ATE304594T1 - Gene und proteine für polyketide biosynthese - Google Patents
Gene und proteine für polyketide biosyntheseInfo
- Publication number
- ATE304594T1 ATE304594T1 AT02724065T AT02724065T ATE304594T1 AT E304594 T1 ATE304594 T1 AT E304594T1 AT 02724065 T AT02724065 T AT 02724065T AT 02724065 T AT02724065 T AT 02724065T AT E304594 T1 ATE304594 T1 AT E304594T1
- Authority
- AT
- Austria
- Prior art keywords
- genes
- proteins
- lactimidomycin
- dorrigocin
- polyketide
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 8
- 229930001119 polyketide Natural products 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 150000003881 polyketide derivatives Chemical class 0.000 title abstract 3
- OYOKHBHOTQDIPM-BRHOHSSQSA-N Lactimidomycin Chemical compound C(/[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)=C(/C)[C@@H]1OC(=O)\C=C\CC\C=C\C=C/[C@@H]1C OYOKHBHOTQDIPM-BRHOHSSQSA-N 0.000 abstract 3
- 229930185162 dorrigocin Natural products 0.000 abstract 3
- OYOKHBHOTQDIPM-UHFFFAOYSA-N lactimidomycin Natural products C1C(=O)NC(=O)CC1CC(O)CC(=O)C(C)C=C(C)C1OC(=O)C=CCCC=CC=CC1C OYOKHBHOTQDIPM-UHFFFAOYSA-N 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000240396 Streptomyces amphibiosporus Species 0.000 abstract 1
- 241001304533 Streptomyces platensis subsp. rosaceus Species 0.000 abstract 1
- 230000001851 biosynthetic effect Effects 0.000 abstract 1
- 238000003889 chemical engineering Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 125000000830 polyketide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28634601P | 2001-04-26 | 2001-04-26 | |
| PCT/CA2002/000591 WO2002088176A2 (en) | 2001-04-26 | 2002-04-26 | Genes and proteins for the biosynthesis of polyketides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE304594T1 true ATE304594T1 (de) | 2005-09-15 |
Family
ID=23098188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02724065T ATE304594T1 (de) | 2001-04-26 | 2002-04-26 | Gene und proteine für polyketide biosynthese |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030171562A1 (de) |
| EP (1) | EP1381685B1 (de) |
| JP (1) | JP2004535175A (de) |
| AT (1) | ATE304594T1 (de) |
| AU (1) | AU2002254822A1 (de) |
| CA (1) | CA2415339A1 (de) |
| DE (1) | DE60206151D1 (de) |
| WO (1) | WO2002088176A2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6884608B2 (en) * | 2001-12-26 | 2005-04-26 | Bristol-Myers Squibb Company | Compositions and methods for hydroxylating epothilones |
| EP1608626A1 (de) | 2003-03-28 | 2005-12-28 | Cornell Research Foundation, Inc. | Migrastatin-analoga enthaltende zusammensetzungen und deren verwendung |
| JP5149001B2 (ja) | 2004-05-25 | 2013-02-20 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | 癌の処置におけるマイグラスタチンアナログ |
| US8188141B2 (en) | 2004-09-23 | 2012-05-29 | Sloan-Kettering Institute For Cancer Research | Isomigrastatin analogs in the treatment of cancer |
| US20060211736A1 (en) * | 2005-01-13 | 2006-09-21 | Wisconsin Alumni Research Foundation | Glutarimide-containing polyketide analogs and methods thereof |
| US20070026488A1 (en) * | 2005-07-27 | 2007-02-01 | Targett Nancy M | Biosynthesis of bryostatins by polyketide synthases (PKS) |
| JP7041898B2 (ja) | 2016-12-27 | 2022-03-25 | ザ ロックフェラー ユニバーシティー | 広域中和抗ｈｉｖ－１抗体およびその使用方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4874748A (en) * | 1986-03-24 | 1989-10-17 | Abbott Laboratories | Cloning vectors for streptomyces and use thereof in macrolide antibiotic production |
| US5149639A (en) * | 1986-03-24 | 1992-09-22 | Abbott Laboratories | Biologically pure cultures of streptomyces and use thereof in macrolide antibiotic production |
| US5063155A (en) * | 1988-03-28 | 1991-11-05 | Eli Lilly And Company | Method for producing 2"'-o-demethyltylosin |
| US5098837A (en) * | 1988-06-07 | 1992-03-24 | Eli Lilly And Company | Macrolide biosynthetic genes for use in streptomyces and other organisms |
| US5712146A (en) * | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
