ATE288744T1 - Arzneiformulierungen zur hormonersatztherapie zur topischen anwendung auf der haut - Google Patents

Arzneiformulierungen zur hormonersatztherapie zur topischen anwendung auf der haut

Info

Publication number: ATE288744T1
Authority: AT; Austria
Prior art keywords: skin; replacement therapy; topical use; hormone replacement; medicinal formulations
Prior art date: 1997-10-16

Application number

AT98952067T

Other languages

English (en)

Inventor

Carlos M Samour

Scott F Krauser

Robert J Gyurik

Original Assignee

Macrochem Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-16

Filing date

1998-10-02

Publication date

2005-02-15

1998-10-02 Application filed by Macrochem Corp filed Critical Macrochem Corp

2005-02-15 Application granted granted Critical

2005-02-15 Publication of ATE288744T1 publication Critical patent/ATE288744T1/de

Links

239000000203 mixture Substances 0.000 title abstract 2
230000000699 topical effect Effects 0.000 title abstract 2
238000002657 hormone replacement therapy Methods 0.000 title 1
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
230000001476 alcoholic effect Effects 0.000 abstract 2
230000035515 penetration Effects 0.000 abstract 2
VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical compound C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 abstract 1
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 1
QPILHXCDZYWYLQ-UHFFFAOYSA-N 2-nonyl-1,3-dioxolane Chemical compound CCCCCCCCCC1OCCO1 QPILHXCDZYWYLQ-UHFFFAOYSA-N 0.000 abstract 1
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
229960005309 estradiol Drugs 0.000 abstract 1
229930182833 estradiol Natural products 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000000499 gel Substances 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
239000000186 progesterone Substances 0.000 abstract 1
229960003387 progesterone Drugs 0.000 abstract 1
229960003604 testosterone Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Prostheses (AREA)

AT98952067T 1997-10-16 1998-10-02 Arzneiformulierungen zur hormonersatztherapie zur topischen anwendung auf der haut ATE288744T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/953,014 US5968919A (en)	1997-10-16	1997-10-16	Hormone replacement therapy drug formulations for topical application to the skin
PCT/US1998/020895 WO1999020257A1 (en)	1997-10-16	1998-10-02	Hormone replacement therapy drug formulations for topical application to the skin

Publications (1)

Publication Number	Publication Date
ATE288744T1 true ATE288744T1 (de)	2005-02-15

Family

ID=25493463

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98952067T ATE288744T1 (de)	1997-10-16	1998-10-02	Arzneiformulierungen zur hormonersatztherapie zur topischen anwendung auf der haut

Country Status (10)

Country	Link
US (1)	US5968919A (de)
EP (1)	EP0971705B1 (de)
JP (1)	JP2001505930A (de)
AT (1)	ATE288744T1 (de)
CA (1)	CA2260185C (de)
DE (1)	DE69828958T2 (de)
DK (1)	DK0971705T3 (de)
ES (1)	ES2238094T3 (de)
PT (1)	PT971705E (de)
WO (1)	WO1999020257A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AUPN814496A0 (en)	1996-02-19	1996-03-14	Monash University	Dermal penetration enhancer
US5942545A (en) *	1998-06-15	1999-08-24	Macrochem Corporation	Composition and method for treating penile erectile dysfunction
US6582683B2 (en)	2000-01-04	2003-06-24	Skinvisible Pharmaceuticals, Inc.	Dermal barrier composition
WO2002007728A1 (en) *	2000-07-19	2002-01-31	Knowles W Roy	Hair loss prevention
US20040198706A1 (en) *	2003-03-11	2004-10-07	Carrara Dario Norberto R.	Methods and formulations for transdermal or transmucosal application of active agents
ATE485837T1 (de)	2000-08-03	2010-11-15	Antares Pharma Ipl Ag	Zusammensetzung zur transdermalen und/oder transmukosalen verabreichung von wirkstoffen, die ausreichende therapeutische spiegel garantiert
US7198801B2 (en) *	2000-08-03	2007-04-03	Antares Pharma Ipl Ag	Formulations for transdermal or transmucosal application
US8980290B2 (en)	2000-08-03	2015-03-17	Antares Pharma Ipl Ag	Transdermal compositions for anticholinergic agents
US20030139384A1 (en) *	2000-08-30	2003-07-24	Dudley Robert E.	Method for treating erectile dysfunction and increasing libido in men
AU2001285367B2 (en) *	2000-08-30	2006-05-18	Besins Healthcare Luxembourg Sarl	Method of increasing testosterone and related steroid concentrations in women
US20040092494A9 (en) *	2000-08-30	2004-05-13	Dudley Robert E.	Method of increasing testosterone and related steroid concentrations in women
US6503894B1 (en) *	2000-08-30	2003-01-07	Unimed Pharmaceuticals, Inc.	Pharmaceutical composition and method for treating hypogonadism
DK1347764T3 (da) *	2000-12-22	2007-07-23	August Wolff Gmbh & Co Kg Arzn	Gelpræparat på alkoholisk basis til behandling af hypogonadisme ved transskrotal applikation
US20020107230A1 (en) *	2000-12-22	2002-08-08	Waldon R. Forrest	Methods and formulations for the treatment of female sexual dysfunction
US20050209208A1 (en) *	2001-04-25	2005-09-22	The Regents Of The University Of California	Use of estriol and other estranes, estrogens and estrogen receptor active compositions in the treatment of psoriasis and other autoimmune disorders
US7244703B2 (en)	2001-06-22	2007-07-17	Bentley Pharmaceuticals, Inc.	Pharmaceutical compositions and methods for peptide treatment
US6756059B2 (en)	2001-08-20	2004-06-29	Skinvisible Pharmaceuticals, Inc.	Topical composition, topical composition precursor, and methods for manufacturing and using
DK1482948T3 (da) *	2002-03-11	2006-11-27	Janssen Pharmaceutica Nv	Kontinuerlig sulfataseinhiberende progestogen-hormonsubstitutionsbehandling
US20030191096A1 (en) *	2002-04-03	2003-10-09	Leonard Thomas W.	Method of hormonal therapy
MY139721A (en) *	2002-04-19	2009-10-30	Cpex Pharmaceuticals Inc	Pharmaceutical composition
AUPS317302A0 (en) *	2002-06-25	2002-07-18	Drug Delivery Solutions Pty Ltd	Metastable pharmaceutical compositions
KR20050045946A (ko)	2002-06-25	2005-05-17	애크럭스 디디에스 피티와이 리미티드	비정질 약학적 조성물을 이용한 경피전달속도의 제어
US20040126339A1 (en) *	2002-12-31	2004-07-01	Roszell James A.	Sunscreen composition and methods for manufacturing and using a sunscreen composition
US20040171992A1 (en) *	2003-02-28	2004-09-02	Waikiwi Corporation	Cream dispenser providing sequential dispensing means
DE10314976A1 (de) *	2003-04-02	2004-10-14	Bayer Healthcare Ag	Verbesserte Penetration von Wirkstoffen in Zellen und Organe
US8883769B2 (en) *	2003-06-18	2014-11-11	White Mountain Pharma, Inc.	Methods for the treatment of fibromyalgia and chronic fatigue syndrome
US20040259852A1 (en) *	2003-06-18	2004-12-23	White Hillary D.	Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome
US20050042182A1 (en) *	2003-08-13	2005-02-24	Moshe Arkin	Topical compositions of urea
US20050036953A1 (en) *	2003-08-13	2005-02-17	Moshe Arkin	Topical compositions of ammonium lactate
US20050037040A1 (en) *	2003-08-13	2005-02-17	Moshe Arkin	Topical compositions of urea and ammonium lactate
US20050042268A1 (en) *	2003-07-16	2005-02-24	Chaim Aschkenasy	Pharmaceutical composition and method for transdermal drug delivery
US20050020552A1 (en) *	2003-07-16	2005-01-27	Chaim Aschkenasy	Pharmaceutical composition and method for transdermal drug delivery
US20050025833A1 (en) *	2003-07-16	2005-02-03	Chaim Aschkenasy	Pharmaceutical composition and method for transdermal drug delivery
ATE534373T1 (de)	2003-10-10	2011-12-15	Antares Pharma Ipl Ag	Transdermale pharmazeutische formulierung zur minimierung von rückständen auf der haut
CN101829319A (zh)	2003-12-08	2010-09-15	Cpex药品公司	用于胰岛素治疗的药用组合物及方法
US7425340B2 (en) *	2004-05-07	2008-09-16	Antares Pharma Ipl Ag	Permeation enhancing compositions for anticholinergic agents
JP2008512425A (ja) *	2004-09-09	2008-04-24	ラボラトワールブザンアンテルナスィヨナル	透過促進剤としてのプロピレングリコールを含むテストステロンゲル
EP1634583A1 (de) *	2004-09-09	2006-03-15	Laboratoires Besins International	Testosterongele enthaltend Propylenglykol als Resorptionsverstärker
US20060110415A1 (en) *	2004-11-22	2006-05-25	Bioderm Research	Topical Delivery System for Cosmetic and Pharmaceutical Agents
US8067399B2 (en)	2005-05-27	2011-11-29	Antares Pharma Ipl Ag	Method and apparatus for transdermal or transmucosal application of testosterone
KR20130114229A (ko) *	2005-06-03	2013-10-16	애크럭스 디디에스 피티와이 리미티드	경피 약물 전달 방법 및 조성물
GEP20125432B (en)	2005-10-12	2012-03-26	Unimed Pharmaceuticals Llc	Improved testosterone gel and use thereof
CN101426475A (zh)	2006-04-21	2009-05-06	安塔雷斯制药Ipl股份公司	使用用于经皮或经粘膜应用的制剂治疗热潮红的方法
WO2008066618A2 (en) *	2006-10-20	2008-06-05	Skinvisible Pharmaceuticals, Inc.	Antifungal composition and methods for using
EA015473B1 (ru)	2007-01-11	2011-08-30	АКРУКС ДиДиЭс ПиТиУай ЭлТиДи	Инструмент для нанесения объема жидкости на обрабатываемую поверхность, система и способ трансдермального введения физиологически активного вещества в организм больного
EP2191833B1 (de) *	2007-09-20	2013-02-13	Shiseido Company, Ltd.	Transdermal absorbierbares präparat
US8128913B1 (en)	2007-12-06	2012-03-06	Skinvisible Pharmaceuticals, Inc.	Sunscreen composition with enhanced UV-A absorber stability and methods
US8299122B2 (en) *	2008-04-14	2012-10-30	Skinvisible Pharmaceuticals, Inc.	Method for stabilizing retinoic acid, retinoic acid containing composition, and method of using a retinoic acid containing composition
EP2640398A4 (de)	2010-11-18	2014-05-14	White Mountain Pharma Inc	Verfahren zur behandlung chronischer bzw. nicht linderbarer schmerzen und/oder erhöhung der schmerzschwelle bei einem patienten und pharmazeutische zusammensetzung zur verwendung darin
US9301920B2 (en)	2012-06-18	2016-04-05	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US8633178B2 (en)	2011-11-23	2014-01-21	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US20130338122A1 (en)	2012-06-18	2013-12-19	Therapeuticsmd, Inc.	Transdermal hormone replacement therapies
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en)	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
USD750788S1 (en)	2013-11-26	2016-03-01	Acrux Dds Pty Ltd	Topical spreading applicator
USD749225S1 (en)	2013-11-26	2016-02-09	Acrux Dds Pty Ltd	Topical spreading applicator
EP3145489A1 (de)	2014-05-22	2017-03-29	TherapeuticsMD, Inc.	Natürliche kombinierte hormonersatzformulierungen und therapien
RU2016141135A (ru)	2014-07-29	2018-08-28	Терапьютиксмд, Инк.	Трансдермальный крем
US10328087B2 (en)	2015-07-23	2019-06-25	Therapeuticsmd, Inc.	Formulations for solubilizing hormones
WO2017173071A1 (en)	2016-04-01	2017-10-05	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical composition
WO2017173044A1 (en)	2016-04-01	2017-10-05	Therapeuticsmd Inc.	Steroid hormone compositions in medium chain oils
US11633405B2 (en)	2020-02-07	2023-04-25	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical formulations
US12472140B2 (en)	2020-02-18	2025-11-18	Ovation Science Inc.	Composition and method for transdermal delivery of cannabidiol (CBD) and tetrahydrocannabinol (THC)
CA3074150C (en)	2020-02-18	2025-12-16	Ovation Science, Inc.	Composition and method for transdermal delivery of cannabidiol (cbd) and delta9-tetrahydrocannabinol (thc)

