PT1080104E - Certos tiois heteroarilo substituidos inibidores da enzima conversora da endotelina - Google Patents

Certos tiois heteroarilo substituidos inibidores da enzima conversora da endotelina

Info

Publication number
PT1080104E
PT1080104E PT99923433T PT99923433T PT1080104E PT 1080104 E PT1080104 E PT 1080104E PT 99923433 T PT99923433 T PT 99923433T PT 99923433 T PT99923433 T PT 99923433T PT 1080104 E PT1080104 E PT 1080104E
Authority
PT
Portugal
Prior art keywords
heteroarilian
endotheline
thyroids
substitute
inhibitors
Prior art date
Application number
PT99923433T
Other languages
English (en)
Inventor
Cynthia Anne Fink
Firooznia Fariborz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1080104E publication Critical patent/PT1080104E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT99923433T 1998-04-23 1999-04-21 Certos tiois heteroarilo substituidos inibidores da enzima conversora da endotelina PT1080104E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6497998A 1998-04-23 1998-04-23

Publications (1)

Publication Number Publication Date
PT1080104E true PT1080104E (pt) 2005-06-30

Family

ID=22059547

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99923433T PT1080104E (pt) 1998-04-23 1999-04-21 Certos tiois heteroarilo substituidos inibidores da enzima conversora da endotelina

Country Status (11)

Country Link
EP (1) EP1080104B1 (pt)
JP (1) JP3646062B2 (pt)
AT (1) ATE288922T1 (pt)
AU (1) AU750048B2 (pt)
CA (1) CA2324251A1 (pt)
DE (1) DE69923676T2 (pt)
ES (1) ES2237917T3 (pt)
IL (1) IL138688A0 (pt)
PT (1) PT1080104E (pt)
WO (1) WO1999055723A1 (pt)
ZA (1) ZA200004679B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6423727B1 (en) 1998-04-23 2002-07-23 Novartis Ag Certain thiol inhibitors of endothelin-converting enzyme
US6426354B1 (en) 1998-04-23 2002-07-30 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
JP4603646B2 (ja) * 1999-11-15 2010-12-22 富士フイルムファインケミカルズ株式会社 新規なジピリジル誘導体
NL1014353C2 (nl) * 2000-02-11 2001-08-15 Dsm Nv Werkwijze voor de bereiding van (R) -2-broom-3-fenylpropaanzuur.
US20020028799A1 (en) * 2000-07-06 2002-03-07 Naylor Alasdair Mark Treatment of male sexual dysfunction
US6670479B2 (en) * 2001-03-07 2003-12-30 Advanced Research And Technology Institute, Inc. Amination process
US6777443B2 (en) 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
CA2456281A1 (en) * 2001-09-21 2003-04-03 Novartis Ag Pyrane derivatives as both ace- and nep- inhibitors
EP1481960A4 (en) * 2002-02-04 2005-04-06 Kaneka Corp PROCESS FOR OBTAINING OPTICALLY ACTIVE 2-HALOGENO-CARBOXYLIC ACIDS
TWI259079B (en) 2002-02-08 2006-08-01 Merck & Co Inc N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives
US7091380B2 (en) 2002-02-08 2006-08-15 Merck & Co., Inc. N-biphenylmethyl aminocycloalkanecarboxamide derivatives
JP3975226B2 (ja) 2006-01-11 2007-09-12 生化学工業株式会社 シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
EP2036920B1 (en) 2006-01-11 2011-05-18 Seikagaku Corporation Cycloalkylcarbonylamino acid ester derivative and process for producing the same
JP4047365B2 (ja) 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432186A (en) * 1993-11-16 1995-07-11 Ciba-Geigy Corporation Cyclic amino acid derivatives
FR2745571B1 (fr) * 1996-03-04 1998-06-19 Inst Nat Sante Rech Med Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
FR2745570B1 (fr) * 1996-03-04 1998-06-19 Roussel Uclaf Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
ES2237917T3 (es) 2005-08-01
CA2324251A1 (en) 1999-11-04
AU750048B2 (en) 2002-07-11
ZA200004679B (en) 2002-04-24
EP1080104B1 (en) 2005-02-09
ATE288922T1 (de) 2005-02-15
WO1999055723A1 (en) 1999-11-04
DE69923676T2 (de) 2006-01-12
EP1080104A1 (en) 2001-03-07
IL138688A0 (en) 2001-10-31
DE69923676D1 (de) 2005-03-17
JP3646062B2 (ja) 2005-05-11
AU4031999A (en) 1999-11-16
JP2002513029A (ja) 2002-05-08

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