ATE294179T1 - Synthese acyclischer nucleosid-derivate - Google Patents

Synthese acyclischer nucleosid-derivate

Info

Publication number: ATE294179T1
Authority: AT; Austria
Prior art keywords: chem; compound; formula; synthesis; nucleoside derivatives
Prior art date: 1998-08-06

Application number

AT99948005T

Other languages

English (en)

Inventor

M Robert Leanna

Steven M Hannick

Michael Rasmussen

Jien-Heh J Tien

Lakshmi Bhagavatula

Pulla Reddy Singam

Bradley D Gates

Lawrence Kolaczkowski

Ramesh R Patel

Greg Wayne

Greg Lannoye

Weijiang Zhang

Kirill A Lukin

Bikshandarkor Narayanan

David A Riley

Howard Morton

Sou-Jen Chang

Cynthia B Curty

Daniel Plata

John Bellettini

Bhadra Shellat

Tiffany Spitz

Cheng-Xi Yang

Zhenping Tian

Original Assignee

Medivir Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-06

Filing date

1999-08-05

Publication date

2005-05-15

1999-08-05 Application filed by Medivir Ab filed Critical Medivir Ab

2005-05-15 Application granted granted Critical

2005-05-15 Publication of ATE294179T1 publication Critical patent/ATE294179T1/de

Links

230000015572 biosynthetic process Effects 0.000 title 1
150000003833 nucleoside derivatives Chemical class 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
229920006395 saturated elastomer Polymers 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT99948005T 1998-08-06 1999-08-05 Synthese acyclischer nucleosid-derivate ATE294179T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/130,214 US6184376B1 (en)	1997-02-10	1998-08-06	Synthesis of acyclic nucleoside derivatives
PCT/SE1999/001339 WO2000008025A1 (en)	1998-08-06	1999-08-05	Synthesis of acyclic nucleoside derivatives

Publications (1)

Publication Number	Publication Date
ATE294179T1 true ATE294179T1 (de)	2005-05-15

Family

ID=22443606

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99948005T ATE294179T1 (de)	1998-08-06	1999-08-05	Synthese acyclischer nucleosid-derivate

Country Status (10)

Country	Link
US (5)	US6184376B1 (de)
EP (2)	EP1131323B1 (de)
JP (1)	JP2002522439A (de)
AT (1)	ATE294179T1 (de)
AU (1)	AU765286B2 (de)
CA (1)	CA2339250C (de)
DE (1)	DE69925023T2 (de)
ES (1)	ES2237942T3 (de)
IL (2)	IL141161A0 (de)
WO (1)	WO2000008025A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AUPQ806700A0 (en) *	2000-06-08	2000-07-06	Commonwealth Scientific And Industrial Research Organisation	Antiviral agents
SE0102273D0 (sv) *	2001-06-26	2001-06-26	Medivir Ab	Improved synthesis of branched acyclic nucleosides
WO2003084957A1 (en) *	2002-04-08	2003-10-16	Sumika Fine Chemicals Co., Ltd.	Crystal and solvate of 2-amino-6-benzyloxypurine and production methods thereof
EP1371658B1 (de) *	2002-06-13	2007-09-12	L'oreal	Glucose und Vitamin F Derivate, Zusammensetzungen, Verwendung und Verfahren zu deren Herstellung
TWI332507B (en) *	2002-11-19	2010-11-01	Hoffmann La Roche	Antiviral nucleoside derivatives
CN1742018A (zh) *	2002-12-10	2006-03-01	弗·哈夫曼-拉罗切有限公司	抗病毒的核苷衍生物
US20080233053A1 (en) *	2005-02-07	2008-09-25	Pharmalight Inc.	Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients
FR2914920B1 (fr) *	2007-04-11	2011-09-09	Clariant Specialty Fine Chem F	Procede de deacetalisation d'alpha-aminoacetals.
AU2008305666B2 (en) *	2007-09-21	2014-08-28	Epiphany Biosciences, Inc.	Valomaciclovir polymorphs
US7939336B2 (en) *	2008-09-30	2011-05-10	Calera Corporation	Compositions and methods using substances containing carbon
WO2014047562A2 (en) *	2012-09-21	2014-03-27	Epiphany Biosciences	Method of treating and/or preventing shingles and method of treating and/or preventing zoster associated pain
US11408892B2 (en)	2013-06-18	2022-08-09	The Trustees Of Columbia University In The City Of New York	Devices, compositions and methods for imaging with raman scattering
WO2014205074A2 (en) *	2013-06-18	2014-12-24	The Trustees Of Columbia University In The City Of New York	Devices, compositions and methods for imaging with raman scattering
US12038377B2 (en)	2013-06-18	2024-07-16	The Trustees Of Columbia University In The City Of New York	Devices, compositions and methods for imaging with Raman scattering
EP3194358A4 (de) *	2014-09-15	2018-02-14	Elevance Renewable Sciences, Inc.	Olefinische esterzusammensetzungen mit niedriger toxizität und verfahren zur verwendung davon

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8801729D0 (sv)	1988-05-06	1988-05-06	Astra Ab	Purine derivatives for use in therapy
US5284837A (en)	1988-05-06	1994-02-08	Medivir Ab	Derivatives of purine, process for their preparation and a pharmaceutical preparation
US5216141A (en)	1988-06-06	1993-06-01	Benner Steven A	Oligonucleotide analogs containing sulfur linkages
US5874578A (en)	1992-07-13	1999-02-23	Bristol-Myers Squibb	Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
US5298651A (en) *	1992-10-15	1994-03-29	Monsanto Company	Process for preparing isocyanates using phosphazine catalysts
WO1995022330A1 (en)	1994-02-17	1995-08-24	Commonwealth Scientific And Industrial Research Organisation	Antiviral agents
PE32296A1 (es)	1994-07-28	1996-08-07	Hoffmann La Roche	Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
JP3906488B2 (ja)	1995-02-21	2007-04-18	味の素株式会社	プリン誘導体の製造方法
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
EP0827960A1 (de)	1996-09-10	1998-03-11	Ajinomoto Co., Inc.	Verfahren zur Herstellung von Purinderivaten
CA2572577C (en)	1997-02-10	2011-04-05	Medivir Ab	Synthesis of acyclic nucleoside derivatives

1998
- 1998-08-06 US US09/130,214 patent/US6184376B1/en not_active Expired - Lifetime
1999
- 1999-08-05 WO PCT/SE1999/001339 patent/WO2000008025A1/en not_active Ceased
- 1999-08-05 CA CA002339250A patent/CA2339250C/en not_active Expired - Fee Related
- 1999-08-05 EP EP99948005A patent/EP1131323B1/de not_active Expired - Lifetime
- 1999-08-05 AU AU61271/99A patent/AU765286B2/en not_active Ceased
- 1999-08-05 DE DE69925023T patent/DE69925023T2/de not_active Expired - Lifetime
- 1999-08-05 ES ES99948005T patent/ES2237942T3/es not_active Expired - Lifetime
- 1999-08-05 AT AT99948005T patent/ATE294179T1/de not_active IP Right Cessation
- 1999-08-05 JP JP2000563658A patent/JP2002522439A/ja active Pending
- 1999-08-05 IL IL14116199A patent/IL141161A0/xx active IP Right Grant
- 1999-08-05 EP EP05001026A patent/EP1535923A1/de not_active Withdrawn
2000
- 2000-10-18 US US09/692,599 patent/US6613936B1/en not_active Expired - Fee Related
2001
- 2001-01-29 IL IL141161A patent/IL141161A/en not_active IP Right Cessation
2002
- 2002-12-09 US US10/315,580 patent/US6878844B2/en not_active Expired - Fee Related
2004
- 2004-06-17 US US10/871,751 patent/US20040248910A1/en not_active Abandoned
2005
- 2005-05-18 US US11/131,646 patent/US7189849B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL141161A0 (en)	2002-02-10
AU765286B2 (en)	2003-09-11
US7189849B2 (en)	2007-03-13
DE69925023D1 (en)	2005-06-02
IL141161A (en)	2007-07-24
WO2000008025A1 (en)	2000-02-17
EP1535923A1 (de)	2005-06-01
US6613936B1 (en)	2003-09-02
US20040248910A1 (en)	2004-12-09
AU6127199A (en)	2000-02-28
US6878844B2 (en)	2005-04-12
DE69925023T2 (de)	2006-03-09
US20040024214A1 (en)	2004-02-05
EP1131323A1 (de)	2001-09-12
CA2339250C (en)	2008-07-15
US20050250795A1 (en)	2005-11-10
US6184376B1 (en)	2001-02-06
ES2237942T3 (es)	2005-08-01
CA2339250A1 (en)	2000-02-17
EP1131323B1 (de)	2005-04-27
JP2002522439A (ja)	2002-07-23

Legal Events

Date	Code	Title	Description
2005-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE294179T1 (de)	2005-05-15	Synthese acyclischer nucleosid-derivate
FI973063A7 (fi)	1997-09-18	Guaniinijohdannainen
MY133531A (en)	2007-11-30	Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds
ATE90358T1 (de)	1993-06-15	Zwischenprodukte in der synthese von diaminandrostan-derivaten.
DK0443606T3 (da)	1995-07-10	4-(4-Alkoxyphenyl)-2-butylaminderivat og fremstilling deraf
ES2151850B1 (es)	2001-08-16	Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
EA199800378A1 (ru)	1998-10-29	Новый способ получения фенилимидазолидиновых производных
EA200000484A1 (ru)	2000-10-30	Способ получения производных тиазолидиндиона
BG105198A (en)	2001-12-29	Process for the synthesis of (1h)-benzo[c]quinolizin-3-ones derivatives
RO85812B (ro)	1984-11-30	Procedeu pentru prepararea de derivati de azolilpentena
Nishiyama et al.	1994	One-Pot Synthesis of Ethyl 3-(2-Hydroxyalkyl) aminoalkanoates by Ring Opening of 1, 3-Oxazolidines Using Reformatsky Reagent.
DE69102315D1 (de)	1994-07-14	Pyridinderivate und Verfahren zu ihrer Synthese.
IL142760A (en)	2005-12-18	Method for producing 4-Ä(2',5'-diamino-6'- halopyrimidine-4' -yl) aminoÜ-cyclopent -2- enyl-methanols
KR940005570A (ko)	1994-03-21	피롤리디닐아세트아미드 유도체의 제조방법
FR2584720B1 (fr)	1987-10-02	Procede de preparation de derives n-methyles de l'ergoline
EP0807617A4 (de)	1999-10-13	Verfahren zur herstellung von 1,5-pentandiol-derivaten
DE69806957D1 (de)	2002-09-05	Vinylether derivate
Trkovnik et al.	1975	4H-BENZPYRANO [3, 4-d] OXAZOL-4-ONES AND 3-[N, N-BIS (CARBOXYMETHYL) AMINO]-4-HYDROXYCOUMARIN DERIVATIVES
ES2018661B3 (es)	1991-05-01	Procedimiento mejorado para la obtencion de dihidro-1h-pirrolizin-3,5-(2h,6h)-diona.
ATE108767T1 (de)	1994-08-15	Acyclische terpene.
DE69933441D1 (de)	2006-11-16	Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position
FR2670490B1 (fr)	1994-09-23	Procede de preparation de derives "syn" du propanamide.
Kreysa et al.	1961	Synthesis of 3, 3'-Thiobis (6-methylphenol)
ES2154632T3 (es)	2001-04-16	Procedimiento para la produccion de derivados de azacicloalcanos.
FR2722112B1 (fr)	1996-08-30	Procede de depollution de composes gazeux avec des produits de synthese