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4704282A (en) *	1984-06-29	1987-11-03	Alza Corporation	Transdermal therapeutic system having improved delivery characteristics
US4883669A (en) *	1985-02-25	1989-11-28	Rutgers, The State University Of New Jersey	Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration
US4861764A (en) *	1986-11-17	1989-08-29	Macro Chem. Corp.	Percutaneous absorption enhancers, compositions containing same and method of use
US4788062A (en) *	1987-02-26	1988-11-29	Alza Corporation	Transdermal administration of progesterone, estradiol esters, and mixtures thereof
CH674618A5 (de) *	1987-04-02	1990-06-29	Ciba Geigy Ag
JPH0813757B2 (ja) *	1987-11-16	1996-02-14	マクロケム・コーポレーション	新規な経皮的吸収促進剤およびそれを含む組成物
US5118676A (en) *	1988-04-08	1992-06-02	Whitby Research, Inc.	Penetration enhancers for transdermal delivery of systemic agents
US5252334A (en) *	1989-09-08	1993-10-12	Cygnus Therapeutic Systems	Solid matrix system for transdermal drug delivery
AR246186A1 (es) *	1989-11-17	1994-07-29	Beta Pharm Co	Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica.
JP2945993B2 (ja) *	1989-12-05	1999-09-06	武田薬品工業株式会社	外用剤
US5198223A (en) *	1990-10-29	1993-03-30	Alza Corporation	Transdermal formulations, methods and devices
US5314694A (en) *	1990-10-29	1994-05-24	Alza Corporation	Transdermal formulations, methods and devices
US5512292A (en) *	1990-10-29	1996-04-30	Alza Corporation	Transdermal contraceptive formulations methods and devices
US5152997A (en) *	1990-12-11	1992-10-06	Theratech, Inc.	Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels
US5164190A (en) *	1990-12-11	1992-11-17	Theratech, Inc.	Subsaturated transdermal drug delivery device exhibiting enhanced drug flux
US5518734A (en) *	1991-09-25	1996-05-21	Beta Pharmaceuticals Co.	Transdermal delivery system for estradiol and process for manufacturing said device
SK286051B6 (sk) *	1993-01-19	2008-02-05	Endorecherche Inc.	Použitie prekurzora pohlavného steroidu na prípravu liečiva na prevenciu alebo liečenie znížených alebo nevyrovnaných koncentrácií pohlavných steroidov
FR2719220A1 (fr) *	1994-04-29	1995-11-03	Lafon Labor	Nouvelle forme galénique pour l'administration transdermique.
FR2740038B1 (fr) *	1995-10-20	1998-01-02	Lafon Labor	Composition pour l'administration transdermique
AUPN814496A0 (en) *	1996-02-19	1996-03-14	Monash University	Dermal penetration enhancer

