ATE295424T1 - Verbesserung der enzymatischen synthese von chiralen aminen - Google Patents

Verbesserung der enzymatischen synthese von chiralen aminen

Info

Publication number
ATE295424T1
ATE295424T1 AT99911250T AT99911250T ATE295424T1 AT E295424 T1 ATE295424 T1 AT E295424T1 AT 99911250 T AT99911250 T AT 99911250T AT 99911250 T AT99911250 T AT 99911250T AT E295424 T1 ATE295424 T1 AT E295424T1
Authority
AT
Austria
Prior art keywords
aminopropane
improvement
enzymatic synthesis
transaminase
chiral amines
Prior art date
Application number
AT99911250T
Other languages
English (en)
Inventor
Wei Wu
Mohit B Bhatia
Craig M Lewis
Wei Lang
Alice Wang
George W Matcham
Original Assignee
Celgro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgro filed Critical Celgro
Application granted granted Critical
Publication of ATE295424T1 publication Critical patent/ATE295424T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99911250T 1998-03-11 1999-03-10 Verbesserung der enzymatischen synthese von chiralen aminen ATE295424T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7752098P 1998-03-11 1998-03-11
PCT/US1999/005150 WO1999046398A1 (en) 1998-03-11 1999-03-10 Improvements in the enzymatic synthesis of chiral amines

Publications (1)

Publication Number Publication Date
ATE295424T1 true ATE295424T1 (de) 2005-05-15

Family

ID=22138554

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99911250T ATE295424T1 (de) 1998-03-11 1999-03-10 Verbesserung der enzymatischen synthese von chiralen aminen

Country Status (23)

Country Link
EP (1) EP1075534B8 (de)
JP (1) JP2002505884A (de)
KR (1) KR20010034561A (de)
CN (1) CN1154746C (de)
AT (1) ATE295424T1 (de)
AU (1) AU753904B2 (de)
BR (1) BR9908797A (de)
CA (1) CA2322605A1 (de)
CZ (1) CZ295882B6 (de)
DE (1) DE69925267T2 (de)
ES (1) ES2243051T3 (de)
FI (1) FI20001805A7 (de)
HU (1) HUP0101056A3 (de)
MX (1) MXPA00008573A (de)
NO (1) NO319671B1 (de)
NZ (1) NZ506405A (de)
PL (1) PL342882A1 (de)
PT (1) PT1075534E (de)
RU (1) RU2213142C2 (de)
SK (1) SK284352B6 (de)
TR (1) TR200002604T2 (de)
UA (1) UA64784C2 (de)
WO (1) WO1999046398A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1038953B1 (de) * 1999-03-19 2004-09-22 Sumitomo Chemical Company, Limited Stereoselektive Transaminase, deren kodierende Gen und deren Verwendungen
JP2001190298A (ja) * 2000-01-13 2001-07-17 Kanegafuchi Chem Ind Co Ltd 光学活性ｎ−メチルアミノ酸の製造方法
EP1818411A1 (de) * 2006-02-13 2007-08-15 Lonza AG Verfahren zur Herstellung von optisch aktiven chiralen Aminen
DE102007042600A1 (de) 2007-09-07 2009-03-12 Evonik Degussa Gmbh Verfahren zur Herstellung von enantiomerenangereichten Aminen
HUE036104T2 (hu) 2009-01-08 2018-06-28 Codexis Inc Transzamináz polipeptidek
JP5707344B2 (ja) 2009-02-26 2015-04-30 コデクシス， インコーポレイテッド トランスアミナーゼ生体触媒
CN102597226B (zh) 2009-06-22 2015-08-19 科德克希思公司 转氨酶反应
EP2862938A3 (de) * 2009-09-02 2015-07-15 Lonza AG Verfahren zur Identifikation und Herstellung von (R)-spezifischer Omega-Transaminase
DK2582799T3 (en) 2010-06-17 2018-02-12 Codexis Inc BIOCATALATORS AND PROCEDURES FOR THE SYNTHESIS OF (S) -3- (1-AMINOETHYL) -PHENOL
US8932836B2 (en) 2010-08-16 2015-01-13 Codexis, Inc. Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
EP2744908A4 (de) * 2011-08-16 2015-05-27 Embio Ltd Enzymatische synthese optisch aktiver chiraler amine
CN104630170A (zh) * 2013-11-08 2015-05-20 中国科学院天津工业生物技术研究所 一种来源于里氏木霉的新(r)-转氨酶及其应用
CN114134126B (zh) * 2021-10-28 2023-12-05 浙江大学杭州国际科创中心 转氨酶及其突变体在制备(s)-1-甲氧基-2-丙胺中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300437A (en) * 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US4950606A (en) * 1989-06-22 1990-08-21 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
WO1997015682A1 (en) * 1995-10-23 1997-05-01 Kaneka Corporation Process for producing optically active amino compounds

Also Published As

Publication number Publication date
MXPA00008573A (es) 2003-07-14
NO20004036L (no) 2000-10-27
FI20001805L (fi) 2000-08-15
NZ506405A (en) 2003-08-29
TR200002604T2 (tr) 2000-11-21
NO319671B1 (no) 2005-09-05
SK13382000A3 (sk) 2001-05-10
ES2243051T3 (es) 2005-11-16
NO20004036D0 (no) 2000-08-11
EP1075534A1 (de) 2001-02-14
EP1075534B8 (de) 2005-07-06
DE69925267T2 (de) 2006-01-26
PL342882A1 (en) 2001-07-16
RU2213142C2 (ru) 2003-09-27
JP2002505884A (ja) 2002-02-26
CZ20003177A3 (cs) 2000-12-13
PT1075534E (pt) 2005-09-30
CN1154746C (zh) 2004-06-23
HUP0101056A2 (hu) 2001-07-30
HK1035000A1 (en) 2001-11-09
AU2993899A (en) 1999-09-27
DE69925267D1 (de) 2005-06-16
EP1075534B1 (de) 2005-05-11
CN1292828A (zh) 2001-04-25
WO1999046398A1 (en) 1999-09-16
HUP0101056A3 (en) 2006-03-28
EP1075534A4 (de) 2003-07-09
SK284352B6 (sk) 2005-02-04
UA64784C2 (en) 2004-03-15
CA2322605A1 (en) 1999-09-16
KR20010034561A (ko) 2001-04-25
BR9908797A (pt) 2000-12-12
AU753904B2 (en) 2002-10-31
FI20001805A7 (fi) 2000-09-11
CZ295882B6 (cs) 2005-11-16

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