ATE304594T1 - Gene und proteine für polyketide biosynthese - Google Patents

Gene und proteine für polyketide biosynthese

Info

Publication number
ATE304594T1
ATE304594T1 AT02724065T AT02724065T ATE304594T1 AT E304594 T1 ATE304594 T1 AT E304594T1 AT 02724065 T AT02724065 T AT 02724065T AT 02724065 T AT02724065 T AT 02724065T AT E304594 T1 ATE304594 T1 AT E304594T1
Authority
AT
Austria
Prior art keywords
genes
proteins
lactimidomycin
dorrigocin
polyketide
Prior art date
Application number
AT02724065T
Other languages
English (en)
Inventor
Chris M Farnet
Emmanuel Zazopoulos
Alfredo Staffa
Xianshu Yang
Original Assignee
Ecopia Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecopia Biosciences Inc filed Critical Ecopia Biosciences Inc
Application granted granted Critical
Publication of ATE304594T1 publication Critical patent/ATE304594T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
AT02724065T 2001-04-26 2002-04-26 Gene und proteine für polyketide biosynthese ATE304594T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28634601P 2001-04-26 2001-04-26
PCT/CA2002/000591 WO2002088176A2 (en) 2001-04-26 2002-04-26 Genes and proteins for the biosynthesis of polyketides

Publications (1)

Publication Number Publication Date
ATE304594T1 true ATE304594T1 (de) 2005-09-15

Family

ID=23098188

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02724065T ATE304594T1 (de) 2001-04-26 2002-04-26 Gene und proteine für polyketide biosynthese

Country Status (8)

Country Link
US (1) US20030171562A1 (de)
EP (1) EP1381685B1 (de)
JP (1) JP2004535175A (de)
AT (1) ATE304594T1 (de)
AU (1) AU2002254822A1 (de)
CA (1) CA2415339A1 (de)
DE (1) DE60206151D1 (de)
WO (1) WO2002088176A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884608B2 (en) * 2001-12-26 2005-04-26 Bristol-Myers Squibb Company Compositions and methods for hydroxylating epothilones
JP4719671B2 (ja) 2003-03-28 2011-07-06 コーネル・リサーチ・ファンデーション・インコーポレイテッド ミグラスタチンアナログ組成物およびその使用
WO2006001967A2 (en) 2004-05-25 2006-01-05 Sloan-Kettering Institute For Cancer Research Migrastatin analogs in the treatment of cancer
CA2582766C (en) 2004-09-23 2014-07-22 Sloan-Kettering Institute For Cancer Research Isomigrastatin analogs in the treatment of cancer
US20060211736A1 (en) * 2005-01-13 2006-09-21 Wisconsin Alumni Research Foundation Glutarimide-containing polyketide analogs and methods thereof
US20070026488A1 (en) * 2005-07-27 2007-02-01 Targett Nancy M Biosynthesis of bryostatins by polyketide synthases (PKS)
BR112019013468A8 (pt) * 2016-12-27 2022-11-22 Univ Rockefeller Anticorpos anti-hiv-1 amplamente neutralizante e métodos de uso dos mesmos

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149639A (en) * 1986-03-24 1992-09-22 Abbott Laboratories Biologically pure cultures of streptomyces and use thereof in macrolide antibiotic production
US4874748A (en) * 1986-03-24 1989-10-17 Abbott Laboratories Cloning vectors for streptomyces and use thereof in macrolide antibiotic production
US5063155A (en) * 1988-03-28 1991-11-05 Eli Lilly And Company Method for producing 2"'-o-demethyltylosin
US5098837A (en) * 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms
EP0725778B1 (de) * 1993-09-20 2001-09-26 The Leland Stanford Junior University Rekombinante herstellung von neuen polyketiden
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US5484799A (en) * 1993-12-09 1996-01-16 Abbott Laboratories Antifungal dorrigocin derivatives
US6927286B1 (en) * 1999-01-06 2005-08-09 The Regents Of The University Of California Bleomycin gene cluster components and their uses
JP2003506022A (ja) * 1999-07-30 2003-02-18 メルク エンド カムパニー インコーポレーテッド アベルメクチンアグリコングリコシル化に関するストレプトマイセスアベルミチリスの遺伝子のクローニング
US7257562B2 (en) * 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters

Also Published As

Publication number Publication date
CA2415339A1 (en) 2002-11-07
EP1381685B1 (de) 2005-09-14
DE60206151D1 (de) 2005-10-20
JP2004535175A (ja) 2004-11-25
WO2002088176A3 (en) 2003-05-30
AU2002254822A1 (en) 2002-11-11
EP1381685A2 (de) 2004-01-21
WO2002088176A2 (en) 2002-11-07
US20030171562A1 (en) 2003-09-11

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Legal Events

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