ATE292684T1 - Ramoplaninbiosynthesegenkluster - Google Patents

Ramoplaninbiosynthesegenkluster

Info

Publication number: ATE292684T1
Authority: AT; Austria
Prior art keywords: gene clusters; biosynthesis gene; ramoplanin; antibiotic; ramoplanin biosynthesis
Prior art date: 2000-10-13

Application number

AT01980080T

Other languages

English (en)

Inventor

Chris M Farnet

Emmanuel Zazopoulos

Alfredo Staffa

Original Assignee

Ecopia Biosciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-13

Filing date

2001-10-15

Publication date

2005-04-15

2001-07-24 Priority claimed from US09/910,813 external-priority patent/US20030054353A1/en

2001-10-15 Application filed by Ecopia Biosciences Inc filed Critical Ecopia Biosciences Inc

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE292684T1 publication Critical patent/ATE292684T1/de

Links

KGZHFKDNSAEOJX-WIFQYKSHSA-N Ramoplanin Chemical compound C([C@H]1C(=O)N[C@H](CCCN)C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(=O)O[C@@H]([C@@H](C(N[C@@H](C(=O)N[C@H](CCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)[C@H](C)O)C=1C=CC(O)=CC=1)C=1C=CC(O)=CC=1)[C@@H](C)O)C=1C=CC(O)=CC=1)=O)NC(=O)[C@H](CC(N)=O)NC(=O)\C=C/C=C/CC(C)C)C(N)=O)C=1C=C(Cl)C(O)=CC=1)C=1C=CC(O)=CC=1)[C@@H](C)O)C=1C=CC(O[C@@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=1)C1=CC=CC=C1 KGZHFKDNSAEOJX-WIFQYKSHSA-N 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title abstract 2
229950003551 ramoplanin Drugs 0.000 title abstract 2
108010076689 ramoplanin Proteins 0.000 title abstract 2
108091008053 gene clusters Proteins 0.000 title 1
108010019477 S-adenosyl-L-methionine-dependent N-methyltransferase Proteins 0.000 abstract 2
230000003115 biocidal effect Effects 0.000 abstract 2
108010000785 non-ribosomal peptide synthase Proteins 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
241000187712 Actinoplanes sp. Species 0.000 abstract 1
230000002068 genetic effect Effects 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Glass Compositions (AREA)
Saccharide Compounds (AREA)

AT01980080T 2000-10-13 2001-10-15 Ramoplaninbiosynthesegenkluster ATE292684T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US23992400P	2000-10-13	2000-10-13
US28329601P	2001-04-12	2001-04-12
US09/910,813 US20030054353A1 (en)	2001-07-24	2001-07-24	High throughput method for discovery of gene clusters
PCT/CA2001/001462 WO2002031155A2 (en)	2000-10-13	2001-10-15	Gene cluster for ramoplanin biosynthesis

Publications (1)

Publication Number	Publication Date
ATE292684T1 true ATE292684T1 (de)	2005-04-15

Family

ID=27399291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01980080T ATE292684T1 (de)	2000-10-13	2001-10-15	Ramoplaninbiosynthesegenkluster

Country Status (8)

Country	Link
US (2)	US7078185B2 (de)
EP (1)	EP1326983B1 (de)
JP (2)	JP2004510449A (de)
AT (1)	ATE292684T1 (de)
AU (1)	AU2002212014A1 (de)
CA (1)	CA2394616C (de)
DE (1)	DE60109952T2 (de)
WO (1)	WO2002031155A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE292684T1 (de) *	2000-10-13	2005-04-15	Ecopia Biosciences Inc	Ramoplaninbiosynthesegenkluster
WO2003060128A2 (en) *	2001-12-26	2003-07-24	Ecopia Biosciences Inc.	Compositions, methods and systems for discovery of lipopeptides
US7799904B2 (en) *	2003-06-13	2010-09-21	University Of Kentucky Research Foundation	Gilvocarcin gene cluster, recombinant production and use thereof
TW200819540A (en)	2006-07-11	2008-05-01	Genelux Corp	Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
WO2008040731A2 (en) *	2006-10-05	2008-04-10	Dsm Ip Assets B.V.	Production of beta-lactam antibiotics
US20110086388A1 (en) *	2009-09-22	2011-04-14	Duke University	Chaperone-assisted protein expression and methods of use
US9422566B2 (en) *	2011-10-12	2016-08-23	Sanofi	Gene cluster for biosynthesis of griselimycin and methylgriselimycin
US9616114B1 (en)	2014-09-18	2017-04-11	David Gordon Bermudes	Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en)	2015-05-11	2020-06-09	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en)	2016-12-07	2021-11-23	David Gordon Bermudes	Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en)	2016-12-07	2021-09-28	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
US20230181684A1 (en) *	2020-05-19	2023-06-15	Duke University	Novel antibiotic compositions and methods of making or using the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA801629B (en)	1979-04-07	1981-03-25	Lepetit Spa	Antibiotic a/16686 and process for the preparation thereof
EP0046201B1 (de)	1980-08-16	1984-04-11	Gruppo Lepetit S.P.A.	Antibiotikum A/16686 Faktor A2, Verfahren zu dessen Herstellung und die gleichzeitig hergestellten Antibiotika A/16686 Faktoren A1 und A3
US4551433A (en) *	1981-05-18	1985-11-05	Genentech, Inc.	Microbial hybrid promoters
GB8621911D0 (en)	1986-09-11	1986-10-15	Lepetit Spa	Increasing ratio of components of anti-biotic complex
US5017478A (en) *	1987-07-16	1991-05-21	Berlex Laboratories, Inc.	Transfected cells containing plasmids having genes oriented in opposing directions and methods of using
EP0427142B1 (de)	1989-11-07	1995-05-17	GRUPPO LEPETIT S.p.A.	Verfahren zur Rückgewinnung von Antibiotikum A/16686
AU2001245263A1 (en)	2000-01-21	2001-07-31	Kosan Biosciences, Inc.	Method for cloning polyketide synthase genes
US20030054353A1 (en) *	2001-07-24	2003-03-20	Ecopia Biosciences Inc	High throughput method for discovery of gene clusters
ATE292684T1 (de) *	2000-10-13	2005-04-15	Ecopia Biosciences Inc	Ramoplaninbiosynthesegenkluster
AU2003222690A1 (en) *	2002-04-17	2003-11-03	Ecopia Biosciences Inc.	Dual condensation/epimerization domain in non-ribosomal peptide synthetase systems

2001
- 2001-10-15 AT AT01980080T patent/ATE292684T1/de not_active IP Right Cessation
- 2001-10-15 EP EP01980080A patent/EP1326983B1/de not_active Expired - Lifetime
- 2001-10-15 US US09/976,059 patent/US7078185B2/en not_active Expired - Fee Related
- 2001-10-15 WO PCT/CA2001/001462 patent/WO2002031155A2/en not_active Ceased
- 2001-10-15 AU AU2002212014A patent/AU2002212014A1/en not_active Abandoned
- 2001-10-15 DE DE60109952T patent/DE60109952T2/de not_active Expired - Fee Related
- 2001-10-15 CA CA002394616A patent/CA2394616C/en not_active Expired - Fee Related
- 2001-10-15 JP JP2002534522A patent/JP2004510449A/ja active Pending
2005
- 2005-08-17 US US11/205,109 patent/US7635765B2/en not_active Expired - Fee Related
2006
- 2006-01-25 JP JP2006016985A patent/JP2006180882A/ja active Pending

Also Published As

Publication number	Publication date
CA2394616A1 (en)	2002-04-18
JP2004510449A (ja)	2004-04-08
EP1326983A2 (de)	2003-07-16
DE60109952T2 (de)	2006-02-09
US20020164747A1 (en)	2002-11-07
WO2002031155A2 (en)	2002-04-18
EP1326983B1 (de)	2005-04-06
CA2394616C (en)	2007-05-15
WO2002031155A3 (en)	2002-09-26
US7078185B2 (en)	2006-07-18
AU2002212014A1 (en)	2002-04-22
US20050287641A1 (en)	2005-12-29
JP2006180882A (ja)	2006-07-13
US7635765B2 (en)	2009-12-22
DE60109952D1 (de)	2005-05-12

Similar Documents

Publication	Publication Date	Title
ATE292684T1 (de)	2005-04-15	Ramoplaninbiosynthesegenkluster
EP1421195A4 (de)	2005-04-27	OBERFLÄCHENEXPRESSIONSVEKTOREN MIT pgsBCA, DEM FÜR POLY-GAMMA-GLUTAMAT-SYNTHETASE CODIERENDEN GEN, SOWIE VERFAHREN ZUR EXPRESSION EINES ZIELPROTEINS AN DER OBERFLÄCHE EINES DEN VEKTOR BENUTZENDEN MIKROORGANISMUS
DE60124759D1 (en)	2007-01-04	Dna methyl transferase inhibitoren
Grünewald et al.	2004	Chemo-and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor
MXPA05005323A (es)	2006-03-10	Policetido-sintasa productora de borrelidina y sus usos.
ATE358135T1 (de)	2007-04-15	Phagen-abhängige superproduktion biologisch aktiver proteine und peptide
NZ591571A (en)	2012-10-26	Modification of flavonoid biosynthesis in plants with transparent testa glabra 1
US20160348088A1 (en)	2016-12-01	Colistin Synthetases and Corresponding Gene Cluster
WO2002077179A8 (en)	2004-08-12	Leinamycin biosynthesis gene cluster and its components and their uses
Kawakami et al.	2012	Genetically encoded libraries of nonstandard peptides
WO2002034922A3 (en)	2003-08-28	Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
WO2001072977A3 (en)	2002-02-21	Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
US20100279347A1 (en)	2010-11-04	Polymyxin synthetase and gene cluster thereof
WO2006066153A8 (en)	2008-10-23	Actinomadura chromoprotein, apoprotein, and gene cluster
WO2002042437A3 (en)	2003-01-09	Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
US20090226964A1 (en)	2009-09-10	Polymyxin Synthetase and Gene Cluster Thereof
AU2002356704A1 (en)	2003-06-10	Novel gene cluster of pederin biosynthesis genes
DE60206151D1 (de)	2005-10-20	Gene und proteine für polyketide biosynthese
DK1002056T3 (da)	2008-02-11	ppGpp-syntease og ekspressionssystem til forbedret fremstilling af protein af interesse
EP1179004A4 (de)	2003-05-02	Der kalium kanal kcnq5
DE69928830D1 (de)	2006-01-12	Proteinproduktion in gram-positiven mikroorganismen
ATE495245T1 (de)	2011-01-15	Verbesserte proteinexpression in bacillus subtilis
WO2002079224A3 (en)	2003-09-12	Isolated human nadph oxidase, nucleic acid molecules encoding said proteins, and uses thereof
WO2003089641A3 (en)	2004-06-10	Dual condensation/epimerization domain in non-ribosomal peptide synthetase systems
AU2002347108A1 (en)	2003-05-19	Pna-conjugates for treating chronic myeloid leukaemia (cml)

Legal Events

Date	Code	Title	Description
2005-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties