-04-24 | Gpc Biotech, Inc. | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
| US6753329B2 (en) | 2001-12-03 | 2004-06-22 | Gpc Biotech Inc. | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
| GB0205688D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| JP2005524672A (ja) | 2002-03-09 | 2005-08-18 | アストラゼネカ アクチボラグ | Ｃｄｋ阻害活性を有するイミダゾリル置換ピリミジン誘導体 |
| GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| AU2003276453A1 (en) * | 2002-11-06 | 2004-06-07 | Cyclacel Limited | Pharmaceutical composition comprising a cdk inhibitor and gemcitabine |
| US7786112B2 (en) | 2003-04-07 | 2010-08-31 | Agennix Usa Inc. | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
| GB0311276D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| GB0311274D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| EA013117B1 (ru) | 2003-12-23 | 2010-02-26 | ДжиПиСи БАЙОТЕК, ИНК. | Ингибиторы циклинзависимых киназ, относящиеся к ним композиции и применения |
| TW200528101A (en) | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
| KR100844864B1 (ko) * | 2004-02-27 | 2008-07-09 | 에프. 호프만-라 로슈 아게 | 헤테로아릴-융합 피라졸로 유도체 |
| WO2007036732A1 (en) | 2005-09-30 | 2007-04-05 | Astrazeneca Ab | Imidazo [1,2-a] pyridine having anti-cell-proliferation activity |
| EP2019101A1 (de) * | 2007-07-26 | 2009-01-28 | GPC Biotech AG | Pyrazol[3,4-d]pyrimidin-4-one nützlich als Kinase-Inhibitor |
| GEP20125635B (en) * | 2007-11-13 | 2012-09-10 | Icos Corp | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
| CN101671336B (zh) * | 2009-09-23 | 2013-11-13 | 辽宁利锋科技开发有限公司 | 芳杂环并嘧啶衍生物和类似物及其制备方法和用途 |
| JP2013525370A (ja) * | 2010-04-22 | 2013-06-20 | ヤンセン ファーマシューティカ エヌ．ベー． | ケトヘキソキナーゼ阻害剤として有用なインダゾール化合物 |
| WO2016020307A1 (en) * | 2014-08-04 | 2016-02-11 | Fundación Para La Investigación Médica Aplicada | Novel compounds for use in cognition improvement |
| WO2016191935A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| WO2016192083A1 (en) | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| WO2017000276A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
| SG11201901747VA (en) | 2016-08-31 | 2019-03-28 | Agios Pharmaceuticals Inc | Inhibitors of cellular metabolic processes |
| EP3548488A1 (de) * | 2016-11-30 | 2019-10-09 | Oncotyrol Center for Personalized Cancer Medicine GmbH | 3-amino-1,5-dihydro-pyrazol[3,4-d]pyrimidin-4-one als cyclinabhängige kinasehemmer |
| EP3668840A1 (de) | 2017-08-15 | 2020-06-24 | Inflazome Limited | Neuartige sulfonamid-carboxamid-verbindungen |
| WO2019222414A1 (en) * | 2018-05-16 | 2019-11-21 | Belite Bio, Llc | Fatty acid analogues and methods of use |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
| US20250188094A1 (en) * | 2022-03-18 | 2025-06-12 | Insilico Medicine Ip Limited | Pyrazole membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase (pkmyt1) inhibitors and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH398626A (de) | 1960-05-11 | 1966-03-15 | Ciba Geigy | Verfahren zur Herstellung neuer Pyrazolopyrimidine |
| DE3131365A1 (de) * | 1981-08-07 | 1983-02-24 | Henkel KGaA, 4000 Düsseldorf | Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit |
| US5026836A (en) * | 1987-12-14 | 1991-06-25 | Nucleic Acid Research Institute | 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides, pharmaceutical compositions, and processes of making |
| TW444018B (en) | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
| US5593997A (en) | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
| US6403599B1 (en) | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
| US5866702A (en) | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| US6531477B1 (en) | 1998-10-13 | 2003-03-11 | Dupont Pharmaceuticals Company | 6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
-
1999
- 1999-10-12 US US09/416,584 patent/US6531477B1/en not_active Expired - Lifetime
- 1999-10-13 DE DE69922823T patent/DE69922823T2/de not_active Expired - Lifetime
- 1999-10-13 AT AT99951875T patent/ATE285411T1/de active
- 1999-10-13 EP EP99951875A patent/EP1121363B1/de not_active Expired - Lifetime
- 1999-10-13 PT PT99951875T patent/PT1121363E/pt unknown
- 1999-10-13 ES ES99951875T patent/ES2235528T3/es not_active Expired - Lifetime
- 1999-10-13 JP JP2000575835A patent/JP2002537223A/ja active Pending
- 1999-10-13 WO PCT/US1999/023512 patent/WO2000021926A2/en not_active Ceased
- 1999-10-13 AU AU64223/99A patent/AU6422399A/en not_active Abandoned
- 1999-10-13 CA CA2345809A patent/CA2345809C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000021926A3 (en) | 2000-08-03 |
| EP1121363A2 (de) | 2001-08-08 |
| EP1121363B1 (de) | 2004-12-22 |
| DE69922823T2 (de) | 2005-12-15 |
| CA2345809A1 (en) | 2000-04-20 |
| AU6422399A (en) | 2000-05-01 |
| PT1121363E (pt) | 2005-04-29 |
| WO2000021926A2 (en) | 2000-04-20 |
| CA2345809C (en) | 2010-04-13 |
| JP2002537223A (ja) | 2002-11-05 |
| US6531477B1 (en) | 2003-03-11 |
| ES2235528T3 (es) | 2005-07-01 |
| DE69922823D1 (de) | 2005-01-27 |
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| UEP | Publication of translation of european patent specification |
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