ATE286719T1 - Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen - Google Patents

Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen

Info

Publication number
ATE286719T1
ATE286719T1 AT00949026T AT00949026T ATE286719T1 AT E286719 T1 ATE286719 T1 AT E286719T1 AT 00949026 T AT00949026 T AT 00949026T AT 00949026 T AT00949026 T AT 00949026T AT E286719 T1 ATE286719 T1 AT E286719T1
Authority
AT
Austria
Prior art keywords
lipid
therapeutic agent
vesicles
preformed
destabilizing
Prior art date
Application number
AT00949026T
Other languages
English (en)
Inventor
Norbert Maurer
Kim F Wong
Pieter R Cullis
Original Assignee
Inex Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inex Pharmaceuticals Corp filed Critical Inex Pharmaceuticals Corp
Application granted granted Critical
Publication of ATE286719T1 publication Critical patent/ATE286719T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT00949026T 1999-07-15 2000-07-14 Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen ATE286719T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14397899P 1999-07-15 1999-07-15
PCT/CA2000/000843 WO2001005374A1 (en) 1999-07-15 2000-07-14 Methods for preparation of lipid-encapsulated therapeutic agents

Publications (1)

Publication Number Publication Date
ATE286719T1 true ATE286719T1 (de) 2005-01-15

Family

ID=22506531

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00949026T ATE286719T1 (de) 1999-07-15 2000-07-14 Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen

Country Status (11)

