ATE289610T1 - Synthone zur herstellung von oligonukleotiden - Google Patents
Synthone zur herstellung von oligonukleotidenInfo
- Publication number
- ATE289610T1 ATE289610T1 AT01963238T AT01963238T ATE289610T1 AT E289610 T1 ATE289610 T1 AT E289610T1 AT 01963238 T AT01963238 T AT 01963238T AT 01963238 T AT01963238 T AT 01963238T AT E289610 T1 ATE289610 T1 AT E289610T1
- Authority
- AT
- Austria
- Prior art keywords
- trivalent phosphorus
- synthone
- oligonucleotides
- production
- phosphorus multimer
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 4
- 229910052698 phosphorus Inorganic materials 0.000 abstract 4
- 239000011574 phosphorus Substances 0.000 abstract 4
- -1 phosphoramidite compounds Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23068500P | 2000-09-07 | 2000-09-07 | |
| PCT/GB2001/003973 WO2002020543A2 (en) | 2000-09-07 | 2001-09-06 | Synthons for oligonucleotide synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE289610T1 true ATE289610T1 (de) | 2005-03-15 |
Family
ID=22866178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01963238T ATE289610T1 (de) | 2000-09-07 | 2001-09-06 | Synthone zur herstellung von oligonukleotiden |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20030229218A1 (de) |
| EP (1) | EP1317466B1 (de) |
| JP (1) | JP2004508379A (de) |
| KR (1) | KR20030081303A (de) |
| CN (1) | CN1471537A (de) |
| AT (1) | ATE289610T1 (de) |
| AU (1) | AU2001284268A1 (de) |
| CA (1) | CA2421489A1 (de) |
| DE (1) | DE60109047T2 (de) |
| WO (1) | WO2002020543A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0209539D0 (en) * | 2002-04-26 | 2002-06-05 | Avecia Ltd | Monomer Polymer and process |
| AU2004274021B2 (en) * | 2003-09-18 | 2009-08-13 | Isis Pharmaceuticals, Inc. | 4'-thionucleosides and oligomeric compounds |
| JP4628686B2 (ja) * | 2004-02-25 | 2011-02-09 | 独立行政法人科学技術振興機構 | ホスホロアミダイトを含む３’末端ヌクレオシドユニット |
| WO2009028345A1 (ja) * | 2007-08-31 | 2009-03-05 | Fujitsu Limited | 核酸合成用ダイマーアミダイド及び核酸合成方法 |
| KR100886139B1 (ko) * | 2007-11-13 | 2009-02-27 | 주식회사 삼천리제약 | 올리고뉴클레오타이드의 제조방법 |
| WO2014197714A1 (en) | 2013-06-05 | 2014-12-11 | Am Chemicals Llc | Phosphoramidite building blocks for sugar-conjugated oligonucleotides |
| EP3500581A4 (de) | 2016-08-17 | 2021-10-06 | Solstice Biologics, Ltd. | Polynukleotidkonstrukte |
| EP3645546A4 (de) | 2017-06-30 | 2021-12-01 | Solstice Biologics, Ltd. | Chirale phosphoramidithilfsmittel und verfahren zu ihrer verwendung |
| CN111479818A (zh) * | 2018-02-13 | 2020-07-31 | 深圳华大生命科学研究院 | 合成寡核苷酸的方法及系统 |
| US11166976B2 (en) | 2018-11-08 | 2021-11-09 | Aligos Therapeutics, Inc. | S-antigen transport inhibiting oligonucleotide polymers and methods |
| EP3805242A1 (de) * | 2019-10-07 | 2021-04-14 | Sterna Biologicals GmbH & Co. KG | Verfahren zur herstellung eines katalytisch aktiven dna-moleküls mit verbesserter aktivität und dessen verwendung in einem verfahren zur behandlung von asthma |
| CN115315430A (zh) * | 2020-01-08 | 2022-11-08 | 日东电工株式会社 | 使用了链段型亚磷酰胺化合物的核酸合成法 |
| CN119751529A (zh) * | 2024-12-27 | 2025-04-04 | 北京炫景瑞医药科技有限公司 | 核苷酸二聚体及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0173356B1 (de) * | 1980-02-29 | 1990-09-19 | University Patents, Inc. | Verfahren zur Herstellung von modifizierten anorganischen Polymeren |
| EP0090789A1 (de) * | 1982-03-26 | 1983-10-05 | Monsanto Company | Chemische DNA-Synthese |
| US5449769A (en) * | 1989-03-06 | 1995-09-12 | Gen-Probe Incorporated | Method and reagent for sulfurization of organophosphorous compounds |
| US5218088A (en) * | 1989-11-02 | 1993-06-08 | Purdue Research Foundation | Process for preparing dithiophosphate oligonucleotide analogs via nucleoside thiophosphoramidite intermediates |
| EP1044987B1 (de) * | 1991-12-24 | 2006-02-15 | Isis Pharmaceuticals, Inc. | Unterbrochene 2'-modifizierte Oligonukleotide |
| WO1994000472A2 (en) * | 1992-06-30 | 1994-01-06 | Research Corporation Technologies, Inc. | Trivalent synthesis of oligonucleotides containing stereospecific alkylphosphonates and arylphosphonates |
| US6087491A (en) * | 1993-01-08 | 2000-07-11 | Hybridon, Inc. | Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks |
| US5856464A (en) * | 1995-06-07 | 1999-01-05 | Lajolla Pharmaceutical Company | Selective capping solution phase oligonucleotide synthesis |
| JP4151751B2 (ja) * | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
-
2001
- 2001-09-06 KR KR10-2003-7003308A patent/KR20030081303A/ko not_active Withdrawn
- 2001-09-06 AT AT01963238T patent/ATE289610T1/de not_active IP Right Cessation
- 2001-09-06 CN CNA018181228A patent/CN1471537A/zh active Pending
- 2001-09-06 CA CA002421489A patent/CA2421489A1/en not_active Abandoned
- 2001-09-06 EP EP01963238A patent/EP1317466B1/de not_active Expired - Lifetime
- 2001-09-06 AU AU2001284268A patent/AU2001284268A1/en not_active Abandoned
- 2001-09-06 DE DE60109047T patent/DE60109047T2/de not_active Expired - Fee Related
- 2001-09-06 WO PCT/GB2001/003973 patent/WO2002020543A2/en not_active Ceased
- 2001-09-06 JP JP2002525164A patent/JP2004508379A/ja active Pending
-
2003
- 2003-03-07 US US10/385,193 patent/US20030229218A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004508379A (ja) | 2004-03-18 |
| DE60109047T2 (de) | 2006-04-06 |
| CN1471537A (zh) | 2004-01-28 |
| EP1317466A2 (de) | 2003-06-11 |
| EP1317466B1 (de) | 2005-02-23 |
| CA2421489A1 (en) | 2002-03-14 |
| DE60109047D1 (de) | 2005-03-31 |
| US20030229218A1 (en) | 2003-12-11 |
| AU2001284268A1 (en) | 2002-03-22 |
| KR20030081303A (ko) | 2003-10-17 |
| WO2002020543A3 (en) | 2002-08-08 |
| WO2002020543A2 (en) | 2002-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |