ATE289572T1 - Zur unterstützung der knochenzellenaktivität besonders geeignete stabilisierte zusammensetzung aus kalziumphosphatphasen - Google Patents

Zur unterstützung der knochenzellenaktivität besonders geeignete stabilisierte zusammensetzung aus kalziumphosphatphasen

Info

Publication number
ATE289572T1
ATE289572T1 AT96928293T AT96928293T ATE289572T1 AT E289572 T1 ATE289572 T1 AT E289572T1 AT 96928293 T AT96928293 T AT 96928293T AT 96928293 T AT96928293 T AT 96928293T AT E289572 T1 ATE289572 T1 AT E289572T1
Authority
AT
Austria
Prior art keywords
compound
particularly suitable
calcium phosphate
cell activity
bone cell
Prior art date
Application number
AT96928293T
Other languages
English (en)
Inventor
Sydney M Pugh
Timothy J N Smith
Michael Sayer
Sarah Dorthea Langstaff
Original Assignee
Millenium Biologix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26671402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE289572(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millenium Biologix Inc filed Critical Millenium Biologix Inc
Application granted granted Critical
Publication of ATE289572T1 publication Critical patent/ATE289572T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3821—Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/80—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone of only ceramics
    • C04B41/81—Coating or impregnation
    • C04B41/85—Coating or impregnation with inorganic materials
    • C04B41/87—Ceramics
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C24/00—Coating starting from inorganic powder
    • C23C24/08—Coating starting from inorganic powder by application of heat or pressure and heat
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C30/00—Coating with metallic material characterised only by the composition of the metallic material, i.e. not characterised by the coating process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
    • C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Ceramic Engineering (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Structural Engineering (AREA)
  • Developmental Biology & Embryology (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Botany (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT96928293T 1995-09-01 1996-08-30 Zur unterstützung der knochenzellenaktivität besonders geeignete stabilisierte zusammensetzung aus kalziumphosphatphasen ATE289572T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US315795P 1995-09-01 1995-09-01
US57623895A 1995-12-21 1995-12-21
PCT/CA1996/000585 WO1997009286A1 (en) 1995-09-01 1996-08-30 An artificial stabilized composition of calcium phosphate phases particularly adapted for supporting bone cell activity

Publications (1)

Publication Number Publication Date
ATE289572T1 true ATE289572T1 (de) 2005-03-15

Family

ID=26671402

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96928293T ATE289572T1 (de) 1995-09-01 1996-08-30 Zur unterstützung der knochenzellenaktivität besonders geeignete stabilisierte zusammensetzung aus kalziumphosphatphasen

Country Status (13)

Country Link
US (4) US6323146B1 (de)
EP (1) EP0847376B1 (de)
JP (2) JP4465046B2 (de)
KR (1) KR100446642B1 (de)
CN (1) CN1183058C (de)
AT (1) ATE289572T1 (de)
AU (1) AU714311B2 (de)
BR (1) BR9610357B1 (de)
CA (1) CA2230057C (de)
DE (1) DE69634384T2 (de)
ES (1) ES2236746T3 (de)
NZ (1) NZ315995A (de)
WO (1) WO1997009286A1 (de)

