ATE293685T1 - Monoklonaler antikörper gegen ratte beta-2- integrin alpha d untereinheit und entsprechendes hybridoma - Google Patents

Monoklonaler antikörper gegen ratte beta-2- integrin alpha d untereinheit und entsprechendes hybridoma

Info

Publication number
ATE293685T1
ATE293685T1 AT97906713T AT97906713T ATE293685T1 AT E293685 T1 ATE293685 T1 AT E293685T1 AT 97906713 T AT97906713 T AT 97906713T AT 97906713 T AT97906713 T AT 97906713T AT E293685 T1 ATE293685 T1 AT E293685T1
Authority
AT
Austria
Prior art keywords
subunit
integrin alpha
monoclonal antibody
antibody against
against rat
Prior art date
Application number
AT97906713T
Other languages
English (en)
Inventor
W Michael Gallatin
Der Vieren Monica Van
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Application granted granted Critical
Publication of ATE293685T1 publication Critical patent/ATE293685T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT97906713T 1996-02-22 1997-02-24 Monoklonaler antikörper gegen ratte beta-2- integrin alpha d untereinheit und entsprechendes hybridoma ATE293685T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/605,672 US5817515A (en) 1993-12-23 1996-02-22 Human B2 integrin alpha subunit antibodies
PCT/US1997/002713 WO1997031099A1 (en) 1996-02-22 1997-02-24 Human beta 2 integrin alpha subunit

Publications (1)

Publication Number Publication Date
ATE293685T1 true ATE293685T1 (de) 2005-05-15

Family

ID=24424704

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97906713T ATE293685T1 (de) 1996-02-22 1997-02-24 Monoklonaler antikörper gegen ratte beta-2- integrin alpha d untereinheit und entsprechendes hybridoma

Country Status (18)

Country Link
US (1) US5817515A (de)
EP (1) EP0835301B1 (de)
JP (1) JP2001526524A (de)
CN (1) CN1103812C (de)
AT (1) ATE293685T1 (de)
AU (1) AU723110B2 (de)
BR (1) BR9702101A (de)
CA (1) CA2218755C (de)
CZ (1) CZ287921B6 (de)
DE (1) DE69733051D1 (de)
FI (1) FI974018L (de)
HU (1) HU223977B1 (de)
IL (1) IL122011A (de)
NO (1) NO318764B1 (de)
PL (1) PL187013B1 (de)
RU (1) RU2183671C2 (de)
SK (1) SK283135B6 (de)
WO (1) WO1997031099A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620915B2 (en) * 1993-12-23 2003-09-16 Icos Corporation Monoclonal antibodies specific for integrin α-d subunit
US5837478A (en) * 1993-12-23 1998-11-17 Icos Corporation Method of identifying modulators of binding between and VCAM-1
US20030055231A1 (en) * 1998-10-28 2003-03-20 Jian Ni 12 human secreted proteins
WO2001070266A2 (en) 2000-03-17 2001-09-27 Millennium Pharmaceuticals, Inc. Method of inhibiting stenosis and restenosis with a mixture of antibodies anti cd18 and anti ccr2
EP4536705A4 (de) * 2022-06-08 2026-04-22 Univ California Antikörper und immuntherapien, die auf die aktive konformation von integrin-beta 2 abzielen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271139A (en) * 1978-03-27 1981-06-02 Hiram Hart Scintillation proximity assay
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
WO1992006697A1 (en) * 1990-10-23 1992-04-30 Repligen Corporation Anti-inflammatory composition
AU667487B2 (en) * 1991-10-01 1996-03-28 General Hospital Corporation, The Preventing allograft rejection with antibodies to adhesion molecules
JP3679112B2 (ja) * 1991-10-04 2005-08-03 アメリカ合衆国 細胞接着分子の遮断による眼の炎症の治療
US5470953A (en) * 1993-12-23 1995-11-28 Icos Corporation Human β2 integrin α subunit
WO1995027736A1 (en) * 1994-04-12 1995-10-19 Boehringer Ingelheim Pharmaceuticals, Inc. Use of agents which block intercellular adhesion molecule/receptor interaction in the treatment of respiratory viral infection

Also Published As

Publication number Publication date
IL122011A0 (en) 1998-03-10
FI974018A0 (fi) 1997-10-21
DE69733051D1 (de) 2005-05-25
IL122011A (en) 2001-05-20
SK283135B6 (sk) 2003-03-04
BR9702101A (pt) 1999-07-20
PL323195A1 (en) 1998-03-16
EP0835301B1 (de) 2005-04-20
CA2218755C (en) 1999-08-31
WO1997031099A1 (en) 1997-08-28
HU223977B1 (hu) 2005-03-29
NO318764B1 (no) 2005-05-02
AU2133397A (en) 1997-09-10
SK140997A3 (en) 1998-09-09
AU723110B2 (en) 2000-08-17
CZ328697A3 (cs) 1998-07-15
RU2183671C2 (ru) 2002-06-20
CA2218755A1 (en) 1997-08-28
HUP9901579A2 (hu) 1999-08-30
NO974852L (no) 1997-12-19
CN1103812C (zh) 2003-03-26
PL187013B1 (pl) 2004-04-30
NO974852D0 (no) 1997-10-21
JP2001526524A (ja) 2001-12-18
HUP9901579A3 (en) 2001-10-29
CZ287921B6 (cs) 2001-03-14
EP0835301A1 (de) 1998-04-15
CN1189851A (zh) 1998-08-05
FI974018A7 (fi) 1997-12-03
US5817515A (en) 1998-10-06
FI974018L (fi) 1997-12-03

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