ATE289311T1 - Kondensierte purinderivate - Google Patents
Kondensierte purinderivateInfo
- Publication number
- ATE289311T1 ATE289311T1 AT00985847T AT00985847T ATE289311T1 AT E289311 T1 ATE289311 T1 AT E289311T1 AT 00985847 T AT00985847 T AT 00985847T AT 00985847 T AT00985847 T AT 00985847T AT E289311 T1 ATE289311 T1 AT E289311T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- group
- unsubstituted
- lower alkyl
- alkyl group
- Prior art date
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 150000003212 purines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000006848 alicyclic heterocyclic group Chemical group 0.000 abstract 2
- -1 -NR<7>R<8> Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP36631399 | 1999-12-24 | ||
| PCT/JP2000/009160 WO2001047931A1 (en) | 1999-12-24 | 2000-12-22 | Fused purine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE289311T1 true ATE289311T1 (de) | 2005-03-15 |
Family
ID=18486475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00985847T ATE289311T1 (de) | 1999-12-24 | 2000-12-22 | Kondensierte purinderivate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7005430B2 (de) |
| EP (1) | EP1251130B1 (de) |
| AT (1) | ATE289311T1 (de) |
| AU (1) | AU2223501A (de) |
| CA (1) | CA2395414A1 (de) |
| DE (1) | DE60018216T2 (de) |
| ES (1) | ES2238335T3 (de) |
| WO (1) | WO2001047931A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451821B1 (en) | 2000-06-09 | 2002-09-17 | Aventis Pharma S.A. | Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase |
| FR2810037B1 (fr) * | 2000-06-09 | 2004-04-23 | Aventis Pharma Sa | Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible |
| AU9598601A (en) | 2000-10-20 | 2002-04-29 | Eisai Co Ltd | Nitrogenous aromatic ring compounds |
| CZ20031513A3 (cs) * | 2000-12-01 | 2003-09-17 | Biogen, Inc. | Kondenzované purinové deriváty jako antagonisty A1 adenosinového receptoru |
| WO2003097064A1 (en) * | 2002-05-17 | 2003-11-27 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for diabetes |
| US20070191402A1 (en) * | 2002-05-17 | 2007-08-16 | Kyowa Hakko Kogyo Co., Ltd. | Method of searching substrate having antidiabetic activity |
| CN1310916C (zh) * | 2002-06-25 | 2007-04-18 | 协和发酵工业株式会社 | 双环类杂环化合物 |
| AU2003252697A1 (en) * | 2002-07-26 | 2004-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Cell differentiation inductor |
| KR20050111306A (ko) | 2002-11-19 | 2005-11-24 | 아칠리온 파르마세우티칼스 인코포레이티드 | 바이러스 복제 억제제로서의 치환된 아릴 티오우레아 및관련 화합물 |
| JP2004224756A (ja) * | 2003-01-24 | 2004-08-12 | Sumika Fine Chemicals Co Ltd | ２，６−ジハロゲノ−８−置換−プリン化合物およびその製造方法 |
| ATE508747T1 (de) * | 2003-03-10 | 2011-05-15 | Eisai R&D Man Co Ltd | C-kit kinase-hemmer |
| EP1637532A1 (de) * | 2003-04-25 | 2006-03-22 | Kyowa Hakko Kogyo Co., Ltd. | Kondensiertes pyrimidinderivat |
| US7683172B2 (en) | 2003-11-11 | 2010-03-23 | Eisai R&D Management Co., Ltd. | Urea derivative and process for preparing the same |
| AU2004309166B2 (en) | 2003-12-23 | 2008-02-21 | Pfizer Inc. | Novel quinoline derivatives |
| TW200600492A (en) | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| ATE428421T1 (de) * | 2004-09-17 | 2009-05-15 | Eisai R&D Man Co Ltd | Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften |
| WO2007015569A1 (ja) * | 2005-08-01 | 2007-02-08 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質の効果を予測する方法 |
| JP4989476B2 (ja) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を検定する方法 |
| CA2620594C (en) * | 2005-09-01 | 2012-08-21 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition having improved disintegratability |
| AU2006309551B2 (en) | 2005-11-07 | 2012-04-19 | Eisai R & D Management Co., Ltd. | Use of combination of anti-angiogenic substance and c-kit kinase inhibitor |
| EP1964837A4 (de) * | 2005-11-22 | 2010-12-22 | Eisai R&D Man Co Ltd | Antitumormittel gegen multiples myelom |
| EP2468748B1 (de) * | 2006-02-15 | 2016-05-25 | AbbVie Inc. | Pyrazolchinolone als starke PARP-Hemmer |
| CN104706637A (zh) * | 2006-05-18 | 2015-06-17 | 卫材R&D管理有限公司 | 针对甲状腺癌的抗肿瘤剂 |
| MX2009000170A (es) | 2006-06-23 | 2009-01-23 | Incyte Corp | Derivados de purinona como agonistas de hm74a. |
| MX2009000169A (es) * | 2006-06-23 | 2009-01-26 | Incyte Corp | Derivados de purinona como agonistas de hm74a. |
| ES2355325T3 (es) * | 2006-06-23 | 2011-03-24 | Incyte Corporation | Derivados de purinona como agonistas de hm74a. |
| RS53230B (sr) * | 2006-06-27 | 2014-08-29 | Takeda Pharmaceutical Company Limited | Kondenzovana ciklična jedinjenja kao modulatori gpr40 receptora |
| JPWO2008001956A1 (ja) * | 2006-06-29 | 2009-12-03 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 肝線維症治療剤 |
| WO2008026748A1 (en) | 2006-08-28 | 2008-03-06 | Eisai R & D Management Co., Ltd. | Antitumor agent for undifferentiated gastric cancer |
| CA2676796C (en) | 2007-01-29 | 2016-02-23 | Eisai R & D Management Co., Ltd. | Composition for treatment of undifferentiated gastric cancer |
| US8952035B2 (en) | 2007-11-09 | 2015-02-10 | Eisai R&D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
| KR101506062B1 (ko) * | 2008-01-29 | 2015-03-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 혈관 저해 물질과 탁산의 병용 |
| MY162940A (en) | 2009-08-19 | 2017-07-31 | Eisai R&D Man Co Ltd | Quinoline derivative-containing pharmaceutical composition |
| CN102958523B (zh) | 2010-06-25 | 2014-11-19 | 卫材R&D管理有限公司 | 使用具有激酶抑制作用的组合的抗肿瘤剂 |
| AU2011306358B2 (en) * | 2010-09-24 | 2014-08-14 | Impetis Biosciences Ltd. | Fused tricyclic compounds as adenosine receptor antagonist |
| CN103402519B (zh) | 2011-04-18 | 2015-11-25 | 卫材R&D管理有限公司 | 肿瘤治疗剂 |
| JP6038128B2 (ja) | 2011-06-03 | 2016-12-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー |
| KR20150098605A (ko) | 2012-12-21 | 2015-08-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 퀴놀린 유도체의 비정질 형태 및 그의 제조방법 |
| NZ714049A (en) | 2013-05-14 | 2020-05-29 | Eisai R&D Man Co Ltd | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
| PT3524595T (pt) | 2014-08-28 | 2022-09-19 | Eisai R&D Man Co Ltd | Derivado de quinolina altamente puro e método para produção do mesmo |
| LT3263106T (lt) | 2015-02-25 | 2024-01-10 | Eisai R&D Management Co., Ltd. | Chinolino darinių kartumo sumažinimo būdas |
| KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| MX373231B (es) | 2015-06-16 | 2020-05-08 | Eisai R&D Man Co Ltd | Agente anticancerigeno. |
| US12220398B2 (en) | 2015-08-20 | 2025-02-11 | Eisai R&D Management Co., Ltd. | Tumor therapeutic agent |
| US12303505B2 (en) | 2017-02-08 | 2025-05-20 | Eisai R&D Management Co., Ltd. | Tumor-treating pharmaceutical composition |
| RU2019134940A (ru) | 2017-05-16 | 2021-06-16 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Лечение гепатоцеллюлярной карциномы |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US527316A (en) * | 1894-10-09 | Millie v | ||
| US4338319A (en) * | 1979-11-27 | 1982-07-06 | Aktiebolaget Draco | Method for the treatment of chronic obstructive airway or cardiac diseases |
| GB8618931D0 (en) | 1986-08-02 | 1986-09-10 | Euro Celtique Sa | 6-thioxanthines |
| DE8900883U1 (de) | 1989-01-26 | 1989-03-16 | INDAG Gesellschaft für Industriebedarf mbH, 6900 Heidelberg | Standbeutel |
| IT1229195B (it) | 1989-03-10 | 1991-07-25 | Poli Ind Chimica Spa | Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche. |
| US5086176A (en) | 1989-03-29 | 1992-02-04 | Merrell Dow Pharmaceuticals Inc. | Tricyclic fused adenine derivatives |
| US5064947A (en) | 1989-03-29 | 1991-11-12 | Merrell Dow Pharmaceuticals Inc. | Selective adenosine reseptor compounds |
| AU623755B2 (en) | 1989-03-29 | 1992-05-21 | Merrell Pharmaceuticals Inc. | Selective adenosine receptor compounds |
| DE69033614T2 (de) * | 1989-10-20 | 2001-04-19 | Kyowa Hakko Kogyo K.K., Tokio/Tokyo | Kondensierte Purinderivate |
| TW252044B (de) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| US5635503A (en) | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Company | Dihydropyridine npy antagonists: piperazine derivatives |
| CA2239881A1 (en) * | 1996-10-07 | 1998-04-16 | Nobuo Kosaka | Condensed purine derivatives |
| JP4354016B2 (ja) * | 1996-11-29 | 2009-10-28 | 株式会社メディサイエンスプラニング | 新規プリン誘導体およびこれを含む医薬組成物 |
| AU740770B2 (en) * | 1997-06-18 | 2001-11-15 | Aderis Pharmaceuticals, Inc. | Compositions and methods for preventing restenosis following revascularization procedures |
| EP1092435B1 (de) | 1998-07-02 | 2007-04-04 | Kyowa Hakko Kogyo Co., Ltd. | Antidiabetische medikamente |
| CZ20031513A3 (cs) * | 2000-12-01 | 2003-09-17 | Biogen, Inc. | Kondenzované purinové deriváty jako antagonisty A1 adenosinového receptoru |
-
2000
- 2000-12-22 EP EP00985847A patent/EP1251130B1/de not_active Expired - Lifetime
- 2000-12-22 AT AT00985847T patent/ATE289311T1/de not_active IP Right Cessation
- 2000-12-22 CA CA002395414A patent/CA2395414A1/en not_active Abandoned
- 2000-12-22 WO PCT/JP2000/009160 patent/WO2001047931A1/ja not_active Ceased
- 2000-12-22 DE DE60018216T patent/DE60018216T2/de not_active Expired - Fee Related
- 2000-12-22 ES ES00985847T patent/ES2238335T3/es not_active Expired - Lifetime
- 2000-12-22 US US10/149,423 patent/US7005430B2/en not_active Expired - Fee Related
- 2000-12-22 AU AU22235/01A patent/AU2223501A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7005430B2 (en) | 2006-02-28 |
| EP1251130A4 (de) | 2003-05-02 |
| EP1251130A1 (de) | 2002-10-23 |
| EP1251130B1 (de) | 2005-02-16 |
| CA2395414A1 (en) | 2001-07-05 |
| AU2223501A (en) | 2001-07-09 |
| DE60018216T2 (de) | 2006-02-16 |
| DE60018216D1 (de) | 2005-03-24 |
| WO2001047931A1 (en) | 2001-07-05 |
| US20030176698A1 (en) | 2003-09-18 |
| ES2238335T3 (es) | 2005-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |