DK0725824T3 - Immunodominante humane T-celleepitoper af hepatitis C virus - Google Patents

Immunodominante humane T-celleepitoper af hepatitis C virus

Info

Publication number
DK0725824T3
DK0725824T3 DK94931000T DK94931000T DK0725824T3 DK 0725824 T3 DK0725824 T3 DK 0725824T3 DK 94931000 T DK94931000 T DK 94931000T DK 94931000 T DK94931000 T DK 94931000T DK 0725824 T3 DK0725824 T3 DK 0725824T3
Authority
DK
Denmark
Prior art keywords
hepatitis
virus
cell epitopes
amino acids
immunodominant
Prior art date
Application number
DK94931000T
Other languages
English (en)
Inventor
Geert Leroux-Roels
Robert Deleys
Geert Maertens
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8214764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0725824(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Application granted granted Critical
Publication of DK0725824T3 publication Critical patent/DK0725824T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK94931000T 1993-11-04 1994-10-28 Immunodominante humane T-celleepitoper af hepatitis C virus DK0725824T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93402718 1993-11-04
PCT/EP1994/003555 WO1995012677A2 (en) 1993-11-04 1994-10-28 Immunodominant human t-cell epitopes of hepatitis c virus

Publications (1)

Publication Number Publication Date
DK0725824T3 true DK0725824T3 (da) 2003-08-11

Family

ID=8214764

Family Applications (2)

Application Number Title Priority Date Filing Date
DK99116671T DK0992580T3 (da) 1993-11-04 1994-10-28 Epitoper på human T-celler, som er immundominante for hepatitis C-virus
DK94931000T DK0725824T3 (da) 1993-11-04 1994-10-28 Immunodominante humane T-celleepitoper af hepatitis C virus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK99116671T DK0992580T3 (da) 1993-11-04 1994-10-28 Epitoper på human T-celler, som er immundominante for hepatitis C-virus

Country Status (11)