| ES2164713T3 (es) * | 1993-09-20 | 2002-03-01 | Univ Leland Stanford Junior | Produccion recombinante de nuevos poliquetidos. |
| US5672491A (en) * | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
| US5484799A (en) * | 1993-12-09 | 1996-01-16 | Abbott Laboratories | Antifungal dorrigocin derivatives |
| US6927286B1 (en) * | 1999-01-06 | 2005-08-09 | The Regents Of The University Of California | Bleomycin gene cluster components and their uses |
| WO2001009155A1 (en) * | 1999-07-30 | 2001-02-08 | Merck & Co., Inc. | Cloning of the streptomyces avermitilis genes for glycosylation of avermectin aglycones |
| US7257562B2 (en) * | 2000-10-13 | 2007-08-14 | Thallion Pharmaceuticals Inc. | High throughput method for discovery of gene clusters |
-
2002
- 2002-04-26 DE DE60206151T patent/DE60206151D1/de not_active Expired - Lifetime
- 2002-04-26 CA CA002415339A patent/CA2415339A1/en not_active Abandoned
- 2002-04-26 AT AT02724065T patent/ATE304594T1/de not_active IP Right Cessation
- 2002-04-26 US US10/132,134 patent/US20030171562A1/en not_active Abandoned
- 2002-04-26 EP EP02724065A patent/EP1381685B1/de not_active Expired - Lifetime
- 2002-04-26 AU AU2002254822A patent/AU2002254822A1/en not_active Abandoned
- 2002-04-26 JP JP2002585474A patent/JP2004535175A/ja not_active Withdrawn
- 2002-04-26 WO PCT/CA2002/000591 patent/WO2002088176A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004535175A (ja) | 2004-11-25 |
| WO2002088176A2 (en) | 2002-11-07 |
| EP1381685B1 (de) | 2005-09-14 |
| EP1381685A2 (de) | 2004-01-21 |
| AU2002254822A1 (en) | 2002-11-11 |
| CA2415339A1 (en) | 2002-11-07 |
| US20030171562A1 (en) | 2003-09-11 |
| DE60206151D1 (de) | 2005-10-20 |
| WO2002088176A3 (en) | 2003-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE346938T1 (de) | Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen | |
| BR0014514A (pt) | Enzimas da via de destinação lisossomal | |
| EP2213738A3 (de) | siRNA moleküle gegen Bcl-2 | |
| BRPI0415774A (pt) | cepa de microorganismos e processos de preparação de cepas otimizadas e de produção de uma molécula de interesse | |
| ATE394410T1 (de) | Hochspezifische primer, amplifizierungsverfahren und kits | |
| WO2004113490A3 (en) | Directed selective solid-phase culturing of stable microbial mixed populations for the continuous preparation of defined enzyme and metabolite mixture and bioreactor | |
| WO2006066048A3 (en) | Compositions for bacterial mediated gene silencing and methods of using same | |
| DE60144434D1 (de) | Mehrfach-induzierbares genregulierungssystem | |
| ATE346074T1 (de) | Dna methyl transferase inhibitoren | |
| ATE361286T1 (de) | Borrelidin-derivate und ihre medizinische anwendung | |
| ATE342989T1 (de) | Mikrobielle beta-glukuronidase gene, genprodukte und deren verwendungen | |
| DE60206151D1 (de) | Gene und proteine für polyketide biosynthese | |
| Fruchard et al. | tRNA-modifying enzymes in bacterial stress adaptation | |
| DK1440151T3 (da) | Fröspecifik 7S-a-promotor til at udtrykke gener i planter | |
| WO2003008578A3 (en) | Reagents and methods for identifying gene targets for treating cancer | |
| ATE403663T1 (de) | Nukleinsäureamplifikation mit duplexzwischenprodukten | |
| WO2002031155A3 (en) | Gene cluster for ramoplanin biosynthesis | |
| WO2007044627A3 (en) | Compositions and methods for delivery of interfering rna | |
| WO2006066153A8 (en) | Actinomadura chromoprotein, apoprotein, and gene cluster | |
| DE60122345D1 (de) | Polyketid-synthasen mit veränderter spezifität, ihre herstellung und verwendung | |
| DK1095032T3 (da) | Hidtil ukendte fluorescerende CYP2D-assayreagenser | |
| WO2004085681A3 (en) | Global linear non-biased nucleic acid amplification | |
| AU2002356704A1 (en) | Novel gene cluster of pederin biosynthesis genes | |
| ATE478149T1 (de) | Verfahren zur gewinnung von indolocarbazolen mit hilfe von rebeccamycin-biosynthesegenen | |
| HUP0101569A2 (hu) | Egy génklaszterből származó gének |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |