ATE286036T1 - Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren - Google Patents

Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren

Info

Publication number
ATE286036T1
ATE286036T1 AT01949294T AT01949294T ATE286036T1 AT E286036 T1 ATE286036 T1 AT E286036T1 AT 01949294 T AT01949294 T AT 01949294T AT 01949294 T AT01949294 T AT 01949294T AT E286036 T1 ATE286036 T1 AT E286036T1
Authority
AT
Austria
Prior art keywords
alkynylphenyl
heteroaromatic
compounds
glucocinase
activators
Prior art date
Application number
AT01949294T
Other languages
English (en)
Inventor
Paige Erin Mahaney
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE286036T1 publication Critical patent/ATE286036T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01949294T 2000-05-03 2001-04-25 Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren ATE286036T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20154600P 2000-05-03 2000-05-03
PCT/EP2001/004654 WO2001083465A2 (en) 2000-05-03 2001-04-25 Alkynyl phenyl heteroaromatic glucokinase activators

Publications (1)

Publication Number Publication Date
ATE286036T1 true ATE286036T1 (de) 2005-01-15

Family

ID=22746271

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01949294T ATE286036T1 (de) 2000-05-03 2001-04-25 Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren

Country Status (18)

Country Link
US (1) US6388071B2 (de)
EP (1) EP1282612B1 (de)
JP (1) JP3788935B2 (de)
KR (1) KR100502033B1 (de)
CN (1) CN1176915C (de)
AR (1) AR032453A1 (de)
AT (1) ATE286036T1 (de)
AU (2) AU2001270494B2 (de)
BR (1) BR0110573A (de)
CA (1) CA2407416C (de)
DE (1) DE60108108T2 (de)
EC (1) ECSP014054A (de)
ES (1) ES2233660T3 (de)
MX (1) MXPA02010745A (de)
PE (1) PE20011310A1 (de)
PT (1) PT1282612E (de)
WO (1) WO2001083465A2 (de)
ZA (1) ZA200208542B (de)

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GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
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Also Published As

Publication number Publication date
PT1282612E (pt) 2005-04-29
US20010053851A1 (en) 2001-12-20
AU2001270494B2 (en) 2005-11-10
CN1432004A (zh) 2003-07-23
ECSP014054A (es) 2002-01-25
AU7049401A (en) 2001-11-12
KR20020093117A (ko) 2002-12-12
CN1176915C (zh) 2004-11-24
EP1282612A2 (de) 2003-02-12
CA2407416A1 (en) 2001-11-08
AR032453A1 (es) 2003-11-12
DE60108108T2 (de) 2005-12-08
JP2003531898A (ja) 2003-10-28
DE60108108D1 (de) 2005-02-03
EP1282612B1 (de) 2004-12-29
BR0110573A (pt) 2003-04-01
KR100502033B1 (ko) 2005-07-25
MXPA02010745A (es) 2003-03-10
CA2407416C (en) 2006-07-18
JP3788935B2 (ja) 2006-06-21
WO2001083465A2 (en) 2001-11-08
PE20011310A1 (es) 2001-12-31
US6388071B2 (en) 2002-05-14
ZA200208542B (en) 2004-01-22
WO2001083465A3 (en) 2002-05-16
ES2233660T3 (es) 2005-06-16

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