ATE291026T1 - 6h-oxazolo(4,5-e)indol-derivative als nikotinische acetylcholinrezeptor-liganden und/oder serotonerge liganden - Google Patents

6h-oxazolo(4,5-e)indol-derivative als nikotinische acetylcholinrezeptor-liganden und/oder serotonerge liganden

Info

Publication number: ATE291026T1
Authority: AT; Austria
Prior art keywords: ligands; oxazolo; acetylcholine receptor; nicotinic acetylcholine; indole derivatives
Prior art date: 2001-04-30

Application number

AT02727527T

Other languages

English (en)

Inventor

Kai Schiemann

Henning Boettcher

Joachim Leibrock

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-30

Filing date

2002-04-05

Publication date

2005-04-15

2002-04-05 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE291026T1 publication Critical patent/ATE291026T1/de

Links

239000003446 ligand Substances 0.000 title 2
CIACKZWMHRQXBR-UHFFFAOYSA-N 6h-pyrrolo[3,2-e][1,3]benzoxazole Chemical class N1C=CC2=C1C=CC1=C2N=CO1 CIACKZWMHRQXBR-UHFFFAOYSA-N 0.000 title 1
102000019315 Nicotinic acetylcholine receptors Human genes 0.000 title 1
108050006807 Nicotinic acetylcholine receptors Proteins 0.000 title 1
230000000862 serotonergic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Diabetes (AREA)
Addiction (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Reproductive Health (AREA)
Child & Adolescent Psychology (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT02727527T 2001-04-30 2002-04-05 6h-oxazolo(4,5-e)indol-derivative als nikotinische acetylcholinrezeptor-liganden und/oder serotonerge liganden ATE291026T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10121217A DE10121217A1 (de)	2001-04-30	2001-04-30	6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
PCT/EP2002/003784 WO2002088139A1 (en)	2001-04-30	2002-04-05	6h-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands

Publications (1)

Publication Number	Publication Date
ATE291026T1 true ATE291026T1 (de)	2005-04-15

Family

ID=7683302

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02727527T ATE291026T1 (de)	2001-04-30	2002-04-05	6h-oxazolo(4,5-e)indol-derivative als nikotinische acetylcholinrezeptor-liganden und/oder serotonerge liganden

Country Status (13)

Country	Link
US (2)	US7291633B2 (de)
EP (1)	EP1392699B1 (de)
JP (1)	JP4485746B2 (de)
AR (1)	AR033267A1 (de)
AT (1)	ATE291026T1 (de)
AU (1)	AU2002257752B2 (de)
CA (1)	CA2445835C (de)
CZ (1)	CZ20033194A3 (de)
DE (2)	DE10121217A1 (de)
ES (1)	ES2239226T3 (de)
HU (1)	HUP0304034A2 (de)
SK (1)	SK14482003A3 (de)
WO (1)	WO2002088139A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10121217A1 (de) *	2001-04-30	2002-10-31	Merck Patent Gmbh	6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
MXPA04011858A (es) *	2002-05-30	2005-03-31	Neurosearch As	Quinuclidinas sustituidas en la posicion 3 y su uso.
WO2005041957A1 (en) *	2003-10-29	2005-05-12	Pfizer Products Inc.	Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
WO2007031846A2 (en) *	2005-09-14	2007-03-22	University Of The Witwatersrand, Johannesburg	Pharmaceutical composition
PT2909204T (pt)	2012-10-12	2019-03-21	Dana Farber Cancer Inst Inc	Inibidores de gsk3 e métodos de utilização dos mesmos
EP3004068A2 (de) *	2013-05-24	2016-04-13	Nestec S.A.	Pfadspezifische assays zur vorhersage von diagnosen des reizdarmsyndroms
WO2018187630A1 (en) *	2017-04-05	2018-10-11	The Broad Institute, Inc.	Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU639301B2 (en) *	1990-01-11	1993-07-22	Pharmacia & Upjohn Company	New centrally acting 6,7,8,9-tetrahydro-3h-benz(e)indole heterocyclics
TW263508B (de) *	1991-02-12	1995-11-21	Pfizer
WO1996003400A1 (en) *	1994-07-26	1996-02-08	Pfizer Inc.	4-indole derivatives as serotonin agonists and antagonists
AU727608B2 (en) *	1995-10-03	2000-12-14	Scripps Research Institute, The	CBI analogs of CC-1065 and the duocarmycins
ATE241615T1 (de)	1998-03-09	2003-06-15	Lundbeck & Co As H	5-heteroaryl-substituierte indole
DE10045112A1 (de)	2000-09-11	2002-03-21	Merck Patent Gmbh	Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
DE10121217A1 (de) *	2001-04-30	2002-10-31	Merck Patent Gmbh	6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden

2001
- 2001-04-30 DE DE10121217A patent/DE10121217A1/de not_active Withdrawn
2002
- 2002-04-05 DE DE60203283T patent/DE60203283T2/de not_active Expired - Lifetime
- 2002-04-05 CZ CZ20033194A patent/CZ20033194A3/cs unknown
- 2002-04-05 CA CA2445835A patent/CA2445835C/en not_active Expired - Fee Related
- 2002-04-05 SK SK1448-2003A patent/SK14482003A3/sk unknown
- 2002-04-05 ES ES02727527T patent/ES2239226T3/es not_active Expired - Lifetime
- 2002-04-05 AT AT02727527T patent/ATE291026T1/de not_active IP Right Cessation
- 2002-04-05 HU HU0304034A patent/HUP0304034A2/hu unknown
- 2002-04-05 AU AU2002257752A patent/AU2002257752B2/en not_active Ceased
- 2002-04-05 WO PCT/EP2002/003784 patent/WO2002088139A1/en not_active Ceased
- 2002-04-05 EP EP02727527A patent/EP1392699B1/de not_active Expired - Lifetime
- 2002-04-05 US US10/476,306 patent/US7291633B2/en not_active Expired - Fee Related
- 2002-04-05 JP JP2002585437A patent/JP4485746B2/ja not_active Expired - Fee Related
- 2002-04-26 AR ARP020101530A patent/AR033267A1/es not_active Application Discontinuation
2007
- 2007-10-30 US US11/928,961 patent/US7741343B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2445835C (en)	2012-01-03
CZ20033194A3 (cs)	2004-02-18
EP1392699B1 (de)	2005-03-16
US20080051394A1 (en)	2008-02-28
US7291633B2 (en)	2007-11-06
AR033267A1 (es)	2003-12-10
DE60203283T2 (de)	2006-03-30
US20050101649A1 (en)	2005-05-12
DE10121217A1 (de)	2002-10-31
AU2002257752B2 (en)	2008-02-28
DE60203283D1 (de)	2005-04-21
HUP0304034A2 (hu)	2004-04-28
ES2239226T3 (es)	2005-09-16
JP2004527562A (ja)	2004-09-09
US7741343B2 (en)	2010-06-22
EP1392699A1 (de)	2004-03-03
CA2445835A1 (en)	2002-11-07
SK14482003A3 (sk)	2004-03-02
JP4485746B2 (ja)	2010-06-23
WO2002088139A1 (en)	2002-11-07

Legal Events

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2006-02-15

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Publication of translation of european patent specification

Ref document number: 1392699

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2007-01-15

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Ceased due to non-payment of the annual fee

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