ATE288887T1 - Substituierte phenylpropionsäurederivate als agonisten des menschlichen peroxisom-proliferator-aktiverten rezeptors alpha(ppar) - Google Patents
Substituierte phenylpropionsäurederivate als agonisten des menschlichen peroxisom-proliferator-aktiverten rezeptors alpha(ppar)Info
- Publication number
- ATE288887T1 ATE288887T1 AT00935582T AT00935582T ATE288887T1 AT E288887 T1 ATE288887 T1 AT E288887T1 AT 00935582 T AT00935582 T AT 00935582T AT 00935582 T AT00935582 T AT 00935582T AT E288887 T1 ATE288887 T1 AT E288887T1
- Authority
- AT
- Austria
- Prior art keywords
- acid derivatives
- ppar
- actived
- agonists
- receptor alpha
- Prior art date
Links
- YPGCWEMNNLXISK-UHFFFAOYSA-N hydratropic acid Chemical class OC(=O)C(C)C1=CC=CC=C1 YPGCWEMNNLXISK-UHFFFAOYSA-N 0.000 title abstract 3
- 102000005962 receptors Human genes 0.000 title abstract 3
- 108020003175 receptors Proteins 0.000 title abstract 3
- 210000002824 peroxisome Anatomy 0.000 title abstract 2
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 102000023984 PPAR alpha Human genes 0.000 abstract 1
- 108010028924 PPAR alpha Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16223599 | 1999-06-09 | ||
| JP2000157600A JP4618845B2 (ja) | 1999-06-09 | 2000-05-29 | ヒトペルオキシゾーム増殖薬活性化受容体（ＰＰＡＲ）αアゴニストとしての置換フェニルプロピオン酸誘導体 |
| PCT/JP2000/003707 WO2000075103A1 (en) | 1999-06-09 | 2000-06-08 | SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) $g(a) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288887T1 true ATE288887T1 (de) | 2005-02-15 |
Family
ID=26488107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00935582T ATE288887T1 (de) | 1999-06-09 | 2000-06-08 | Substituierte phenylpropionsäurederivate als agonisten des menschlichen peroxisom-proliferator-aktiverten rezeptors alpha(ppar) |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6506797B1 (de) |
| EP (1) | EP1184366B1 (de) |
| JP (1) | JP4618845B2 (de) |
| KR (1) | KR100704142B1 (de) |
| CN (1) | CN1157368C (de) |
| AT (1) | ATE288887T1 (de) |
| AU (1) | AU773445B2 (de) |
| BR (1) | BR0011734A (de) |
| CA (1) | CA2376094C (de) |
| DE (1) | DE60018064T2 (de) |
| DK (1) | DK1184366T3 (de) |
| ES (1) | ES2235886T3 (de) |
| HU (1) | HUP0201654A3 (de) |
| NO (1) | NO327957B1 (de) |
| NZ (1) | NZ515705A (de) |
| PT (1) | PT1184366E (de) |
| WO (1) | WO2000075103A1 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186315C (zh) * | 1999-09-17 | 2005-01-26 | 杏林制药株式会社 | o－茴香酰胺衍生物 |
| TWI262185B (en) * | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| US6768008B2 (en) * | 2000-04-24 | 2004-07-27 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US7049342B2 (en) * | 2000-05-29 | 2006-05-23 | Kyorin Pharmaceutical Co., Ltd. | Substituted phenylpropionic acid derivatives |
| CA2410647C (en) * | 2000-05-29 | 2010-02-09 | Kyorin Pharmaceutical Co., Ltd. | Substituted phenylpropanoic acid derivatives |
| JPWO2002044129A1 (ja) * | 2000-11-29 | 2004-04-02 | 杏林製薬株式会社 | 置換カルボン酸誘導体 |
| JPWO2002044131A1 (ja) * | 2000-11-29 | 2004-04-02 | 杏林製薬株式会社 | 置換カルボン酸誘導体 |
| JPWO2002044130A1 (ja) * | 2000-11-29 | 2004-04-02 | 杏林製薬株式会社 | 置換カルボン酸誘導体 |
| WO2002044127A1 (fr) * | 2000-11-29 | 2002-06-06 | Kyorin Pharmaceutical Co., Ltd. | Dérivés d'acide carboxylique substitué |
| US7176204B2 (en) | 2000-12-05 | 2007-02-13 | Kyorin Pahrmaceutical Co., Ltd. | Substituted carboxylic acid derivatives |
| AU2002222573A1 (en) * | 2000-12-05 | 2002-06-18 | Kyorin Pharmaceutical Co. Ltd. | Substituted carboxylic acid derivatives |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| EP1911462A3 (de) | 2001-01-26 | 2011-11-30 | Schering Corporation | Zusammensetzungen enthaltend einen Sterolabsorptionshemmer |
| ES2274013T3 (es) | 2001-01-26 | 2007-05-16 | Schering Corporation | Combinaciones de activador(es) del receptor activado por el proliferador de los peroxisomas (ppar) e inhibidor(es)m de la absorcion de estelores y tratamientos para trastornos vasculares. |
| PT1355644E (pt) | 2001-01-26 | 2006-11-30 | Schering Corp | Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia |
| US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| WO2002079162A1 (en) * | 2001-03-28 | 2002-10-10 | Eisai Co., Ltd. | Carboxylic acids |
| US7244861B2 (en) | 2001-03-30 | 2007-07-17 | Eisai Co., Ltd. | Benzene compound and salt thereof |
| WO2002080899A1 (fr) * | 2001-03-30 | 2002-10-17 | Eisai Co., Ltd. | Agent de traitement de maladie digestive |
| TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
| WO2002098840A1 (en) | 2001-06-04 | 2002-12-12 | Eisai Co., Ltd. | Carboxylic acid derivative and medicine comprising salt or ester of the same |
| US7371777B2 (en) | 2001-08-17 | 2008-05-13 | Eisai Co., Ltd. | Cyclic compound and PPAR agonist |
| EP1426046A4 (de) * | 2001-09-14 | 2005-11-02 | Shionogi & Co | Neuartige verwendung einer tricyclischen verbindung |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| JP2005504091A (ja) | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
| PT1462439E (pt) * | 2001-12-11 | 2008-04-10 | Kyorin Seiyaku Kk | Novos cristais estáveis de derivado do ácido fenilpropiónico substituído e processo para a sua produção |
| GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| SE0104334D0 (sv) * | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| GB0314079D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| ITRM20020014A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del |
| AU2003235429A1 (en) * | 2002-05-27 | 2003-12-12 | Kyorin Pharmaceutical Co., Ltd. | (2s)-2-ethylphenylpropionic acid derivative |
| US7351858B2 (en) | 2002-06-20 | 2008-04-01 | Astrazeneca Ab | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
| SE0201936D0 (sv) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | Therapeutic agents |
| BR0311932A (pt) * | 2002-06-20 | 2005-03-22 | Astrazeneca Ab | Composto, formulação farmacêutica, método para tratar ou prevenir resistência à insulina, uso de um composto, processo para preparar um composto, e, tratamento combinado |
| SE0201937D0 (sv) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | Therapeutic agents |
| US7560449B2 (en) | 2002-11-06 | 2009-07-14 | Schering Corporation | Methods and therapeutic combinations for the treatment of demyelination |
| EP1606287B1 (de) | 2003-03-07 | 2013-10-02 | Merck Sharp & Dohme Corp. | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| WO2004081003A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholeterolemia |
| ES2311806T3 (es) | 2003-03-07 | 2009-02-16 | Schering Corporation | Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| US20070154543A1 (en) * | 2003-04-16 | 2007-07-05 | Kyorin Pharmaceutical Co., Ltd | Solid preparation for oral use |
| JPWO2005009942A1 (ja) * | 2003-07-28 | 2006-09-07 | 杏林製薬株式会社 | 光学活性置換フェニルプロピオン酸誘導体 |
| AU2005272389B2 (en) * | 2004-08-11 | 2011-08-04 | Kyorin Pharmaceutical Co., Ltd. | Novel cyclic aminobenzoic acid derivative |
| PL371841A1 (pl) | 2004-12-20 | 2006-06-26 | ADAMED Sp.z o.o. | Nowe związki pochodne kwasu 3-fenylopropionowego |
| PL372332A1 (pl) | 2005-01-19 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| PL372356A1 (pl) * | 2005-01-20 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| JPWO2006090756A1 (ja) * | 2005-02-25 | 2008-07-24 | 杏林製薬株式会社 | 脂質代謝異常、肥満および糖尿病の新規な予防または治療剤およびそのための使用 |
| WO2006093354A1 (ja) * | 2005-03-04 | 2006-09-08 | Kyorin Pharmaceutical Co., Ltd. | (ｓ)−２−[３−(ｎ−{[４−(４−フルオロフェノキシ)フェニル]メチル}カルバモイル)−４−メトキシフェニルメチル]ブタン酸の製造中間体 |
| EP1862464A4 (de) * | 2005-03-23 | 2010-08-25 | Kyorin Seiyaku Kk | Neues cyclisches aminophenylalkansäurederivat |
| JP2007001912A (ja) * | 2005-06-22 | 2007-01-11 | Univ Of Tokyo | 置換フェニルプロピオン酸誘導体 |
| FR2898892A1 (fr) * | 2006-03-24 | 2007-09-28 | Genfit Sa | Derives de n-(phenethyl)benzamide substitues,preparation et utilisations |
| CN101054372B (zh) * | 2006-04-11 | 2010-10-13 | 中国科学院上海药物研究所 | 嘧啶取代苯丙酸衍生化合物、其制法和在治疗多囊肾疾病中的用途 |
| NZ572268A (en) * | 2006-04-18 | 2011-09-30 | Nippon Chemiphar Co | Activating agent for peroxisome proliferator activated receptor delta (ppar) |
| AU2013202514B2 (en) * | 2006-04-18 | 2015-09-17 | Nippon Chemiphar Co., Ltd. | Activating agent for peroxisome proliferator activated receptor delta |
| WO2008004341A1 (fr) * | 2006-07-03 | 2008-01-10 | The University Of Tokyo | DÉRIVÉS DE L'ACIDE PHÉNYLPROPIONIQUE SUBSTITUÉS EN α |
| WO2008030604A2 (en) | 2006-09-08 | 2008-03-13 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced brain disease |
| AU2008221673B2 (en) * | 2007-03-08 | 2013-03-28 | Albireo Ab | 2 -substituted- 3 -phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease |
| HRP20181168T1 (hr) | 2008-04-15 | 2018-11-02 | Nippon Chemiphar Co., Ltd. | Aktivator za receptore koji se aktiviraju peroksisom proliferatorom |
| EP2291182A1 (de) * | 2008-05-13 | 2011-03-09 | Genmedica Therapeutics SL | Salicylat-konjugate zur behandlung von stoffwechselerkrankungen |
| JP5357894B2 (ja) | 2008-12-01 | 2013-12-04 | 田辺三菱製薬株式会社 | チアゾール環を含むカルボン酸誘導体およびその医薬用途 |
| JP2012520342A (ja) | 2009-03-16 | 2012-09-06 | ジェンメディカ・セラピューティックス・ソシエダッド・リミターダ | 代謝障害を処置するのに有用な抗炎症剤および抗酸化剤のコンジュゲート |
| US8466197B2 (en) | 2010-12-14 | 2013-06-18 | Genmedica Therapeutics Sl | Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders |
| SG11201506920QA (en) | 2013-03-15 | 2015-09-29 | Bristol Myers Squibb Co | Ido inhibitors |
| WO2015046317A1 (ja) * | 2013-09-30 | 2015-04-02 | 国立大学法人岡山大学 | 新規アセチレンアミド誘導体 |
| US10927069B2 (en) * | 2015-07-02 | 2021-02-23 | The Medical College Of Wisconsin, Inc. | Diabetes and metabolic syndrome treatment with a novel dual modulator of soluble epoxide hydrolase and peroxisome proliferator-activated receptors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK148576A (da) * | 1975-04-18 | 1976-10-19 | Boehringer Mannheim Gmbh | Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling |
| GB9600464D0 (en) * | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| GB9606805D0 (en) | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
-
2000
- 2000-05-29 JP JP2000157600A patent/JP4618845B2/ja not_active Expired - Fee Related
- 2000-06-08 HU HU0201654A patent/HUP0201654A3/hu unknown
- 2000-06-08 EP EP00935582A patent/EP1184366B1/de not_active Expired - Lifetime
- 2000-06-08 AU AU51067/00A patent/AU773445B2/en not_active Ceased
- 2000-06-08 AT AT00935582T patent/ATE288887T1/de active
- 2000-06-08 ES ES00935582T patent/ES2235886T3/es not_active Expired - Lifetime
- 2000-06-08 DE DE60018064T patent/DE60018064T2/de not_active Expired - Lifetime
- 2000-06-08 NZ NZ515705A patent/NZ515705A/xx not_active IP Right Cessation
- 2000-06-08 CA CA002376094A patent/CA2376094C/en not_active Expired - Fee Related
- 2000-06-08 US US10/009,175 patent/US6506797B1/en not_active Expired - Fee Related
- 2000-06-08 KR KR1020017015777A patent/KR100704142B1/ko not_active Expired - Fee Related
- 2000-06-08 CN CNB008086869A patent/CN1157368C/zh not_active Expired - Fee Related
- 2000-06-08 WO PCT/JP2000/003707 patent/WO2000075103A1/ja not_active Ceased
- 2000-06-08 PT PT00935582T patent/PT1184366E/pt unknown
- 2000-06-08 DK DK00935582T patent/DK1184366T3/da active
- 2000-06-08 BR BR0011734-0A patent/BR0011734A/pt not_active IP Right Cessation
-
2001
- 2001-12-07 NO NO20016001A patent/NO327957B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60018064T2 (de) | 2006-01-12 |
| CN1157368C (zh) | 2004-07-14 |
| HUP0201654A2 (en) | 2002-09-28 |
| CA2376094C (en) | 2007-06-05 |
| AU5106700A (en) | 2000-12-28 |
| ES2235886T3 (es) | 2005-07-16 |
| HUP0201654A3 (en) | 2004-03-01 |
| NO327957B1 (no) | 2009-10-26 |
| EP1184366B1 (de) | 2005-02-09 |
| KR100704142B1 (ko) | 2007-04-09 |
| US6506797B1 (en) | 2003-01-14 |
| DK1184366T3 (da) | 2005-05-23 |
| PT1184366E (pt) | 2005-06-30 |
| CN1354742A (zh) | 2002-06-19 |
| JP2001055367A (ja) | 2001-02-27 |
| AU773445B2 (en) | 2004-05-27 |
| JP4618845B2 (ja) | 2011-01-26 |
| DE60018064D1 (de) | 2005-03-17 |
| NZ515705A (en) | 2003-02-28 |
| CA2376094A1 (en) | 2000-12-04 |
| NO20016001L (no) | 2002-02-11 |
| KR20020008221A (ko) | 2002-01-29 |
| EP1184366A4 (de) | 2002-10-31 |
| EP1184366A1 (de) | 2002-03-06 |
| BR0011734A (pt) | 2002-03-05 |
| WO2000075103A1 (en) | 2000-12-14 |
| NO20016001D0 (no) | 2001-12-07 |
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