ATE286036T1 - Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren - Google Patents
Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatorenInfo
- Publication number
- ATE286036T1 ATE286036T1 AT01949294T AT01949294T ATE286036T1 AT E286036 T1 ATE286036 T1 AT E286036T1 AT 01949294 T AT01949294 T AT 01949294T AT 01949294 T AT01949294 T AT 01949294T AT E286036 T1 ATE286036 T1 AT E286036T1
- Authority
- AT
- Austria
- Prior art keywords
- alkynylphenyl
- heteroaromatic
- compounds
- glucocinase
- activators
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20154600P | 2000-05-03 | 2000-05-03 | |
| PCT/EP2001/004654 WO2001083465A2 (en) | 2000-05-03 | 2001-04-25 | Alkynyl phenyl heteroaromatic glucokinase activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE286036T1 true ATE286036T1 (de) | 2005-01-15 |
Family
ID=22746271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01949294T ATE286036T1 (de) | 2000-05-03 | 2001-04-25 | Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6388071B2 (de) |
| EP (1) | EP1282612B1 (de) |
| JP (1) | JP3788935B2 (de) |
| KR (1) | KR100502033B1 (de) |
| CN (1) | CN1176915C (de) |
| AR (1) | AR032453A1 (de) |
| AT (1) | ATE286036T1 (de) |
| AU (2) | AU2001270494B2 (de) |
| BR (1) | BR0110573A (de) |
| CA (1) | CA2407416C (de) |
| DE (1) | DE60108108T2 (de) |
| EC (1) | ECSP014054A (de) |
| ES (1) | ES2233660T3 (de) |
| MX (1) | MXPA02010745A (de) |
| PE (1) | PE20011310A1 (de) |
| PT (1) | PT1282612E (de) |
| WO (1) | WO2001083465A2 (de) |
| ZA (1) | ZA200208542B (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102300D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| EP1336607A1 (de) * | 2002-02-19 | 2003-08-20 | Novo Nordisk A/S | Amidderivate als Glucokinase-Aktivatoren |
| US6911545B2 (en) | 2001-12-19 | 2005-06-28 | Hoffman-La Roche Inc. | Crystals of glucokinase and methods of growing them |
| GB2409678B (en) * | 2001-12-19 | 2005-09-21 | Hoffmann La Roche | Crystals of glucokinase and methods of growing them and ligands of glucokinase |
| RU2374236C2 (ru) | 2001-12-21 | 2009-11-27 | Ново Нордиск А/С | Амидные производные в качестве активаторов gk |
| KR101124245B1 (ko) | 2002-06-27 | 2012-07-02 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
| AU2003243921B2 (en) | 2002-06-27 | 2009-05-07 | Novo Nordisk A/S | Aryl carbonyl derivatives as therapeutic agents |
| JP2006509774A (ja) * | 2002-10-03 | 2006-03-23 | ノバルティス アクチエンゲゼルシャフト | ２型糖尿病の処置において有用なグルコキナーゼアクチベーターとしての置換（チアゾール−２−イル）−アミドまたはスルホンアミド |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| US7132425B2 (en) | 2002-12-12 | 2006-11-07 | Hoffmann-La Roche Inc. | 5-substituted-six-membered heteroaromatic glucokinase activators |
| JP4716734B2 (ja) * | 2003-01-06 | 2011-07-06 | イーライ リリー アンド カンパニー | グルコキナーゼ活性化物質としての置換されたアリールシクロプロピルアセトアミド |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| WO2005066145A1 (en) | 2004-01-06 | 2005-07-21 | Novo Nordisk A/S | Heteroaryl-ureas and their use as glucokinase activators |
| ATE426597T1 (de) * | 2004-02-18 | 2009-04-15 | Astrazeneca Ab | Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel |
| BRPI0507734A (pt) * | 2004-02-18 | 2007-07-10 | Astrazeneca Ab | composto ou um sal, pró-droga ou solvato do mesmo, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto |
| EP1737870A1 (de) | 2004-04-02 | 2007-01-03 | Novartis AG | Thiazolopyridinderivate, pharmazeutische zusammensetzungen, die diese enthalten, und verfahren zur behandlung von durch glucokinase vermittelten leiden |
| CN1960995B (zh) * | 2004-04-02 | 2010-12-08 | 诺瓦提斯公司 | 作为葡糖激酶活化剂、可用于治疗ⅱ型糖尿病的磺酰胺-噻唑并吡啶衍生物 |
| TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| KR20070085371A (ko) | 2004-10-16 | 2007-08-27 | 아스트라제네카 아베 | 페녹시 벤즈아미드 화합물의 제조 방법 |
| GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| AU2005311269B2 (en) | 2004-12-03 | 2011-11-10 | Transtech Pharma, Inc. | Heteroaromatic glucokinase activators |
| EP1891069A1 (de) * | 2005-05-24 | 2008-02-27 | AstraZeneca AB | 2-phenylsubstituierte imidazol[4,5b]pyridin/pyrazin- und purinderivate als glucokinasemodulatoren |
| TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
| CA2614518A1 (en) | 2005-07-08 | 2007-01-18 | Novo-Nordisk A/S | Dicycloalkyl urea glucokinase activators |
| US7642259B2 (en) * | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| EP2027113A1 (de) * | 2005-07-09 | 2009-02-25 | AstraZeneca AB | Heteroarylbenzamidderivate zur verwendung als glk-aktivatoren bei der behandlung von diabetes |
| JP2009500442A (ja) * | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物 |
| WO2007015805A1 (en) | 2005-07-20 | 2007-02-08 | Eli Lilly And Company | 1-amino linked compounds |
| US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
| RU2008112184A (ru) | 2005-08-31 | 2009-10-10 | Астеллас Фарма Инк. (Jp) | Производное тиазола |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| JP2009509988A (ja) | 2005-09-29 | 2009-03-12 | サノフィ−アベンティス | フェニル−及びピリジニル−１，２，４−オキサジアゾロン誘導体、その製造方法、及び医薬品としてのその使用 |
| GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
| GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
| CA2626475A1 (en) * | 2005-11-03 | 2007-05-10 | Prosidion Limited | Tricyclo substituted amides |
| WO2007123581A1 (en) | 2005-11-17 | 2007-11-01 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| WO2007061923A2 (en) * | 2005-11-18 | 2007-05-31 | Takeda San Diego, Inc. | Glucokinase activators |
| TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
| US8034822B2 (en) | 2006-03-08 | 2011-10-11 | Takeda San Diego, Inc. | Glucokinase activators |
| US8211925B2 (en) | 2006-04-28 | 2012-07-03 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| US8008332B2 (en) | 2006-05-31 | 2011-08-30 | Takeda San Diego, Inc. | Substituted indazoles as glucokinase activators |
| CA2657566A1 (en) | 2006-07-24 | 2008-01-31 | F. Hoffmann-La Roche Ag | Pyrazoles as glucokinase activators |
| TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
| SA07280576B1 (ar) * | 2006-10-26 | 2011-06-22 | استرازينيكا ايه بي | مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز |
| WO2008079787A2 (en) | 2006-12-20 | 2008-07-03 | Takeda San Diego, Inc. | Glucokinase activators |
| TW200833339A (en) * | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Novel crystalline compound |
| TW200831081A (en) * | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
| US8940900B2 (en) | 2007-02-28 | 2015-01-27 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
| CN101687800B (zh) * | 2007-03-07 | 2012-03-21 | 杏林制药株式会社 | 葡糖激酶活化物质 |
| US8173645B2 (en) * | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
| CL2009000004A1 (es) * | 2008-01-15 | 2010-02-19 | Lilly Co Eli | Forma cristalina de r-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida; composicion farmaceutica que comprende a dicha forma cristalina; y uso para el tratamiento de diabetes o hiperglicemia. |
| AU2009205070A1 (en) | 2008-01-18 | 2009-07-23 | Astellas Pharma Inc. | Phenyl acetamide derivative |
| US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| MY163114A (en) | 2008-04-28 | 2017-08-15 | Kyorin Seiyaku Kk | Cyclopentylacrylamide derivative |
| MX2011001333A (es) | 2008-08-04 | 2011-03-15 | Astrazeneca Ab | Derivados de pirazolo [3, 4] pirimidin-4-ilo y sus usos para tratar la diabetes y obesidad. |
| UA104742C2 (uk) | 2008-12-19 | 2014-03-11 | Эли Лилли Энд Компани | Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази |
| GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
| GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
| AR076221A1 (es) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
| WO2010116177A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity |
| US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
| JP5909482B2 (ja) | 2010-03-31 | 2016-04-26 | ザ スクリプス リサーチ インスティテュート | 細胞の再プログラム |
| US8877754B2 (en) * | 2010-09-06 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| WO2014035872A1 (en) * | 2012-08-27 | 2014-03-06 | Amgen Inc. | Tricyclic alkynes that interact with glucokinase regulatory protein |
| EP2878339A1 (de) | 2013-12-02 | 2015-06-03 | Siena Biotech S.p.A. | SIP3-Antagonisten |
| EP3053834B1 (de) | 2015-02-04 | 2019-03-27 | Tetra Laval Holdings & Finance S.A. | Anordnung und verfahren zur herstellung mehrerer versiegelter verpackungen für fliessfähige nahrungsmittel aus schlauchförmigem verpackungsmaterial |
| KR20210020866A (ko) | 2018-06-12 | 2021-02-24 | 브이티브이 테라퓨틱스 엘엘씨 | 인슐린 또는 인슐린 유사체와 조합된 글루코키나제 활성제의 치료적 용도 |
| WO2021167840A1 (en) | 2020-02-18 | 2021-08-26 | Vtv Therapeutics Llc | Sulfoxide and sulfone glucokinase activators and methods of use thereof |
| EP4161640A4 (de) | 2020-06-08 | 2024-01-17 | vTv Therapeutics LLC | Salze oder cokristalle von {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido)-thiazol-5-ylsulfanyl}-essigsäure und verwendungen davon |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61115054A (ja) * | 1984-11-08 | 1986-06-02 | Taisho Pharmaceut Co Ltd | スチレンアルカン酸誘導体 |
| EP0831795A2 (de) * | 1995-06-07 | 1998-04-01 | Sugen, Inc. | Phosphatase inhibitoren |
| WO1998058918A1 (en) * | 1997-06-24 | 1998-12-30 | Zeria Pharmaceutical Co., Ltd. | Process for producing 2-hydroxybenzamide derivatives |
-
2001
- 2001-04-25 PT PT01949294T patent/PT1282612E/pt unknown
- 2001-04-25 AU AU2001270494A patent/AU2001270494B2/en not_active Ceased
- 2001-04-25 AT AT01949294T patent/ATE286036T1/de not_active IP Right Cessation
- 2001-04-25 MX MXPA02010745A patent/MXPA02010745A/es active IP Right Grant
- 2001-04-25 US US09/841,983 patent/US6388071B2/en not_active Expired - Fee Related
- 2001-04-25 CN CNB018089127A patent/CN1176915C/zh not_active Expired - Fee Related
- 2001-04-25 JP JP2001580894A patent/JP3788935B2/ja not_active Expired - Fee Related
- 2001-04-25 WO PCT/EP2001/004654 patent/WO2001083465A2/en not_active Ceased
- 2001-04-25 EP EP01949294A patent/EP1282612B1/de not_active Expired - Lifetime
- 2001-04-25 AU AU7049401A patent/AU7049401A/xx active Pending
- 2001-04-25 DE DE60108108T patent/DE60108108T2/de not_active Expired - Lifetime
- 2001-04-25 CA CA002407416A patent/CA2407416C/en not_active Expired - Fee Related
- 2001-04-25 ES ES01949294T patent/ES2233660T3/es not_active Expired - Lifetime
- 2001-04-25 BR BR0110573-6A patent/BR0110573A/pt not_active IP Right Cessation
- 2001-04-25 KR KR10-2002-7014725A patent/KR100502033B1/ko not_active Expired - Fee Related
- 2001-04-27 PE PE2001000383A patent/PE20011310A1/es not_active Application Discontinuation
- 2001-04-30 AR ARP010102035A patent/AR032453A1/es not_active Application Discontinuation
- 2001-05-03 EC EC2001004054A patent/ECSP014054A/es unknown
-
2002
- 2002-10-22 ZA ZA200208542A patent/ZA200208542B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1282612E (pt) | 2005-04-29 |
| KR20020093117A (ko) | 2002-12-12 |
| CN1432004A (zh) | 2003-07-23 |
| AU2001270494B2 (en) | 2005-11-10 |
| JP3788935B2 (ja) | 2006-06-21 |
| JP2003531898A (ja) | 2003-10-28 |
| CA2407416A1 (en) | 2001-11-08 |
| ZA200208542B (en) | 2004-01-22 |
| AU7049401A (en) | 2001-11-12 |
| BR0110573A (pt) | 2003-04-01 |
| AR032453A1 (es) | 2003-11-12 |
| PE20011310A1 (es) | 2001-12-31 |
| WO2001083465A3 (en) | 2002-05-16 |
| US6388071B2 (en) | 2002-05-14 |
| MXPA02010745A (es) | 2003-03-10 |
| EP1282612A2 (de) | 2003-02-12 |
| US20010053851A1 (en) | 2001-12-20 |
| WO2001083465A2 (en) | 2001-11-08 |
| CA2407416C (en) | 2006-07-18 |
| CN1176915C (zh) | 2004-11-24 |
| ES2233660T3 (es) | 2005-06-16 |
| DE60108108T2 (de) | 2005-12-08 |
| ECSP014054A (es) | 2002-01-25 |
| DE60108108D1 (de) | 2005-02-03 |
| EP1282612B1 (de) | 2004-12-29 |
| KR100502033B1 (ko) | 2005-07-25 |
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