ATE293459T1 - Konjugate enthaltend zwei wirkstoffe - Google Patents

Konjugate enthaltend zwei wirkstoffe

Info

Publication number
ATE293459T1
ATE293459T1 AT98954603T AT98954603T ATE293459T1 AT E293459 T1 ATE293459 T1 AT E293459T1 AT 98954603 T AT98954603 T AT 98954603T AT 98954603 T AT98954603 T AT 98954603T AT E293459 T1 ATE293459 T1 AT E293459T1
Authority
AT
Austria
Prior art keywords
active ingredients
conjugates containing
carrier
linker
functional group
Prior art date
Application number
AT98954603T
Other languages
English (en)
Inventor
Nicola Jane Church
Roy Harris
Original Assignee
Quadrant Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadrant Drug Delivery Ltd filed Critical Quadrant Drug Delivery Ltd
Application granted granted Critical
Publication of ATE293459T1 publication Critical patent/ATE293459T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98954603T 1997-11-14 1998-11-16 Konjugate enthaltend zwei wirkstoffe ATE293459T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9724143.4A GB9724143D0 (en) 1997-11-14 1997-11-14 Pharmaceutical conjugate
PCT/GB1998/003442 WO1999025383A1 (en) 1997-11-14 1998-11-16 Conjugates comprising two active agents

Publications (1)

Publication Number Publication Date
ATE293459T1 true ATE293459T1 (de) 2005-05-15

Family

ID=10822123

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98954603T ATE293459T1 (de) 1997-11-14 1998-11-16 Konjugate enthaltend zwei wirkstoffe

Country Status (9)

Country Link
US (1) US7001989B2 (de)
EP (1) EP1047452B1 (de)
JP (1) JP2001523648A (de)
AT (1) ATE293459T1 (de)
AU (1) AU1165899A (de)
DE (1) DE69829880T2 (de)
ES (1) ES2238774T3 (de)
GB (1) GB9724143D0 (de)
WO (1) WO1999025383A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6933366B2 (en) * 1996-12-27 2005-08-23 Tripep Ab Specificity exchangers that redirect antibodies to bacterial adhesion receptors
WO1999064072A1 (de) * 1998-06-10 1999-12-16 Baxter Aktiengesellschaft Konjugat, bestehend aus einem lektin und einem blutgerinnungsfaktor
GB9825105D0 (en) * 1998-11-16 1999-01-13 Andaris Ltd Pharamaceutical conjugates
GB9827813D0 (en) * 1998-12-17 1999-02-10 Andaris Ltd Pharmaceutical conjugates
DE19926475A1 (de) * 1999-06-10 2000-12-14 Ktb Tumorforschungs Gmbh Träger-Pharmaka-Konjugate
AU6389000A (en) * 1999-07-28 2001-02-19 Valentis, Inc. Sonoporation of tumors
GB0323378D0 (en) * 2003-10-07 2003-11-05 Univ Leicester Therapeutic agent
NZ572531A (en) 2006-05-05 2011-09-30 Univ Michigan Bivalent smac mimetics and the uses thereof
GB0623607D0 (en) * 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
US20090170195A1 (en) * 2007-12-28 2009-07-02 Kent State University Curcumin-hyaluronan compounds
CN102112144A (zh) * 2008-05-16 2011-06-29 拜耳医药保健有限公司 靶向性凝固因子及其使用方法
ES2427627T3 (es) * 2009-04-06 2013-10-31 Novo Nordisk A/S Entrega dirigida de proteínas de Factor VIII a plaquetas
GB201101740D0 (en) 2011-02-01 2011-03-16 Haemostatix Ltd Therapeutic agents with improved fibrinogen binding

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970300A (en) * 1985-02-01 1990-11-13 New York University Modified factor VIII
IL85372A (en) * 1987-02-12 1992-12-01 Us Health Penta to nona-peptides with laminin - like activity having an amino acid sequence and anti- metastatic compositions containing them
US5716614A (en) * 1994-08-05 1998-02-10 Molecular/Structural Biotechnologies, Inc. Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier
BR9510462A (pt) * 1994-12-16 1998-12-15 Andaris Ltd Micropartículas reticuladas e seu uso como veículos terapéuticos
AU6100296A (en) 1995-06-06 1996-12-24 Hemosphere, Inc. Protein particles for therapeutic and diagnostic use
WO1998017319A2 (en) * 1996-10-21 1998-04-30 Quadrant Healthcare (Uk) Limited Platelet substitutes and conjugation methods suitable for their preparation

Also Published As

Publication number Publication date
DE69829880D1 (de) 2005-05-25
AU1165899A (en) 1999-06-07
GB9724143D0 (en) 1998-01-14
EP1047452A1 (de) 2000-11-02
DE69829880T2 (de) 2005-09-22
US7001989B2 (en) 2006-02-21
US20030087826A1 (en) 2003-05-08
WO1999025383A1 (en) 1999-05-27
JP2001523648A (ja) 2001-11-27
ES2238774T3 (es) 2005-09-01
EP1047452B1 (de) 2005-04-20

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