ATE289506T1 - Hemmung der tnf-aktivität mit zusammensetzungen enthaltend heparin und lösliche tnf rezeptoren - Google Patents

Hemmung der tnf-aktivität mit zusammensetzungen enthaltend heparin und lösliche tnf rezeptoren

Info

Publication number: ATE289506T1
Authority: AT; Austria
Prior art keywords: tnf; inhibition; compositions containing; heparin; soluble
Prior art date: 1998-12-30

Application number

AT99961268T

Other languages

English (en)

Inventor

Dan Aderka

Englender Talma Eshed

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-30

Filing date

1999-12-30

Publication date

2005-03-15

1999-12-30 Application filed by Applied Research Systems filed Critical Applied Research Systems

2005-03-15 Application granted granted Critical

2005-03-15 Publication of ATE289506T1 publication Critical patent/ATE289506T1/de

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 5
108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 title abstract 5
229960002897 heparin Drugs 0.000 title abstract 5
229920000669 heparin Polymers 0.000 title abstract 5
102000003298 tumor necrosis factor receptor Human genes 0.000 title abstract 5
239000000203 mixture Substances 0.000 title abstract 3
230000005764 inhibitory process Effects 0.000 title abstract 2

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Oncology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Rheumatology (AREA)
Cell Biology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)

AT99961268T 1998-12-30 1999-12-30 Hemmung der tnf-aktivität mit zusammensetzungen enthaltend heparin und lösliche tnf rezeptoren ATE289506T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL12785198A IL127851A0 (en)	1998-12-30	1998-12-30	Inhibition of TNF activity
PCT/IL1999/000709 WO2000040225A2 (en)	1998-12-30	1999-12-30	Inhibition of tnf activity

Publications (1)

Publication Number	Publication Date
ATE289506T1 true ATE289506T1 (de)	2005-03-15

Family

ID=11072323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99961268T ATE289506T1 (de)	1998-12-30	1999-12-30	Hemmung der tnf-aktivität mit zusammensetzungen enthaltend heparin und lösliche tnf rezeptoren

Country Status (12)

Country	Link
US (1)	US6608044B1 (de)
EP (1)	EP1058544B1 (de)
JP (1)	JP2002534375A (de)
AT (1)	ATE289506T1 (de)
AU (1)	AU780203B2 (de)
CA (1)	CA2322229C (de)
DE (1)	DE69923832T2 (de)
DK (1)	DK1058544T3 (de)
ES (1)	ES2237959T3 (de)
IL (2)	IL127851A0 (de)
PT (1)	PT1058544E (de)
WO (1)	WO2000040225A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1192963A4 (de) *	2000-04-05	2004-08-25	Toray Industries	Adsorbentien für proteine der gruppe high mobility protein und säule zum reinigen von körperflüssigkeiten
ATE290874T1 (de) *	2000-12-16	2005-04-15	Aventis Pharma Gmbh	Verwendung von niedermolekularen heparin zur behandlung von osteoarthrose
EP1575534B1 (de)	2002-05-03	2013-04-10	Massachusetts Institute Of Technology	D4,5 glycuronidase und ihre verwendungen
US7307361B1 (en)	2006-11-13	2007-12-11	Drs Power & Control Technologies, Inc.	Medium voltage power converter formed using low voltage drives
US7576604B2 (en) *	2006-12-15	2009-08-18	Bin Xu	All-digital class-D audio amplifier
WO2009141821A1 (en) *	2008-05-20	2009-11-26	Crystal Clear Partnership	Separation of polysaccharides by charge density gradient
EP2310409A2 (de) *	2008-06-17	2011-04-20	Apogenix GmbH	Multimere tnf-rezeptoren
WO2010013231A2 (en) *	2008-07-29	2010-02-04	Yeda Research And Development Co. Ltd.	Modulation of coagulation factors and effectors of same for control of transplant organ size
WO2018165656A1 (en)	2017-03-10	2018-09-13	The University Of North Carolina At Chapel Hill	Short-acting heparin-based anticoagulant compounds and methods
US11865137B2 (en)	2017-11-03	2024-01-09	The University Of North Carolina At Chapel Hill	Sulfated oligosaccharides having anti-inflammatory activity
WO2021097345A1 (en)	2019-11-13	2021-05-20	The University Of North Carolina At Chapel Hill	Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL98078A0 (en) *	1991-05-07	1992-06-21	Yeda Res & Dev	Pharmaceutical compositions comprising an anticytokyne
EP0583360B1 (de) *	1991-05-02	2002-05-22	Yeda Research And Development Co. Ltd.	Zusammensetzungen zur verhütung und/oder behandlung von pathologischen prozessen
NZ256293A (en) *	1992-09-15	1997-06-24	Immunex Corp	Method of treating tumour necrosis factor - mediated inflammation by use of tnf antagonist
PT710121E (pt) *	1993-07-30	2001-04-30	Kennedy Inst Of Rheumatology T	Metodo para o tratamento da esclerose multipla
DE4435612A1 (de) *	1994-10-05	1996-04-11	Braun Melsungen Ag	Verfahren zur simultanen Entfernung von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus einer wäßrigen Flüssigkeit
AUPN673995A0 (en) *	1995-11-22	1995-12-14	Down Hole Technologies Pty Ltd	A sleeve for orientating a tool
US6623472B1 (en)	1997-08-16	2003-09-23	Orthogen Gentechnologic. Gmbh	Method for inducing therapeutically-effective proteins

1998
- 1998-12-30 IL IL12785198A patent/IL127851A0/xx unknown
1999
- 1999-12-30 JP JP2000591982A patent/JP2002534375A/ja active Pending
- 1999-12-30 DE DE69923832T patent/DE69923832T2/de not_active Expired - Fee Related
- 1999-12-30 WO PCT/IL1999/000709 patent/WO2000040225A2/en not_active Ceased
- 1999-12-30 PT PT99961268T patent/PT1058544E/pt unknown
- 1999-12-30 EP EP99961268A patent/EP1058544B1/de not_active Expired - Lifetime
- 1999-12-30 ES ES99961268T patent/ES2237959T3/es not_active Expired - Lifetime
- 1999-12-30 US US09/623,225 patent/US6608044B1/en not_active Expired - Fee Related
- 1999-12-30 AU AU17961/00A patent/AU780203B2/en not_active Ceased
- 1999-12-30 CA CA002322229A patent/CA2322229C/en not_active Expired - Fee Related
- 1999-12-30 DK DK99961268T patent/DK1058544T3/da active
- 1999-12-30 AT AT99961268T patent/ATE289506T1/de not_active IP Right Cessation
2000
- 2000-08-23 IL IL138024A patent/IL138024A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2322229C (en)	2008-05-06
AU1796100A (en)	2000-07-24
US6608044B1 (en)	2003-08-19
JP2002534375A (ja)	2002-10-15
EP1058544A1 (de)	2000-12-13
ES2237959T3 (es)	2005-08-01
EP1058544B1 (de)	2005-02-23
DE69923832D1 (de)	2005-03-31
IL127851A0 (en)	1999-10-28
DE69923832T2 (de)	2005-12-29
PT1058544E (pt)	2005-04-29
IL138024A (en)	2006-09-05
DK1058544T3 (da)	2005-03-14
CA2322229A1 (en)	2000-07-13
AU780203B2 (en)	2005-03-10
WO2000040225A3 (en)	2000-09-21
WO2000040225A2 (en)	2000-07-13

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