Country Link
US (4) US6555114B1 (da)
EP (4) EP0979867A3 (da)
JP (2) JPH09504534A (da)
AT (3) ATE274578T1 (da)
AU (1) AU698878B2 (da)
CA (1) CA2175692A1 (da)
DE (3) DE69432475T2 (da)
DK (2) DK0992580T3 (da)
ES (2) ES2197170T3 (da)
PT (2) PT725824E (da)
WO (1) WO1995012677A2 (da)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0697888B1 (en) 1993-05-12 2003-09-17 Chiron Corporation Conserved motif of hepatitis c virus e2/ns1 region
US7070790B1 (en) * 1993-06-29 2006-07-04 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
ES2197170T3 (es) * 1993-11-04 2004-01-01 Innogenetics N.V. Epitopos de celulas t humanas inmunologicamente dominantes del virus de la hepatitis c.
US5709995A (en) * 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
DE69517521T2 (de) * 1994-04-08 2001-03-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville Peptid aus dem inneren des hepatitis-c-virus brauchbar für die stimulation cytotoxischer t-lymphocyten und die diagnose des hcv-kontaktes
WO1999024466A2 (en) * 1997-11-06 1999-05-20 Innogenetics N.V. Multi-mer peptides derived from hepatitis c virus envelope proteins for diagnostic use and vaccination purposes
AU751362B2 (en) 1998-04-17 2002-08-15 Innogenetics N.V. Improved immunodiagnostic assays using reducing agents
WO1999058561A1 (fr) * 1998-05-14 1999-11-18 Pasteur Merieux Serums & Vaccins Mimotopes du virus de l'hepatite c
AU748700B2 (en) * 1998-06-12 2002-06-13 Aventis Pasteur HIV virus mimotopes
AU765940B2 (en) * 1998-06-24 2003-10-02 Innogenetics N.V. Particles of HCV envelope proteins: use for vaccination
US7108855B2 (en) 1998-06-24 2006-09-19 Innogenetics N.V. Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
AU5776799A (en) 1998-08-21 2000-03-14 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Modified hcv peptide vaccines
DE19908423A1 (de) * 1999-02-26 2000-08-31 Deutsches Krebsforsch An der Entwicklung des ZNS beteiligtes Protein (TP)
AT408721B (de) * 1999-10-01 2002-02-25 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung enthaltend ein antigen
EP1535628B1 (en) * 1999-11-24 2013-07-31 Novartis Vaccines and Diagnostics, Inc. Hbv/hcv virus-like particle
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6858590B2 (en) * 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
ATE502952T1 (de) * 2000-09-01 2011-04-15 Epimmune Inc Hla-bindungspeptide und ihre anwendungszwecke
GB0026094D0 (en) * 2000-10-25 2000-12-13 Imp College Innovations Ltd Methods
US7402567B2 (en) * 2000-10-27 2008-07-22 The Regents Of The University Of California Treatment of disease by inducing cell apoptosis
US8129349B2 (en) * 2000-10-27 2012-03-06 The Regents Of The University Of California Treatment of disease by inducing cell apoptosis
US7101561B2 (en) 2000-12-01 2006-09-05 Innogenetics N.V. Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
AR035868A1 (es) 2001-04-24 2004-07-21 Innogenetics Nv Un acido nucleico recombinante que codifica una proteina de un peptido lider de lisozima de ave o equivalente funcional, un vector que lo comprende, una celula huesped, un metodo para producir una proteina de envoltura del hcv o una parte de la misma.
FR2825093B1 (fr) * 2001-05-28 2003-07-18 Bio Merieux Polypeptide reagissant avecles anticorps de patients infectes par vhc et utilisations
FR2825363A1 (fr) * 2001-05-31 2002-12-06 Bio Merieux Polypeptides reagissant avec les anticorps de patients infectes par vhc et utilisations
US7736677B2 (en) * 2001-06-20 2010-06-15 Metaproteomics, Llc Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment
JP2003064096A (ja) * 2001-08-29 2003-03-05 Mitsubishi Kagaku Bio-Clinical Laboratories Inc C型肝炎ウイルス特異的細胞障害性t細胞認識エピトープ
GB0126782D0 (en) * 2001-11-07 2002-01-02 Medical Res Council Assay
US20040126395A1 (en) * 2001-12-18 2004-07-01 Geert Maertens Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
CN1622828A (zh) * 2001-12-18 2005-06-01 基因创新有限公司 用于诊断和治疗用途的纯化的丙型肝炎病毒外被蛋白
US7201904B2 (en) 2002-05-16 2007-04-10 The General Hospital Corporation Epitopes of hepatitis C virus
US8029803B2 (en) * 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8025873B2 (en) 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
PL374349A1 (en) * 2002-07-02 2005-10-17 Chiron Corporation Hcv fusion proteins with modified ns3 domains
AU2003283365A1 (en) * 2002-11-08 2004-06-07 Innogenetics N.V. HCV vaccine compositions comprising E1 and NS3 peptides
AU2003303889A1 (en) * 2003-01-07 2004-08-30 Biomerieux Polypeptides f' of the hepatitis c virus, epitopes, and the diagnostic and therapeutic applications thereof
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
US7785875B2 (en) 2004-07-03 2010-08-31 Mogam Biotechnology Research Institute Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same
CN1976946A (zh) * 2004-07-03 2007-06-06 财团法人牧岩生命工学研究所 诱导抗hcv有效ctl应答的超型表位、其编码寡核苷酸及其应用
CU23470A1 (es) * 2004-08-11 2009-12-17 Ct Ingenieria Genetica Biotech Vectores vivos recombinantes y su uso en composiciones farmacéuticas contra el virus de la hepatitis c
DE602005022463D1 (de) * 2004-09-29 2010-09-02 Univ Tulane Inhibitoren des hepatitis-c-virus
KR20070068460A (ko) * 2004-10-18 2007-06-29 글로브이뮨 만성 c형 간염에 대한 효모계 치료
EP1888751A2 (en) * 2005-05-25 2008-02-20 Tripep Ab A hepatitis c virus non-structural ns3/4a fusion gene
EP1948802A4 (en) * 2005-10-13 2009-01-14 Virexx Medical Corp CHIMERIC ANTIGEN WITH HEPATITIS C VIRUS POLYPEPTIDE AND FC FRAGMENT FOR CALLING UP AN IMMUNE RESPONSE
US20080033057A1 (en) * 2006-06-20 2008-02-07 Metaproteomics, Llc Hexahydro-isoalpha acid based protein kinase modulation cancer treatment
KR20090024292A (ko) * 2006-06-28 2009-03-06 스태튼스 세룸 인스티튜트 단백질 단편 또는 펩타이드 혼합물로서 전달되는 항원을 가진 백신접종에 의해 준우성 항원결정기를 포함하는 t세포 레퍼토리 확장
WO2009022236A2 (en) 2007-08-16 2009-02-19 Tripep Ab Immunogen platform
ES2303496B1 (es) * 2008-02-21 2009-07-07 Fundacion Para El Estudio De Las Hepatitis Virales Metodo analitico perfeccionado para la deteccion de hepatitis c oculta, aplicaciones del mismo y su correspondiente kit de diagnostico.
WO2009130588A2 (en) * 2008-04-22 2009-10-29 Tripep Ab Immunogen platform
EP2331125A4 (en) 2008-09-19 2013-03-27 Globeimmune Inc IMMUNOTHERAPY FOR CHRONIC HEPATITIS C-VIRUS INFECTIONS
KR101793195B1 (ko) * 2009-03-27 2017-11-02 아카데미아 시니카 바이러스에 대한 면역을 위한 방법 및 조성물
CN102378914B (zh) * 2009-03-30 2014-12-10 生物梅里埃公司 用于hcv检测的固体支持物
WO2012033142A1 (ja) * 2010-09-08 2012-03-15 学校法人 埼玉医科大学 C型肝炎ウイルスリポソームワクチン
TWI537385B (zh) 2010-11-04 2016-06-11 中央研究院 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法
JP6069212B2 (ja) 2010-12-02 2017-02-01 ビオノール イミュノ エーエスBionor Immuno As ペプチド骨格設計
JP6294076B2 (ja) 2011-01-06 2018-03-14 ビオノール イミュノ エーエスBionor Immuno As 多量体ペプチド
WO2013182661A1 (en) 2012-06-06 2013-12-12 Bionor Immuno As Peptides derived from viral proteins for use as immunogens and dosage reactants
CN105073989A (zh) * 2013-02-19 2015-11-18 国立大学法人神户大学 免疫原性多肽表层表达双歧杆菌
WO2014143342A1 (en) 2013-03-14 2014-09-18 Abbott Laboratories Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection
CN105378099B (zh) * 2013-03-14 2021-05-11 雅培制药有限公司 Hcv核心脂质结合结构域单克隆抗体
MX362075B (es) 2013-03-14 2019-01-07 Abbott Lab Ensayo de combinación de antígeno-anticuerpo del virus de la hepatitis c (vhc) y métodos y composiciones para usarlo.
WO2015006337A2 (en) * 2013-07-08 2015-01-15 Nanjingjinsirui Science & Technology Biology Corporation Compositions and methods for increasing protein half-life in a serum
AU2017332854B2 (en) 2016-09-21 2024-11-14 The Governors Of The University Of Alberta Hepatitis C virus immunogenic compositions and methods of use thereof
CN112601548A (zh) * 2018-03-16 2021-04-02 艾伯塔大学理事会 丙型肝炎病毒肽组合物及其使用方法
CN109160942B (zh) * 2018-09-26 2021-06-29 广州市第八人民医院 Hcv包膜蛋白高度保守区域的肽段502-518及其用途
WO2020154635A1 (en) * 2019-01-25 2020-07-30 Senti Biosciences, Inc. Fusion constructs for controlling protein function

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US6027729A (en) 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
US5747239A (en) * 1990-02-16 1998-05-05 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines
US5639594A (en) 1990-02-16 1997-06-17 United Biomedical, Inc. Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis
WO1991015596A1 (en) * 1990-04-04 1991-10-17 Protos, Inc. Hepatitis c virus protease inhibitors
US5747339A (en) * 1990-06-25 1998-05-05 Research Foundation For Microbial Diseases Of Osaka Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide
KR0181517B1 (ko) * 1990-07-09 1999-04-01 나까하라 노부유끼 비-에이 비-비형 간염-특이 항원 및 간염 진단에서 그의 용도
CA2047792C (en) * 1990-07-26 2002-07-02 Chang Y. Wang Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines
CA2049679C (en) * 1990-08-24 2005-06-21 Sushil G. Devare Hepatitis c assay utilizing recombinant antigens
EP0485209A1 (en) 1990-11-08 1992-05-13 Immuno Japan Inc. Non A, non B hepatitis virus related antigen, antibody detection systems, polynucleotides and polypeptides
WO1992022571A1 (en) * 1991-06-13 1992-12-23 Baxter Diagnostics Inc. Immunoassay for non-a non-b hepatitis
KR0185426B1 (ko) * 1991-06-24 1999-04-01 로버트 피. 블랙버언 씨형 간염 바이러스 폴리펩티드
DE4209215A1 (de) * 1991-07-04 1993-01-07 Boehringer Mannheim Gmbh Hcv peptidantigene und verfahren zur bestimmung von hcv
US5428145A (en) 1991-08-09 1995-06-27 Immuno Japan, Inc. Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
WO1993004088A1 (en) * 1991-08-21 1993-03-04 Abbott Laboratories Hepatitis c assay utilizing recombinant antigens to ns1
DK0608261T3 (da) 1991-09-13 2003-03-17 Chiron Corp Sammensætninger med immunreaktivt hepatitis C virus polypeptid
WO1993006247A1 (en) * 1991-09-16 1993-04-01 Abbott Laboratories Hepatitis c assay
ATE219522T1 (de) * 1992-02-04 2002-07-15 Chiron Corp Hepatistherapeutikum
ES2287969T3 (es) 1992-03-06 2007-12-16 Innogenetics N.V. Peptidos de vih.
EP0728764A4 (en) * 1993-10-19 1999-01-20 Ajinomoto Kk PEPTIDE THE IMMUNE RESPONSE TO HIV UNDUCED AND MEDICINAL PRODUCTS CONTAINING THE PREVENTION OR TREATMENT OF AIDS
ES2197170T3 (es) * 1993-11-04 2004-01-01 Innogenetics N.V. Epitopos de celulas t humanas inmunologicamente dominantes del virus de la hepatitis c.
US5709995A (en) 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
US5543657A (en) * 1994-10-07 1996-08-06 International Business Machines Corporation Single layer leadframe design with groundplane capability

Also Published As

Publication number Publication date
EP0992581B1 (en) 2004-08-25
ATE274578T1 (de) 2004-09-15
DE69434295D1 (de) 2005-04-14
AU698878B2 (en) 1998-11-12
EP0725824A1 (en) 1996-08-14
PT992580E (pt) 2005-07-29
ES2239819T3 (es) 2005-10-01
DK0992580T3 (da) 2005-07-11
US6689368B1 (en) 2004-02-10
PT725824E (pt) 2003-08-29
EP0992580B1 (en) 2005-03-09
JP2004194668A (ja) 2004-07-15
US20040047877A1 (en) 2004-03-11
US6613333B1 (en) 2003-09-02
WO1995012677A2 (en) 1995-05-11
EP0979867A2 (en) 2000-02-16
EP0992581A3 (en) 2001-03-07
EP0992581B2 (en) 2011-05-25
AU7993294A (en) 1995-05-23
ES2197170T3 (es) 2004-01-01
EP0992581A2 (en) 2000-04-12
DE69432475T2 (de) 2004-03-04
CA2175692A1 (en) 1995-05-11
ATE236981T1 (de) 2003-04-15
DE69434295T2 (de) 2006-02-16
EP0979867A3 (en) 2007-06-13
EP0725824B1 (en) 2003-04-09
JPH09504534A (ja) 1997-05-06
US6555114B1 (en) 2003-04-29
WO1995012677A3 (en) 1995-07-27
DE69432475D1 (de) 2003-05-15
DE69433971D1 (de) 2004-09-30
EP0992580A2 (en) 2000-04-12
ATE290592T1 (de) 2005-03-15
EP0992580A3 (en) 2000-08-09
DE69433971T2 (de) 2005-09-08

Similar Documents

Publication Publication Date Title
DE69433971D1 (de) Von menschlichen T-Zellen immunodominante Epitopen des Virus der C-Hepatitis
FI935808A0 (fi) Hepatit-C-virus (HCV) polypeptider
FI894580L (fi) Non-a, non-b -hepatitisvirusantigenpeptid.
FI941199L (fi) Immunoreaktiiviset hepatiitti-C-viruksen polypeptidikoostumukset
DK643387A (da) T-celle-epitoper af hepatitis b-virus-nucleocapsid-protein
ES2138784T3 (es) Antigenos sinteticos para la deteccion de anticuerpos contra el virus de la hepatitis c.
ATE170220T1 (de) Zusammensetzung verwendbar als therapeutisches mittel gegen chronische virale leberkrankheiten
ATE359089T1 (de) Peptide zum induzieren einer antwort der zytotoxischen t-lymphozyten gerichtet gegen das hepatitis-b-virus
FI910127A7 (fi) Ei-A-, ei-B-hepatiittiviruksen perimän cDNA ja antigeenipolypeptidi
AU2370592A (en) Epitopes of the env protein of the hepatitis c virus
DK0492500T3 (da) Protektive Plasmodium falciparum-hybridproteiner, der indeholder delsekvenser af malaria-antigenerne HRPII og SERP
DK204588D0 (da) Humane rhinoviruspeptider, fremgangsmaade til deres fremstilling samt vacciner med inhold af saadanne peptider
FI914673A7 (fi) Peptidejä, jotka reagoivat immuunikemiallisesti hepatiitti-ei-A, ei-B-viruksen vastaisten vasta-aineiden kanssa
DE69132717D1 (en) Hepatitis-a-impfstoff
FI920910A7 (fi) Peptidejä, jotka kykenevät immunokemiallisesti reagoimaan hepatiitti ei-A, ei-B -virusta vastaan suunnattujen vasta-aineiden kanssa
FI943929L (fi) Hepatiitti C-viruspeptidejä
EP0637631A3 (de) Hoch effiziente Expression eines Polypeptids, das eine modifizierte preS1-Region des grossen Hepatitis B-Virus-Antigens enthält.
IT1270941B (it) Peptidi di hcv e loro usi.