DK1058544T3 - Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer - Google Patents

Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer

Info

Publication number: DK1058544T3
Authority: DK; Denmark
Prior art keywords: heparin; tnf; inhibition; preparations; soluble
Prior art date: 1998-12-30

Application number

DK99961268T

Other languages

English (en)

Inventor

Dan Aderka

Englender Talma Eshed

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-30

Filing date

1999-12-30

Publication date

2005-03-14

1999-12-30 Application filed by Applied Research Systems filed Critical Applied Research Systems

2005-03-14 Application granted granted Critical

2005-03-14 Publication of DK1058544T3 publication Critical patent/DK1058544T3/da

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 5
108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 title abstract 5
229960002897 heparin Drugs 0.000 title abstract 5
229920000669 heparin Polymers 0.000 title abstract 5
102000003298 tumor necrosis factor receptor Human genes 0.000 title abstract 5
230000005764 inhibitory process Effects 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
239000000203 mixture Substances 0.000 abstract 2

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Epidemiology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Heart & Thoracic Surgery (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Cell Biology (AREA)
Neurosurgery (AREA)
Tropical Medicine & Parasitology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)

DK99961268T 1998-12-30 1999-12-30 Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer DK1058544T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL12785198A IL127851A0 (en)	1998-12-30	1998-12-30	Inhibition of TNF activity
PCT/IL1999/000709 WO2000040225A2 (en)	1998-12-30	1999-12-30	Inhibition of tnf activity

Publications (1)

Publication Number	Publication Date
DK1058544T3 true DK1058544T3 (da)	2005-03-14

Family

ID=11072323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99961268T DK1058544T3 (da)	1998-12-30	1999-12-30	Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer

Country Status (12)

Country	Link
US (1)	US6608044B1 (da)
EP (1)	EP1058544B1 (da)
JP (1)	JP2002534375A (da)
AT (1)	ATE289506T1 (da)
AU (1)	AU780203B2 (da)
CA (1)	CA2322229C (da)
DE (1)	DE69923832T2 (da)
DK (1)	DK1058544T3 (da)
ES (1)	ES2237959T3 (da)
IL (2)	IL127851A0 (da)
PT (1)	PT1058544E (da)
WO (1)	WO2000040225A2 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001074420A1 (en) *	2000-04-05	2001-10-11	Toray Industries, Inc.	Adsorbents for high mobility group proteins and column for purifying body fluid
AU2002221935A1 (en) *	2000-12-16	2002-06-24	Aventis Pharma Deutschland Gmbh	Use of low molecular heparin for treating osteoarthritis
CA2484604C (en)	2002-05-03	2011-08-02	Massachusetts Institute Of Technology	.delta. 4,5 glycuronidase and uses thereof
US7307361B1 (en)	2006-11-13	2007-12-11	Drs Power & Control Technologies, Inc.	Medium voltage power converter formed using low voltage drives
US7576604B2 (en) *	2006-12-15	2009-08-18	Bin Xu	All-digital class-D audio amplifier
AU2009250803A1 (en) *	2008-05-20	2009-11-26	Crystal Clear Partnership	Separation of polysaccharides by charge density gradient
EP2540740B1 (en) *	2008-06-17	2014-09-10	Apogenix GmbH	Multimeric TNF receptors
WO2010013231A2 (en) *	2008-07-29	2010-02-04	Yeda Research And Development Co. Ltd.	Modulation of coagulation factors and effectors of same for control of transplant organ size
CN110446511B (zh)	2017-03-10	2024-04-02	北卡罗来纳大学查珀尔希尔分校	短效的基于肝素的抗凝血剂化合物和方法
JP7495061B2 (ja)	2017-11-03	2024-06-04	ザユニバーシティオブノースカロライナアットチャペルヒル	抗炎症作用を有する硫酸化オリゴ糖
WO2021097345A1 (en)	2019-11-13	2021-05-20	The University Of North Carolina At Chapel Hill	Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL98078A0 (en) *	1991-05-07	1992-06-21	Yeda Res & Dev	Pharmaceutical compositions comprising an anticytokyne
SK120193A3 (en) *	1991-05-02	1994-07-06	Yeda Res & Dev	Pharmaceutical composition for the prevention and/or treatment of pathological processes
KR100232688B1 (ko) *	1992-09-15	1999-12-01	스코트 쥐. 홀퀴스트	종양 괴사 인자 길항제를 함유하는 tnf-의존성 염증 치료용 제약 조성물
ES2153384T3 (es) *	1993-07-30	2001-03-01	Kennedy Inst Of Rheumatology	Metodo para tratar la esclerosis multiple.
DE4435612A1 (de) *	1994-10-05	1996-04-11	Braun Melsungen Ag	Verfahren zur simultanen Entfernung von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus einer wäßrigen Flüssigkeit
AUPN673995A0 (en) *	1995-11-22	1995-12-14	Down Hole Technologies Pty Ltd	A sleeve for orientating a tool
CA2301174C (en)	1997-08-16	2007-11-27	Orthogen Gentechnologie Gmbh	A method for inducing therapeutically-effective proteins

