ATE289311T1 - Kondensierte purinderivate - Google Patents
Kondensierte purinderivateInfo
- Publication number
- ATE289311T1 ATE289311T1 AT00985847T AT00985847T ATE289311T1 AT E289311 T1 ATE289311 T1 AT E289311T1 AT 00985847 T AT00985847 T AT 00985847T AT 00985847 T AT00985847 T AT 00985847T AT E289311 T1 ATE289311 T1 AT E289311T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- group
- unsubstituted
- lower alkyl
- alkyl group
- Prior art date
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 150000003212 purines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000006848 alicyclic heterocyclic group Chemical group 0.000 abstract 2
- -1 -NR<7>R<8> Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP36631399 | 1999-12-24 | ||
| PCT/JP2000/009160 WO2001047931A1 (en) | 1999-12-24 | 2000-12-22 | Fused purine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE289311T1 true ATE289311T1 (de) | 2005-03-15 |
Family
ID=18486475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00985847T ATE289311T1 (de) | 1999-12-24 | 2000-12-22 | Kondensierte purinderivate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7005430B2 (de) |
| EP (1) | EP1251130B1 (de) |
| AT (1) | ATE289311T1 (de) |
| AU (1) | AU2223501A (de) |
| CA (1) | CA2395414A1 (de) |
| DE (1) | DE60018216T2 (de) |
| ES (1) | ES2238335T3 (de) |
| WO (1) | WO2001047931A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451821B1 (en) | 2000-06-09 | 2002-09-17 | Aventis Pharma S.A. | Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase |
| FR2810037B1 (fr) * | 2000-06-09 | 2004-04-23 | Aventis Pharma Sa | Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible |
| DE60137273D1 (de) * | 2000-10-20 | 2009-02-12 | Eisai R&D Man Co Ltd | Verfahren zur Herstellung von 4-Phenoxy chinolin Derivaten |
| UA75625C2 (en) * | 2000-12-01 | 2006-05-15 | Biogen Inc | Condensed purine derivatives as a1 adenosine receptor antagonists |
| AU2003231538A1 (en) * | 2002-05-17 | 2003-12-02 | Kyowa Hakko Kogyo Co., Ltd. | Method of searching substane having antidiabetic activity |
| AU2003234929A1 (en) * | 2002-05-17 | 2003-12-02 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for diabetes |
| JPWO2004000841A1 (ja) * | 2002-06-25 | 2005-10-20 | 協和醗酵工業株式会社 | 二環性複素環化合物 |
| WO2004011469A1 (ja) * | 2002-07-26 | 2004-02-05 | Kyowa Hakko Kogyo Co., Ltd. | 細胞分化誘導剤 |
| AP2005003319A0 (en) | 2002-11-19 | 2005-06-30 | Achillion Pharmaceitucals Inc | Substituted aryl thioureas and related compounds; inhibitors of viral replication |
| JP2004224756A (ja) * | 2003-01-24 | 2004-08-12 | Sumika Fine Chemicals Co Ltd | ２，６−ジハロゲノ−８−置換−プリン化合物およびその製造方法 |
| JPWO2004080462A1 (ja) * | 2003-03-10 | 2006-06-08 | エーザイ株式会社 | ｃ−Ｋｉｔキナーゼ阻害剤 |
| CN1777608A (zh) * | 2003-04-25 | 2006-05-24 | 协和发酵工业株式会社 | 稠合嘧啶衍生物 |
| CN100450998C (zh) | 2003-11-11 | 2009-01-14 | 卫材R&D管理有限公司 | 脲衍生物的制备方法 |
| KR100807920B1 (ko) | 2003-12-23 | 2008-02-27 | 화이자 인코포레이티드 | 신규한 퀴놀린 유도체 |
| TW200600492A (en) | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| EP1797881B1 (de) | 2004-09-17 | 2009-04-15 | Eisai R&D Management Co., Ltd. | Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften |
| EP1925941B1 (de) * | 2005-08-01 | 2012-11-28 | Eisai R&D Management Co., Ltd. | Verfahren zur vorhersage der wirksamkeit eines vaskularisierungsinhibitors |
| WO2007015578A1 (ja) | 2005-08-02 | 2007-02-08 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質の効果を検定する方法 |
| KR100990590B1 (ko) * | 2005-09-01 | 2010-10-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 붕해성이 개선된 의약 조성물의 제조 방법 |
| AU2006309551B2 (en) * | 2005-11-07 | 2012-04-19 | Eisai R & D Management Co., Ltd. | Use of combination of anti-angiogenic substance and c-kit kinase inhibitor |
| WO2007061127A1 (ja) * | 2005-11-22 | 2007-05-31 | Eisai R & D Management Co., Ltd. | 多発性骨髄腫に対する抗腫瘍剤 |
| AU2007214411B2 (en) * | 2006-02-15 | 2010-07-01 | Abbott Laboratories | Pyrazoloquinolones are potent PARP inhibitors |
| CA2652442C (en) * | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| CN101479273B (zh) * | 2006-06-23 | 2011-11-30 | 英赛特股份有限公司 | 作为hm74a激动剂的嘌呤酮衍生物 |
| KR20090025262A (ko) * | 2006-06-23 | 2009-03-10 | 인사이트 코포레이션 | Ｈｍ７４ａ 아고니스트로서 푸리논 유도체 |
| CN101466714B (zh) | 2006-06-23 | 2013-02-06 | 英赛特股份有限公司 | 作为hm74a激动剂的嘌呤酮衍生物 |
| BRPI0713378A8 (pt) * | 2006-06-27 | 2018-01-02 | Takeda Pharmaceutical | composto, pró-droga, modulador da função do receptor gpr40, agente farmacêutico uso do composto, e, método de produção de uma forma opticamente ativa de um composto |
| WO2008001956A1 (en) * | 2006-06-29 | 2008-01-03 | Eisai R & D Management Co., Ltd. | Therapeutic agent for liver fibrosis |
| US8865737B2 (en) | 2006-08-28 | 2014-10-21 | Eisai R&D Management Co., Ltd. | Antitumor agent for undifferentiated gastric cancer |
| US8962655B2 (en) | 2007-01-29 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Composition for treatment of undifferentiated gastric cancer |
| KR101513326B1 (ko) | 2007-11-09 | 2015-04-17 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 혈관 신생 저해 물질과 항종양성 백금 착물의 병용 |
| WO2009096377A1 (ja) * | 2008-01-29 | 2009-08-06 | Eisai R & D Management Co., Ltd. | 血管阻害物質とタキサンとの併用 |
| ME02359B (de) | 2009-08-19 | 2016-06-20 | Eisai R&D Man Co Ltd | Chinolinderivathaltige pharmazeutische zusammensetzung |
| RU2560683C2 (ru) | 2010-06-25 | 2015-08-20 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противоопухолевое средство, задействующее соединения с ингибирующим эффектом к киназам в комбинации |
| JP5843869B2 (ja) * | 2010-09-24 | 2016-01-13 | アドヴィナス・セラピューティックス・リミテッド | アデノシン受容体拮抗薬としての縮合三環化合物 |
| EP2700403B1 (de) | 2011-04-18 | 2015-11-25 | Eisai R&D Management Co., Ltd. | Therapeutikum für tumor |
| ES2841809T3 (es) | 2011-06-03 | 2021-07-09 | Eisai R&D Man Co Ltd | Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib |
| BR112015009004A8 (pt) | 2012-12-21 | 2021-07-20 | Eisai R&D Man Co Ltd | forma amorfa de derivado de quinolina e método de produção da mesma |
| MX368099B (es) | 2013-05-14 | 2019-09-19 | Eisai R&D Man Co Ltd | Biomarcadores para predecir y evaluar el grado de respuesta de sujetos con cancer de endometrio a compuestos de tipo lenvatinib. |
| JO3783B1 (ar) | 2014-08-28 | 2021-01-31 | Eisai R&D Man Co Ltd | مشتق كوينولين عالي النقاء وطريقة لإنتاجه |
| JP6792546B2 (ja) | 2015-02-25 | 2020-11-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キノリン誘導体の苦味抑制方法 |
| CA2978226C (en) | 2015-03-04 | 2025-02-18 | Eisai R&D Management Co., Ltd. | COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR TO TREAT CANCER |
| JP6757959B2 (ja) | 2015-06-16 | 2020-09-23 | 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ | 抗がん剤 |
| RU2718048C2 (ru) | 2015-08-20 | 2020-03-30 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противоопухолевое терапевтическое средство |
| ES2971448T3 (es) | 2017-02-08 | 2024-06-05 | Eisai R&D Man Co Ltd | Composición farmacéutica para el tratamiento de tumores |
| MX2019013014A (es) | 2017-05-16 | 2020-08-06 | Eisai R&D Man Co Ltd | Tratamiento de carcinoma hepatocelular. |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US527316A (en) * | 1894-10-09 | Millie v | ||
| US4338319A (en) | 1979-11-27 | 1982-07-06 | Aktiebolaget Draco | Method for the treatment of chronic obstructive airway or cardiac diseases |
| GB8618931D0 (en) | 1986-08-02 | 1986-09-10 | Euro Celtique Sa | 6-thioxanthines |
| DE8900883U1 (de) | 1989-01-26 | 1989-03-16 | INDAG Gesellschaft für Industriebedarf mbH, 6900 Heidelberg | Standbeutel |
| IT1229195B (it) | 1989-03-10 | 1991-07-25 | Poli Ind Chimica Spa | Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche. |
| US5064947A (en) | 1989-03-29 | 1991-11-12 | Merrell Dow Pharmaceuticals Inc. | Selective adenosine reseptor compounds |
| US5086176A (en) | 1989-03-29 | 1992-02-04 | Merrell Dow Pharmaceuticals Inc. | Tricyclic fused adenine derivatives |
| AU623755B2 (en) * | 1989-03-29 | 1992-05-21 | Merrell Pharmaceuticals Inc. | Selective adenosine receptor compounds |
| CA2028235C (en) * | 1989-10-20 | 1997-01-21 | Fumio Suzuki | Condensed purine derivatives |
| TW252044B (de) | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| US5635503A (en) | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Company | Dihydropyridine npy antagonists: piperazine derivatives |
| WO1998015555A1 (en) * | 1996-10-07 | 1998-04-16 | Kyowa Hakko Kogyo Co., Ltd. | Fused purine derivatives |
| JP4354016B2 (ja) | 1996-11-29 | 2009-10-28 | 株式会社メディサイエンスプラニング | 新規プリン誘導体およびこれを含む医薬組成物 |
| CA2295195C (en) * | 1997-06-18 | 2009-12-15 | Aderis Pharmaceuticals, Inc. | Compositions and methods for preventing restenosis following revascularization procedures |
| AU4396899A (en) * | 1998-07-02 | 2000-01-24 | Kyowa Hakko Kogyo Co. Ltd. | Remedies for diabetes |
| UA75625C2 (en) * | 2000-12-01 | 2006-05-15 | Biogen Inc | Condensed purine derivatives as a1 adenosine receptor antagonists |
-
2000
- 2000-12-22 AT AT00985847T patent/ATE289311T1/de not_active IP Right Cessation
- 2000-12-22 EP EP00985847A patent/EP1251130B1/de not_active Expired - Lifetime
- 2000-12-22 US US10/149,423 patent/US7005430B2/en not_active Expired - Fee Related
- 2000-12-22 DE DE60018216T patent/DE60018216T2/de not_active Expired - Fee Related
- 2000-12-22 CA CA002395414A patent/CA2395414A1/en not_active Abandoned
- 2000-12-22 WO PCT/JP2000/009160 patent/WO2001047931A1/ja not_active Ceased
- 2000-12-22 ES ES00985847T patent/ES2238335T3/es not_active Expired - Lifetime
- 2000-12-22 AU AU22235/01A patent/AU2223501A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7005430B2 (en) | 2006-02-28 |
| EP1251130A4 (de) | 2003-05-02 |
| AU2223501A (en) | 2001-07-09 |
| CA2395414A1 (en) | 2001-07-05 |
| EP1251130A1 (de) | 2002-10-23 |
| DE60018216T2 (de) | 2006-02-16 |
| US20030176698A1 (en) | 2003-09-18 |
| WO2001047931A1 (en) | 2001-07-05 |
| EP1251130B1 (de) | 2005-02-16 |
| DE60018216D1 (de) | 2005-03-24 |
| ES2238335T3 (es) | 2005-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |