ATE288922T1 - Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen - Google Patents

Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen

Info

Publication number: ATE288922T1
Authority: AT; Austria
Prior art keywords: endothelin; heteroaryl substituted; substituted thiol; certain heteroaryl; thiol inhibitors
Prior art date: 1998-04-23

Application number

AT99923433T

Other languages

English (en)

Inventor

Cynthia Anne Fink

Fariborz Firooznia

Original Assignee

Novartis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-23

Filing date

1999-04-21

Publication date

2005-02-15

1999-04-21 Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh

2005-02-15 Application granted granted Critical

2005-02-15 Publication of ATE288922T1 publication Critical patent/ATE288922T1/de

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
102000004190 Enzymes Human genes 0.000 title 1
108090000790 Enzymes Proteins 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
239000003774 sulfhydryl reagent Substances 0.000 title 1
125000003396 thiol group Chemical class [H]S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

AT99923433T 1998-04-23 1999-04-21 Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen ATE288922T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6497998A	1998-04-23	1998-04-23
PCT/EP1999/002694 WO1999055723A1 (en)	1998-04-23	1999-04-21	Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme

Publications (1)

Publication Number	Publication Date
ATE288922T1 true ATE288922T1 (de)	2005-02-15

Family

ID=22059547

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99923433T ATE288922T1 (de)	1998-04-23	1999-04-21	Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen

Country Status (11)

Country	Link
EP (1)	EP1080104B1 (de)
JP (1)	JP3646062B2 (de)
AT (1)	ATE288922T1 (de)
AU (1)	AU750048B2 (de)
CA (1)	CA2324251A1 (de)
DE (1)	DE69923676T2 (de)
ES (1)	ES2237917T3 (de)
IL (1)	IL138688A0 (de)
PT (1)	PT1080104E (de)
WO (1)	WO1999055723A1 (de)
ZA (1)	ZA200004679B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6423727B1 (en)	1998-04-23	2002-07-23	Novartis Ag	Certain thiol inhibitors of endothelin-converting enzyme
US6426354B1 (en)	1998-04-23	2002-07-30	Novartis Ag	Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
JP4603646B2 (ja) *	1999-11-15	2010-12-22	富士フイルムファインケミカルズ株式会社	新規なジピリジル誘導体
NL1014353C2 (nl) *	2000-02-11	2001-08-15	Dsm Nv	Werkwijze voor de bereiding van (R) -2-broom-3-fenylpropaanzuur.
US20020028799A1 (en) *	2000-07-06	2002-03-07	Naylor Alasdair Mark	Treatment of male sexual dysfunction
US6670479B2 (en) *	2001-03-07	2003-12-30	Advanced Research And Technology Institute, Inc.	Amination process
US6777443B2 (en)	2001-05-15	2004-08-17	Novartis Ag	Dipeptide derivatives
PT1430045E (pt) *	2001-09-21	2007-01-31	Novartis Ag	Derivados de pirano como inibidores de ace e nep
AU2003244467A1 (en) *	2002-02-04	2003-09-02	Kaneka Corporation	Process for production of optically active 2-halogeno- carboxylic acids
WO2003065789A2 (en)	2002-02-08	2003-08-14	Merck & Co., Inc.	N-biphenylmethyl aminocycloalkanecarboxamide derivatives
US6919343B2 (en)	2002-02-08	2005-07-19	Merck & Co., Inc.	N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives
JP3975226B2 (ja)	2006-01-11	2007-09-12	生化学工業株式会社	シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
EP2036920B1 (de) *	2006-01-11	2011-05-18	Seikagaku Corporation	Cycloalkylcarbonylaminosäureester-derivat und herstellungsverfahren dafür
JP4047365B2 (ja)	2006-01-11	2008-02-13	生化学工業株式会社	シクロアルカンカルボキサミド誘導体及びその製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5432186A (en) *	1993-11-16	1995-07-11	Ciba-Geigy Corporation	Cyclic amino acid derivatives
FR2745570B1 (fr) *	1996-03-04	1998-06-19	Roussel Uclaf	Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
FR2745571B1 (fr) *	1996-03-04	1998-06-19	Inst Nat Sante Rech Med	Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant

1999
- 1999-04-21 AU AU40319/99A patent/AU750048B2/en not_active Ceased
- 1999-04-21 AT AT99923433T patent/ATE288922T1/de not_active IP Right Cessation
- 1999-04-21 EP EP99923433A patent/EP1080104B1/de not_active Expired - Lifetime
- 1999-04-21 CA CA002324251A patent/CA2324251A1/en not_active Abandoned
- 1999-04-21 IL IL13868899A patent/IL138688A0/xx unknown
- 1999-04-21 PT PT99923433T patent/PT1080104E/pt unknown
- 1999-04-21 ES ES99923433T patent/ES2237917T3/es not_active Expired - Lifetime
- 1999-04-21 JP JP2000545881A patent/JP3646062B2/ja not_active Expired - Fee Related
- 1999-04-21 WO PCT/EP1999/002694 patent/WO1999055723A1/en not_active Ceased
- 1999-04-21 DE DE69923676T patent/DE69923676T2/de not_active Expired - Fee Related
2000
- 2000-09-06 ZA ZA200004679A patent/ZA200004679B/en unknown

Also Published As

Publication number	Publication date
JP3646062B2 (ja)	2005-05-11
DE69923676D1 (de)	2005-03-17
ZA200004679B (en)	2002-04-24
PT1080104E (pt)	2005-06-30
EP1080104A1 (de)	2001-03-07
WO1999055723A1 (en)	1999-11-04
AU4031999A (en)	1999-11-16
ES2237917T3 (es)	2005-08-01
EP1080104B1 (de)	2005-02-09
IL138688A0 (en)	2001-10-31
CA2324251A1 (en)	1999-11-04
JP2002513029A (ja)	2002-05-08
DE69923676T2 (de)	2006-01-12
AU750048B2 (en)	2002-07-11

Legal Events

Date

Code

Title

Description

2006-08-15

UEP

Publication of translation of european patent specification

Ref document number: 1080104

Country of ref document: EP

2012-01-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ES2182234T3 (es)	2003-03-01	Inhibidores de metaloproteasa.
BR0207278A (pt)	2004-02-10	Derivados de ftalazinona-piperidina como inibidores de pde4
BR0313330A (pt)	2005-06-14	Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4
TR200100605T2 (tr)	2001-08-21	Arilpiperazinler ve bunların metaloproteinaz inhibe edici maddeler (MMP) olarak kullanımı
MY136789A (en)	2008-11-28	Metalloproteinase inhibitors
BR0209149A (pt)	2004-07-13	Ftalazinonas
ATE280160T1 (de)	2004-11-15	Substituierte aryl-oder heteroarylamide mit retinoid-ähnlicher biologischer aktivität
DE69923676D1 (de)	2005-03-17	Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen
BR9909805A (pt)	2000-12-26	Certos inibidores de tiol de enzima de conversão de endotelina
SE0103710D0 (sv)	2001-11-07	Compounds
BR0014990A (pt)	2002-06-18	Derivados de tetrahidrotiopirano ranftalazinona como inibidores de pde4
MY128164A (en)	2007-01-31	Compounds
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DE60033809D1 (de)	2007-04-19	Inhibitoren von metalloproteinasen
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DE60202669D1 (de)	2005-02-24	6-phenylbenzonaphthyidine
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