1997
- 1997-10-16 US US08/953,014 patent/US5968919A/en not_active Expired - Fee Related
1998
- 1998-10-02 JP JP52411099A patent/JP2001505930A/ja not_active Ceased
- 1998-10-02 EP EP98952067A patent/EP0971705B1/de not_active Expired - Lifetime
- 1998-10-02 PT PT98952067T patent/PT971705E/pt unknown
- 1998-10-02 WO PCT/US1998/020895 patent/WO1999020257A1/en not_active Ceased
- 1998-10-02 AT AT98952067T patent/ATE288744T1/de not_active IP Right Cessation
- 1998-10-02 DE DE69828958T patent/DE69828958T2/de not_active Expired - Fee Related
- 1998-10-02 ES ES98952067T patent/ES2238094T3/es not_active Expired - Lifetime
- 1998-10-02 DK DK98952067T patent/DK0971705T3/da active
- 1998-10-02 CA CA002260185A patent/CA2260185C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69828958D1 (de)	2005-03-17
DE69828958T2 (de)	2006-01-19
JP2001505930A (ja)	2001-05-08
US5968919A (en)	1999-10-19
CA2260185C (en)	2008-12-23
CA2260185A1 (en)	1999-04-17
ES2238094T3 (es)	2005-08-16
EP0971705A1 (de)	2000-01-19
PT971705E (pt)	2005-06-30
EP0971705A4 (de)	2001-01-31
WO1999020257A1 (en)	1999-04-29
DK0971705T3 (da)	2005-06-13
EP0971705B1 (de)	2005-02-09