Families Citing this family (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6846493B2 (en) 1995-09-01 2005-01-25 Millenium Biologix Inc. Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity
ATE289572T1 (de) * 1995-09-01 2005-03-15 Millenium Biologix Inc Zur unterstützung der knochenzellenaktivität besonders geeignete stabilisierte zusammensetzung aus kalziumphosphatphasen
BR9815668A (pt) * 1998-01-29 2001-01-30 Millenium Biologix Inc Composto biomaterial sintético
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US6383519B1 (en) * 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
US6840995B2 (en) 1999-07-14 2005-01-11 Calcitec, Inc. Process for producing fast-setting, bioresorbable calcium phosphate cements
US7094282B2 (en) 2000-07-13 2006-08-22 Calcitec, Inc. Calcium phosphate cement, use and preparation thereof
US7169373B2 (en) * 1999-07-14 2007-01-30 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
US7270705B2 (en) * 1999-07-14 2007-09-18 Jiin-Huey Chern Lin Method of increasing working time of tetracalcium phosphate cement paste
US6960249B2 (en) * 1999-07-14 2005-11-01 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface
US6375935B1 (en) 2000-04-28 2002-04-23 Brent R. Constantz Calcium phosphate cements prepared from silicate solutions
US7820191B2 (en) 2000-04-28 2010-10-26 Skeletal Kinetics, Llc Calcium phosphate cements prepared from silicate solutions
US7182928B2 (en) 2000-07-13 2007-02-27 Calcitec, Inc. Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
US7156915B2 (en) 2000-07-13 2007-01-02 Calcitec, Inc. Tetracalcium phosphate (TTCP) with surface whiskers and method of making same
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
FR2820043A1 (fr) * 2001-01-19 2002-08-02 Technology Corp Poprieatry Ltd Un implant
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
EP1429817B8 (de) * 2001-09-24 2007-09-12 Millenium Biologix Technologies Inc. Poröse keramische komposit-knochenimplantate
KR100481042B1 (ko) * 2001-10-09 2005-04-07 요업기술원 실리콘 및 마그네슘을 함유하는 하이드록시아파타이트 및 그 제조방법
DE10161827A1 (de) * 2001-12-15 2003-06-26 Dot Gmbh Verfahren zur Beschichtung eines Substrats mit Calciumphosphat
TW200400062A (en) * 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
WO2003087292A2 (en) 2002-04-08 2003-10-23 Millenium Biologix Inc. Automated tissue engineering system
KR100460685B1 (ko) * 2002-04-10 2004-12-09 재단법인서울대학교산학협력재단 인산칼슘계 화합물을 이용한 인공 골 충진재 및 그 제조방법
US7491691B2 (en) 2002-05-03 2009-02-17 Sindrey Dennis R Connective tissue stimulating peptides
US20030216777A1 (en) * 2002-05-16 2003-11-20 Yin-Chun Tien Method of enhancing healing of interfacial gap between bone and tendon or ligament
WO2004053205A2 (en) * 2002-07-22 2004-06-24 Massachusetts Institute Of Technolgoy Porous material formation by chemical vapor deposition onto colloidal crystal templates
GB2422843B (en) 2002-08-12 2007-03-14 Pentax Corp Cell culture base
FR2850282B1 (fr) 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
US20040250730A1 (en) * 2003-06-12 2004-12-16 David Delaney Calcium phosphate cements prepared from silicate-phosphate solutions
US7306786B2 (en) * 2003-07-28 2007-12-11 Skeletal Kinetics, Llc Calcium phosphate cements comprising a water-soluble contrast agent
US7118705B2 (en) * 2003-08-05 2006-10-10 Calcitec, Inc. Method for making a molded calcium phosphate article
US6994726B2 (en) 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
US7163651B2 (en) 2004-02-19 2007-01-16 Calcitec, Inc. Method for making a porous calcium phosphate article
US7744869B2 (en) * 2003-08-20 2010-06-29 Ebi, Llc Methods of treatment using electromagnetic field stimulated mesenchymal stem cells
EP1686934B1 (de) * 2003-11-07 2020-03-18 Vivex Biologics Group, Inc. Injizierbare knochensubstitut
KR101132991B1 (ko) * 2003-12-18 2012-06-21 이무노사이언스 가부시키가이샤 티탄화합물의 소결체
EP1730267B1 (de) * 2004-03-05 2013-01-16 Octane Biotech Inc. Umkehrflussperfusion dreidimensionaler gerüste
WO2005094553A2 (en) * 2004-03-24 2005-10-13 Doctor's Research Group, Inc. Compositions for promoting bone growth and methods thereof
US7498043B2 (en) 2004-04-07 2009-03-03 Warsaw Orthopedic, Inc. Silicon substituted oxyapatite
WO2005102281A2 (en) * 2004-04-16 2005-11-03 University Of Massachusetts Porous calcium phosphate networks for synthetic bone material
US20050244499A1 (en) * 2004-05-03 2005-11-03 Robert Diaz Method and device for reducing susceptibility to fractures in long bones
US20050244451A1 (en) * 2004-05-03 2005-11-03 Robert Diaz Method and device for reducing susceptibility to fractures in vertebral bodies
US20060089642A1 (en) * 2004-10-27 2006-04-27 Diaz Robert L Prefracture spinal implant for osteoporotic unfractured bone
EP1819375A2 (de) 2004-12-08 2007-08-22 Interpore Spine Ltd. Komposit mit kontinuierlicher phase für die muskel-skelett-reparatur
US8535357B2 (en) 2004-12-09 2013-09-17 Biomet Sports Medicine, Llc Continuous phase compositions for ACL repair
US7740794B1 (en) 2005-04-18 2010-06-22 Biomet Sports Medicine, Llc Methods of making a polymer and ceramic composite
US9763788B2 (en) 2005-09-09 2017-09-19 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
EP1931401A2 (de) * 2005-09-09 2008-06-18 University of Arkansas at Little Rock System und verfahren für die gewebegeneration und knochenregeneration
US8936805B2 (en) 2005-09-09 2015-01-20 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US20070105769A1 (en) * 2005-11-07 2007-05-10 Ebi, L.P. Methods of treating tissue defects
DE102005058125B3 (de) * 2005-11-29 2007-07-19 BAM Bundesanstalt für Materialforschung und -prüfung Verfahren zur Herstellung eines metallischen Substrates mit biokompatibler Oberfläche und das damit hergestellte Substrat
US8455088B2 (en) 2005-12-23 2013-06-04 Boston Scientific Scimed, Inc. Spun nanofiber, medical devices, and methods
US7674864B2 (en) 2005-12-23 2010-03-09 Boston Scientific Scimed, Inc. Polymeric hybrid precursors, polymeric hybrid precursor composite matrices, medical devices, and methods
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8623737B2 (en) * 2006-03-31 2014-01-07 Intel Corporation Sol-gel and mask patterning for thin-film capacitor fabrication, thin-film capacitors fabricated thereby, and systems containing same
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
EP2054537A2 (de) 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprothese mit dreidimensionaler desintegrationssteuerung
ATE508708T1 (de) 2006-09-14 2011-05-15 Boston Scient Ltd Medizinprodukte mit wirkstofffreisetzender beschichtung
EP2959925B1 (de) 2006-09-15 2018-08-29 Boston Scientific Limited Medizinische vorrichtungen und verfahren zu ihrer herstellung
EP2121068B1 (de) 2006-09-15 2010-12-08 Boston Scientific Scimed, Inc. Biologisch erodierbare endoprothese mit biostabilen anorganischen schichten
CA2663250A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
JP2010503494A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 生分解性内部人工器官およびその製造方法
US8002821B2 (en) 2006-09-18 2011-08-23 Boston Scientific Scimed, Inc. Bioerodible metallic ENDOPROSTHESES
US8388626B2 (en) * 2006-11-08 2013-03-05 Warsaw Orthopedic, Inc. Methods of employing calcium phosphate cement compositions and osteoinductive proteins to effect vertebrae interbody fusion absent an interbody device
US20080294236A1 (en) * 2007-05-23 2008-11-27 Boston Scientific Scimed, Inc. Endoprosthesis with Select Ceramic and Polymer Coatings
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US7931651B2 (en) 2006-11-17 2011-04-26 Wake Lake University Health Sciences External fixation assembly and method of use
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
CA2674195A1 (en) 2006-12-28 2008-07-10 Boston Scientific Limited Bioerodible endoprostheses and methods of making same
US8377016B2 (en) 2007-01-10 2013-02-19 Wake Forest University Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8034014B2 (en) 2007-03-06 2011-10-11 Biomet Biologics, Llc Angiogenesis initation and growth
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7901344B2 (en) * 2007-05-11 2011-03-08 Biomet Biologics, Llc Methods of reducing surgical complications in cancer patients
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
JP2010533563A (ja) 2007-07-19 2010-10-28 ボストン サイエンティフィック リミテッド 吸着抑制表面を有する内部人工器官
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
JP2010535541A (ja) 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド 広い表面積を有する医療器具用のコーティング
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
ES2661762T3 (es) 2007-10-10 2018-04-03 Wake Forest University Health Sciences Dispositivos para tratar el tejido de la médula espinal
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
NZ601533A (en) * 2007-11-15 2014-12-24 Univ Rutgers Method of hydrothermal liquid phase sintering of ceramic materials and products derived therefrom
EP2077126A1 (de) * 2008-01-07 2009-07-08 Graftys Analgesischer und apatitischer Calciumphosphatzement
RU2517588C2 (ru) 2008-01-09 2014-05-27 Уэйк Форест Юниверсити Хелс Сайенсиз Устройство и способ лечения патологий центральной нервной системы
US20090226668A1 (en) * 2008-03-10 2009-09-10 Ebi, L.P. Optimized surface for cellular proliferation and differentiation
BRPI0822576A2 (pt) * 2008-04-07 2015-06-23 Medmat Innovation Materiais Médicos Ltda Substituto ósseo á base de hidroxiapatite, vidro biocompatível e silício, respectivo processo de produção e utilizações
EP2271380B1 (de) 2008-04-22 2013-03-20 Boston Scientific Scimed, Inc. Medizinprodukte mit einer beschichtung aus anorganischem material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
AU2009255648A1 (en) * 2008-05-30 2009-12-10 Warsaw Orthopedic, Inc. Bioceramic and biopolymer composite
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
CN104771197A (zh) 2008-07-18 2015-07-15 韦克福里斯特大学健康科学院 局部施用真空以使细胞死亡和损伤减到最小的心脏组织调节的装置和方法
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
TWI501793B (zh) * 2008-11-12 2015-10-01 Howmedica Osteonics Corp 以磷酸四鈣為主之有機磷組合物及方法
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
EP2389204B1 (de) 2009-01-23 2019-07-03 Royal College of Surgeons in Ireland Geschichtetes gerüst, das zur osteochondralen reparatur geeignet ist
ES2344397B1 (es) * 2009-02-24 2011-06-24 Universitat Politècnica De Catalunya Metodo de obtencion de fosfato tricalcico alfa-estabilizado con elementos alfagenos y fosfato tricalcico alfa-estabilizado obtenido.
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US20100292795A1 (en) * 2009-05-13 2010-11-18 Jensen Ole T Biomedical implant surface topography
US20100330194A1 (en) * 2009-06-24 2010-12-30 Brancato Donald H Silicon Substituted Phosphates
US9399086B2 (en) 2009-07-24 2016-07-26 Warsaw Orthopedic, Inc Implantable medical devices
US8529933B2 (en) 2009-07-27 2013-09-10 Warsaw Orthopedic, Inc. Biphasic calcium phosphate cement for drug delivery
WO2011031821A1 (en) * 2009-09-09 2011-03-17 The Ohio State University Research Foundation Glass ceramic scaffolds with complex topography
US8252549B2 (en) * 2009-11-25 2012-08-28 Corning Incorporated Multi-purpose substrates useful for cell culture and methods for making
JP5095034B2 (ja) * 2009-12-18 2012-12-12 ハウメディカ・オステオニクス・コーポレイション 照射後貯蔵安定性の直接注入可能なデュアルペースト型骨セメントを製造するシステムおよびリン酸カルシウム組成物
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
AU2011250934B2 (en) 2010-05-11 2016-02-25 Howmedica Osteonics Corp., Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
FR2967073A1 (fr) * 2010-11-04 2012-05-11 Catherine Cadorel Materiau greffon de comblement osseux, a usage medical ou veterinaire, son procede d'obtention, le materiau obtenu et ses applications
EP2633869B1 (de) * 2010-10-29 2018-04-25 Mitsubishi Electric Corporation Implantatmaterial, implantatteil, verfahren zur herstellung des implantatteils, laserbearbeitungsverfahren und laserbearbeitungsvorrichtung
WO2012062360A1 (en) 2010-11-10 2012-05-18 Stryker Trauma Gmbh Polymeric bone foam composition and method
US8613938B2 (en) 2010-11-15 2013-12-24 Zimmer Orthobiologics, Inc. Bone void fillers
US8765189B2 (en) 2011-05-13 2014-07-01 Howmedica Osteonic Corp. Organophosphorous and multivalent metal compound compositions and methods
SG11201704277XA (en) * 2014-11-27 2017-06-29 Toyo Boseki Porous composite, bone regeneration material, and method for producing porous composite
US10219986B2 (en) 2015-03-04 2019-03-05 Modern Ideas LLC Stabilized calcium phosphate and methods of forming same
DE102015110367A1 (de) * 2015-06-26 2016-12-29 Karlsruher Institut für Technologie Online-Phosphor-Nachweis durch Infrarotspektroskopie
WO2017011448A1 (en) 2015-07-13 2017-01-19 Bone Solutions, Inc. Bio-material composition and methods of use
US9956314B2 (en) 2016-01-26 2018-05-01 Modern Ideas LLC Adhesive for use with bone and bone-like structures
CN107226717B (zh) * 2017-06-23 2020-04-07 陶合体科技(苏州)有限责任公司 由纳米孔活性玻璃包覆的多孔生物陶瓷及其制备方法
IL315340A (en) 2017-09-01 2024-10-01 Lonza Walkersville Inc End-to-end cell therapy automation
KR102036371B1 (ko) 2017-11-16 2019-10-25 김주회 애완동물 목욕장치
KR102816402B1 (ko) 2018-09-28 2025-06-04 옥테인 바이오테크 인코포레이티드 자기 분리
EP3898932A4 (de) 2018-12-21 2022-08-03 Octane Biotech Inc. Karussell für modulare biologische produktionseinheiten
KR20210108406A (ko) 2018-12-21 2021-09-02 론자 워커스빌 아이엔씨. 바이러스 벡터의 자동화된 생산
WO2020132743A1 (en) 2018-12-28 2020-07-02 Octane Biotech Inc. Cell culture and tissue engineering systems with controlled environmental zones
WO2020163454A1 (en) 2019-02-08 2020-08-13 Lonza Walkersville, Inc. Cell concentration methods and devices for use in automated bioreactors
JP7340798B2 (ja) * 2019-06-13 2023-09-08 国立研究開発法人物質・材料研究機構 積層体の製造方法、及び積層体
EP4048773A4 (de) 2019-10-24 2024-01-03 Octane Biotech Inc. Zellkulturkammer mit verbesserten zellkontaktflächen
US12163146B2 (en) 2019-11-11 2024-12-10 Lonza Walkersville, Inc. Quality control methods for automated cell processing
CN114074931B (zh) * 2020-08-18 2023-04-18 中山职业技术学院 3D打印用高血管生成活性α磷酸三钙纳米粉体的制备方法
CN113121118A (zh) * 2021-03-08 2021-07-16 四川大学 一种钒掺杂硅钙磷介孔生物活性玻璃粉

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1395037A (en) * 1972-10-10 1975-05-21 Doulton & Co Ltd Bone china
JPS5839533B2 (ja) * 1975-12-30 1983-08-30 住友化学工業株式会社 インプラントノセイゾウホウホウ
US4308064A (en) * 1978-10-19 1981-12-29 Ngk Spark Plugs Co., Ltd. Phosphate of calcium ceramics
JPS5917567A (ja) 1982-07-22 1984-01-28 Fuji Xerox Co Ltd 静電印刷方法
US4503157A (en) 1982-09-25 1985-03-05 Ina Seito Co., Ltd. Sintered apatite bodies and composites thereof
JPS59174567A (ja) * 1983-03-24 1984-10-03 工業技術院長 β−リン酸三カルシウム焼結体の製法
US5034352A (en) 1985-06-25 1991-07-23 Lifecore Biomedical, Inc. Calcium phosphate materials
US4861733A (en) 1987-02-13 1989-08-29 Interpore International Calcium phosphate bone substitute materials
JP2527323B2 (ja) 1987-03-06 1996-08-21 ライオン株式会社 セラミツクス焼結成形体及びその製造方法
DE3711426A1 (de) 1987-04-04 1988-10-13 Mtu Muenchen Gmbh Implantat mit bioaktivem ueberzug
JPH01111763A (ja) * 1987-10-27 1989-04-28 Jgc Corp リン酸カルシウム系化合物焼結体およびその製造方法
JPH01133969A (ja) * 1987-11-20 1989-05-26 Seiko Epson Corp 骨，歯の代替材料
DE68917947T2 (de) 1988-02-08 1995-03-16 Mitsubishi Chem Ind Keramisches Implantat und Verfahren zu dessen Herstellung.
JPH062154B2 (ja) 1988-03-30 1994-01-12 工業技術院長 リン酸カルシウム系物質コーティング用粉体、コーティング方法及び複合生体セラミックス
JPH01298055A (ja) 1988-05-27 1989-12-01 Tdk Corp リン酸カルシウム焼結体の製造方法
US4990163A (en) 1989-02-06 1991-02-05 Trustees Of The University Of Pennsylvania Method of depositing calcium phosphate cermamics for bone tissue calcification enhancement
US5232878A (en) 1989-06-30 1993-08-03 Hoya Corporation Process for producing inorganic biomaterial
JP2830262B2 (ja) * 1990-01-08 1998-12-02 住友化学工業株式会社 ハイドロキシアパタイト皮膜の形成方法
US5011495A (en) 1990-02-16 1991-04-30 The United States Of America As Represented By The Secretary Of The Army Unique bone regeneration tricalcium phosphate
US5164187A (en) * 1990-04-05 1992-11-17 Norian Corporation Hydroxyapatite prosthesis coatings
JP2657847B2 (ja) 1990-05-10 1997-09-30 寅雄 大塚 水酸化アパタイト多孔質生体充▲てん▼材並びにその製造方法
US5074916A (en) 1990-05-18 1991-12-24 Geltech, Inc. Alkali-free bioactive sol-gel compositions
FR2664501B1 (fr) * 1990-07-16 1995-05-12 Osteal Medical Laboratoires Materiau composite pour implant osseux et procede de mise en óoeuvre comme revetement.
GB9310194D0 (en) * 1993-05-18 1993-06-30 Millenium Bioligix Inc Assessment of osteoclast activity
US6302913B1 (en) 1994-05-24 2001-10-16 Implico B.V. Biomaterial and bone implant for bone repair and replacement
JPH08165216A (ja) * 1994-12-13 1996-06-25 Mitsubishi Materials Corp 抗菌性フィラー
ATE289572T1 (de) * 1995-09-01 2005-03-15 Millenium Biologix Inc Zur unterstützung der knochenzellenaktivität besonders geeignete stabilisierte zusammensetzung aus kalziumphosphatphasen
GB2316940A (en) * 1996-08-30 1998-03-11 Queen Mary & Westfield College Silicon-substituted hydroxyapatite
US6037519A (en) * 1997-10-20 2000-03-14 Sdgi Holdings, Inc. Ceramic fusion implants and compositions
JP3143660B2 (ja) * 1997-11-27 2001-03-07 工業技術院長 亜鉛含有リン酸三カルシウムからなるセラミックス及び亜鉛徐放性生体用セラミックス
US6338752B1 (en) * 2000-04-20 2002-01-15 Purzer Pharmaceutical Co., Ltd. α-TCP/HAP biphasic cement and its preparing process

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