1998
- 1998-12-30 IL IL12785198A patent/IL127851A0/xx unknown
1999
- 1999-12-30 EP EP99961268A patent/EP1058544B1/en not_active Expired - Lifetime
- 1999-12-30 WO PCT/IL1999/000709 patent/WO2000040225A2/en not_active Ceased
- 1999-12-30 DE DE69923832T patent/DE69923832T2/de not_active Expired - Fee Related
- 1999-12-30 ES ES99961268T patent/ES2237959T3/es not_active Expired - Lifetime
- 1999-12-30 AT AT99961268T patent/ATE289506T1/de not_active IP Right Cessation
- 1999-12-30 PT PT99961268T patent/PT1058544E/pt unknown
- 1999-12-30 CA CA002322229A patent/CA2322229C/en not_active Expired - Fee Related
- 1999-12-30 AU AU17961/00A patent/AU780203B2/en not_active Ceased
- 1999-12-30 US US09/623,225 patent/US6608044B1/en not_active Expired - Fee Related
- 1999-12-30 JP JP2000591982A patent/JP2002534375A/ja active Pending
- 1999-12-30 DK DK99961268T patent/DK1058544T3/da active
2000
- 2000-08-23 IL IL138024A patent/IL138024A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
US6608044B1 (en)	2003-08-19
CA2322229C (en)	2008-05-06
WO2000040225A2 (en)	2000-07-13
ES2237959T3 (es)	2005-08-01
CA2322229A1 (en)	2000-07-13
WO2000040225A3 (en)	2000-09-21
ATE289506T1 (de)	2005-03-15
EP1058544A1 (en)	2000-12-13
IL138024A (en)	2006-09-05
AU780203B2 (en)	2005-03-10
JP2002534375A (ja)	2002-10-15
EP1058544B1 (en)	2005-02-23
DE69923832T2 (de)	2005-12-29
DE69923832D1 (de)	2005-03-31
PT1058544E (pt)	2005-04-29
IL127851A0 (en)	1999-10-28
AU1796100A (en)	2000-07-24

Similar Documents

Publication	Publication Date	Title
NL300136I2 (nl)	2004-02-02	Farmacologisch actieve catecholderivaten en samenstellingen ervan.
UY26082A1 (es)	2000-10-31	Derivados de 1,4-diazabiciclo [3.2.2] nonan-4-carboxilato y -carboxamidas, su preparacion y su aplicacion en terapeutica
ITRM910922A1 (it)	1993-06-11	Composizione farmaceutica anticefalalgica per somministrazione endonasale, procedimento per prepararla e suo impiego terapeutico
SE8804629D0 (sv)	1988-12-22	New therapeutically active compounds
NO981436D0 (no)	1998-03-30	Farmasöytiske angiostatiske dipeptidsammensetninger og anvendelse derav
DK0902789T3 (da)	2002-05-06	Androstenderivater
DK1058544T3 (da)	2005-03-14	Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer
DK1187611T3 (da)	2004-10-11	Oftalmiske histaminholdige sammensætninger og anvendelse deraf
IL126175A0 (en)	1999-05-09	Method or treating heart failure with endothelin antagonists and pharmaceutical compositions containing the same
IT9020020A0 (it)	1990-04-12	"n,n'-ditrimetossibenzoilpiperazine 2-sostituite, procedimento per la loro preparazione e composizioni terapeutiche che le contengono
DK0862454T3 (da)	2002-12-30	CTLA-8 i kombination med G-CSF eller med G-CSF og IL-6 og anvendelse af CTLA-8 til behandling af infektioner
ITMI911445A1 (it)	1992-11-28	Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva
LV10917A (lv)	1995-12-20	Bambuterina pielietojums lipidu saturu pazeminosu farmaceitisku kompoziciju pagatavosanai
IT8622783A0 (it)	1986-12-19	Derivati imidazolici adattivita' terapeutica, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
IT9022371A0 (it)	1990-12-13	Derivati dell'1-arilsolfonil 2-pirrolidone, loro procedimento di preparazione e i nuovi intermedi cosi' ottenuti, il loro impiego come farmaci e le composizioni farmaceutiche che li contengono.
IT9048605A0 (it)	1990-12-21	Derivati della 1,2,3,4,-tetraidronaftilammina ad attivita' nootropica e composizioni farmaceutiche che li contengono.
ITMI911653A0 (it)	1991-06-17	Derivati dell'eseridina ad attivita' amticolinesterasi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT8520150A0 (it)	1985-03-29	Nuovi derivati ad attivita'terapeutica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
ITMI922832A1 (it)	1994-06-11	DERIVATI DELL'ESEROLINA AD ATTIVITAy ANTICOLINESTERASICA, PROCEDIMENTO PER LA LORO PREPARAZIONE E COMPOSIZIONI FARMACEUTICHE CHE LI CONTENGONO.
IT8321740A0 (it)	1983-06-22	Derivati dell'isoindolina e composizioni terapeutiche che li comprendono come principio attivo.
ITMI912465A0 (it)	1991-09-18	Derivati imidazotiadiazolici ad attivita' diuretica,procedimenti per la loro preparazione e composizioni che li contengono
IT9047769A0 (it)	1990-03-16	Derivati 8-azaxantinici, loro sali fisiologicamente accettabili e loro composizioni farmaceutiche ad attivita' antibroncospastica.
IT8819879A0 (it)	1988-03-22	Composizioni farmaceutiche atte all'impiego nella terapia dell'ipotensione arteriosa.
IT8025473A0 (it)	1980-10-21	Derivati piridossinici ad attivita' terapeutica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
ITRM910829A0 (it)	1991-10-31	Derivati dell'ipoxantina dotati di attivita' immunomodulante e composizioni farmaceutiche che li contengono