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2005-10-15

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Publication of translation of european patent specification

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2010-07-15

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Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE288744T1 (de)	2005-02-15	Arzneiformulierungen zur hormonersatztherapie zur topischen anwendung auf der haut
DE69919863D1 (de)	2004-10-07	Stabilgelmischung in form einer mischung eines öligen gels und eines wässrigen gels
BR0113670A (pt)	2004-11-09	Composição farmacêutica e método para tratar hipogonadismo
DK0742714T3 (da)	2001-04-30	Flydende farmaceutiske præparater omfattende thyroideahormoner
ES2106029T3 (es)	1997-11-01	Composiciones que mejoran la penetracion a traves de la piel.
PT748190E (pt)	2003-12-31	Metodos e formulacoes para uso no tratamento de disturbios ginecologicos benignos
ES2132216T3 (es)	1999-08-16	Nuevos derivados de amidinas, su preparacion y utilizacion como medicamentos con efecto antagonista de ltb4.
DE69724647D1 (de)	2003-10-09	Acyclovirhaltige antiherpesarzneistift zur topischen anwendung
ATE165521T1 (de)	1998-05-15	Verminderung der hautreizung während einer iontophoretischen abgabe von medikamenten
HN1999000124A (es)	1999-07-27	Derivados de pirazol substituido.
ES2157307T3 (es)	2001-08-16	Composicion topica que contiene un antagonista de sustancia p.
ATE238778T1 (de)	2003-05-15	Transdermales therapeutisches system zur abgabe von hormonen
AR002944A1 (es)	1998-05-27	Uso de una composicion de gel acuosa que contiene una o mas drogas que son eficaces para tratar hemorroides para la preparacion de un medicamento y dicha composicion de gel acuosa
EA200201000A1 (ru)	2003-02-27	Гормон-заместительная терапия
MXPA02012075A (es)	2004-08-19	Composicion para mediar el dolor y aparato y metodo para utilizarla.
ES2172937T3 (es)	2002-10-01	21-hidroxi-6,19-oxidoprogesterona(21oh-6op) como medicamento para tratar el exceso de glucocorticoides.
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NO970178L (no)	1997-01-15	Terpenoidderivater (sarcodictyiner) som er nyttige som antitumormidler
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DE59301120D1 (de)	1996-01-18	Zubereitung zur topischen anwendung.
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AR006034A1 (es)	1999-07-21	Una composicion antitranspirante, un sistema antitranspirante que la comprende y la utilizacion de un emoliente en la preparacion de la misma