ATE292959T1 - Verfahren zur herstellung von pankreasenzym enthaltende mikrosphären mit hoher stabilität - Google Patents

Verfahren zur herstellung von pankreasenzym enthaltende mikrosphären mit hoher stabilität

Info

Publication number
ATE292959T1
ATE292959T1 AT01994654T AT01994654T ATE292959T1 AT E292959 T1 ATE292959 T1 AT E292959T1 AT 01994654 T AT01994654 T AT 01994654T AT 01994654 T AT01994654 T AT 01994654T AT E292959 T1 ATE292959 T1 AT E292959T1
Authority
AT
Austria
Prior art keywords
high stability
containing high
microspheres containing
pancreatic enzyme
producing microspheres
Prior art date
Application number
AT01994654T
Other languages
English (en)
Inventor
Mario Maio
Original Assignee
Eurand Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11446110&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE292959(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eurand Int filed Critical Eurand Int
Application granted granted Critical
Publication of ATE292959T1 publication Critical patent/ATE292959T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT01994654T 2000-11-15 2001-11-13 Verfahren zur herstellung von pankreasenzym enthaltende mikrosphären mit hoher stabilität ATE292959T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI002456A IT1319655B1 (it) 2000-11-15 2000-11-15 Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
PCT/EP2001/013115 WO2002040045A2 (en) 2000-11-15 2001-11-13 Microspheres of pancreatic enzymes with high stability

Publications (1)

Publication Number Publication Date
ATE292959T1 true ATE292959T1 (de) 2005-04-15

Family

ID=11446110

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01994654T ATE292959T1 (de) 2000-11-15 2001-11-13 Verfahren zur herstellung von pankreasenzym enthaltende mikrosphären mit hoher stabilität

Country Status (11)

Country Link
US (2) US9259393B2 (de)
EP (1) EP1335706B1 (de)
JP (1) JP4555981B2 (de)
KR (1) KR20030060105A (de)
AT (1) ATE292959T1 (de)
AU (1) AU2002224843A1 (de)
CA (1) CA2428837A1 (de)
DE (1) DE60110106T2 (de)
ES (1) ES2240559T3 (de)
IT (1) IT1319655B1 (de)
WO (1) WO2002040045A2 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632429B1 (en) 1999-12-17 2003-10-14 Joan M. Fallon Methods for treating pervasive development disorders
US20070053895A1 (en) * 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US8100844B2 (en) * 2002-04-25 2012-01-24 Ultraflex Systems, Inc. Ambulating ankle and knee joints with bidirectional dampening and assistance using elastomeric restraint
DE602005009677D1 (de) * 2004-03-22 2008-10-23 Solvay Pharm Gmbh Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin, mit tensiden
US20060198838A1 (en) * 2004-09-28 2006-09-07 Fallon Joan M Combination enzyme for cystic fibrosis
RU2413532C2 (ru) * 2005-07-29 2011-03-10 Зольвай Фармасьютиклз Гмбх Способ получения стерилизованного порошкообразного панкреатина
RU2440101C2 (ru) * 2005-08-15 2012-01-20 Зольвай Фармасьютиклз Гмбх Фармацевтические композиции регулируемого высвобождения нестабильных в кислой среде лекарственных средств
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
DE602006012346D1 (de) * 2005-08-15 2010-04-01 Solvay Pharm Gmbh Pharmazeutische zusammensetzungen mit kontrollierter freisetzung für säurelabile arzneimittel
KR101302841B1 (ko) * 2005-08-15 2013-09-02 애보트 프러덕츠 게엠베하 장용코팅에 적합한 판크레아틴 미세펠릿 코어
UA89102C2 (ru) * 2005-08-15 2009-12-25 Солвей Фармасьютикалс Гмбх Ядра микропеллета панреатита, пригодные для нанесеня энтеросолюбильного покрытия
US11266607B2 (en) * 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
US20070116695A1 (en) * 2005-09-21 2007-05-24 Fallon Joan M Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
RU2445952C2 (ru) * 2007-02-20 2012-03-27 Юранд Фармасьютикалз Лимитед Стабильные композиции пищеварительных ферментов
DK2079445T3 (en) * 2007-02-20 2016-02-15 Allergan Pharmaceuticals Internat Ltd Stable digestive compositions
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US9320780B2 (en) * 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
US20090324730A1 (en) * 2008-06-26 2009-12-31 Fallon Joan M Methods and compositions for the treatment of symptoms of complex regional pain syndrome
EP2318035B1 (de) * 2008-07-01 2019-06-12 Curemark, Llc Verfahren und zusammensetzungen zur behandlung von symptomen von neurologischen und geistesstörungen
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
US20100092447A1 (en) * 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
US9084784B2 (en) 2009-01-06 2015-07-21 Curelon Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces
ES2668909T3 (es) 2009-01-06 2018-05-23 Galenagen, Llc Composiciones que comprenden proteasa, amilasa y lipasa para su uso en el tratamiento de infecciones por Staphylococcus aureus
US9056050B2 (en) * 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza
CA2785860A1 (en) * 2009-12-29 2011-07-28 Impax Laboratories, Inc. Gastroretentive solid oral dosage forms with swellable hydrophilic polymer
AU2011248293A1 (en) * 2010-05-03 2012-11-15 Eurand Pharmaceuticals Limited Micropellet compositions comprising pancreatin containing digestive enzyme mixtures
KR20140019292A (ko) 2010-10-01 2014-02-14 아프탈리스 파르마 리미티드 장용 코팅된 저 강도 췌장 리파제 제제
WO2012067621A1 (en) * 2010-11-19 2012-05-24 Curemark Llc Preparation and use of combination enzyme and gastrointestinal modulator delivery systems
CN106310242B (zh) 2011-04-21 2020-02-28 柯尔马克有限责任公司 用于治疗神经精神障碍的化合物
ES2558756T3 (es) 2011-08-08 2016-02-08 Aptalis Pharma Limited Método para la prueba de disolución de composiciones sólidas que contienen enzimas digestivas
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
US9988686B2 (en) 2012-09-27 2018-06-05 Cynvenio Biosystems, Inc. Stimulus-sensitive microparticles and methods of use
US10184121B2 (en) 2013-06-28 2019-01-22 Allergan Pharmaceuticals International Limited Methods for removing viral contaminants from pancreatic extracts
RU2679832C2 (ru) 2013-08-09 2019-02-13 Аллерган Фармасьютикалз Интернэйшнл Лимитед Композиция пищеварительных ферментов, подходящая для энтерального введения
MX391630B (es) 2014-11-05 2025-03-19 Abbott Laboratories Gmbh Procesos para la producción de composiciones con perfil de seguridad mejorado teniendo actividad lipasa y composiciones adecuadas para medicamentos
WO2018191233A1 (en) 2017-04-10 2018-10-18 Curemark, Llc Compositions for treating addiction
CN110075279A (zh) * 2019-04-25 2019-08-02 淮安麦德森制药有限公司 胰酶微球及其生产方法
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses
CN113046233B (zh) * 2021-03-15 2022-07-15 中国科学院过程工程研究所 一种微球-膜集成酶反应器及其制备方法和应用
US12350641B2 (en) * 2021-07-16 2025-07-08 Clearh2O, Inc. Methods of high throughput hydrocolloid bead production and apparatuses thereof

Family Cites Families (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1342409A (en) 1970-07-23 1974-01-03 Ciba Geigy Ag Flowable pancreatin preparation of low microorgan ism content and a process for its manufacture
US4237229A (en) 1975-06-10 1980-12-02 W. R. Grace & Co. Immobilization of biological material with polyurethane polymers
GB1509866A (en) 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
GB1590432A (en) 1976-07-07 1981-06-03 Novo Industri As Process for the production of an enzyme granulate and the enzyme granuate thus produced
JPS5535031A (en) 1978-09-04 1980-03-11 Shin Etsu Chem Co Ltd Enteric coating composition
DE2923279C2 (de) * 1979-06-08 1987-07-09 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von Pankreatin-Pellets und diese enthaltende Arzneimittel
JPS5855125B2 (ja) 1980-03-10 1983-12-08 信越化学工業株式会社 固形薬剤用腸溶性コ−テイング剤組成物
JPS5885159A (ja) 1981-11-17 1983-05-21 Furointo Sangyo Kk 溶出試験装置
EP0115023B1 (de) 1982-12-30 1988-07-27 Nordmark Arzneimittel GmbH Verfahren zur Gewinnung von Pankreatin
US4447412A (en) 1983-02-01 1984-05-08 Bilton Gerald L Enzyme-containing digestive aid compostions
US4704295A (en) 1983-09-19 1987-11-03 Colorcon, Inc. Enteric film-coating compositions
DE3445301A1 (de) 1984-12-12 1986-06-12 Hoechst Ag, 6230 Frankfurt Pankreasenzympraeparate und verfahren zu deren herstellung
US4940665A (en) * 1985-12-27 1990-07-10 Showa Denko K. K. Method for granulation of enzyme
HU207452B (en) 1986-03-21 1993-04-28 Eurasiam Lab Method for producing therapeutical preparations containing active ingredient having biologicallu active protein structure
US4849227A (en) 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
IT1205716B (it) 1987-01-21 1989-03-31 Samil Spa Procedimento per la preparazione di microsfere gastroresistenti ed enterosolubili di enzima digestivo e preparato faramceutico a microsfere cosi' prodotto
DK435687D0 (da) 1987-08-21 1987-08-21 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
JPH0757312B2 (ja) * 1987-12-11 1995-06-21 昭和電工株式会社 造粒用バインダー
JP2598674B2 (ja) * 1988-05-06 1997-04-09 昭和電工株式会社 酵素含有水溶性マイクロカプセルの製造法
US5733763A (en) 1988-08-19 1998-03-31 Novo Nordisk A/S Enzyme granulate formed of an enzyme-containing core and an enzyme-containing shell
DK78089D0 (da) 1989-02-20 1989-02-20 Novo Industri As Detergentholdigt granulat og fremgangsmaade til fremstilling deraf
DK78189D0 (da) 1989-02-20 1989-02-20 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
DK306289D0 (da) 1989-06-21 1989-06-21 Novo Nordisk As Detergentadditiv i granulatform
CA2030581C (en) 1989-11-24 2000-06-27 Gunther Atzl Pancreatin preparations
IT1246350B (it) 1990-07-11 1994-11-17 Eurand Int Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili
JP3055799B2 (ja) * 1990-11-21 2000-06-26 塩野義製薬株式会社 パンクレアチン含有組成物
BR9107280A (pt) * 1990-12-31 1994-06-14 Pioneer Hi Bred Int Bactérias microencapsuladas em disco rotatório em ácido graxo, secas
JPH0790565B2 (ja) 1991-08-06 1995-10-04 株式会社日本製鋼所 樹脂成形プレスのスライド制御方法及びその装置
US5225202A (en) 1991-09-30 1993-07-06 E. R. Squibb & Sons, Inc. Enteric coated pharmaceutical compositions
WO1993007859A1 (en) 1991-10-23 1993-04-29 Warner-Lambert Company Novel pharmaceutical pellets and process for their production
SE9200858L (sv) 1992-03-20 1993-09-21 Kabi Pharmacia Ab Metod för framställning av pellets med fördröjd frisättning
US5616483A (en) 1992-06-11 1997-04-01 Aktiebolaget Astra Genomic DNA sequences encoding human BSSL/CEL
US5260074A (en) 1992-06-22 1993-11-09 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5460812A (en) 1992-06-22 1995-10-24 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5578304A (en) 1992-06-22 1996-11-26 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
DE4227385A1 (de) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh Pankreatinmikropellets
JP3264027B2 (ja) 1993-02-24 2002-03-11 ソニー株式会社 放電セル及びその製造方法
JP2865548B2 (ja) * 1994-03-08 1999-03-08 澁谷油脂株式会社 流動性洗浄用粉粒体およびその製造法
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
DE4422433A1 (de) 1994-06-28 1996-01-04 Cognis Bio Umwelt Mehrenzymgranulat
PL179210B1 (pl) 1994-08-05 2000-08-31 Smithkline Beecham Plc Pojemnik z substancja wrazliwa na wilgoc PL PL PL PL
US5733575A (en) 1994-10-07 1998-03-31 Bpsi Holdings, Inc. Enteric film coating compositions, method of coating therewith, and coated forms
WO1996038170A1 (en) 1995-05-31 1996-12-05 Medzyme N.V. Composition to improve digestibility and utilisation of nutrients
US6057139A (en) 1995-06-29 2000-05-02 Mcneil-Ppc, Inc. Preblend of microcrystalline cellulose and lactase for making tablets
JP3510387B2 (ja) * 1995-06-30 2004-03-29 ライオン株式会社 漂白活性化剤造粒物の製造方法、該漂白活性化剤造粒物を含有する漂白剤又は洗剤の製造方法
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5750104A (en) 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
DE19622131A1 (de) 1996-06-01 1997-12-04 Solvay Enzymes Gmbh & Co Kg Neue Enzymgranulate
AU729814B2 (en) 1996-06-04 2001-02-08 Delphian Technology Inc. Improvements in detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
JPH1023888A (ja) 1996-07-10 1998-01-27 Kao Corp 酵素造粒物の製造方法
US8828432B2 (en) 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
GB9623205D0 (en) 1996-11-07 1997-01-08 Eurand Int Novel pharmaceutical compositions
US5861291A (en) 1997-02-24 1999-01-19 Biozymes Inc. Method for producing pancreatin which contains low amounts of residual organic solvent and product thereof
JPH10295374A (ja) 1997-04-30 1998-11-10 Amano Pharmaceut Co Ltd 安定な酵素顆粒の製造法
DE19721467A1 (de) * 1997-05-22 1998-11-26 Basf Ag Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe
SE9702338D0 (sv) 1997-06-18 1997-06-18 Astra Ab An analytical method and industrial process including the same
ES2137862B1 (es) 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
JP3611456B2 (ja) 1997-09-30 2005-01-19 日研化学株式会社 テオフィリン徐放性錠剤
KR19990072826A (ko) 1998-02-26 1999-09-27 우재영 판크레아틴장용코팅과립의제조방법
US7201923B1 (en) 1998-03-23 2007-04-10 General Mills, Inc. Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles
US20010024660A1 (en) 1999-09-29 2001-09-27 Ismat Ullah Enteric coated pharmaceutical composition and method of manufacturing
US7122207B2 (en) 1998-05-22 2006-10-17 Bristol-Myers Squibb Company High drug load acid labile pharmaceutical composition
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
JP3071427B2 (ja) * 1998-10-09 2000-07-31 花王株式会社 酵素粒子
DK1126826T6 (en) 1998-11-02 2019-06-24 Alkermes Pharma Ireland Ltd Multiparticulate modified release of methylphenidate
AU7405200A (en) * 1999-10-01 2001-05-10 Novozymes A/S Spray dried enzyme product
US20010046493A1 (en) 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
AU2001254730A1 (en) 2000-03-24 2001-10-03 Societe Des Produits Nestle S.A. Nutritional composition comprising hydrolysed protein
AU2001244093A1 (en) 2000-04-03 2001-10-15 Novozymes A/S Enzyme tablets for cleaning improvement
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
AR032392A1 (es) 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
AUPR272901A0 (en) 2001-01-25 2001-02-22 Gainful Plan Limited Method of preparing biological materials and preparations produced using same
EP1279402B1 (de) 2001-07-26 2006-11-29 Ethypharm Umgehüllte Allylamine oder Benzylamine enthaltende Granulate, Verfahren zur Herstellung und in der Mundhöhle dispergierbare Tabletten enthaltend die umgehüllten Granulate
JP4187085B2 (ja) 2001-08-24 2008-11-26 三菱電機株式会社 車両用乗員保護装置
US20040197321A1 (en) 2002-03-19 2004-10-07 Tibor Sipos Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients
CN1156308C (zh) 2002-04-19 2004-07-07 北京世诺医药科技有限公司 多酶组合胶囊
US20040132826A1 (en) 2002-10-25 2004-07-08 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
AU2003288988A1 (en) 2002-11-29 2004-06-23 Freund Corporation Water-based shellac coating material, process for producing the same, coated food obtained with the coating material, process for producing the same, coated medicine, process for producing the same, glazing composition for oily snack, method of glazing, and glazed oily snack
CA2419572A1 (en) 2003-02-18 2004-08-18 Axcan Pharma Inc. High dosage protease formulation
US20040213847A1 (en) 2003-04-23 2004-10-28 Matharu Amol Singh Delayed release pharmaceutical compositions containing proton pump inhibitors
ES2421538T3 (es) 2003-10-29 2013-09-03 Cystic Fibrosis Foundation Therapeutics Inc Proteasas no pancreáticas para controlar la concentración de colecistocinina (CCK) en plasma y para tratar el dolor
US7670624B2 (en) 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
DE602005009677D1 (de) 2004-03-22 2008-10-23 Solvay Pharm Gmbh Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin, mit tensiden
US20050281876A1 (en) 2004-06-18 2005-12-22 Shun-Por Li Solid dosage form for acid-labile active ingredient
US20060198838A1 (en) 2004-09-28 2006-09-07 Fallon Joan M Combination enzyme for cystic fibrosis
ES2352086T3 (es) 2004-10-14 2011-02-15 Cystic Fibrosis Foundation Therapeutics, Inc. Composiciones que contienen lipasa, proteasa y amilasa para el tratamiento de la insuficiencia pancreática.
US20070025977A1 (en) 2005-07-21 2007-02-01 Mulberg Andrew E Method of treating steatorrhea in infants
KR101199196B1 (ko) 2005-07-25 2012-11-07 (주)다산메디켐 구형의 판크레아틴 과립의 제조방법
RU2413532C2 (ru) 2005-07-29 2011-03-10 Зольвай Фармасьютиклз Гмбх Способ получения стерилизованного порошкообразного панкреатина
RU2440101C2 (ru) 2005-08-15 2012-01-20 Зольвай Фармасьютиклз Гмбх Фармацевтические композиции регулируемого высвобождения нестабильных в кислой среде лекарственных средств
KR101302841B1 (ko) 2005-08-15 2013-09-02 애보트 프러덕츠 게엠베하 장용코팅에 적합한 판크레아틴 미세펠릿 코어
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US8071089B2 (en) 2005-11-01 2011-12-06 Bio-Cat, Inc. Composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrosis as well as people suffering from pancreatic lipase insufficiency
US20070141151A1 (en) 2005-12-20 2007-06-21 Silver David I Lansoprazole orally disintegrating tablets
JP5053865B2 (ja) 2005-12-28 2012-10-24 武田薬品工業株式会社 口腔内崩壊性固形製剤の製造法
AU2007205866B2 (en) 2006-01-21 2012-11-29 Abbott Gmbh & Co. Kg Dosage form and method for the delivery of drugs of abuse
US8815312B2 (en) 2006-05-26 2014-08-26 Nestec S.A. Methods of use and nutritional compositions of Touchi Extract
US20080031998A1 (en) 2006-08-07 2008-02-07 Novozymes A/S Enzyme Granules for Animal Feed
KR100804096B1 (ko) 2006-08-31 2008-02-18 (주)아모레퍼시픽 고농도 계면활성제 계에서도 안정한 효소 캡슐 제제를포함하는 피부 세정용 조성물 및 그 제조방법
US20080199448A1 (en) 2007-02-16 2008-08-21 Ross Mairi R Enzyme composition for improving food digestion
US20090117180A1 (en) 2007-02-20 2009-05-07 Giovanni Ortenzi Stable digestive enzyme compositions
DK2079445T3 (en) 2007-02-20 2016-02-15 Allergan Pharmaceuticals Internat Ltd Stable digestive compositions
AU2008239737A1 (en) 2007-04-13 2008-10-23 Beth Israel Deaconess Medical Center, Inc. Novel nutritional food products for improved digestion and intestinal absorption
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
CN101430279A (zh) 2008-10-27 2009-05-13 江南大学 荧光分光光度法筛选催化非水相体系转酯化反应用酶的方法
US8784884B2 (en) 2009-09-17 2014-07-22 Stephen Perrett Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency
US20110135728A1 (en) 2009-12-08 2011-06-09 Miller Jennifer L Gastric retentive pharmaceutical compositions for extended release of polypeptides
CN102883712A (zh) 2010-03-19 2013-01-16 加拿大阿普塔利斯制药公司 耐胃液酶药物组合物
GB201006178D0 (en) 2010-04-14 2010-06-02 Ayanda As Composition
UY33548A (es) 2010-08-06 2012-02-29 Eurand Pharmaceuticals Inc Formula nutricional predigerida
KR20140019292A (ko) 2010-10-01 2014-02-14 아프탈리스 파르마 리미티드 장용 코팅된 저 강도 췌장 리파제 제제
WO2012052853A2 (en) 2010-10-21 2012-04-26 Aptalis Pharma Limited Oral dosing device for administration of medication
CA2831213C (en) 2011-03-27 2016-05-17 Cellresin Technologies, Llc Cyclodextrin compositions, articles, and methods
ES2558756T3 (es) 2011-08-08 2016-02-08 Aptalis Pharma Limited Método para la prueba de disolución de composiciones sólidas que contienen enzimas digestivas
KR20160055721A (ko) 2013-03-15 2016-05-18 앨러간 파마슈티컬스 인터내셔널 리미티드 장용 투여에 적합한 영양소 및 소화 효소를 함유하는 조성물
US10184121B2 (en) 2013-06-28 2019-01-22 Allergan Pharmaceuticals International Limited Methods for removing viral contaminants from pancreatic extracts
CA2919114A1 (en) 2013-07-22 2015-02-12 Aptalis Pharma Ltd. High potency pancreatin pharmaceutical compositions
RU2679832C2 (ru) 2013-08-09 2019-02-13 Аллерган Фармасьютикалз Интернэйшнл Лимитед Композиция пищеварительных ферментов, подходящая для энтерального введения
CA2915671A1 (en) 2013-11-05 2015-05-14 Allergan Pharmaceuticals International Limited High potency pancreatin pharmaceutical compositions

Also Published As

Publication number Publication date
EP1335706B1 (de) 2005-04-13
US20040101562A1 (en) 2004-05-27
CA2428837A1 (en) 2002-05-23
ES2240559T3 (es) 2005-10-16
DE60110106D1 (de) 2005-05-19
JP4555981B2 (ja) 2010-10-06
ITMI20002456A1 (it) 2002-05-15
IT1319655B1 (it) 2003-10-23
WO2002040045A2 (en) 2002-05-23
AU2002224843A1 (en) 2002-05-27
US20160120815A1 (en) 2016-05-05
US9259393B2 (en) 2016-02-16
US9884025B2 (en) 2018-02-06
JP2004513645A (ja) 2004-05-13
EP1335706A2 (de) 2003-08-20
KR20030060105A (ko) 2003-07-12
DE60110106T2 (de) 2006-03-02
WO2002040045A3 (en) 2002-10-31

Similar Documents

Publication Publication Date Title
ATE292959T1 (de) Verfahren zur herstellung von pankreasenzym enthaltende mikrosphären mit hoher stabilität
DE68925002D1 (de) Verfahren zur Herstellung von optisch-aktiven alpha-substituierten organischen Säuren und Mikroorganismen und Enzyme, die dafür verwendet werden.
ATE315050T2 (de) Verfahren zur herstellung von mehrfach vernetzten hyaluronsäurederivaten
MY129998A (en) Saccharin derivative proteolytic enzyme inhibitors
DK0966465T3 (da) Inhibitorer af IMPDH-enzymer
ATE340857T1 (de) Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph
ATE407664T1 (de) Hydrogel zusammensetzungen, geeignet zur verzögerten freisetzung von makromolekülen sowie verfahren zur herstellung derselben.
NO944448D0 (no) Nye farmasöytiske anvendelser av krill-enzymer
HUP9901418A2 (hu) Eljárás levobupivakain és analóg hatóanyagok racemizálására
DE60034885D1 (de) Enzymlauge und verfahren zu deren herstellung, enzymzubereitung, proteasezubereitungen und proteaseproduzierendes bakterium
ATE397088T1 (de) Verfahren zur herstellung von (s)- oder (r)-3,3,3-trifluor-2-hydroxy-2-methylpropionsaü e
ES2181897T3 (es) Composicion enzimatica.
DE60213874D1 (de) Verfahren zur herstellung von protease hemmenden zwischenprodukten
DE59106876D1 (de) Verfahren zur enzymatischen Herstellung optisch aktiver Cyanhydrine.
DE69632472D1 (de) Verfahren und zusammensetzung zur herstellung von austrocknungstoleranten sporen von paecitomyces fumosoroseus
ATE389010T1 (de) Verfahren zur herstellung von optisch aktiven pyridinethanol-derivaten
HUP9801439A2 (hu) Béta-D-Galakotpiranozil-D-xilózok alkalmazása bél laktáz kimutatására alkalmas készítmények és oldatok előállításánál, valamint eljárás a vegyületek előállítására
ATE417919T1 (de) Mikrobiologisches verfahren zur herstellung von amiden
ATE445702T1 (de) Butinol i esterase
BR0009636B1 (pt) processo para a preparação de insulina madura ou um derivado de insulina madura.
DE60128461D1 (de) Verfahren zur herstellung von optisch aktiven beta-amino alkoholen
DE60012802D1 (de) Verfahren zur Herstellung von optisch aktiven Cyanhydrinen
ATE540104T1 (de) Suspensionskultur von mykobakterien
ATE522604T1 (de) Verfahren zur herstellung von proteinen durch elektropulsierung
DE50109809D1 (de) Verfahren zur Herstellung von D- oder L-Menthol

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties