ES478056A1 - Procedimiento de fabricacion de capsulas lipidicas que con- tienen uno o varios materiales biologicamente activos. - Google Patents

Procedimiento de fabricacion de capsulas lipidicas que con- tienen uno o varios materiales biologicamente activos.

Info

Publication number
ES478056A1
ES478056A1 ES478056A ES478056A ES478056A1 ES 478056 A1 ES478056 A1 ES 478056A1 ES 478056 A ES478056 A ES 478056A ES 478056 A ES478056 A ES 478056A ES 478056 A1 ES478056 A1 ES 478056A1
Authority
ES
Spain
Prior art keywords
biologically active
utilisation
preparation
encapsulation
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES478056A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES478056A1 publication Critical patent/ES478056A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/98—Preparation of granular or free-flowing enzyme compositions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Procedimiento de fabricación de capsulas lipídicas que contienen uno o varios materiales biológicamente activos, caracterizado porque: se prepara una mezcla en un disolvente orgánico de un compuesto formador de paredes de cápsulas y una mezcla acuosa del material biológicamente activo destinado a encapsularse, siendo la relación entre la fase orgánica y la fase acuosa de un valor adecuado para proporcionar una emulsión del tipo de agua en aceite, se forma una emulsión homogénea de la citada mezcla, del tipo de la producida por exposición a ondas ultrasonoras, se extrae el disolvente orgánico de la emulsión con lo que se obtiene una mezcla del carácter de un gel y se transforma la mezcla análoga a un gel en una suspensión de cápsulas oligolaminares sintéticas que contienen el material biológicamente activo, ya sea agitando dicha mezcla con carácter de gel, ya sea dispersando la misma en un medio acuoso.
ES478056A 1978-02-24 1979-02-24 Procedimiento de fabricacion de capsulas lipidicas que con- tienen uno o varios materiales biologicamente activos. Expired ES478056A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/881,116 US4235871A (en) 1978-02-24 1978-02-24 Method of encapsulating biologically active materials in lipid vesicles

Publications (1)

Publication Number Publication Date
ES478056A1 true ES478056A1 (es) 1980-04-16

Family

ID=25377816

Family Applications (1)

Application Number Title Priority Date Filing Date
ES478056A Expired ES478056A1 (es) 1978-02-24 1979-02-24 Procedimiento de fabricacion de capsulas lipidicas que con- tienen uno o varios materiales biologicamente activos.

Country Status (7)

Country Link
US (1) US4235871A (es)
EP (1) EP0004223B1 (es)
BE (1) BE874408A (es)
DE (1) DE2907303A1 (es)
ES (1) ES478056A1 (es)
FR (1) FR2418023A1 (es)
GB (1) GB2015464B (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2034877A1 (es) * 1990-10-30 1993-04-01 Gador Y Cia S A C I Lab Dr Procedimiento para la preparacion de liposomas de drogas insolubles en aceite en capsulas blandas de gelatina enterosolubles.
ES2070778A1 (es) * 1993-10-07 1995-06-01 Vinas Lab Composicion de liposomas y su procedimiento de obtencion.

Families Citing this family (1879)

* Cited by examiner, † Cited by third party
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GB2015464A (en) 1979-09-12
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US4235871A (en) 1980-11-25
FR2418023A1 (fr) 1979-09-21
FR2418023B1 (es) 1983-05-13
GB2015464B (en) 1982-08-18
DE2907303A1 (de) 1979-09-06

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