Country Link
EP (2) EP1196145A1 (de)
JP (3) JP2003504390A (de)
CN (1) CN1228041C (de)
AT (1) ATE286719T1 (de)
AU (2) AU771706B2 (de)
BR (1) BR0012624B1 (de)
CA (2) CA2378438C (de)
DE (1) DE60017406T2 (de)
ES (1) ES2235916T3 (de)
IL (2) IL147089A0 (de)
WO (2) WO2001005373A1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119188A1 (en) * 2000-02-08 2002-08-29 Susan Niemiec Method of manufacturing liposomes
US7189705B2 (en) 2000-04-20 2007-03-13 The University Of British Columbia Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
AU5454801A (en) * 2000-04-20 2001-11-07 Univ British Columbia Methods of enhancing splp-mediated transfection using endosomal membrane destabilizers
JP2005530704A (ja) * 2002-03-05 2005-10-13 トランセイブ， インク． 細胞内感染を予防及び治療するための吸入システム
WO2003097805A2 (en) 2002-05-15 2003-11-27 California Pacific Medical Center Delivery of nucleic acid-like compounds
EP1530465B2 (de) 2002-06-26 2015-12-16 MediGene AG Herstellung einer kationisch liposomalen zubereitung, einen lipophilen wirkstoff enthaltend
EP1519714B1 (de) 2002-06-28 2010-10-20 Protiva Biotherapeutics Inc. Verfahren und vorrichtung zur herstellung von liposomen
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
CA2532228C (en) * 2003-07-16 2017-02-14 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
WO2006069782A2 (en) 2004-12-27 2006-07-06 Silence Therapeutics Ag. Lipid complexes coated with peg and their use
MXPA06012722A (es) 2004-05-05 2007-02-14 Atugen Ag Lipidos, complejos de lipido y su uso.
JP4764426B2 (ja) * 2004-06-07 2011-09-07 プロチバ バイオセラピューティクス インコーポレイティッド カチオン性脂質および使用方法
CA2569664C (en) 2004-06-07 2013-07-16 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
EP1773857A4 (de) 2004-07-02 2009-05-13 Protiva Biotherapeutics Inc Das immunsystem stimulierende sirna-moleküle und anwendungen davon
CN101267805A (zh) 2005-07-27 2008-09-17 普洛体维生物治疗公司 制造脂质体的系统和方法
CN101346393B (zh) 2005-11-02 2015-07-22 普洛体维生物治疗公司 修饰的siRNA分子及其应用
EP3067047B1 (de) 2005-12-08 2022-04-20 Insmed Incorporated Antiinfektive zusammensetzungen auf lipidbasis zur behandlung von lungeninfekten
EP2004141A2 (de) * 2006-03-17 2008-12-24 Novosom AG Effizientes verfahren zum beladen von amphoteren liposomen mit nukleinsäure-wirkstoffen
EP2012750B1 (de) * 2006-04-06 2018-02-21 Insmed Incorporated Verfahren für koazervationsinduzierte liposomale verkapselung und formulierungen daraus
KR101670085B1 (ko) 2006-07-21 2016-10-28 사일런스 테라퓨틱스 게엠베하 단백질 키나아제 3의 발현을 억제하기 위한 수단
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
WO2009038540A1 (en) * 2007-09-17 2009-03-26 Microspace Rapid Pte Ltd System and method for providing control of a vehicle
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
CA2740000C (en) 2008-10-09 2017-12-12 Tekmira Pharmaceuticals Corporation Improved amino lipids and methods for the delivery of nucleic acids
JP2012505913A (ja) 2008-10-16 2012-03-08 マリーナ バイオテック，インコーポレイテッド 遺伝子発現を抑制する治療におけるリポソームによる効率的な送達のプロセスおよび組成物
CN111808084A (zh) 2008-11-10 2020-10-23 阿布特斯生物制药公司 用于递送治疗剂的新型脂质和组合物
EA020604B1 (ru) * 2008-12-17 2014-12-30 Онкотиреон, Инк. Композиция, содержащая липосомы малого размера, и способ ее получения
WO2011000107A1 (en) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Novel lipid formulations for delivery of therapeutic agents to solid tumors
EP2449106B1 (de) 2009-07-01 2015-04-08 Protiva Biotherapeutics Inc. Zusammensetzungen und verfahren zur ausschaltung von apolipoprotein b
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
JP5854559B2 (ja) 2009-07-06 2016-02-09 ヴァリエーション バイオテクノロジーズ インコーポレイテッド 小胞を調製する方法及びこれから製造される製剤
CA2803282C (en) 2009-07-06 2018-05-01 David E. Anderson Methods for preparing vesicles and formulations produced therefrom
WO2011056682A1 (en) 2009-10-27 2011-05-12 The University Of British Columbia Reverse head group lipids, lipid particle compositions comprising reverse headgroup lipids, and methods for the delivery of nucleic acids
WO2011120023A1 (en) 2010-03-26 2011-09-29 Marina Biotech, Inc. Nucleic acid compounds for inhibiting survivin gene expression uses thereof
US20130037977A1 (en) 2010-04-08 2013-02-14 Paul A. Burke Preparation of Lipid Nanoparticles
WO2011133584A2 (en) 2010-04-19 2011-10-27 Marina Biotech, Inc. Nucleic acid compounds for inhibiting hras gene expression and uses thereof
WO2011139843A2 (en) 2010-04-28 2011-11-10 Marina Biotech, Inc. Multi-sirna compositions for reducing gene expression
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
WO2012006367A2 (en) 2010-07-06 2012-01-12 Variation Biotechnologies, Inc. Compositions and methods for treating influenza
US10736844B2 (en) * 2011-01-13 2020-08-11 Variation Biotechnologies Inc. Compositions and methods for treating viral infections
EP3485875A1 (de) * 2011-11-04 2019-05-22 Nitto Denko Corporation Einmal verwendbares system zur sterilen herstellung von lipid-nukleinsäure-partikeln
US9579338B2 (en) * 2011-11-04 2017-02-28 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
AU2013208693B2 (en) 2012-01-12 2017-12-07 Variation Biotechnologies Inc. Compositions and methods for treating viral infections
EP2806894A4 (de) 2012-01-27 2015-11-04 Variation Biotechnologies Inc Verfahren und zusammensetzungen für therapeutika
PL2852391T3 (pl) 2012-05-21 2022-04-11 Insmed Incorporated Układy do leczenia infekcji płuc
US10124066B2 (en) 2012-11-29 2018-11-13 Insmed Incorporated Stabilized vancomycin formulations
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
EP2968141B1 (de) * 2013-03-14 2016-10-05 Biorest Ltd. Liposomenformulierung und herstellung
US9693958B2 (en) 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
US9636034B2 (en) 2013-10-23 2017-05-02 Verily Life Sciences Llc Non-invasive analyte detection system with modulation source
LT3466432T (lt) 2014-05-15 2020-12-28 Insmed Incorporated Būdai, skirti plaučių netuberkuliozinėms mikobakterinėms infekcijoms gydyti
BR112016030852A2 (pt) * 2014-07-02 2018-01-16 Shire Human Genetic Therapies encapsulação de rna mensageiro
US9861710B1 (en) 2015-01-16 2018-01-09 Verily Life Sciences Llc Composite particles, methods, and in vivo diagnostic system
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
AU2017357758B2 (en) * 2016-11-10 2023-11-16 Translate Bio, Inc. Improved process of preparing mRNA-loaded lipid nanoparticles
MA49421A (fr) 2017-06-15 2020-04-22 Modernatx Inc Formulations d'arn
EP3675817A1 (de) 2017-08-31 2020-07-08 Modernatx, Inc. Verfahren zur herstellung von lipidnanopartikeln
RS67724B1 (sr) * 2017-10-20 2026-03-31 BioNTech SE Priprema i skladištenje lipozomskih rnk formulacija koje su pogodne za terapiju
EP3773505B1 (de) 2018-03-30 2026-04-29 Insmed Incorporated Verfahren zur kontinuierlichen herstellung von liposomalen arzneimittelprodukten
JP7449275B2 (ja) 2018-05-02 2024-03-13 インスメッド インコーポレイテッド リポソーム薬物製剤の製造方法
KR20210091120A (ko) 2018-08-29 2021-07-21 트랜슬레이트 바이오 인코포레이티드 Mrna-로딩된 지질 나노입자를 제조하는 개선된 공정
EP3620519A1 (de) * 2018-09-04 2020-03-11 F. Hoffmann-La Roche AG Verwendung von isolierten extrazellulären vesikeln aus milch zur oralen verabreichung von oligonukleotiden
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
RU2697390C1 (ru) * 2019-03-15 2019-08-14 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кемеровский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ синтеза липосомальной формы тироксина
SG11202110036RA (en) 2019-03-19 2021-10-28 Arcturus Therapeutics Inc Method of making lipid-encapsulated rna nanoparticles
EP3711749A1 (de) 2019-03-19 2020-09-23 Polymun Scientific Immunbiologische Forschung GmbH Verfahren zur herstellung von lipidnanopartikeln
CN118203546A (zh) 2019-05-07 2024-06-18 米尼翁大学 生产脂质体的方法
CN115427021A (zh) 2020-02-25 2022-12-02 翻译生物公司 制备负载mrna的脂质纳米颗粒的改进方法
ES3054438T3 (en) 2020-07-16 2026-02-03 Acuitas Therapeutics Inc Cationic lipids for use in lipid nanoparticles
IL301253A (en) 2020-09-13 2023-05-01 Arcturus Therapeutics Inc As a mass of large RNA lipid nanoparticles
WO2022115645A1 (en) 2020-11-25 2022-06-02 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids, and related methods of use
EP4059491A1 (de) 2021-03-17 2022-09-21 Evonik Operations GmbH Vorrichtung und verfahren zur herstellung von nanocarriern und/oder nanoformulierungen
CA3242402A1 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
CA3256897A1 (en) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Lipid nanoparticles for the administration of nucleic acids and their methods of use
EP4584011A1 (de) 2022-09-08 2025-07-16 Evonik Operations GmbH Verbesserte nanoträgerherstellung
EP4669453A1 (de) 2023-02-23 2025-12-31 Evonik Operations GmbH Leicht zu handhabender liposomextruder
CN120769775A (zh) 2023-02-23 2025-10-10 赢创运营有限公司 小型脂质体挤出器
WO2025219199A1 (en) 2024-04-19 2025-10-23 Evonik Operations Gmbh Process for producing nanocarriers and/or nanoformulations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4752425A (en) * 1986-09-18 1988-06-21 Liposome Technology, Inc. High-encapsulation liposome processing method
US4895452A (en) * 1988-03-03 1990-01-23 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
JPH0665382B2 (ja) * 1991-03-20 1994-08-24 雪印乳業株式会社 リポソーム調製装置とその装置を使用するリポソーム調製方法
US5776486A (en) * 1993-05-28 1998-07-07 Aphios Corporation Methods and apparatus for making liposomes containing hydrophobic drugs
CA2163860A1 (en) * 1993-06-30 1995-01-12 Chung C. Hsu Method for preparing liposomes
EP1179340A3 (de) * 1994-09-30 2003-05-07 INEX Pharmaceutical Corp. Zusammensetzungen zum Einbringen polyanionischer Materialien in Zellen
AU733310C (en) * 1997-05-14 2001-11-29 University Of British Columbia, The High efficiency encapsulation of charged therapeutic agents in lipid vesicles
CA2309727C (en) * 1997-10-10 2012-12-04 Inex Pharmaceuticals Corporation Methods for encapsulating nucleic acids in lipid bilayers
AU752802C (en) * 1997-11-14 2006-04-13 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
WO2000029103A1 (en) * 1998-11-13 2000-05-25 Optime Therapeutics, Inc. Method and apparatus for liposome production

Also Published As

Publication number Publication date
BR0012624B1 (pt) 2011-08-09
JP2011225618A (ja) 2011-11-10
DE60017406T2 (de) 2005-09-29
AU6256100A (en) 2001-02-05
CN1361681A (zh) 2002-07-31
JP5388395B2 (ja) 2014-01-15
BR0012624A (pt) 2002-04-02
WO2001005373A1 (en) 2001-01-25
DE60017406D1 (de) 2005-02-17
WO2001005373A9 (en) 2002-08-29
AU771706B2 (en) 2004-04-01
ES2235916T3 (es) 2005-07-16
IL147089A (en) 2006-08-20
JP2003504391A (ja) 2003-02-04
CA2378438C (en) 2010-05-04
JP2003504390A (ja) 2003-02-04
AU769357B2 (en) 2004-01-22
WO2001005374A1 (en) 2001-01-25
CA2378438A1 (en) 2001-01-25
EP1194122B1 (de) 2005-01-12
IL147089A0 (en) 2002-08-14
EP1196145A1 (de) 2002-04-17
CA2378430A1 (en) 2001-01-25
AU6256200A (en) 2001-02-05
CN1228041C (zh) 2005-11-23
EP1194122A1 (de) 2002-04-10

Similar Documents

Publication Publication Date Title
ATE286719T1 (de) Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen
ATE324907T1 (de) Verbindung und arzneizusammensetzung zur verabreichung von wirkstoffen
IL101225A0 (en) Bi-and tricyclic amino alcohol esters,their preparation and pharmaceutical compositions containing them
EP1226109A4 (de) Phenylamin-carbonsäure-verbindungen und zubereitungen zur verabreichung von wirkstoffen
IL139113A0 (en) Pharmaceutical compositions capable of being gelled
ATE249422T1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiver stoffe
CA2068324A1 (en) Metal-peptide compositions and methods for stimulating hair growth
PL347671A1 (en) Compounds and compositions for delivering active agents
ES478056A1 (es) Procedimiento de fabricacion de capsulas lipidicas que con- tienen uno o varios materiales biologicamente activos.
NO20010264D0 (no) Bionedbrytbare preparater for kontrollert frigivelse av innkapslede stoffer
BG102254A (en) Oral fast soluble compositions as dopamine antagonists
ES8600060A1 (es) Procedimiento para preparar un medicamento envasado que contiene como sustancia activa un antagonista del calcio tal como nifedipina, verapamil diltiazem y otros.
MXPA01008611A (es) Compuestos y composiciones para suministrar agentes activos.
AU7315301A (en) Compounds and compositions for delivering active agents
DE69516540D1 (de) AMINO-IMIDAZO [4,5-c] CHINOLINE
HUT75513A (en) Taxane class derivative based pharmaceutical compositions and their preparation
GEP20022734B (en) Pharmaceutical Preparation Comprising Lyophilized Liposomes Encapsulating an Active Principle Which Is Highly Insoluble in Water, and the Process for Preparing the Said Preparation
TWI255720B (en) Novel preparation and administration form comprising an acid-labile active compound and process for production thereof
ES2134237T3 (es) Composiciones farmaceuticas que contienen acido ursodesoxicolico.
GEP19991872B (en) Novel Taxoids, Preparations Thereof, and Pharmaceutical Compositions Containing Same
GEP20033054B (en) 2,4,4-Trisubstituted-1,3-Dioxolane Antifungals
SU1394227A1 (ru) Способ моделировани карбункула кожи
TW358740B (en) The method to get the optimum composition of liposomes encapsulated hemoglobin solution as artificial red blood cells
RU94023370A (ru) Анальгезирующее средство

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties