ATE294164T1 - Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening - Google Patents

Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening

Info

Publication number
ATE294164T1
ATE294164T1 AT99964612T AT99964612T ATE294164T1 AT E294164 T1 ATE294164 T1 AT E294164T1 AT 99964612 T AT99964612 T AT 99964612T AT 99964612 T AT99964612 T AT 99964612T AT E294164 T1 ATE294164 T1 AT E294164T1
Authority
AT
Austria
Prior art keywords
fluorescent dyes
screening
solid phase
liquid phase
phase
Prior art date
Application number
AT99964612T
Other languages
English (en)
Inventor
Manfred Auer
Hubert Gstach
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE294164T1 publication Critical patent/ATE294164T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
AT99964612T 1998-12-21 1999-12-20 Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening ATE294164T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/217,795 US6207831B1 (en) 1998-12-21 1998-12-21 Fluorescent dyes (AIDA) for solid phase and solution phase screening
PCT/EP1999/010126 WO2000037448A1 (en) 1998-12-21 1999-12-20 Fluorescent dyes for solid phase and solution phase screening

Publications (1)

Publication Number Publication Date
ATE294164T1 true ATE294164T1 (de) 2005-05-15

Family

ID=22812559

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99964612T ATE294164T1 (de) 1998-12-21 1999-12-20 Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening

Country Status (8)

Country Link
US (3) US6207831B1 (de)
EP (1) EP1140856B1 (de)
JP (1) JP2002533329A (de)
AT (1) ATE294164T1 (de)
AU (1) AU3040300A (de)
CA (1) CA2356344A1 (de)
DE (1) DE69925032T2 (de)
WO (1) WO2000037448A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207831B1 (en) * 1998-12-21 2001-03-27 Novartis Ag Fluorescent dyes (AIDA) for solid phase and solution phase screening
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
EP3034627B1 (de) 2000-10-06 2019-01-30 The Trustees of Columbia University in the City of New York Massives paralleles verfahren zum entschlüsseln von dna und rna
GB0026560D0 (en) * 2000-10-30 2000-12-13 Novartis Ag Organic compounds
US6972326B2 (en) * 2001-12-03 2005-12-06 Molecular Probes, Inc. Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes
GB0208989D0 (en) * 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
GB0228429D0 (en) * 2002-12-05 2003-01-08 Novartis Ag Organic compounds
DE102004016247A1 (de) * 2004-04-02 2005-10-20 Chromeon Gmbh Feste Trägersysteme zum homogenen Nachweis von Wechselwirkungen von Biomolekülen ohne Waschschritte
WO2007053702A2 (en) 2005-10-31 2007-05-10 The Trustees Of Columbia University In The City Of New York Synthesis of four color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods
US8796432B2 (en) * 2005-10-31 2014-08-05 The Trustees Of Columbia University In The City Of New York Chemically cleavable 3'-o-allyl-DNTP-allyl-fluorophore fluorescent nucleotide analogues and related methods
GB2457402B (en) 2006-12-01 2011-10-19 Univ Columbia Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
WO2009000775A1 (en) * 2007-06-22 2008-12-31 Novartis Ag Post-screening labeling of on-bead compounds
EP2207900B1 (de) 2007-10-19 2015-04-29 The Trustees of Columbia University in the City of New York Konstruktion und synthese spaltbarer fluoreszenznukleotide als reversible terminatoren für die dna-sequenzierung mittels synthese
EP2209911B1 (de) 2007-10-19 2013-10-16 The Trustees of Columbia University in the City of New York Dna-sequenzierung mit reversiblen nicht-fluoreszenz-nukleotid-terminatoren und mit einer spaltbaren markierung modifizierten nukleotidterminatoren und eine deoxyinosineverbindung mit einer reversiblen terminatorgruppe
US20110039289A1 (en) * 2008-03-14 2011-02-17 Pierre Graves Fluorogenic peptides and their method of production
CA2748500C (en) 2009-01-29 2017-10-17 Commonwealth Scientific And Industrial Research Organisation Measuring g protein coupled receptor activation
DE102009013147A1 (de) * 2009-03-05 2010-09-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Spektroskopie heterogener Proben
CA2812208C (en) * 2010-09-24 2019-10-22 The Governing Council Of The University Of Toronto Synthesis of fluorescent noble metal nanoparticles
WO2012162429A2 (en) 2011-05-23 2012-11-29 The Trustees Of Columbia University In The City Of New York Dna sequencing by synthesis using raman and infrared spectroscopy detection
JP6182525B2 (ja) * 2011-06-23 2017-08-16 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー ｉＦＲＥＴ用探針及びその用途
KR101320097B1 (ko) * 2011-06-23 2013-10-18 한국생명공학연구원 고유 형광 공명 에너지 전이용 탐침을 이용한 단백질 검출 또는 이미지화 현미경 장치 및 이를 이용한 단백질 검출 또는 이미징방법
WO2014144883A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
DE102013012685A1 (de) * 2013-07-31 2015-02-05 Johann-Wolfgang-Goethe Universität Frankfurt am Main Arylierte Pyrazolderivate und deren Verwendung als Fluoreszenzfarbstoffe
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
US20210255104A1 (en) * 2020-02-18 2021-08-19 Reflectronics, Inc. Light extinction of fluorescence for composition measurements
CN113702342B (zh) * 2021-04-21 2022-12-06 苏州科技大学 一种利用荧光转换检测溶液中汞离子的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003385A1 (fr) 1987-10-13 1989-04-20 Yoshitomi Pharmaceutical Industries, Ltd. Composes de pyrazole fusionnes, procede de preparation et utilisation en medecine
CA2136228A1 (en) 1992-05-21 1993-11-25 Masao Hisadome Use for treating thrombocytopenia, use for treating erythropenia and optically active fused pyrazole compound
WO1998041866A1 (en) 1997-03-14 1998-09-24 Merck & Co., Inc. A high throughput assay using fusion proteins
US6207831B1 (en) * 1998-12-21 2001-03-27 Novartis Ag Fluorescent dyes (AIDA) for solid phase and solution phase screening
US7135288B2 (en) * 2002-09-27 2006-11-14 Ut-Battelle, Llc Combinatorial synthesis of ceramic materials

Also Published As

Publication number Publication date
DE69925032T2 (de) 2006-03-09
WO2000037448A1 (en) 2000-06-29
US20050227299A1 (en) 2005-10-13
JP2002533329A (ja) 2002-10-08
DE69925032D1 (de) 2005-06-02
US20010005752A1 (en) 2001-06-28
US6207831B1 (en) 2001-03-27
EP1140856A1 (de) 2001-10-10
CA2356344A1 (en) 2000-06-29
EP1140856B1 (de) 2005-04-27
AU3040300A (en) 2000-07-12

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